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Protein

Macrophage scavenger receptor types I and II

Gene

Msr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL).By similarity

GO - Molecular functioni

  • low-density lipoprotein particle binding Source: BHF-UCL
  • scavenger receptor activity Source: InterPro

GO - Biological processi

  • cellular response to organic cyclic compound Source: Ensembl
  • cholesterol transport Source: BHF-UCL
  • lipoprotein transport Source: MGI
  • plasma lipoprotein particle clearance Source: BHF-UCL
  • positive regulation of cholesterol storage Source: BHF-UCL
  • positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  • receptor-mediated endocytosis Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Enzyme and pathway databases

ReactomeiR-BTA-3000480. Scavenging by Class A Receptors.
R-MMU-3000480. Scavenging by Class A Receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage scavenger receptor types I and II
Alternative name(s):
Macrophage acetylated LDL receptor I and II
Scavenger receptor type A
Short name:
SR-A
CD_antigen: CD204
Gene namesi
Name:Msr1
Synonyms:Scvr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:98257. Msr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 55CytoplasmicSequence analysisAdd BLAST55
Transmembranei56 – 78Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini79 – 458ExtracellularSequence analysisAdd BLAST380

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

LDL, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4399.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001816281 – 458Macrophage scavenger receptor types I and IIAdd BLAST458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineCombined sources1
Modified residuei36PhosphoserineCombined sources1
Glycosylationi94N-linked (GlcNAc...)Sequence analysis1
Glycosylationi107N-linked (GlcNAc...)Sequence analysis1
Glycosylationi147N-linked (GlcNAc...)Sequence analysis1
Glycosylationi188N-linked (GlcNAc...)Sequence analysis1
Glycosylationi253N-linked (GlcNAc...)Sequence analysis1
Glycosylationi271N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi382 ↔ 446PROSITE-ProRule annotation
Disulfide bondi395 ↔ 456PROSITE-ProRule annotation
Disulfide bondi426 ↔ 436PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP30204.
PaxDbiP30204.
PeptideAtlasiP30204.
PRIDEiP30204.

PTM databases

iPTMnetiP30204.
PhosphoSitePlusiP30204.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025044.
CleanExiMM_MSR1.
ExpressionAtlasiP30204. baseline and differential.
GenevisibleiP30204. MM.

Interactioni

Subunit structurei

Homotrimer (PubMed:8394868). Interacts with MYO18A (By similarity).By similarity1 Publication

Protein-protein interaction databases

IntActiP30204. 1 interactor.
STRINGi10090.ENSMUSP00000026021.

Chemistry databases

BindingDBiP30204.

Structurei

3D structure databases

ProteinModelPortaliP30204.
SMRiP30204.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini277 – 350Collagen-likeAdd BLAST74
Domaini357 – 457SRCRPROSITE-ProRule annotationAdd BLAST101

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni79 – 114SpacerCuratedAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili209 – 259Sequence analysisAdd BLAST51

Sequence similaritiesi

Contains 1 collagen-like domain.Curated
Contains 1 SRCR domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Collagen, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK8A. Eukaryota.
ENOG410YQBT. LUCA.
GeneTreeiENSGT00850000132310.
HOGENOMiHOG000085659.
HOVERGENiHBG002473.
InParanoidiP30204.
KOiK06558.
OMAiDQRFNDV.
OrthoDBiEOG091G02XD.
TreeFamiTF330855.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiIPR008160. Collagen.
IPR003543. Macro_scav_rcpt.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF01391. Collagen. 2 hits.
PF03523. Macscav_rec. 1 hit.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR01408. MACSCAVRCPTR.
PR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 1 hit.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 1 hit.
PROSITEiPS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform I (identifier: P30204-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTKEMTENQR LCPHEQEDAD CSSESVKFDA RSMTASLPHS TKNGPSLQEK
60 70 80 90 100
LKSFKAALIA LYLLVFAVLI PVVGIVTAQL LNWEMKNCLV CSLNTSDTSQ
110 120 130 140 150
GPMEKENTSK VEMRFTIIME HMKDMEERIE SISNSKADLI DTERFQNFSM
160 170 180 190 200
ATDQRLNDIL LQLNSLISSV QEHGNSLDAI SKSLQSLNMT LLDVQLHTET
210 220 230 240 250
LNVRVRESTA KQQEDISKLE ERVYKVSAEV QSVKEEQAHV EQEVKQEVRV
260 270 280 290 300
LNNITNDLRL KDWEHSQTLK NITFIQGPPG PQGEKGDRGL TGQTGPPGAP
310 320 330 340 350
GIRGIPGVKG DRGQIGFPGG RGNPGAPGKP GRSGSPGPKG QKGEKGSVGG
360 370 380 390 400
STPLKTVRLV GGSGAHEGRV EIFHQGQWGT ICDDRWDIRA GQVVCRSLGY
410 420 430 440 450
QEVLAVHKRA HFGQGTGPIW LNEVMCFGRE SSIENCKINQ WGVLSCSHSE

DAGVTCTS
Length:458
Mass (Da):50,170
Last modified:July 27, 2011 - v3
Checksum:iDA069B90A6B59EB5
GO
Isoform II (identifier: P30204-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     352-354: TPL → RSV
     355-458: Missing.

