Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P30276

- CCNB2_MOUSE

UniProt

P30276 - CCNB2_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

G2/mitotic-specific cyclin-B2

Gene

Ccnb2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition.

GO - Biological processi

  1. growth Source: MGI
  2. in utero embryonic development Source: MGI
  3. mitotic nuclear division Source: UniProtKB-KW
  4. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
  5. T cell homeostasis Source: MGI
  6. thymus development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiREACT_196632. Condensation of Prometaphase Chromosomes.
REACT_196635. Regulation of PLK1 Activity at G2/M Transition.
REACT_196645. Activation of NIMA Kinases NEK9, NEK6, NEK7.
REACT_196650. Nuclear Pore Complex (NPC) Disassembly.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_206803. Cyclin A/B1 associated events during G2/M transition.
REACT_209377. Cyclin B2 mediated events.
REACT_223573. G2/M DNA replication checkpoint.

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-B2
Gene namesi
Name:Ccnb2
Synonyms:Cycb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:88311. Ccnb2.

Subcellular locationi

GO - Cellular componenti

  1. centrosome Source: Ensembl
  2. membrane Source: MGI
  3. nucleus Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398G2/mitotic-specific cyclin-B2PRO_0000080363Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei99 – 991PhosphoserineBy similarity
Modified residuei392 – 3921PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP30276.
PRIDEiP30276.

Expressioni

Developmental stagei

Accumulates steadily during G2 and is abruptly destroyed at mitosis.

Gene expression databases

BgeeiP30276.
CleanExiMM_CCNB2.
GenevestigatoriP30276.

Interactioni

Subunit structurei

Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034742.

Structurei

3D structure databases

ProteinModelPortaliP30276.
SMRiP30276. Positions 131-390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiCOG5024.
GeneTreeiENSGT00760000118939.
HOGENOMiHOG000167672.
HOVERGENiHBG061650.
InParanoidiP30276.
KOiK05868.
OMAiMCVAIMD.
OrthoDBiEOG7ZGX3C.
TreeFamiTF101001.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30276-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALLRRPTVS SDLKNIDTEV IPKAKSHVTI RRAVLEEIGN KVRNRTTQVA
60 70 80 90 100
KKPQNTKVPA LPTKVTNVNK QPKPTASVKP VQMEALAPKD RPPAPEDVSM
110 120 130 140 150
KEESLCQAFS DALLCKIEDI DNEDRENPQL CSDYVKDIYQ YLRQLEVLQS
160 170 180 190 200
INPHFLDGRD INGRMRAILV DWLVQVHSKF RLLQETLYMC IAIMDRFLQA
210 220 230 240 250
QLVCRKKLQL VGITALLLAS KYEEMFSPNI EDFVYITDNA YTSSQIREME
260 270 280 290 300
TLILKELKFE LGRPLPLHFL RRASKAGEVD VEQHTLAKYL MELTLVDYDM
310 320 330 340 350
VHYHPSQVAA AASCLSQKVL GQGKWNLKQQ YYTGYMESEV LEVMQHMAKN
360 370 380 390
VVKVNDNRTK FIAVKNKYAS SRLLKISTIP QLNSKIIKDL ASPLLGSP
Length:398
Mass (Da):45,383
Last modified:July 27, 2011 - v2
Checksum:i8AB8F569550BE32C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621P → S in CAA46831. (PubMed:8375336)Curated
Sequence conflicti192 – 1921A → G in CAA46831. (PubMed:8375336)Curated
Sequence conflicti210 – 2101L → V in CAA46831. (PubMed:8375336)Curated
Sequence conflicti377 – 3793STI → KHD in CAA46831. (PubMed:8375336)Curated
Sequence conflicti391 – 3911A → V in CAA46831. (PubMed:8375336)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X66032 mRNA. Translation: CAA46831.1.
AK076122 mRNA. Translation: BAC36200.1.
CT010286 mRNA. Translation: CAJ18494.1.
CH466522 Genomic DNA. Translation: EDL26195.1.
BC008247 mRNA. Translation: AAH08247.1.
CCDSiCCDS23320.1.
PIRiI48315. S21529.
RefSeqiNP_031656.2. NM_007630.2.
UniGeneiMm.22592.

Genome annotation databases

EnsembliENSMUST00000034742; ENSMUSP00000034742; ENSMUSG00000032218.
GeneIDi12442.
KEGGimmu:12442.
UCSCiuc009qny.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X66032 mRNA. Translation: CAA46831.1 .
AK076122 mRNA. Translation: BAC36200.1 .
CT010286 mRNA. Translation: CAJ18494.1 .
CH466522 Genomic DNA. Translation: EDL26195.1 .
BC008247 mRNA. Translation: AAH08247.1 .
CCDSi CCDS23320.1.
PIRi I48315. S21529.
RefSeqi NP_031656.2. NM_007630.2.
UniGenei Mm.22592.

3D structure databases

ProteinModelPortali P30276.
SMRi P30276. Positions 131-390.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000034742.

Proteomic databases

MaxQBi P30276.
PRIDEi P30276.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034742 ; ENSMUSP00000034742 ; ENSMUSG00000032218 .
GeneIDi 12442.
KEGGi mmu:12442.
UCSCi uc009qny.1. mouse.

Organism-specific databases

CTDi 9133.
MGIi MGI:88311. Ccnb2.

Phylogenomic databases

eggNOGi COG5024.
GeneTreei ENSGT00760000118939.
HOGENOMi HOG000167672.
HOVERGENi HBG061650.
InParanoidi P30276.
KOi K05868.
OMAi MCVAIMD.
OrthoDBi EOG7ZGX3C.
TreeFami TF101001.

Enzyme and pathway databases

Reactomei REACT_196632. Condensation of Prometaphase Chromosomes.
REACT_196635. Regulation of PLK1 Activity at G2/M Transition.
REACT_196645. Activation of NIMA Kinases NEK9, NEK6, NEK7.
REACT_196650. Nuclear Pore Complex (NPC) Disassembly.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_206803. Cyclin A/B1 associated events during G2/M transition.
REACT_209377. Cyclin B2 mediated events.
REACT_223573. G2/M DNA replication checkpoint.

Miscellaneous databases

NextBioi 281250.
PROi P30276.
SOURCEi Search...

Gene expression databases

Bgeei P30276.
CleanExi MM_CCNB2.
Genevestigatori P30276.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
InterProi IPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view ]
Pfami PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTi SM00385. CYCLIN. 2 hits.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS00292. CYCLINS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of the murine cyclin B2 cDNA and characterization of the lineage and temporal specificity of expression of the B1 and B2 cyclins during oogenesis, spermatogenesis and early embryogenesis."
    Chapman D.L., Wolgemuth D.J.
    Development 118:229-240(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
    Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiCCNB2_MOUSE
AccessioniPrimary (citable) accession number: P30276
Secondary accession number(s): Q922E9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3