Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P30273 (FCERG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
High affinity immunoglobulin epsilon receptor subunit gamma
Alternative name(s):
Fc receptor gamma-chain
Short name=FcRgamma
Fc-epsilon RI-gamma
IgE Fc receptor subunit gamma
Short name=FceRI gamma
Gene names
Name:FCER1G
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length86 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin. Ref.3

Subunit structure

IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors like FCGR1A. Associated with CLEC6A By similarity. Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages By similarity. Interacts with CD300LH; the interaction may be indirect By similarity. Interacts with CD300LD By similarity. Interacts with CLEC4E. Ref.3 Ref.5

Subcellular location

Cell membrane; Single-pass type I membrane protein Ref.3.

Sequence similarities

Belongs to the CD3Z/FCER1G family.

Contains 1 ITAM domain.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   LigandIgE-binding protein
   Molecular functionReceptor
   PTMDisulfide bond
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processFc receptor mediated stimulatory signaling pathway

Inferred from electronic annotation. Source: Ensembl

Fc-epsilon receptor signaling pathway

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class I

Inferred from electronic annotation. Source: Ensembl

antigen processing and presentation of exogenous peptide antigen via MHC class II

Inferred from electronic annotation. Source: Ensembl

blood coagulation

Traceable author statement. Source: Reactome

defense response to bacterium

Inferred from electronic annotation. Source: Ensembl

immunoglobulin mediated immune response

Inferred from electronic annotation. Source: Ensembl

innate immune response

Traceable author statement. Source: Reactome

integrin-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

leukocyte migration

Traceable author statement. Source: Reactome

mast cell activation

Inferred from electronic annotation. Source: Ensembl

negative regulation of mast cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

neutrophil activation involved in immune response

Inferred from electronic annotation. Source: Ensembl

neutrophil chemotaxis

Inferred from electronic annotation. Source: Ensembl

phagocytosis, engulfment

Inferred from electronic annotation. Source: Ensembl

platelet activation

Traceable author statement. Source: Reactome

positive regulation of interleukin-10 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-6 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of mast cell cytokine production

Inferred from electronic annotation. Source: Ensembl

positive regulation of mast cell degranulation

Inferred from electronic annotation. Source: Ensembl

positive regulation of phagocytosis

Inferred from electronic annotation. Source: Ensembl

positive regulation of tumor necrosis factor production

Inferred from electronic annotation. Source: Ensembl

positive regulation of type I hypersensitivity

Inferred from electronic annotation. Source: Ensembl

positive regulation of type III hypersensitivity

Inferred from electronic annotation. Source: Ensembl

positive regulation of type IIa hypersensitivity

Inferred from electronic annotation. Source: Ensembl

regulation of platelet activation

Inferred from electronic annotation. Source: Ensembl

serotonin secretion by platelet

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentFc-epsilon receptor I complex

Inferred from electronic annotation. Source: Ensembl

cell surface

Inferred from direct assay PubMed 1535625. Source: UniProtKB

external side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionIgE receptor activity

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction PubMed 8810294PubMed 9280292. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SYKP434052EBI-515289,EBI-78302

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 8668High affinity immunoglobulin epsilon receptor subunit gamma
PRO_0000016501

Regions

Topological domain19 – 235Extracellular Potential
Transmembrane24 – 4421Helical; Potential
Topological domain45 – 8642Cytoplasmic Potential
Domain54 – 8229ITAM

Amino acid modifications

Modified residue651Phosphotyrosine By similarity
Modified residue761Phosphotyrosine By similarity
Modified residue781Phosphothreonine By similarity
Disulfide bond25Interchain By similarity

Sequences

Sequence LengthMass (Da)Tools
P30273 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 2F2C7536513D6165

FASTA869,667
        10         20         30         40         50         60 
MIPAVVLLLL LLVEQAAALG EPQLCYILDA ILFLYGIVLT LLYCRLKIQV RKAAITSYEK 

        70         80 
SDGVYTGLST RNQETYETLK HEKPPQ 

« Hide

References

« Hide 'large scale' references
[1]"Characterization and expression of the gene for the human Fc receptor gamma subunit. Definition of a new gene family."
Kuester H., Thompson H., Kinet J.-P.
J. Biol. Chem. 265:6448-6452(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo."
van Vugt M.J., Heijnen I.A.F.M., Capel P.J.A., Park S.Y., Ra C., Saito T., Verbeek J.S., van de Winkel J.G.J.
Blood 87:3593-3599(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH FCGR1A, SUBCELLULAR LOCATION.
[4]"Phosphoproteome of resting human platelets."
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A.
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Platelet.
[5]"Mincle is an ITAM-coupled activating receptor that senses damaged cells."
Yamasaki S., Ishikawa E., Sakuma M., Hara H., Ogata K., Saito T.
Nat. Immunol. 9:1179-1188(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CLEC4E.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M33195 mRNA. Translation: AAA35828.1.
M33196 Genomic DNA. No translation available.
AL590714 Genomic DNA. Translation: CAH72149.1.
CCDSCCDS1225.1.
PIRA35241.
RefSeqNP_004097.1. NM_004106.1.
UniGeneHs.433300.

3D structure databases

DisProtDP00509.
ProteinModelPortalP30273.
SMRP30273. Positions 21-53.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108501. 3 interactions.
DIPDIP-29514N.
IntActP30273. 5 interactions.
MINTMINT-6622796.
STRING9606.ENSP00000289902.

Chemistry

DrugBankDB00895. Benzylpenicilloyl Polylysine.

PTM databases

PhosphoSiteP30273.

Polymorphism databases

DMDM232085.

Proteomic databases

PaxDbP30273.
PRIDEP30273.

Protocols and materials databases

DNASU2207.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000289902; ENSP00000289902; ENSG00000158869.
GeneID2207.
KEGGhsa:2207.
UCSCuc001fyz.1. human.

Organism-specific databases

CTD2207.
GeneCardsGC01P161185.
HGNCHGNC:3611. FCER1G.
HPACAB022108.
HPA026872.
MIM147139. gene.
neXtProtNX_P30273.
PharmGKBPA28057.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47881.
HOGENOMHOG000293158.
HOVERGENHBG051601.
KOK07983.
OMALYCRLKL.
PhylomeDBP30273.
TreeFamTF330937.

Enzyme and pathway databases

ReactomeREACT_604. Hemostasis.
REACT_6900. Immune System.

Gene expression databases

ArrayExpressP30273.
BgeeP30273.
CleanExHS_FCER1G.
GenevestigatorP30273.

Family and domain databases

InterProIPR021663. CR3_zeta/IgE_Fc_rcpt_gamma.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PfamPF02189. ITAM. 1 hit.
PF11628. TCR_zetazeta. 1 hit.
[Graphical view]
SMARTSM00077. ITAM. 1 hit.
[Graphical view]
PROSITEPS51055. ITAM_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi2207.
NextBio8939.
PROP30273.
SOURCESearch...

Entry information

Entry nameFCERG_HUMAN
AccessionPrimary (citable) accession number: P30273
Secondary accession number(s): Q5VTW4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 9, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM