P30273 (FCERG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
High affinity immunoglobulin epsilon receptor subunit gamma

Alternative name(s):
Fc receptor gamma-chain
Short name=FcRgamma
Fc-epsilon RI-gamma
IgE Fc receptor subunit gamma
Short name=FceRI gamma

Gene names

Name:

FCER1G

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	86 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin. Ref.3
Subunit structure	IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors like FCGR1A. Associated with CLEC6A By similarity. Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages By similarity. Interacts with CD300LH; the interaction may be indirect By similarity. Interacts with CD300LD By similarity. Interacts with CLEC4E. Ref.3 Ref.5
Subcellular location	Cell membrane; Single-pass type I membrane protein Ref.3.
Sequence similarities	Belongs to the CD3Z/FCER1G family. Contains 1 ITAM domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	IgE-binding protein
Molecular function	Receptor
PTM	Disulfide bond Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Fc receptor mediated stimulatory signaling pathway Inferred from electronic annotation. Source: Compara antigen processing and presentation of exogenous peptide antigen via MHC class I Inferred from electronic annotation. Source: Compara antigen processing and presentation of exogenous peptide antigen via MHC class II Inferred from electronic annotation. Source: Compara defense response to bacterium Inferred from electronic annotation. Source: Compara immunoglobulin mediated immune response Inferred from electronic annotation. Source: Compara integrin-mediated signaling pathway Inferred from electronic annotation. Source: Compara leukocyte migration Traceable author statement. Source: Reactome mast cell activation Inferred from electronic annotation. Source: Compara negative regulation of mast cell apoptotic process Inferred from electronic annotation. Source: Compara neutrophil activation involved in immune response Inferred from electronic annotation. Source: Compara neutrophil chemotaxis Inferred from electronic annotation. Source: Compara phagocytosis, engulfment Inferred from electronic annotation. Source: Compara platelet activation Traceable author statement. Source: Reactome positive regulation of interleukin-10 production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-6 production Inferred from electronic annotation. Source: Compara positive regulation of mast cell cytokine production Inferred from electronic annotation. Source: Compara positive regulation of mast cell degranulation Inferred from electronic annotation. Source: Compara positive regulation of phagocytosis Inferred from electronic annotation. Source: Compara positive regulation of tumor necrosis factor production Inferred from electronic annotation. Source: Compara positive regulation of type I hypersensitivity Inferred from electronic annotation. Source: Compara positive regulation of type III hypersensitivity Inferred from electronic annotation. Source: Compara positive regulation of type IIa hypersensitivity Inferred from electronic annotation. Source: Compara regulation of platelet activation Inferred from electronic annotation. Source: Compara serotonin secretion by platelet Inferred from electronic annotation. Source: Compara
Cellular_component	Fc-epsilon receptor I complex Inferred from electronic annotation. Source: Compara external side of plasma membrane Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement PubMed 1535625. Source: ProtInc
Molecular_function	IgE receptor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 86	68	High affinity immunoglobulin epsilon receptor subunit gamma		PRO_0000016501
Regions
	Topological domain	19 – 23	5	Extracellular Potential
	Transmembrane	24 – 44	21	Helical; Potential
	Topological domain	45 – 86	42	Cytoplasmic Potential
	Domain	54 – 82	29	ITAM
Amino acid modifications
	Modified residue	65	1	Phosphotyrosine By similarity
	Modified residue	76	1	Phosphotyrosine By similarity
	Modified residue	78	1	Phosphothreonine By similarity
	Disulfide bond	25		Interchain By similarity

Sequences

	Sequence		Length	Mass (Da)
	P30273 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 2F2C7536513D6165	FASTA	86	9,667
	10 20 30 40 50 60 MIPAVVLLLL LLVEQAAALG EPQLCYILDA ILFLYGIVLT LLYCRLKIQV RKAAITSYEK 70 80 SDGVYTGLST RNQETYETLK HEKPPQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization and expression of the gene for the human Fc receptor gamma subunit. Definition of a new gene family." Kuester H., Thompson H., Kinet J.-P. J. Biol. Chem. 265:6448-6452(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo." van Vugt M.J., Heijnen I.A.F.M., Capel P.J.A., Park S.Y., Ra C., Saito T., Verbeek J.S., van de Winkel J.G.J. Blood 87:3593-3599(1996) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH FCGR1A, SUBCELLULAR LOCATION.
[4]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Platelet.
[5]	"Mincle is an ITAM-coupled activating receptor that senses damaged cells." Yamasaki S., Ishikawa E., Sakuma M., Hara H., Ogata K., Saito T. Nat. Immunol. 9:1179-1188(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CLEC4E.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M33195 mRNA. Translation: AAA35828.1. M33196 Genomic DNA. No translation available. AL590714 Genomic DNA. Translation: CAH72149.1.
IPI	IPI00025804.
PIR	A35241.
RefSeq	NP_004097.1. NM_004106.1.
UniGene	Hs.433300.
3D structure databases
DisProt	DP00509.
ProteinModelPortal	P30273.
SMR	P30273. Positions 21-52.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-29514N.
IntAct	P30273. 5 interactions.
STRING	9606.ENSP00000289902.
PTM databases
PhosphoSite	P30273.
Polymorphism databases
DMDM	232085.
Proteomic databases
PaxDb	P30273.
PRIDE	P30273.
Protocols and materials databases
DNASU	2207.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000289902; ENSP00000289902; ENSG00000158869.
GeneID	2207.
KEGG	hsa:2207.
UCSC	uc001fyz.1. human.
Organism-specific databases
CTD	2207.
GeneCards	GC01P161185.
HGNC	HGNC:3611. FCER1G.
HPA	CAB022108. HPA026872.
MIM	147139. gene.
neXtProt	NX_P30273.
PharmGKB	PA28057.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47881.
HOGENOM	HOG000293158.
HOVERGEN	HBG051601.
KO	K07983.
OMA	LYCRLKL.
PhylomeDB	P30273.
Enzyme and pathway databases
Pathway_Interaction_DB	fcer1pathway. Fc-epsilon receptor I signaling in mast cells.
Reactome	REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	P30273.
Bgee	P30273.
CleanEx	HS_FCER1G.
Genevestigator	P30273.
GermOnline	ENSG00000158869. Homo sapiens.
Family and domain databases
InterPro	IPR021663. CR3_zeta/IgE_Fc_rcpt_gamma. IPR003110. Phos_immunorcpt_sig_ITAM. [Graphical view]
Pfam	PF02189. ITAM. 1 hit. PF11628. TCR_zetazeta. 1 hit. [Graphical view]
SMART	SM00077. ITAM. 1 hit. [Graphical view]
PROSITE	PS51055. ITAM_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00895. Benzylpenicilloyl Polylysine.
GenomeRNAi	2207.
NextBio	8939.
SOURCE	Search...

Entry information

Entry name

FCERG_HUMAN

Accession

Primary (citable) accession number: P30273
Secondary accession number(s): Q5VTW4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	April 3, 2013
This is version 117 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.