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Reviewed, UniProtKB/Swiss-Prot P30203 (CD6_HUMAN)

Last modified November 24, 2009. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    T-cell differentiation antigen CD6
Alternative name(s):
    T12
    TP120
    CD_antigen=CD6
Gene names
Name: CD6
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length668 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Involved in cell adhesion. Binds to CD166.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.

Post-translational modification

After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues. Ref.3 Ref.4

Contains intrachain disulfide bond(s).

Sequence similarities

Contains 3 SRCR domains.

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Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Signal
Transmembrane
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to plasma membrane Ref.1

Traceable author statement. Source: ProtInc

   Molecular functionscavenger receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform CD6A (identifier: P30203-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform CD6B (identifier: P30203-2)

The sequence of this isoform differs from the canonical sequence as follows:
     431-462: Missing.
Isoform CD6C (identifier: P30203-3)

The sequence of this isoform differs from the canonical sequence as follows:
     431-462: Missing.
     463-504: VFMLPIQVQAPPPEDSDSGSDSDYEHYDFSAQPPVALTTFYN → D
Isoform CD6D (identifier: P30203-4)

The sequence of this isoform differs from the canonical sequence as follows:
     431-462: Missing.
     613-647: Missing.
Isoform CD6E (identifier: P30203-5)

The sequence of this isoform differs from the canonical sequence as follows:
     463-504: VFMLPIQVQAPPPEDSDSGSDSDYEHYDFSAQPPVALTTFYN → D
     613-647: Missing.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 668651T-cell differentiation antigen CD6
PRO_0000033227

Regions

Topological domain18 – 402385Extracellular Potential
Transmembrane403 – 42321 Potential
Topological domain424 – 668245Cytoplasmic Potential
Domain45 – 156112SRCR 1
Domain161 – 260100SRCR 2
Domain265 – 36197SRCR 3

Amino acid modifications

Glycosylation281N-linked (GlcNAc...) Potential
Glycosylation491N-linked (GlcNAc...) Potential
Glycosylation1121N-linked (GlcNAc...) Potential
Glycosylation1181N-linked (GlcNAc...) Potential
Glycosylation2291N-linked (GlcNAc...) Potential
Glycosylation3391N-linked (GlcNAc...) Potential
Glycosylation3451N-linked (GlcNAc...) Potential
Glycosylation3681N-linked (GlcNAc...) Potential
Disulfide bond70 ↔ 144 By similarity
Disulfide bond83 ↔ 155 By similarity
Disulfide bond129 ↔ 137 By similarity
Disulfide bond186 ↔ 249 By similarity
Disulfide bond199 ↔ 259 By similarity
Disulfide bond230 ↔ 240 By similarity
Disulfide bond290 ↔ 350 By similarity
Disulfide bond303 ↔ 360 By similarity
Disulfide bond330 ↔ 340 By similarity

Natural variations

Alternative sequence431 – 46232Missing in isoform CD6B, isoform CD6C and isoform CD6D.
VSP_006221
Alternative sequence463 – 50442VFMLP…TTFYN → D in isoform CD6C and isoform CD6E.
VSP_006222
Alternative sequence613 – 64735Missing in isoform CD6D and isoform CD6E.
VSP_006223
Natural variant2171T → M: dbSNP rs11230562.
VAR_059809
Natural variant2251R → W: dbSNP rs11230563.
VAR_057202
Natural variant2711A → T: dbSNP rs12360861.
VAR_057203
Natural variant3511S → N: dbSNP rs34974368.
VAR_057204
Natural variant6061G → S: dbSNP rs2074233.
VAR_057205

Experimental info

Sequence conflict463 – 4686VFMLPI → GPGPAP in CAA43306. Ref.1
Sequence conflict6131Missing in AAC51162. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
Isoform CD6A [UniParc].

Last modified April 27, 2001. Version 2.
Checksum: EFB434608012C49E

FASTA66871,829
        10         20         30         40         50         60 
MWLFFGITGL LTAALSGHPS PAPPDQLNTS SAESELWEPG ERLPVRLTNG SSSCSGTVEV 

        70         80         90        100        110        120 
RLEASWEPAC GALWDSRAAE AVCRALGCGG AEAASQLAPP TPELPPPPAA GNTSVAANAT 

       130        140        150        160        170        180 
LAGAPALLCS GAEWRLCEVV EHACRSDGRR ARVTCAENRA LRLVDGGGAC AGRVEMLEHG 

       190        200        210        220        230        240 
EWGSVCDDTW DLEDAHVVCR QLGCGWAVQA LPGLHFTPGR GPIHRDQVNC SGAEAYLWDC 

       250        260        270        280        290        300 
PGLPGQHYCG HKEDAGVVCS EHQSWRLTGG ADRCEGQVEV HFRGVWNTVC DSEWYPSEAK 