Show »
Length:354
Mass (Da):38,773
Checksum:i348E084D2D8B644B
GO

Sequence cautioni

The sequence AAA39747 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAA39748 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16Q → R in AAA39747 (PubMed:8394868).Curated1
Sequence conflicti16Q → R in AAA39748 (PubMed:8394868).Curated1
Sequence conflicti16Q → R in BAA02650 (PubMed:8380589).Curated1
Sequence conflicti16Q → R in AAF14001 (Ref. 3) Curated1
Sequence conflicti16Q → R in BAC40779 (PubMed:16141072).Curated1
Sequence conflicti16Q → R in AAH03814 (PubMed:15489334).Curated1
Sequence conflicti47L → V in AAA39747 (PubMed:8394868).Curated1
Sequence conflicti47L → V in AAA39748 (PubMed:8394868).Curated1
Sequence conflicti47L → V in BAA02650 (PubMed:8380589).Curated1
Sequence conflicti47L → V in BAC40779 (PubMed:16141072).Curated1
Sequence conflicti47L → V in AAH03814 (PubMed:15489334).Curated1
Sequence conflicti93L → R in AAA39747 (PubMed:8394868).Curated1
Sequence conflicti93L → R in AAA39748 (PubMed:8394868).Curated1
Sequence conflicti93L → R in BAA02650 (PubMed:8380589).Curated1
Sequence conflicti93L → R in AAF14001 (Ref. 3) Curated1
Sequence conflicti93L → R in BAC40779 (PubMed:16141072).Curated1
Sequence conflicti93L → R in AAH03814 (PubMed:15489334).Curated1
Sequence conflicti110K → N in AAA39747 (PubMed:8394868).Curated1
Sequence conflicti110K → N in AAA39748 (PubMed:8394868).Curated1
Sequence conflicti110K → N in BAA02650 (PubMed:8380589).Curated1
Sequence conflicti110K → N in BAC40779 (PubMed:16141072).Curated1
Sequence conflicti110K → N in AAH03814 (PubMed:15489334).Curated1
Sequence conflicti120E → A in AAA39747 (PubMed:8394868).Curated1
Sequence conflicti120E → A in AAA39748 (PubMed:8394868).Curated1
Sequence conflicti120E → A in BAA02650 (PubMed:8380589).Curated1
Sequence conflicti120E → A in BAC40779 (PubMed:16141072).Curated1
Sequence conflicti120E → A in AAH03814 (PubMed:15489334).Curated1
Sequence conflicti130E → Q in AAA39747 (PubMed:8394868).Curated1
Sequence conflicti130E → Q in AAA39748 (PubMed:8394868).Curated1
Sequence conflicti130E → Q in BAA02650 (PubMed:8380589).Curated1
Sequence conflicti130E → Q in BAC40779 (PubMed:16141072).Curated1
Sequence conflicti130E → Q in AAH03814 (PubMed:15489334).Curated1
Sequence conflicti143E → G in AAA39747 (PubMed:8394868).Curated1
Sequence conflicti143E → G in AAA39748 (PubMed:8394868).Curated1
Sequence conflicti143E → G in BAA02650 (PubMed:8380589).Curated1
Sequence conflicti143E → G in AAF14001 (Ref. 3) Curated1
Sequence conflicti143E → G in BAC40779 (PubMed:16141072).Curated1
Sequence conflicti143E → G in AAH03814 (PubMed:15489334).Curated1
Sequence conflicti168S → L in AAA39747 (PubMed:8394868).Curated1
Sequence conflicti168S → L in AAA39748 (PubMed:8394868).Curated1
Sequence conflicti168S → L in BAA02650 (PubMed:8380589).Curated1
Sequence conflicti168S → L in BAC40779 (PubMed:16141072).Curated1
Sequence conflicti168S → L in AAH03814 (PubMed:15489334).Curated1
Sequence conflicti202N → H in AAA39747 (PubMed:8394868).Curated1
Sequence conflicti202N → H in AAA39748 (PubMed:8394868).Curated1
Sequence conflicti202N → H in BAA02650 (PubMed:8380589).Curated1
Sequence conflicti202N → H in BAC40779 (PubMed:16141072).Curated1
Sequence conflicti202N → H in AAH03814 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006231352 – 354TPL → RSV in isoform II. 4 Publications3
Alternative sequenceiVSP_006232355 – 458Missing in isoform II. 4 PublicationsAdd BLAST104

