Reviewed, UniProtKB/Swiss-Prot P30265 (CATA_LACSK)

Names and origin

Protein names

Recommended name:
    Catalase
    EC=1.11.1.6

Gene names

Name:

katA

Organism

Lactobacillus sakei

Taxonomic identifier

1599 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
Catalytic activity	2 H2O2 = O2 + 2 H2O.
Cofactor	Heme group.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the catalase family.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Cellular component	Cytoplasm
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	catalase activity Inferred from electronic annotation. Source: EC heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 478	478	Catalase		PRO_0000084989
Sites
	Active site	53	1	By similarity
	Active site	126	1	By similarity
	Metal binding	336	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P30265-1 [UniParc]. Last modified July 15, 1999. Version 2. Checksum: 85952A05DB16EF3D	FASTA	478	54,076
	10 20 30 40 50 60 MTNQLTTNEG QPWADNQHSQ TAGQRGPVLI QDYQLLEKLA HFNRERIPER VVHAKGAGAK 70 80 90 100 110 120 GYFKVTKDMS AYTKAAVFSG VGKKTPLITR FSQVAGEAGY PDTYRDVRGF AVKFYTEEGN 130 140 150 160 170 180 YDIVGNNTPV FFVNDPLKFP DFIHSQKRDP RTHARSQDMQ WDFWSLSPES VHQVTILMSD 190 200 210 220 230 240 RGIPASYRMM HGFGSHTFKW VNAQGEQFWV KYHFKTNQGI HNLSNELADE LAGKDTDYLQ 250 260 270 280 290 300 NDLFDAIETG DYPSWTVAVQ LVPYEDGLNY PQDIFDVTKV ISQKDYPLIE IGQMVLDENP 310 320 330 340 350 360 TNNFEDIQEL AFSPANLVPG IEASPDKLLQ GRLFGYKDAE RYRLGANYEQ LPVNRPKVPV 370 380 390 400 410 420 HNYERDGAMA QNQATGVNYE PNSQDGPTEV PAAKIHGDQL SGTTGNFSAD PDYYSAAGKL 430 440 450 460 470 YRLLSADEQT RLIENIRMNL GQVTKPEIQI REVKQFYQAD PEYGRRVATS VKLRFSSV

References

[1]	"Cloning, sequence, and phenotypic expression of katA, which encodes the catalase of Lactobacillus sake LTH677." Knauf H.J., Vogel R.F., Hammes W.P. Appl. Environ. Microbiol. 58:832-839(1992) [PubMed: 1575485] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LTH677.
[2]	"Oxygen-dependent regulation of the expression of the catalase gene katA of Lactobacillus sakei LTH677." Hertel C., Schmidt G., Fischer M., Oellers K., Hammes W.P. Appl. Environ. Microbiol. 64:1359-1365(1998) [PubMed: 9546173] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION. Strain: LTH677.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M84015 Genomic DNA. Translation: AAC19139.1.
PIR	T09652.
3D structure databases
SMR	P30265. Positions 4-472.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.11.1.6. 273663.
Family and domain databases
InterPro	IPR002226. Catalase. IPR020835. Catalase-like_haem-dep. IPR010582. Catalase-rel_immune_responsive. IPR011614. Catalase_N. IPR018028. Catalase_rel_subgroup. [Graphical view]
Gene3D	G3DSA:2.40.180.10. Catalase_N. 1 hit.
PANTHER	PTHR11465. Catalase. 1 hit.
Pfam	PF00199. Catalase. 1 hit. PF06628. Catalase-rel. 1 hit. [Graphical view]
PRINTS	PR00067. CATALASE.
PROSITE	PS00437. CATALASE_1. 1 hit. PS00438. CATALASE_2. 1 hit. PS51402. CATALASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATA_LACSK

Accession

Primary (citable) accession number: P30265

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	July 15, 1999
Last modified:	January 19, 2010
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)