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P30211 (SIGM3_REOVJ) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Outer capsid protein sigma-3

Short name=Sigma3
Gene names
Name:S4
OrganismReovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2) [Complete proteome]
Taxonomic identifier10885 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostMammalia [TaxID: 40674]

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Stimulates translation by blocking the activation of the dsRNA-dependent protein kinase EIF2AK2/PKR, thereby inhibiting the host interferon response. Sigma3 prevents the activation of EIF2AK2 by competing with the kinase for dsRNA-binding By similarity.

The viral outer shell polypeptides, of which sigma-3 is one, impose structural constraints that prevent elongation of nascent transcripts by the RNA-dependent RNA polymerase lambda-3 By similarity.

Subunit structure

Heterohexamer of three sigma-3 and three Mu-1 proteins. The RNA-binding form is probably a homodimer By similarity.

Subcellular location

Virion By similarity. Note: Found in the outer capsid. Each subunit is positioned with the small lobe anchoring it to the protein mu1 on the surface of the virion, and the large lobe, the site of initial cleavages during entry-related proteolytic disassembly, protruding outwards By similarity.

Post-translational modification

Cleaved during virus the endosomal proteolytic disassembly of the outer capsid By similarity.

Sequence similarities

Belongs to the orthoreovirus sigma-3 protein family.

Contains 1 CCHC-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 365365Outer capsid protein sigma-3
PRO_0000222753

Regions

Zinc finger51 – 7323CCHC-type By similarity

Sequences

Sequence LengthMass (Da)Tools
P30211 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 574350AEDFE04478

FASTA36541,226
        10         20         30         40         50         60 
MEVCLPNGHQ IVDWINNAFE GRVSIYSAQQ GWDKTISAQP DMMVCGGAVV CMHCLGVVGS 

        70         80         90        100        110        120 
LQRKLKHLPH HKCNQQLRQQ DYVDVQFADR VTAHWKRGML SFVSQMHAIM NDVTPEELER 

       130        140        150        160        170        180 
VRTDGGSLAE LNWLQVDPGS MFRSIHSSWT DPLQVVEDLD TQLDRYWTAL NLMIDSSDLV 

       190        200        210        220        230        240 
PNFMMRDPSH AFNGVKLEGE ARQTQFSRTF DSRSNLEWGV MIYDYSELER DPLKGRAYRK 

       250        260        270        280        290        300 
EVVTPARDFG HFGLSHYSRA TTPILGKMPA VFSGMLTGNC KMYPFIKGTA KLRTVKKLVD 

       310        320        330        340        350        360 
AVNHTWGSEK IRYALGPGGM TGWYNRTMQQ APIVLTPAAL TMFPDMTKFG DLQYPIMIGD 


PAVLG 

« Hide

References

[1]"Translational effects and sequence comparisons of the three serotypes of the reovirus S4 gene."
Seliger L.S., Giantini M., Shatkin A.J.
Virology 187:202-210(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X60066 mRNA. Translation: CAA42670.1.
PIRMNXRSJ. B42192.

3D structure databases

ProteinModelPortalP30211.
SMRP30211. Positions 1-365.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000153. Reo_capsid_sigma3.
IPR023634. Reovirus_capsid_sigma-3_dom.
[Graphical view]
PfamPF00979. Reovirus_cap. 1 hit.
[Graphical view]
SUPFAMSSF64465. SSF64465. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSIGM3_REOVJ
AccessionPrimary (citable) accession number: P30211
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families