Reviewed, UniProtKB/Swiss-Prot P30263 (CATA_PICAN)

Names and origin

Protein names

Recommended name:
    Peroxisomal catalase
    EC=1.11.1.6

Gene names

Name:	PXP9
Synonyms:	PXP-9

Organism

Pichia angusta (Yeast) (Hansenula polymorpha)

Taxonomic identifier

4905 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Pichia

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
Catalytic activity	2 H2O2 = O2 + 2 H2O.
Cofactor	Heme group.
Subunit structure	Homotetramer.
Subcellular location	Peroxisome.
Sequence similarities	Belongs to the catalase family.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Cellular component	Peroxisome
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	catalase activity Inferred from electronic annotation. Source: EC heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 507	507	Peroxisomal catalase		PRO_0000084926
Regions
	Motif	505 – 507	3	Microbody targeting signal Potential
Sites
	Active site	65	1	By similarity
	Active site	138	1	By similarity
	Metal binding	348	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P30263-1 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 3536ED0A49539CC3	FASTA	507	57,849
	10 20 30 40 50 60 MSNPPVFTTS QGCPVSDPFT TQRIPLDSTG YKYAPPIGPL LLQDFKLIDT LSHFDRERIP 70 80 90 100 110 120 ERVVHAKGAG AYGVFEVTDD ITDVCSAKFL DTVGKKTRIF TRFSTVGGEK GSADTARDPR 130 140 150 160 170 180 GFATKFYTED GNLDLVYNNT PIFFIRDPIK FPHFIHTQKR NPATNLKDPN MFWDYLTAND 190 200 210 220 230 240 ESLHQVMYLF SNRGTPASYR TMNGYSGHTY KWYNSKGEWV YVQVHFIANQ GVHNLLDEEA 250 260 270 280 290 300 GRLAGEDPDH STRDLWEAIE KGDYPSWECY IQTMTLEQSK KLPFSVFDLT KVWPHKDFPL 310 320 330 340 350 360 RHFGRFTLNE NPKNYYAETE QIAFSPSHTV PGMEPSNDPV LQSRLFSYPD THRHRLGPNY 370 380 390 400 410 420 HQIPVNCPLK SGSFNPINRD GPMCVDGNLG GTPNYANAYN CPIQYAVSPK ASGNKPDEKY 430 440 450 460 470 480 TGEVVPYHWE HTDYDYFQPK MFWKVLGRTP GEQESLVKNV ANHVSAADEF IQDRVYEYFS 490 500 KAEPIIGDLI RKKVQELKRK ASSPSKI

References

[1]	"Targeting signal of the peroxisomal catalase in the methylotrophic yeast Hansenula polymorpha." Didion T., Roggenkamp R.O. FEBS Lett. 303:113-116(1992) [PubMed: 1607006] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 34438 / CBS 4732 / DSM 70277 / IFO 1476 / NRRL Y-5445.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X56501 Genomic DNA. Translation: CAA39856.1.
PIR	S23422.
3D structure databases
SMR	P30263. Positions 1-493.
ModBase	Search...
Protein family/group databases
PeroxiBase	5260. PangKat01.
Enzyme and pathway databases
BRENDA	1.11.1.6. 276392.
Family and domain databases
InterPro	IPR002226. Catalase. IPR020835. Catalase-like_haem-dep. IPR010582. Catalase-rel_immune_responsive. IPR011614. Catalase_N. IPR018028. Catalase_rel_subgroup. [Graphical view]
Gene3D	G3DSA:2.40.180.10. Catalase_N. 1 hit.
PANTHER	PTHR11465. Catalase. 1 hit.
Pfam	PF00199. Catalase. 1 hit. PF06628. Catalase-rel. 1 hit. [Graphical view]
PRINTS	PR00067. CATALASE.
PROSITE	PS00437. CATALASE_1. 1 hit. PS00438. CATALASE_2. 1 hit. PS51402. CATALASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATA_PICAN

Accession

Primary (citable) accession number: P30263

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	January 19, 2010
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)