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P30273

- FCERG_HUMAN

UniProt

P30273 - FCERG_HUMAN

Protein

High affinity immunoglobulin epsilon receptor subunit gamma

Gene

FCER1G

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin.1 Publication

    GO - Molecular functioni

    1. IgE receptor activity Source: Ensembl
    2. protein binding Source: IntAct

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Ensembl
    2. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Ensembl
    3. blood coagulation Source: Reactome
    4. defense response to bacterium Source: Ensembl
    5. Fc-epsilon receptor signaling pathway Source: Reactome
    6. Fc receptor mediated stimulatory signaling pathway Source: Ensembl
    7. immunoglobulin mediated immune response Source: Ensembl
    8. innate immune response Source: Reactome
    9. integrin-mediated signaling pathway Source: Ensembl
    10. leukocyte migration Source: Reactome
    11. mast cell activation Source: Ensembl
    12. negative regulation of mast cell apoptotic process Source: Ensembl
    13. neutrophil activation involved in immune response Source: Ensembl
    14. neutrophil chemotaxis Source: Ensembl
    15. phagocytosis, engulfment Source: Ensembl
    16. platelet activation Source: Reactome
    17. positive regulation of interleukin-10 production Source: Ensembl
    18. positive regulation of interleukin-6 production Source: Ensembl
    19. positive regulation of mast cell cytokine production Source: Ensembl
    20. positive regulation of mast cell degranulation Source: Ensembl
    21. positive regulation of phagocytosis Source: Ensembl
    22. positive regulation of tumor necrosis factor production Source: Ensembl
    23. positive regulation of type I hypersensitivity Source: Ensembl
    24. positive regulation of type IIa hypersensitivity Source: Ensembl
    25. positive regulation of type III hypersensitivity Source: Ensembl
    26. regulation of platelet activation Source: Ensembl
    27. serotonin secretion by platelet Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Ligandi

    IgE-binding protein

    Enzyme and pathway databases

    ReactomeiREACT_12051. Cell surface interactions at the vascular wall.
    REACT_1230. Platelet Adhesion to exposed collagen.
    REACT_163701. FCERI mediated MAPK activation.
    REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
    REACT_163834. FCERI mediated Ca+2 mobilization.
    REACT_163936. Fc epsilon receptor (FCERI) signaling.
    REACT_163994. FCERI mediated NF-kB activation.
    REACT_1695. GPVI-mediated activation cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    High affinity immunoglobulin epsilon receptor subunit gamma
    Alternative name(s):
    Fc receptor gamma-chain
    Short name:
    FcRgamma
    Fc-epsilon RI-gamma
    IgE Fc receptor subunit gamma
    Short name:
    FceRI gamma
    Gene namesi
    Name:FCER1G
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:3611. FCER1G.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication

    GO - Cellular componenti

    1. cell surface Source: UniProtKB
    2. external side of plasma membrane Source: Ensembl
    3. Fc-epsilon receptor I complex Source: Ensembl
    4. integral component of plasma membrane Source: Ensembl
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28057.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 8668High affinity immunoglobulin epsilon receptor subunit gammaPRO_0000016501Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi25 – 25InterchainBy similarity
    Modified residuei65 – 651PhosphotyrosinePROSITE-ProRule annotation
    Modified residuei76 – 761PhosphotyrosinePROSITE-ProRule annotation
    Modified residuei78 – 781PhosphothreonineBy similarity

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    PaxDbiP30273.
    PRIDEiP30273.

    PTM databases

    PhosphoSiteiP30273.

    Expressioni

    Gene expression databases

    ArrayExpressiP30273.
    BgeeiP30273.
    CleanExiHS_FCER1G.
    GenevestigatoriP30273.

    Organism-specific databases

    HPAiCAB022108.
    HPA026872.

    Interactioni

    Subunit structurei

    IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors like FCGR1A. Associated with CLEC6A By similarity. Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages By similarity. Interacts with CD300LH; the interaction may be indirect By similarity. Interacts with CD300LD By similarity. Interacts with CLEC4E.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SYKP434052EBI-515289,EBI-78302

    Protein-protein interaction databases

    BioGridi108501. 3 interactions.
    DIPiDIP-29514N.
    IntActiP30273. 5 interactions.
    MINTiMINT-6622796.
    STRINGi9606.ENSP00000289902.

    Structurei

    3D structure databases

    DisProtiDP00509.
    ProteinModelPortaliP30273.
    SMRiP30273. Positions 21-53.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 235ExtracellularSequence Analysis
    Topological domaini45 – 8642CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini54 – 8229ITAMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CD3Z/FCER1G family.Curated
    Contains 1 ITAM domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47881.
    HOGENOMiHOG000293158.
    HOVERGENiHBG051601.
    KOiK07983.
    OMAiLYCRLKL.
    PhylomeDBiP30273.
    TreeFamiTF330937.

