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Protein

High affinity immunoglobulin epsilon receptor subunit gamma

Gene

FCER1G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

IgE-binding protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158869-MONOMER.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-202733. Cell surface interactions at the vascular wall.
R-HSA-2454202. Fc epsilon receptor (FCERI) signaling.
R-HSA-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-2871809. FCERI mediated Ca+2 mobilization.
R-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-5621480. Dectin-2 family.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-75892. Platelet Adhesion to exposed collagen.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin epsilon receptor subunit gamma
Alternative name(s):
Fc receptor gamma-chain
Short name:
FcRgamma
Fc-epsilon RI-gamma
IgE Fc receptor subunit gamma
Short name:
FceRI gamma
Gene namesi
Name:FCER1G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:3611. FCER1G.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 23ExtracellularSequence analysis5
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Topological domaini45 – 86CytoplasmicSequence analysisAdd BLAST42

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2207.
OpenTargetsiENSG00000158869.
PharmGKBiPA28057.

Chemistry databases

DrugBankiDB00895. Benzylpenicilloyl Polylysine.

Polymorphism and mutation databases

BioMutaiFCER1G.
DMDMi232085.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001650119 – 86High affinity immunoglobulin epsilon receptor subunit gammaAdd BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25InterchainBy similarity
Modified residuei65PhosphotyrosinePROSITE-ProRule annotationBy similarity1
Modified residuei69PhosphoserineCombined sources1
Modified residuei76PhosphotyrosinePROSITE-ProRule annotationBy similarity1
Modified residuei78PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiP30273.
PaxDbiP30273.
PeptideAtlasiP30273.
PRIDEiP30273.
TopDownProteomicsiP30273.

PTM databases

iPTMnetiP30273.
PhosphoSitePlusiP30273.

Expressioni

Gene expression databases

BgeeiENSG00000158869.
CleanExiHS_FCER1G.
ExpressionAtlasiP30273. baseline and differential.
GenevisibleiP30273. HS.

Organism-specific databases

HPAiCAB022108.
HPA026872.

Interactioni

Subunit structurei

IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors like FCGR1A. Associated with CLEC6A (By similarity). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages (By similarity). Interacts with CD300LH; the interaction may be indirect (By similarity). Interacts with CD300LD (By similarity). Interacts with CLEC4E.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SYKP434052EBI-515289,EBI-78302

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108501. 2 interactors.
DIPiDIP-29514N.
IntActiP30273. 5 interactors.
MINTiMINT-6622796.
STRINGi9606.ENSP00000289902.

Structurei

3D structure databases

DisProtiDP00509.
ProteinModelPortaliP30273.
SMRiP30273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 82ITAMPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the CD3Z/FCER1G family.Curated
Contains 1 ITAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J5TQ. Eukaryota.
ENOG410Z3W0. LUCA.
GeneTreeiENSGT00390000003894.
HOGENOMiHOG000293158.
HOVERGENiHBG051601.
InParanoidiP30273.
KOiK07983.
OMAiLYCRLKL.
PhylomeDBiP30273.
TreeFamiTF330937.

Family and domain databases

InterProiIPR021663. CD3_zeta/IgE_Fc_rcpt_gamma.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PfamiPF02189. ITAM. 1 hit.
PF11628. TCR_zetazeta. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 1 hit.
[Graphical view]
PROSITEiPS51055. ITAM_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPAVVLLLL LLVEQAAALG EPQLCYILDA ILFLYGIVLT LLYCRLKIQV
60 70 80
RKAAITSYEK SDGVYTGLST RNQETYETLK HEKPPQ
Length:86
Mass (Da):9,667
Last modified:April 1, 1993 - v1
Checksum:i2F2C7536513D6165
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33195 mRNA. Translation: AAA35828.1.
M33196 Genomic DNA. No translation available.
AL590714 Genomic DNA. Translation: CAH72149.1.
CCDSiCCDS1225.1.
PIRiA35241.
RefSeqiNP_004097.1. NM_004106.1.
UniGeneiHs.433300.

Genome annotation databases

EnsembliENST00000289902; ENSP00000289902; ENSG00000158869.
GeneIDi2207.
KEGGihsa:2207.
UCSCiuc001fyz.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33195 mRNA. Translation: AAA35828.1.
M33196 Genomic DNA. No translation available.
AL590714 Genomic DNA. Translation: CAH72149.1.
CCDSiCCDS1225.1.
PIRiA35241.
RefSeqiNP_004097.1. NM_004106.1.
UniGeneiHs.433300.

3D structure databases

DisProtiDP00509.
ProteinModelPortaliP30273.
SMRiP30273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108501. 2 interactors.
DIPiDIP-29514N.
IntActiP30273. 5 interactors.
MINTiMINT-6622796.
STRINGi9606.ENSP00000289902.

Chemistry databases

DrugBankiDB00895. Benzylpenicilloyl Polylysine.

PTM databases

iPTMnetiP30273.
PhosphoSitePlusiP30273.

Polymorphism and mutation databases

BioMutaiFCER1G.
DMDMi232085.

Proteomic databases

EPDiP30273.
PaxDbiP30273.
PeptideAtlasiP30273.
PRIDEiP30273.
TopDownProteomicsiP30273.

Protocols and materials databases

DNASUi2207.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289902; ENSP00000289902; ENSG00000158869.
GeneIDi2207.
KEGGihsa:2207.
UCSCiuc001fyz.1. human.

Organism-specific databases

CTDi2207.
DisGeNETi2207.
GeneCardsiFCER1G.
HGNCiHGNC:3611. FCER1G.
HPAiCAB022108.
HPA026872.
MIMi147139. gene.
neXtProtiNX_P30273.
OpenTargetsiENSG00000158869.
PharmGKBiPA28057.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J5TQ. Eukaryota.
ENOG410Z3W0. LUCA.
GeneTreeiENSGT00390000003894.
HOGENOMiHOG000293158.
HOVERGENiHBG051601.
InParanoidiP30273.
KOiK07983.
OMAiLYCRLKL.
PhylomeDBiP30273.
TreeFamiTF330937.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158869-MONOMER.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-202733. Cell surface interactions at the vascular wall.
R-HSA-2454202. Fc epsilon receptor (FCERI) signaling.
R-HSA-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-2871809. FCERI mediated Ca+2 mobilization.
R-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-5621480. Dectin-2 family.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-75892. Platelet Adhesion to exposed collagen.

Miscellaneous databases

ChiTaRSiFCER1G. human.
GenomeRNAii2207.
PROiP30273.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158869.
CleanExiHS_FCER1G.
ExpressionAtlasiP30273. baseline and differential.
GenevisibleiP30273. HS.

Family and domain databases

InterProiIPR021663. CD3_zeta/IgE_Fc_rcpt_gamma.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PfamiPF02189. ITAM. 1 hit.
PF11628. TCR_zetazeta. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 1 hit.
[Graphical view]
PROSITEiPS51055. ITAM_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFCERG_HUMAN
AccessioniPrimary (citable) accession number: P30273
Secondary accession number(s): Q5VTW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 30, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.