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Protein

High affinity immunoglobulin epsilon receptor subunit gamma

Gene

FCER1G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

IgE-binding protein

Enzyme and pathway databases

ReactomeiREACT_12051. Cell surface interactions at the vascular wall.
REACT_1230. Platelet Adhesion to exposed collagen.
REACT_163701. FCERI mediated MAPK activation.
REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_163936. Fc epsilon receptor (FCERI) signaling.
REACT_163994. FCERI mediated NF-kB activation.
REACT_1695. GPVI-mediated activation cascade.
REACT_355442. Dectin-2 family.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin epsilon receptor subunit gamma
Alternative name(s):
Fc receptor gamma-chain
Short name:
FcRgamma
Fc-epsilon RI-gamma
IgE Fc receptor subunit gamma
Short name:
FceRI gamma
Gene namesi
Name:FCER1G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:3611. FCER1G.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 235ExtracellularSequence Analysis
Transmembranei24 – 4421HelicalSequence AnalysisAdd
BLAST
Topological domaini45 – 8642CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28057.

Chemistry

DrugBankiDB00895. Benzylpenicilloyl Polylysine.

Polymorphism and mutation databases

BioMutaiFCER1G.
DMDMi232085.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 8668High affinity immunoglobulin epsilon receptor subunit gammaPRO_0000016501Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 – 25InterchainBy similarity
Modified residuei65 – 651PhosphotyrosinePROSITE-ProRule annotation
Modified residuei69 – 691Phosphoserine1 Publication
Modified residuei76 – 761PhosphotyrosinePROSITE-ProRule annotation
Modified residuei78 – 781PhosphothreonineBy similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP30273.
PRIDEiP30273.

PTM databases

PhosphoSiteiP30273.

Expressioni

Gene expression databases

BgeeiP30273.
CleanExiHS_FCER1G.
ExpressionAtlasiP30273. baseline and differential.
GenevisibleiP30273. HS.

Organism-specific databases

HPAiCAB022108.
HPA026872.

Interactioni

Subunit structurei

IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors like FCGR1A. Associated with CLEC6A (By similarity). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages (By similarity). Interacts with CD300LH; the interaction may be indirect (By similarity). Interacts with CD300LD (By similarity). Interacts with CLEC4E.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SYKP434052EBI-515289,EBI-78302

Protein-protein interaction databases

BioGridi108501. 3 interactions.
DIPiDIP-29514N.
IntActiP30273. 5 interactions.
MINTiMINT-6622796.
STRINGi9606.ENSP00000289902.

Structurei

3D structure databases

DisProtiDP00509.
ProteinModelPortaliP30273.
SMRiP30273. Positions 21-53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 8229ITAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CD3Z/FCER1G family.Curated
Contains 1 ITAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47881.
GeneTreeiENSGT00390000003894.
HOGENOMiHOG000293158.
HOVERGENiHBG051601.
InParanoidiP30273.
KOiK07983.
OMAiLYCRLKL.
PhylomeDBiP30273.
TreeFamiTF330937.

Family and domain databases

InterProiIPR021663. CR3_zeta/IgE_Fc_rcpt_gamma.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PfamiPF02189. ITAM. 1 hit.
PF11628. TCR_zetazeta. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 1 hit.
[Graphical view]
PROSITEiPS51055. ITAM_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPAVVLLLL LLVEQAAALG EPQLCYILDA ILFLYGIVLT LLYCRLKIQV
60 70 80
RKAAITSYEK SDGVYTGLST RNQETYETLK HEKPPQ
Length:86
Mass (Da):9,667
Last modified:April 1, 1993 - v1
Checksum:i2F2C7536513D6165
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33195 mRNA. Translation: AAA35828.1.
M33196 Genomic DNA. No translation available.
AL590714 Genomic DNA. Translation: CAH72149.1.
CCDSiCCDS1225.1.
PIRiA35241.
RefSeqiNP_004097.1. NM_004106.1.
UniGeneiHs.433300.