    Family and domain databases

    InterProiIPR021663. CR3_zeta/IgE_Fc_rcpt_gamma.
    IPR003110. Phos_immunorcpt_sig_ITAM.
    [Graphical view]
    PfamiPF02189. ITAM. 1 hit.
    PF11628. TCR_zetazeta. 1 hit.
    [Graphical view]
    SMARTiSM00077. ITAM. 1 hit.
    [Graphical view]
    PROSITEiPS51055. ITAM_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P30273-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIPAVVLLLL LLVEQAAALG EPQLCYILDA ILFLYGIVLT LLYCRLKIQV   50
    RKAAITSYEK SDGVYTGLST RNQETYETLK HEKPPQ 86
    Length:86
    Mass (Da):9,667
    Last modified:April 1, 1993 - v1
    Checksum:i2F2C7536513D6165
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33195 mRNA. Translation: AAA35828.1.
    M33196 Genomic DNA. No translation available.
    AL590714 Genomic DNA. Translation: CAH72149.1.
    CCDSiCCDS1225.1.
    PIRiA35241.
    RefSeqiNP_004097.1. NM_004106.1.
    UniGeneiHs.433300.

    Genome annotation databases

    EnsembliENST00000289902; ENSP00000289902; ENSG00000158869.
    GeneIDi2207.
    KEGGihsa:2207.
    UCSCiuc001fyz.1. human.

    Polymorphism databases

    DMDMi232085.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33195 mRNA. Translation: AAA35828.1 .
    M33196 Genomic DNA. No translation available.
    AL590714 Genomic DNA. Translation: CAH72149.1 .
    CCDSi CCDS1225.1.
    PIRi A35241.
    RefSeqi NP_004097.1. NM_004106.1.
    UniGenei Hs.433300.

    3D structure databases

    DisProti DP00509.
    ProteinModelPortali P30273.
    SMRi P30273. Positions 21-53.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108501. 3 interactions.
    DIPi DIP-29514N.
    IntActi P30273. 5 interactions.
    MINTi MINT-6622796.
    STRINGi 9606.ENSP00000289902.

    Chemistry

    DrugBanki DB00895. Benzylpenicilloyl Polylysine.

    PTM databases

    PhosphoSitei P30273.

    Polymorphism databases

    DMDMi 232085.

    Proteomic databases

    PaxDbi P30273.
    PRIDEi P30273.

    Protocols and materials databases

    DNASUi 2207.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000289902 ; ENSP00000289902 ; ENSG00000158869 .
    GeneIDi 2207.
    KEGGi hsa:2207.
    UCSCi uc001fyz.1. human.

    Organism-specific databases

    CTDi 2207.
    GeneCardsi GC01P161185.
    HGNCi HGNC:3611. FCER1G.
    HPAi CAB022108.
    HPA026872.
    MIMi 147139. gene.
    neXtProti NX_P30273.
    PharmGKBi PA28057.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47881.
    HOGENOMi HOG000293158.
    HOVERGENi HBG051601.
    KOi K07983.
    OMAi LYCRLKL.
    PhylomeDBi P30273.
    TreeFami TF330937.

    Enzyme and pathway databases

    Reactomei REACT_12051. Cell surface interactions at the vascular wall.
    REACT_1230. Platelet Adhesion to exposed collagen.
    REACT_163701. FCERI mediated MAPK activation.
    REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
    REACT_163834. FCERI mediated Ca+2 mobilization.
    REACT_163936. Fc epsilon receptor (FCERI) signaling.
    REACT_163994. FCERI mediated NF-kB activation.
    REACT_1695. GPVI-mediated activation cascade.

    Miscellaneous databases

    GenomeRNAii 2207.
    NextBioi 8939.
    PROi P30273.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P30273.
    Bgeei P30273.
    CleanExi HS_FCER1G.
    Genevestigatori P30273.

    Family and domain databases

    InterProi IPR021663. CR3_zeta/IgE_Fc_rcpt_gamma.
    IPR003110. Phos_immunorcpt_sig_ITAM.
    [Graphical view ]
    Pfami PF02189. ITAM. 1 hit.
    PF11628. TCR_zetazeta. 1 hit.
    [Graphical view ]
    SMARTi SM00077. ITAM. 1 hit.
    [Graphical view ]
    PROSITEi PS51055. ITAM_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and expression of the gene for the human Fc receptor gamma subunit. Definition of a new gene family."
      Kuester H., Thompson H., Kinet J.-P.
      J. Biol. Chem. 265:6448-6452(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo."
      van Vugt M.J., Heijnen I.A.F.M., Capel P.J.A., Park S.Y., Ra C., Saito T., Verbeek J.S., van de Winkel J.G.J.
      Blood 87:3593-3599(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH FCGR1A, SUBCELLULAR LOCATION.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    5. "Mincle is an ITAM-coupled activating receptor that senses damaged cells."
      Yamasaki S., Ishikawa E., Sakuma M., Hara H., Ogata K., Saito T.
      Nat. Immunol. 9:1179-1188(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CLEC4E.

    Entry informationi

    Entry nameiFCERG_HUMAN
    AccessioniPrimary (citable) accession number: P30273
    Secondary accession number(s): Q5VTW4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3