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P30279 (CCND2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified August 10, 2010. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
Customize displayNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents

Names and origin

Protein namesRecommended name:
G1/S-specific cyclin-D2
Gene names
Name:CCND2
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Essential for the control of the cell cycle at the G1/S (start) transition.

Subunit structure

Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.

Sequence similarities

Belongs to the cyclin family. Cyclin D subfamily.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CDK4P118021EBI-748789,EBI-295644

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289G1/S-specific cyclin-D2
PRO_0000080437

Natural variations

Natural variant2681G → R. [dbSNP:rs3217921] Ref.5
VAR_018820

Experimental info

Sequence conflict166 – 1672KL → NV in AAA51928. Ref.9
Sequence conflict2241T → H in AAA51928. Ref.9

Sequences

Sequence LengthMass (Da)Tools
P30279-1 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: E4E5FEF476D76D90

FASTA28933,067
        10         20         30         40         50         60 
MELLCHEVDP VRRAVRDRNL LRDDRVLQNL LTIEERYLPQ CSYFKCVQKD IQPYMRRMVA 

        70         80         90        100        110        120 
TWMLEVCEEQ KCEEEVFPLA MNYLDRFLAG VPTPKSHLQL LGAVCMFLAS KLKETSPLTA 

       130        140        150        160        170        180 
EKLCIYTDNS IKPQELLEWE LVVLGKLKWN LAAVTPHDFI EHILRKLPQQ REKLSLIRKH 

       190        200        210        220        230        240 
AQTFIALCAT DFKFAMYPPS MIATGSVGAA ICGLQQDEEV SSLTCDALTE LLAKITNTDV 

       250        260        270        280 
DCLKACQEQI EAVLLNSLQQ YRQDQRDGSK SEDELDQAST PTDVRDIDL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins."
Xiong Y., Menninger J., Beach D., Ward D.C.
Genomics 13:575-584(1992) [PubMed: 1386336] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines."
Palmero I., Holder A., Sinclair A.J., Dickson C., Peters G.
Oncogene 8:1049-1054(1993) [PubMed: 8455931] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]Miyajima N.
Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Bone marrow.
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]NIEHS SNPs program
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-268.
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone marrow and Uterus.
[9]"Genomic organization, chromosomal localization, and independent expression of human cyclin D genes."
Inaba T., Matsushime H., Valentine M., Roussel M.F., Sherr C.J., Look A.T.
Genomics 13:565-574(1992) [PubMed: 1386335] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-240.
Tissue: Placenta.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M90813 mRNA. Translation: AAA51926.1.
X68452 mRNA. Translation: CAA48493.1.
D13639 mRNA. Translation: BAA02802.1.
BT019847 mRNA. Translation: AAV38650.1.
AF518005 Genomic DNA. Translation: AAM54041.1.
AK291146 mRNA. Translation: BAF83835.1.
CH471116 Genomic DNA. Translation: EAW88851.1.
BC010958 mRNA. Translation: AAH10958.1.
BC089384 mRNA. Translation: AAH89384.1.
M88083 expand/collapse EMBL AC list , M88080, M88081, M88082 Genomic DNA. Translation: AAA51928.1.
IPIIPI00025810.
PIRA42822.
RefSeqNP_001750.1.
UniGeneHs.376071.

3D structure databases

ProteinModelPortalP30279.
SMRP30279. Positions 21-254.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-178N.
IntActP30279. 5 interactions.
MINTMINT-1433179.
STRINGP30279.

PTM databases

PhosphoSiteP30279.

Proteomic databases

PRIDEP30279.

Genome annotation databases

EnsemblENST00000261254; ENSP00000261254; ENSG00000118971; Homo sapiens. [Genome view]
GeneID894.
KEGGhsa:894.
UCSCuc001qmo.1. human.

Organism-specific databases

CTD894.
GeneCardsGC12P004382.
H-InvDBHIX0010346.
HGNCHGNC:1583. CCND2.
MIM123833. gene.
PharmGKBPA26150.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG10224.
HOGENOMHBG713252.
HOVERGENHBG050837.
InParanoidP30279.
OMAICGLQLD.
OrthoDBEOG98WFM7.
PhylomeDBP30279.

Enzyme and pathway databases

Pathway_Interaction_DBil2_stat5pathway. IL2 signaling events mediated by STAT5.
ReactomeREACT_152. Cell Cycle, Mitotic.

Gene expression databases

ArrayExpressP30279.
BgeeP30279.
CleanExHS_CCND2.
GenevestigatorP30279.
GermOnlineENSG00000118971. Homo sapiens.

Family and domain databases

InterProIPR015451. CycD.
IPR006670. Cyclin.
IPR011028. Cyclin-like.
IPR014400. Cyclin_A_B_D_E.
IPR004367. Cyclin_C.
IPR006671. Cyclin_N.
IPR013763. Cyclin_related.
[Graphical view]
Gene3DG3DSA:1.10.472.10. Cyclin_related. 1 hit.
PANTHERPTHR10177:SF12. CycD. 1 hit.
PfamPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMSSF47954. Cyclin_like. 2 hits.
PROSITEPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio3696.
SOURCESearch...

Entry information

Entry nameCCND2_HUMAN
AccessionPrimary (citable) accession number: P30279
Secondary accession number(s): A8K531, Q13955, Q5U035
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: August 10, 2010
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families