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P30276

- CCNB2_MOUSE

UniProt

P30276 - CCNB2_MOUSE

Protein

G2/mitotic-specific cyclin-B2

Gene

Ccnb2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Essential for the control of the cell cycle at the G2/M (mitosis) transition.

    GO - Biological processi

    1. growth Source: MGI
    2. in utero embryonic development Source: MGI
    3. mitotic nuclear division Source: UniProtKB-KW
    4. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
    5. T cell homeostasis Source: MGI
    6. thymus development Source: MGI

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Enzyme and pathway databases

    ReactomeiREACT_196632. Condensation of Prometaphase Chromosomes.
    REACT_196635. Regulation of PLK1 Activity at G2/M Transition.
    REACT_196645. Activation of NIMA Kinases NEK9, NEK6, NEK7.
    REACT_196650. Nuclear Pore Complex (NPC) Disassembly.
    REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_206803. Cyclin A/B1 associated events during G2/M transition.
    REACT_209377. Cyclin B2 mediated events.
    REACT_223573. G2/M DNA replication checkpoint.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G2/mitotic-specific cyclin-B2
    Gene namesi
    Name:Ccnb2
    Synonyms:Cycb2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:88311. Ccnb2.

    Subcellular locationi

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. membrane Source: MGI
    3. nucleus Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 398398G2/mitotic-specific cyclin-B2PRO_0000080363Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei99 – 991PhosphoserineBy similarity
    Modified residuei392 – 3921PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP30276.

    Expressioni

    Developmental stagei

    Accumulates steadily during G2 and is abruptly destroyed at mitosis.

    Gene expression databases

    BgeeiP30276.
    CleanExiMM_CCNB2.
    GenevestigatoriP30276.

    Interactioni

    Subunit structurei

    Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000034742.

    Structurei

    3D structure databases

    ProteinModelPortaliP30276.
    SMRiP30276. Positions 131-390.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin AB subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG5024.
    GeneTreeiENSGT00750000117276.
    HOGENOMiHOG000167672.
    HOVERGENiHBG061650.
    InParanoidiQ922E9.
    KOiK05868.
    OMAiMCVAIMD.
    OrthoDBiEOG7ZGX3C.
    TreeFamiTF101001.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    InterProiIPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR004367. Cyclin_C-dom.
    IPR006671. Cyclin_N.
    [Graphical view]
    PfamiPF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTiSM00385. CYCLIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    PROSITEiPS00292. CYCLINS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30276-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALLRRPTVS SDLKNIDTEV IPKAKSHVTI RRAVLEEIGN KVRNRTTQVA    50
    KKPQNTKVPA LPTKVTNVNK QPKPTASVKP VQMEALAPKD RPPAPEDVSM 100
    KEESLCQAFS DALLCKIEDI DNEDRENPQL CSDYVKDIYQ YLRQLEVLQS 150
    INPHFLDGRD INGRMRAILV DWLVQVHSKF RLLQETLYMC IAIMDRFLQA 200
    QLVCRKKLQL VGITALLLAS KYEEMFSPNI EDFVYITDNA YTSSQIREME 250
    TLILKELKFE LGRPLPLHFL RRASKAGEVD VEQHTLAKYL MELTLVDYDM 300
    VHYHPSQVAA AASCLSQKVL GQGKWNLKQQ YYTGYMESEV LEVMQHMAKN 350
    VVKVNDNRTK FIAVKNKYAS SRLLKISTIP QLNSKIIKDL ASPLLGSP 398
    Length:398
    Mass (Da):45,383
    Last modified:July 27, 2011 - v2
    Checksum:i8AB8F569550BE32C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti62 – 621P → S in CAA46831. (PubMed:8375336)Curated
    Sequence conflicti192 – 1921A → G in CAA46831. (PubMed:8375336)Curated
    Sequence conflicti210 – 2101L → V in CAA46831. (PubMed:8375336)Curated
    Sequence conflicti377 – 3793STI → KHD in CAA46831. (PubMed:8375336)Curated
    Sequence conflicti391 – 3911A → V in CAA46831. (PubMed:8375336)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X66032 mRNA. Translation: CAA46831.1.
    AK076122 mRNA. Translation: BAC36200.1.
    CT010286 mRNA. Translation: CAJ18494.1.
    CH466522 Genomic DNA. Translation: EDL26195.1.
    BC008247 mRNA. Translation: AAH08247.1.
    CCDSiCCDS23320.1.
    PIRiI48315. S21529.
    RefSeqiNP_031656.2. NM_007630.2.
    UniGeneiMm.22592.

    Genome annotation databases

    EnsembliENSMUST00000034742; ENSMUSP00000034742; ENSMUSG00000032218.
    GeneIDi12442.
    KEGGimmu:12442.
    UCSCiuc009qny.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X66032 mRNA. Translation: CAA46831.1 .
    AK076122 mRNA. Translation: BAC36200.1 .
    CT010286 mRNA. Translation: CAJ18494.1 .
    CH466522 Genomic DNA. Translation: EDL26195.1 .
    BC008247 mRNA. Translation: AAH08247.1 .
    CCDSi CCDS23320.1.
    PIRi I48315. S21529.
    RefSeqi NP_031656.2. NM_007630.2.
    UniGenei Mm.22592.

    3D structure databases

    ProteinModelPortali P30276.
    SMRi P30276. Positions 131-390.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000034742.

    Proteomic databases

    PRIDEi P30276.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034742 ; ENSMUSP00000034742 ; ENSMUSG00000032218 .
    GeneIDi 12442.
    KEGGi mmu:12442.
    UCSCi uc009qny.1. mouse.

    Organism-specific databases

    CTDi 9133.
    MGIi MGI:88311. Ccnb2.

    Phylogenomic databases

    eggNOGi COG5024.
    GeneTreei ENSGT00750000117276.
    HOGENOMi HOG000167672.
    HOVERGENi HBG061650.
    InParanoidi Q922E9.
    KOi K05868.
    OMAi MCVAIMD.
    OrthoDBi EOG7ZGX3C.
    TreeFami TF101001.

    Enzyme and pathway databases

    Reactomei REACT_196632. Condensation of Prometaphase Chromosomes.
    REACT_196635. Regulation of PLK1 Activity at G2/M Transition.
    REACT_196645. Activation of NIMA Kinases NEK9, NEK6, NEK7.
    REACT_196650. Nuclear Pore Complex (NPC) Disassembly.
    REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_206803. Cyclin A/B1 associated events during G2/M transition.
    REACT_209377. Cyclin B2 mediated events.
    REACT_223573. G2/M DNA replication checkpoint.

    Miscellaneous databases

    NextBioi 281250.
    PROi P30276.
    SOURCEi Search...

    Gene expression databases

    Bgeei P30276.
    CleanExi MM_CCNB2.
    Genevestigatori P30276.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    InterProi IPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR004367. Cyclin_C-dom.
    IPR006671. Cyclin_N.
    [Graphical view ]
    Pfami PF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTi SM00385. CYCLIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    PROSITEi PS00292. CYCLINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of the murine cyclin B2 cDNA and characterization of the lineage and temporal specificity of expression of the B1 and B2 cyclins during oogenesis, spermatogenesis and early embryogenesis."
      Chapman D.L., Wolgemuth D.J.
      Development 118:229-240(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    3. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
      Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiCCNB2_MOUSE
    AccessioniPrimary (citable) accession number: P30276
    Secondary accession number(s): Q922E9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3