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P30273

- FCERG_HUMAN

UniProt

P30273 - FCERG_HUMAN

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Protein

High affinity immunoglobulin epsilon receptor subunit gamma

Gene

FCER1G

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin.1 Publication

GO - Molecular functioni

  1. IgE receptor activity Source: Ensembl

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Ensembl
  2. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Ensembl
  3. blood coagulation Source: Reactome
  4. defense response to bacterium Source: Ensembl
  5. Fc-epsilon receptor signaling pathway Source: Reactome
  6. Fc receptor mediated stimulatory signaling pathway Source: Ensembl
  7. immunoglobulin mediated immune response Source: Ensembl
  8. innate immune response Source: Reactome
  9. integrin-mediated signaling pathway Source: Ensembl
  10. leukocyte migration Source: Reactome
  11. mast cell activation Source: Ensembl
  12. negative regulation of mast cell apoptotic process Source: Ensembl
  13. neutrophil activation involved in immune response Source: Ensembl
  14. neutrophil chemotaxis Source: Ensembl
  15. phagocytosis, engulfment Source: Ensembl
  16. platelet activation Source: Reactome
  17. positive regulation of interleukin-10 production Source: Ensembl
  18. positive regulation of interleukin-6 production Source: Ensembl
  19. positive regulation of mast cell cytokine production Source: Ensembl
  20. positive regulation of mast cell degranulation Source: Ensembl
  21. positive regulation of phagocytosis Source: Ensembl
  22. positive regulation of tumor necrosis factor production Source: Ensembl
  23. positive regulation of type I hypersensitivity Source: Ensembl
  24. positive regulation of type IIa hypersensitivity Source: Ensembl
  25. positive regulation of type III hypersensitivity Source: Ensembl
  26. protein localization to plasma membrane Source: Ensembl
  27. regulation of platelet activation Source: Ensembl
  28. serotonin secretion by platelet Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

IgE-binding protein

Enzyme and pathway databases

ReactomeiREACT_12051. Cell surface interactions at the vascular wall.
REACT_1230. Platelet Adhesion to exposed collagen.
REACT_163701. FCERI mediated MAPK activation.
REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_163936. Fc epsilon receptor (FCERI) signaling.
REACT_163994. FCERI mediated NF-kB activation.
REACT_1695. GPVI-mediated activation cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin epsilon receptor subunit gamma
Alternative name(s):
Fc receptor gamma-chain
Short name:
FcRgamma
Fc-epsilon RI-gamma
IgE Fc receptor subunit gamma
Short name:
FceRI gamma
Gene namesi
Name:FCER1G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:3611. FCER1G.

Subcellular locationi

Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. external side of plasma membrane Source: Ensembl
  3. Fc-epsilon receptor I complex Source: Ensembl
  4. integral component of plasma membrane Source: Ensembl
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28057.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 8668High affinity immunoglobulin epsilon receptor subunit gammaPRO_0000016501Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 – 25InterchainBy similarity
Modified residuei65 – 651PhosphotyrosinePROSITE-ProRule annotation
Modified residuei76 – 761PhosphotyrosinePROSITE-ProRule annotation
Modified residuei78 – 781PhosphothreonineBy similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP30273.
PRIDEiP30273.

PTM databases

PhosphoSiteiP30273.

Expressioni

Gene expression databases

BgeeiP30273.
CleanExiHS_FCER1G.
ExpressionAtlasiP30273. baseline and differential.
GenevestigatoriP30273.

Organism-specific databases

HPAiCAB022108.
HPA026872.

Interactioni

Subunit structurei

IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors like FCGR1A. Associated with CLEC6A (By similarity). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages (By similarity). Interacts with CD300LH; the interaction may be indirect (By similarity). Interacts with CD300LD (By similarity). Interacts with CLEC4E.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SYKP434052EBI-515289,EBI-78302

Protein-protein interaction databases

BioGridi108501. 3 interactions.
DIPiDIP-29514N.
IntActiP30273. 5 interactions.
MINTiMINT-6622796.
STRINGi9606.ENSP00000289902.

Structurei

3D structure databases

DisProtiDP00509.
ProteinModelPortaliP30273.
SMRiP30273. Positions 21-53.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 235ExtracellularSequence Analysis
Topological domaini45 – 8642CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 8229ITAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CD3Z/FCER1G family.Curated
Contains 1 ITAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47881.
GeneTreeiENSGT00390000003894.
HOGENOMiHOG000293158.
HOVERGENiHBG051601.
InParanoidiP30273.
KOiK07983.
OMAiLYCRLKL.
PhylomeDBiP30273.
TreeFamiTF330937.

Family and domain databases

InterProiIPR021663. CR3_zeta/IgE_Fc_rcpt_gamma.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PfamiPF02189. ITAM. 1 hit.
PF11628. TCR_zetazeta. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 1 hit.
[Graphical view]
PROSITEiPS51055. ITAM_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30273-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIPAVVLLLL LLVEQAAALG EPQLCYILDA ILFLYGIVLT LLYCRLKIQV
60 70 80
RKAAITSYEK SDGVYTGLST RNQETYETLK HEKPPQ
Length:86
Mass (Da):9,667
Last modified:April 1, 1993 - v1
Checksum:i2F2C7536513D6165
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M33195 mRNA. Translation: AAA35828.1.
M33196 Genomic DNA. No translation available.
AL590714 Genomic DNA. Translation: CAH72149.1.
CCDSiCCDS1225.1.
PIRiA35241.
RefSeqiNP_004097.1. NM_004106.1.
UniGeneiHs.433300.

Genome annotation databases

EnsembliENST00000289902; ENSP00000289902; ENSG00000158869.
GeneIDi2207.
KEGGihsa:2207.
UCSCiuc001fyz.1. human.

Polymorphism databases

DMDMi232085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M33195 mRNA. Translation: AAA35828.1 .
M33196 Genomic DNA. No translation available.
AL590714 Genomic DNA. Translation: CAH72149.1 .
CCDSi CCDS1225.1.
PIRi A35241.
RefSeqi NP_004097.1. NM_004106.1.
UniGenei Hs.433300.

3D structure databases

DisProti DP00509.
ProteinModelPortali P30273.
SMRi P30273. Positions 21-53.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108501. 3 interactions.
DIPi DIP-29514N.
IntActi P30273. 5 interactions.
MINTi MINT-6622796.
STRINGi 9606.ENSP00000289902.

Chemistry

DrugBanki DB00895. Benzylpenicilloyl Polylysine.

PTM databases

PhosphoSitei P30273.

Polymorphism databases

DMDMi 232085.

Proteomic databases

PaxDbi P30273.
PRIDEi P30273.

Protocols and materials databases

DNASUi 2207.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000289902 ; ENSP00000289902 ; ENSG00000158869 .
GeneIDi 2207.
KEGGi hsa:2207.
UCSCi uc001fyz.1. human.

Organism-specific databases

CTDi 2207.
GeneCardsi GC01P161185.
HGNCi HGNC:3611. FCER1G.
HPAi CAB022108.
HPA026872.
MIMi 147139. gene.
neXtProti NX_P30273.
PharmGKBi PA28057.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47881.
GeneTreei ENSGT00390000003894.
HOGENOMi HOG000293158.
HOVERGENi HBG051601.
InParanoidi P30273.
KOi K07983.
OMAi LYCRLKL.
PhylomeDBi P30273.
TreeFami TF330937.

Enzyme and pathway databases

Reactomei REACT_12051. Cell surface interactions at the vascular wall.
REACT_1230. Platelet Adhesion to exposed collagen.
REACT_163701. FCERI mediated MAPK activation.
REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_163936. Fc epsilon receptor (FCERI) signaling.
REACT_163994. FCERI mediated NF-kB activation.
REACT_1695. GPVI-mediated activation cascade.

Miscellaneous databases

GenomeRNAii 2207.
NextBioi 8939.
PROi P30273.
SOURCEi Search...

Gene expression databases

Bgeei P30273.
CleanExi HS_FCER1G.
ExpressionAtlasi P30273. baseline and differential.
Genevestigatori P30273.

Family and domain databases

InterProi IPR021663. CR3_zeta/IgE_Fc_rcpt_gamma.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view ]
Pfami PF02189. ITAM. 1 hit.
PF11628. TCR_zetazeta. 1 hit.
[Graphical view ]
SMARTi SM00077. ITAM. 1 hit.
[Graphical view ]
PROSITEi PS51055. ITAM_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization and expression of the gene for the human Fc receptor gamma subunit. Definition of a new gene family."
    Kuester H., Thompson H., Kinet J.-P.
    J. Biol. Chem. 265:6448-6452(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo."
    van Vugt M.J., Heijnen I.A.F.M., Capel P.J.A., Park S.Y., Ra C., Saito T., Verbeek J.S., van de Winkel J.G.J.
    Blood 87:3593-3599(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH FCGR1A, SUBCELLULAR LOCATION.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  5. "Mincle is an ITAM-coupled activating receptor that senses damaged cells."
    Yamasaki S., Ishikawa E., Sakuma M., Hara H., Ogata K., Saito T.
    Nat. Immunol. 9:1179-1188(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CLEC4E.

Entry informationi

Entry nameiFCERG_HUMAN
AccessioniPrimary (citable) accession number: P30273
Secondary accession number(s): Q5VTW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 29, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3