Genome annotation databases

EnsembliENST00000289902; ENSP00000289902; ENSG00000158869.
GeneIDi2207.
KEGGihsa:2207.
UCSCiuc001fyz.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33195 mRNA. Translation: AAA35828.1.
M33196 Genomic DNA. No translation available.
AL590714 Genomic DNA. Translation: CAH72149.1.
CCDSiCCDS1225.1.
PIRiA35241.
RefSeqiNP_004097.1. NM_004106.1.
UniGeneiHs.433300.

3D structure databases

DisProtiDP00509.
ProteinModelPortaliP30273.
SMRiP30273. Positions 21-53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108501. 3 interactions.
DIPiDIP-29514N.
IntActiP30273. 5 interactions.
MINTiMINT-6622796.
STRINGi9606.ENSP00000289902.

Chemistry

DrugBankiDB00895. Benzylpenicilloyl Polylysine.

PTM databases

PhosphoSiteiP30273.

Polymorphism and mutation databases

BioMutaiFCER1G.
DMDMi232085.

Proteomic databases

PaxDbiP30273.
PRIDEiP30273.

Protocols and materials databases

DNASUi2207.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289902; ENSP00000289902; ENSG00000158869.
GeneIDi2207.
KEGGihsa:2207.
UCSCiuc001fyz.1. human.

Organism-specific databases

CTDi2207.
GeneCardsiGC01P161185.
HGNCiHGNC:3611. FCER1G.
HPAiCAB022108.
HPA026872.
MIMi147139. gene.
neXtProtiNX_P30273.
PharmGKBiPA28057.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47881.
GeneTreeiENSGT00390000003894.
HOGENOMiHOG000293158.
HOVERGENiHBG051601.
InParanoidiP30273.
KOiK07983.
OMAiLYCRLKL.
PhylomeDBiP30273.
TreeFamiTF330937.

Enzyme and pathway databases

ReactomeiREACT_12051. Cell surface interactions at the vascular wall.
REACT_1230. Platelet Adhesion to exposed collagen.
REACT_163701. FCERI mediated MAPK activation.
REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_163936. Fc epsilon receptor (FCERI) signaling.
REACT_163994. FCERI mediated NF-kB activation.
REACT_1695. GPVI-mediated activation cascade.
REACT_355442. Dectin-2 family.

Miscellaneous databases

ChiTaRSiFCER1G. human.
GenomeRNAii2207.
NextBioi8939.
PROiP30273.
SOURCEiSearch...

Gene expression databases

BgeeiP30273.
CleanExiHS_FCER1G.
ExpressionAtlasiP30273. baseline and differential.
GenevisibleiP30273. HS.

Family and domain databases

InterProiIPR021663. CR3_zeta/IgE_Fc_rcpt_gamma.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PfamiPF02189. ITAM. 1 hit.
PF11628. TCR_zetazeta. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 1 hit.
[Graphical view]
PROSITEiPS51055. ITAM_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization and expression of the gene for the human Fc receptor gamma subunit. Definition of a new gene family."
    Kuester H., Thompson H., Kinet J.-P.
    J. Biol. Chem. 265:6448-6452(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo."
    van Vugt M.J., Heijnen I.A.F.M., Capel P.J.A., Park S.Y., Ra C., Saito T., Verbeek J.S., van de Winkel J.G.J.
    Blood 87:3593-3599(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH FCGR1A, SUBCELLULAR LOCATION.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  5. "Mincle is an ITAM-coupled activating receptor that senses damaged cells."
    Yamasaki S., Ishikawa E., Sakuma M., Hara H., Ogata K., Saito T.
    Nat. Immunol. 9:1179-1188(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CLEC4E.
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiFCERG_HUMAN
AccessioniPrimary (citable) accession number: P30273
Secondary accession number(s): Q5VTW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 24, 2015
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.