P30279 (CCND2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G1/S-specific cyclin-D2

Gene names

Name:

CCND2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Essential for the control of the cell cycle at the G1/S (start) transition.
Subunit structure	Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.
Sequence similarities	Belongs to the cyclin family. Cyclin D subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Coding sequence diversity	Polymorphism
Molecular function	Cyclin
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of cyclin-dependent protein kinase activity Inferred from direct assay. Source: BHF-UCL positive regulation of protein amino acid phosphorylation Inferred from direct assay. Source: BHF-UCL
Cellular component	cyclin-dependent protein kinase holoenzyme complex Inferred from direct assay. Source: BHF-UCL nucleus Inferred from electronic annotation. Source: InterPro
Molecular function	protein kinase binding Inferred from physical interaction. Source: BHF-UCL
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CDK4	P11802	1	EBI-748789,EBI-295644

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 289	289	G1/S-specific cyclin-D2		PRO_0000080437
Natural variations
	Natural variant	268	1	G → R. [dbSNP:rs3217921] Ref.5		VAR_018820
Experimental info
	Sequence conflict	166 – 167	2	KL → NV in AAA51928. Ref.9
	Sequence conflict	224	1	T → H in AAA51928. Ref.9

Sequences

	Sequence		Length	Mass (Da)
	P30279-1 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: E4E5FEF476D76D90	FASTA	289	33,067
	10 20 30 40 50 60 MELLCHEVDP VRRAVRDRNL LRDDRVLQNL LTIEERYLPQ CSYFKCVQKD IQPYMRRMVA 70 80 90 100 110 120 TWMLEVCEEQ KCEEEVFPLA MNYLDRFLAG VPTPKSHLQL LGAVCMFLAS KLKETSPLTA 130 140 150 160 170 180 EKLCIYTDNS IKPQELLEWE LVVLGKLKWN LAAVTPHDFI EHILRKLPQQ REKLSLIRKH 190 200 210 220 230 240 AQTFIALCAT DFKFAMYPPS MIATGSVGAA ICGLQQDEEV SSLTCDALTE LLAKITNTDV 250 260 270 280 DCLKACQEQI EAVLLNSLQQ YRQDQRDGSK SEDELDQAST PTDVRDIDL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins." Xiong Y., Menninger J., Beach D., Ward D.C. Genomics 13:575-584(1992) [PubMed: 1386336] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines." Palmero I., Holder A., Sinclair A.J., Dickson C., Peters G. Oncogene 8:1049-1054(1993) [PubMed: 8455931] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	Miyajima N. Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Bone marrow.
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	NIEHS SNPs program Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-268.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow and Uterus.
[9]	"Genomic organization, chromosomal localization, and independent expression of human cyclin D genes." Inaba T., Matsushime H., Valentine M., Roussel M.F., Sherr C.J., Look A.T. Genomics 13:565-574(1992) [PubMed: 1386335] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-240. Tissue: Placenta.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	M90813 mRNA. Translation: AAA51926.1. X68452 mRNA. Translation: CAA48493.1. D13639 mRNA. Translation: BAA02802.1. BT019847 mRNA. Translation: AAV38650.1. AF518005 Genomic DNA. Translation: AAM54041.1. AK291146 mRNA. Translation: BAF83835.1. CH471116 Genomic DNA. Translation: EAW88851.1. BC010958 mRNA. Translation: AAH10958.1. BC089384 mRNA. Translation: AAH89384.1. M88083 , M88080, M88081, M88082 Genomic DNA. Translation: AAA51928.1.
IPI	IPI00025810.
PIR	A42822.
RefSeq	NP_001750.1.
UniGene	Hs.376071.
3D structure databases
ProteinModelPortal	P30279.
SMR	P30279. Positions 21-254.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-178N.
IntAct	P30279. 5 interactions.
MINT	MINT-1433179.
STRING	P30279.
PTM databases
PhosphoSite	P30279.
Proteomic databases
PRIDE	P30279.
Genome annotation databases
Ensembl	ENST00000261254; ENSP00000261254; ENSG00000118971; Homo sapiens. [Genome view]
GeneID	894.
KEGG	hsa:894.
UCSC	uc001qmo.1. human.
Organism-specific databases
CTD	894.
GeneCards	GC12P004382.
H-InvDB	HIX0010346.
HGNC	HGNC:1583. CCND2.
MIM	123833. gene.
PharmGKB	PA26150.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10224.
HOGENOM	HBG713252.
HOVERGEN	HBG050837.
InParanoid	P30279.
OMA	ICGLQLD.
OrthoDB	EOG98WFM7.
PhylomeDB	P30279.
Enzyme and pathway databases
Pathway_Interaction_DB	il2_stat5pathway. IL2 signaling events mediated by STAT5.
Reactome	REACT_152. Cell Cycle, Mitotic.
Gene expression databases
ArrayExpress	P30279.
Bgee	P30279.
CleanEx	HS_CCND2.
Genevestigator	P30279.
GermOnline	ENSG00000118971. Homo sapiens.
Family and domain databases
InterPro	IPR015451. CycD. IPR006670. Cyclin. IPR011028. Cyclin-like. IPR014400. Cyclin_A_B_D_E. IPR004367. Cyclin_C. IPR006671. Cyclin_N. IPR013763. Cyclin_related. [Graphical view]
Gene3D	G3DSA:1.10.472.10. Cyclin_related. 1 hit.
PANTHER	PTHR10177:SF12. CycD. 1 hit.
Pfam	PF02984. Cyclin_C. 1 hit. PF00134. Cyclin_N. 1 hit. [Graphical view]
PIRSF	PIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMART	SM00385. CYCLIN. 1 hit. [Graphical view]
SUPFAM	SSF47954. Cyclin_like. 2 hits.
PROSITE	PS00292. CYCLINS. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	3696.
SOURCE	Search...

Entry information

Entry name

CCND2_HUMAN

Accession

Primary (citable) accession number: P30279
Secondary accession number(s): A8K531, Q13955, Q5U035

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	August 10, 2010
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.