       310        320        330        340        350        360 
VLCQSLGCGT AVERPKGLPH SLSGRMYYSC NGEELTLSNC SWRFNNSNLC SQSLAARVLC 

       370        380        390        400        410        420 
SASRSLHNLS TPEVPASVQT VTIESSVTVK IENKESRELM LLIPSIVLGI LLLGSLIFIA 

       430        440        450        460        470        480 
FILLRIKGKY ALPVMVNHQH LPTTIPAGSN SYQPVPITIP KEVFMLPIQV QAPPPEDSDS 

       490        500        510        520        530        540 
GSDSDYEHYD FSAQPPVALT TFYNSQRHRV TDEEVQQSRF QMPPLEEGLE ELHASHIPTA 

       550        560        570        580        590        600 
NPGHCITDPP SLGPQYHPRS NSESSTSSGE DYCNSPKSKL PPWNPQVFSS ERSSFLEQPP 

       610        620        630        640        650        660 
NLELAGTQPA FSAGPPADDS SSTSSGEWYQ NFQPPPQPPS EEQFGCPGSP SPQPDSTDND 


DYDDISAA

« Hide

Isoform CD6B.

Checksum: 59932D29D8F2C151
Show »

FASTA63668,396
Isoform CD6C.

Checksum: 7A72D1A9AB0CE7A4
Show »

FASTA59563,852
Isoform CD6D.

Checksum: DC7DBDBA509C1484
Show »

FASTA60164,691
Isoform CD6E.

Checksum: 593CA86D768552F0
Show »

FASTA59263,580

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References

[1]"The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins."
Aruffo A., Melnick M.B., Linsley P.S., Seed B.
J. Exp. Med. 174:949-952(1991) [PubMed: 1919444] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-468.
[2]"Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms."
Bowen M.A., Whitney G.S., Neubauer M., Starling G.C., Palmer D., Zhang J., Nowak N.J., Shows T.B., Aruffo A.
J. Immunol. 158:1149-1156(1997) [PubMed: 9013954] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING.
[3]"Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule."
Swack J.A., Mier J.W., Romain P.L., Hull S.R., Rudd C.E.
J. Biol. Chem. 266:7137-7143(1991) [PubMed: 2016320] [Abstract]
Cited for: PHOSPHORYLATION AT SERINE RESIDUES, DISULFIDE BONDS, GLYCOSYLATION.
[4]"Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors."
Wee S., Schieven G.L., Kirihara J.M., Tsu T.T., Ledbetter J.A., Aruffo A.
J. Exp. Med. 177:219-223(1993) [PubMed: 7678115] [Abstract]
Cited for: PHOSPHORYLATION AT TYROSINE RESIDUES.
+Additional computationally mapped references.

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Cross-references

Sequence databases

X60992 mRNA. Translation: CAA43306.1.
U66142 mRNA. Translation: AAC51161.1.
U66143 Genomic DNA. Translation: AAC51162.1.
U66144 Genomic DNA. Translation: AAC51163.1.
U66145 mRNA. Translation: AAC51164.1.
U66146 mRNA. Translation: AAC51165.1.
IPIIPI00025700.
IPI00218871.
IPI00218872.
IPI00218873.
IPI00374647.
PIRS26741.
UniGeneHs.712554

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGP30203.

PTM databases

PhosphoSiteP30203.

Proteomic databases

PRIDEP30203.

Genome annotation databases

EnsemblENST00000313421; ENSP00000323280; ENSG00000013725; Homo sapiens. [Genome view]
UCSCuc001nqq.1. human.
uc001nqr.1. human.
uc001nqt.1. human.

Organism-specific databases

GeneCardsGC11P060495.
H-InvDBHIX0009678.
HGNCHGNC:1691. CD6.
HPACAB002489.
CAB016252.
MIM186720. gene.
PharmGKBPA26230.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP30203.
HOVERGENP30203.

Gene expression databases

ArrayExpressP30203.
BgeeP30203.
CleanExHS_CD6.
GenevestigatorP30203.
GermOnlineENSG00000013725. Homo sapiens.

Family and domain databases

InterProIPR001190. Srcr_rcpt.
IPR017448. Srcr_rcpt-rel.
[Graphical view]
PfamPF00530. SRCR. 3 hits.
[Graphical view]
PRINTSPR00258. SPERACTRCPTR.
SMARTSM00202. SR. 3 hits.
[Graphical view]
PROSITEPS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameCD6_HUMAN
AccessionPrimary (citable) accession number: P30203
Secondary accession number(s): Q9UMF2 expand/collapse secondary AC list , Q9Y4K7, Q9Y4K8, Q9Y4K9, Q9Y4L0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 27, 2001
Last modified: November 24, 2009
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents