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Protein

G2/mitotic-specific cyclin-B2

Gene

Ccnb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition.

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • growth Source: MGI
  • in utero embryonic development Source: MGI
  • mitotic nuclear division Source: UniProtKB-KW
  • T cell homeostasis Source: MGI
  • thymus development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-2500257. Resolution of Sister Chromatid Cohesion.
R-MMU-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-MMU-2980767. Activation of NIMA Kinases NEK9, NEK6, NEK7.
R-MMU-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-MMU-69273. Cyclin A/B1 associated events during G2/M transition.
R-MMU-69478. G2/M DNA replication checkpoint.
R-MMU-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-B2
Gene namesi
Name:Ccnb2
Synonyms:Cycb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:88311. Ccnb2.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: MGI
  • centrosome Source: MGI
  • membrane Source: MGI
  • microtubule cytoskeleton Source: MGI
  • nucleus Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000803631 – 398G2/mitotic-specific cyclin-B2Add BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphothreonineBy similarity1
Modified residuei11PhosphoserineBy similarity1
Modified residuei77PhosphoserineBy similarity1
Modified residuei99PhosphoserineBy similarity1
Modified residuei392PhosphoserineBy similarity1
Modified residuei397PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP30276.
MaxQBiP30276.
PaxDbiP30276.
PeptideAtlasiP30276.
PRIDEiP30276.

PTM databases

iPTMnetiP30276.
PhosphoSitePlusiP30276.

Expressioni

Developmental stagei

Accumulates steadily during G2 and is abruptly destroyed at mitosis.

Gene expression databases

BgeeiENSMUSG00000032218.
CleanExiMM_CCNB2.
GenevisibleiP30276. MM.

Interactioni

Subunit structurei

Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034742.

Structurei

3D structure databases

ProteinModelPortaliP30276.
SMRiP30276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
GeneTreeiENSGT00760000118939.
HOGENOMiHOG000167672.
HOVERGENiHBG061650.
InParanoidiP30276.
KOiK05868.
OMAiDHEDWEN.
OrthoDBiEOG091G0E9B.
TreeFamiTF101001.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30276-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLRRPTVS SDLKNIDTEV IPKAKSHVTI RRAVLEEIGN KVRNRTTQVA
60 70 80 90 100
KKPQNTKVPA LPTKVTNVNK QPKPTASVKP VQMEALAPKD RPPAPEDVSM
110 120 130 140 150
KEESLCQAFS DALLCKIEDI DNEDRENPQL CSDYVKDIYQ YLRQLEVLQS
160 170 180 190 200
INPHFLDGRD INGRMRAILV DWLVQVHSKF RLLQETLYMC IAIMDRFLQA
210 220 230 240 250
QLVCRKKLQL VGITALLLAS KYEEMFSPNI EDFVYITDNA YTSSQIREME
260 270 280 290 300
TLILKELKFE LGRPLPLHFL RRASKAGEVD VEQHTLAKYL MELTLVDYDM
310 320 330 340 350
VHYHPSQVAA AASCLSQKVL GQGKWNLKQQ YYTGYMESEV LEVMQHMAKN
360 370 380 390
VVKVNDNRTK FIAVKNKYAS SRLLKISTIP QLNSKIIKDL ASPLLGSP
Length:398
Mass (Da):45,383
Last modified:July 27, 2011 - v2
Checksum:i8AB8F569550BE32C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62P → S in CAA46831 (PubMed:8375336).Curated1
Sequence conflicti192A → G in CAA46831 (PubMed:8375336).Curated1
Sequence conflicti210L → V in CAA46831 (PubMed:8375336).Curated1
Sequence conflicti377 – 379STI → KHD in CAA46831 (PubMed:8375336).Curated3
Sequence conflicti391A → V in CAA46831 (PubMed:8375336).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66032 mRNA. Translation: CAA46831.1.
AK076122 mRNA. Translation: BAC36200.1.
CT010286 mRNA. Translation: CAJ18494.1.
CH466522 Genomic DNA. Translation: EDL26195.1.
BC008247 mRNA. Translation: AAH08247.1.
CCDSiCCDS23320.1.
PIRiI48315. S21529.
RefSeqiNP_031656.2. NM_007630.2.
UniGeneiMm.22592.

Genome annotation databases

EnsembliENSMUST00000034742; ENSMUSP00000034742; ENSMUSG00000032218.
GeneIDi12442.
KEGGimmu:12442.
UCSCiuc009qny.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66032 mRNA. Translation: CAA46831.1.
AK076122 mRNA. Translation: BAC36200.1.
CT010286 mRNA. Translation: CAJ18494.1.
CH466522 Genomic DNA. Translation: EDL26195.1.
BC008247 mRNA. Translation: AAH08247.1.
CCDSiCCDS23320.1.
PIRiI48315. S21529.
RefSeqiNP_031656.2. NM_007630.2.
UniGeneiMm.22592.

3D structure databases

ProteinModelPortaliP30276.
SMRiP30276.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034742.

PTM databases

iPTMnetiP30276.
PhosphoSitePlusiP30276.

Proteomic databases

EPDiP30276.
MaxQBiP30276.
PaxDbiP30276.
PeptideAtlasiP30276.
PRIDEiP30276.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034742; ENSMUSP00000034742; ENSMUSG00000032218.
GeneIDi12442.
KEGGimmu:12442.
UCSCiuc009qny.1. mouse.

Organism-specific databases

CTDi9133.
MGIiMGI:88311. Ccnb2.

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
GeneTreeiENSGT00760000118939.
HOGENOMiHOG000167672.
HOVERGENiHBG061650.
InParanoidiP30276.
KOiK05868.
OMAiDHEDWEN.
OrthoDBiEOG091G0E9B.
TreeFamiTF101001.

Enzyme and pathway databases

ReactomeiR-MMU-2500257. Resolution of Sister Chromatid Cohesion.
R-MMU-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-MMU-2980767. Activation of NIMA Kinases NEK9, NEK6, NEK7.
R-MMU-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-MMU-69273. Cyclin A/B1 associated events during G2/M transition.
R-MMU-69478. G2/M DNA replication checkpoint.
R-MMU-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.

Miscellaneous databases

PROiP30276.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032218.
CleanExiMM_CCNB2.
GenevisibleiP30276. MM.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCNB2_MOUSE
AccessioniPrimary (citable) accession number: P30276
Secondary accession number(s): Q922E9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.