P30216 (VP7_ROTHE) Reviewed, UniProtKB/Swiss-Prot
Last modified October 16, 2013. Version 57. History...
Names and origin
|Sequence length||332 AA.|
|Sequence processing||The displayed sequence is further processed into a mature form.|
|Protein existence||Evidence at transcript level|
General annotation (Comments)
Outer capsid protein involved in attachment and possibly entry into the host epithelial cell. It is subsequently lost, together with VP4, following virus entry into the host cell. The outer layer contains 780 copies of VP7, grouped as 260 trimers. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors By similarity.
Homotrimer; in the presence of calcium By similarity. Acquisition of the capsid outer layer requires a high calcium concentration inside the endoplasmic reticulum. Following cell entry, the low calcium concentration in the cytoplasm is probably responsible for the solubilization of the outer layer By similarity.
Virion By similarity. Host endoplasmic reticulum lumen Potential. Note: Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles By similarity.
N-glycosylated By similarity.
Intramolecular disulfide bonds By similarity.
Belongs to the rotavirus VP7 family.
|Cellular component||Host endoplasmic reticulum|
|Molecular function||Capsid protein|
Outer capsid protein
T=13 icosahedral capsid protein
|Gene Ontology (GO)|
|Cellular_component||T=13 icosahedral viral capsid|
Inferred from electronic annotation. Source: UniProtKB-KWhost cell endoplasmic reticulum lumen
Inferred from electronic annotation. Source: UniProtKB-SubCellviral outer capsid
Inferred from electronic annotation. Source: UniProtKB-KW
|Complete GO annotation...|
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Signal peptide||1 – 49||49||Potential|
|Chain||50 – 332||283||Outer capsid glycoprotein VP7||PRO_0000041129|
Amino acid modifications
|Glycosylation||67||1||N-linked (GlcNAc...); by host Potential|
|Glycosylation||152||1||N-linked (GlcNAc...); by host Potential|
|Glycosylation||225||1||N-linked (GlcNAc...); by host Potential|
|||"Sequence conservation of gene 8 between human and porcine group C rotaviruses and its relationship to the VP7 gene of group A rotaviruses."|
Qian Y.A., Jiang B., Saif L.J., Kang S.Y., Ishimaru Y., Yamashita Y., Oseto M., Green K.Y.
Virology 182:562-569(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
|||"Sequence conservation and expression of the gene encoding the outer capsid glycoprotein among human group C rotaviruses of global distribution."|
Jiang B., Tsunemitsu H., Dennehy P.H., Oishi I., Brown D., Schnagl R.D., Oseto M., Fang Z.Y., Avendano L.F., Saif L.J., Glass R.I.
Arch. Virol. 141:381-390(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
|M61100 mRNA. Translation: AAA47352.1.|
U20991 Genomic RNA. Translation: AAC54785.1.
|PIR||VGXR88. B39988. |
3D structure databases
Protocols and materials databases
Family and domain databases
|InterPro||IPR001963. VP7. |
|Pfam||PF00434. VP7. 1 hit. |
|ProDom||PD000191. VP7. 1 hit. |
[Graphical view] [Entries sharing at least one domain]
|Accession||Primary (citable) accession number: P30216|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families