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Protein

DNA polymerase delta subunit 3

Gene

cdc27

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processCell cycle, Cell division, DNA replication, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase delta subunit 3
Alternative name(s):
Cell division control protein 27
Gene namesi
Name:cdc27
ORF Names:SPBC1734.02c, SPBC337.18c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1734.02c.
PomBaseiSPBC1734.02c. cdc27.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • delta DNA polymerase complex Source: PomBase
  • nuclear replication fork Source: PomBase
  • nucleus Source: PomBase

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi57G → E: Cell cycle arrest at 35 degrees Celsius. 1
Mutagenesisi57G → R: Cell cycle arrest at 35 degrees Celsius. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001860491 – 372DNA polymerase delta subunit 3Add BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei163Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP30261.
PRIDEiP30261.

PTM databases

iPTMnetiP30261.

Interactioni

Subunit structurei

Heterotetramer that consist of the pol3, cdc1, cdc27 and cdm1 subunits. Cdc27 interacts with cdc1 and is required for dimerization of the tetramer.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi276184. 20 interactors.
ELMiP30261.
IntActiP30261. 2 interactors.
MINTiMINT-4688159.
STRINGi4896.SPBC1734.02c.1.

Structurei

3D structure databases

SMRiP30261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

InParanoidiP30261.
KOiK03504.
OrthoDBiEOG092C4F36.

Family and domain databases

InterProiView protein in InterPro
IPR019038. DNA_polymerase_subunit_Cdc27.
PANTHERiPTHR17598. PTHR17598. 1 hit.
PfamiView protein in Pfam
PF09507. CDC27. 2 hits.

Sequencei

Sequence statusi: Complete.

P30261-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEWRNFLDI KVINESSLVT VDNLSLQLDI SSEKAQEYLN MFYQGNDFLY
60 70 80 90 100
PIYLIHGQPI DDEINLEIDE ESQPISNFPV LQYILCDKSS LQEKQSRLKS
110 120 130 140 150
GYKTVIFALS SAPLSDFDEL LPAVYEIREK DVLYKKEDAD KYGFIFNENS
160 170 180 190 200
VPRVLKKAPS THSPQLSVPS KTSTIDKTDT RSTEKTKGKD IFSNARNQKG
210 220 230 240 250
NSSRKNKKAP LENHKEKEPL LPKEEKLSEQ AKRERDDLKN IMQLEDESVS
260 270 280 290 300
TTSVHDSEDD NLDSNNFQLE IGTEAKSAAP DEPQEIIKSV SGGKRRGKRK
310 320 330 340 350
VKKYATTKDE EGFLVTKEEE VWESFSEDEN ISTGTSNVVR NKPTTVNIAT
360 370
KKKNTAQSKP QQKSIMSFFG KK
Length:372
Mass (Da):42,350
Last modified:April 1, 1993 - v1
Checksum:i6E6F9AD407B17673
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74062 Genomic DNA. Translation: AAA35295.1.
M83307 mRNA. Translation: AAA35296.1.
CU329671 Genomic DNA. Translation: CAA21288.1.
PIRiT39649.
RefSeqiNP_595419.1. NM_001021326.2.

Genome annotation databases

EnsemblFungiiSPBC1734.02c.1; SPBC1734.02c.1:pep; SPBC1734.02c.
GeneIDi2539627.
KEGGispo:SPBC1734.02c.

Entry informationi

Entry nameiDPOD3_SCHPO
AccessioniPrimary (citable) accession number: P30261
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: August 30, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names