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04274 mRNA. Translation: AAA39747.1. Different initiation.
L04275 mRNA. Translation: AAA39748.1. Different initiation.
D13382 mRNA. Translation: BAA02650.1.
AF203781 mRNA. Translation: AAF14001.1.
M59445 mRNA. Translation: AAA37464.1.
M59446 mRNA. Translation: AAA37465.1.
U13873 Genomic DNA. Translation: AAC13774.1.
AK089178 mRNA. Translation: BAC40779.1.
AC111028 Genomic DNA. No translation available.
BC003814 mRNA. Translation: AAH03814.1.
CCDSiCCDS52542.1. [P30204-1]
CCDS52543.1. [P30204-2]
PIRiB44407.
I73338.
RefSeqiNP_001106797.1. NM_001113326.1. [P30204-1]
UniGeneiMm.239291.

Genome annotation databases

EnsembliENSMUST00000026021; ENSMUSP00000026021; ENSMUSG00000025044. [P30204-1]
ENSMUST00000170091; ENSMUSP00000132535; ENSMUSG00000025044. [P30204-2]
GeneIDi20288.
KEGGimmu:20288.
UCSCiuc012gcm.1. mouse. [P30204-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04274 mRNA. Translation: AAA39747.1. Different initiation.
L04275 mRNA. Translation: AAA39748.1. Different initiation.
D13382 mRNA. Translation: BAA02650.1.
AF203781 mRNA. Translation: AAF14001.1.
M59445 mRNA. Translation: AAA37464.1.
M59446 mRNA. Translation: AAA37465.1.
U13873 Genomic DNA. Translation: AAC13774.1.
AK089178 mRNA. Translation: BAC40779.1.
AC111028 Genomic DNA. No translation available.
BC003814 mRNA. Translation: AAH03814.1.
CCDSiCCDS52542.1. [P30204-1]
CCDS52543.1. [P30204-2]
PIRiB44407.
I73338.
RefSeqiNP_001106797.1. NM_001113326.1. [P30204-1]
UniGeneiMm.239291.

3D structure databases

ProteinModelPortaliP30204.
SMRiP30204.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP30204. 1 interactor.
STRINGi10090.ENSMUSP00000026021.

Chemistry databases

BindingDBiP30204.
ChEMBLiCHEMBL4399.

PTM databases

iPTMnetiP30204.
PhosphoSitePlusiP30204.

Proteomic databases

MaxQBiP30204.
PaxDbiP30204.
PeptideAtlasiP30204.
PRIDEiP30204.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026021; ENSMUSP00000026021; ENSMUSG00000025044. [P30204-1]
ENSMUST00000170091; ENSMUSP00000132535; ENSMUSG00000025044. [P30204-2]
GeneIDi20288.
KEGGimmu:20288.
UCSCiuc012gcm.1. mouse. [P30204-1]

Organism-specific databases

CTDi4481.
MGIiMGI:98257. Msr1.

Phylogenomic databases

eggNOGiENOG410IK8A. Eukaryota.
ENOG410YQBT. LUCA.
GeneTreeiENSGT00850000132310.
HOGENOMiHOG000085659.
HOVERGENiHBG002473.
InParanoidiP30204.
KOiK06558.
OMAiDQRFNDV.
OrthoDBiEOG091G02XD.
TreeFamiTF330855.

Enzyme and pathway databases

ReactomeiR-BTA-3000480. Scavenging by Class A Receptors.
R-MMU-3000480. Scavenging by Class A Receptors.

Miscellaneous databases

ChiTaRSiMsr1. mouse.
PROiP30204.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025044.
CleanExiMM_MSR1.
ExpressionAtlasiP30204. baseline and differential.
GenevisibleiP30204. MM.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiIPR008160. Collagen.
IPR003543. Macro_scav_rcpt.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF01391. Collagen. 2 hits.
PF03523. Macscav_rec. 1 hit.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR01408. MACSCAVRCPTR.
PR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 1 hit.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 1 hit.
PROSITEiPS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSRE_MOUSE
AccessioniPrimary (citable) accession number: P30204
Secondary accession number(s): E9QNQ5, Q923G0, Q9QZ56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 162 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.