P30203 (CD6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
T-cell differentiation antigen CD6

Alternative name(s):
T12
TP120
CD_antigen=CD6

Gene names

Name:

CD6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	668 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in cell adhesion. Binds to CD166.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.
Post-translational modification	After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues. Ref.4 Ref.5 Contains intrachain disulfide bond(s).
Sequence similarities	Contains 3 SRCR domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cell surface Inferred from direct assay PubMed 12493773. Source: UniProtKB integral to plasma membrane Traceable author statement Ref.3. Source: ProtInc
Molecular_function	scavenger receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform CD6A (identifier: P30203-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform CD6B (identifier: P30203-2)

The sequence of this isoform differs from the canonical sequence as follows:
     431-462: Missing.

Isoform CD6C (identifier: P30203-3)

The sequence of this isoform differs from the canonical sequence as follows:
     431-462: Missing.
     463-504: VFMLPIQVQAPPPEDSDSGSDSDYEHYDFSAQPPVALTTFYN → D

Isoform CD6D (identifier: P30203-4)

The sequence of this isoform differs from the canonical sequence as follows:
     431-462: Missing.
     613-647: Missing.

Isoform CD6E (identifier: P30203-5)

The sequence of this isoform differs from the canonical sequence as follows:
     463-504: VFMLPIQVQAPPPEDSDSGSDSDYEHYDFSAQPPVALTTFYN → D
     613-647: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 668	651	T-cell differentiation antigen CD6		PRO_0000033227
Regions
	Topological domain	18 – 402	385	Extracellular Potential
	Transmembrane	403 – 423	21	Helical; Potential
	Topological domain	424 – 668	245	Cytoplasmic Potential
	Domain	45 – 156	112	SRCR 1
	Domain	161 – 260	100	SRCR 2
	Domain	265 – 361	97	SRCR 3
Amino acid modifications
	Glycosylation	28	1	N-linked (GlcNAc...) Potential
	Glycosylation	49	1	N-linked (GlcNAc...) Potential
	Glycosylation	112	1	N-linked (GlcNAc...) Potential
	Glycosylation	118	1	N-linked (GlcNAc...) Potential
	Glycosylation	229	1	N-linked (GlcNAc...) Potential
	Glycosylation	339	1	N-linked (GlcNAc...) Potential
	Glycosylation	345	1	N-linked (GlcNAc...) Potential
	Glycosylation	368	1	N-linked (GlcNAc...) Potential
	Disulfide bond	70 ↔ 144		By similarity
	Disulfide bond	83 ↔ 155		By similarity
	Disulfide bond	129 ↔ 137		By similarity
	Disulfide bond	186 ↔ 249		By similarity
	Disulfide bond	199 ↔ 259		By similarity
	Disulfide bond	230 ↔ 240		By similarity
	Disulfide bond	290 ↔ 350		By similarity
	Disulfide bond	303 ↔ 360		By similarity
	Disulfide bond	330 ↔ 340		By similarity
Natural variations
	Alternative sequence	431 – 462	32	Missing in isoform CD6B, isoform CD6C and isoform CD6D.		VSP_006221
	Alternative sequence	463 – 504	42	VFMLP…TTFYN → D in isoform CD6C and isoform CD6E.		VSP_006222
	Alternative sequence	613 – 647	35	Missing in isoform CD6D and isoform CD6E.		VSP_006223
	Natural variant	217	1	T → M. Corresponds to variant rs11230562 [ dbSNP | Ensembl ].		VAR_059809
	Natural variant	225	1	R → W. Corresponds to variant rs11230563 [ dbSNP | Ensembl ].		VAR_057202
	Natural variant	257	1	A → V. Ref.1 Ref.3 Corresponds to variant rs2074225 [ dbSNP | Ensembl ].		VAR_060790
	Natural variant	271	1	A → T. Corresponds to variant rs12360861 [ dbSNP | Ensembl ].		VAR_057203
	Natural variant	351	1	S → N. Corresponds to variant rs34974368 [ dbSNP | Ensembl ].		VAR_057204
	Natural variant	606	1	G → S. Corresponds to variant rs2074233 [ dbSNP | Ensembl ].		VAR_057205
Experimental info
	Sequence conflict	463 – 468	6	VFMLPI → GPGPAP in CAA43306. Ref.3
	Sequence conflict	613	1	Missing in AAC51162. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform CD6A [UniParc]. Last modified December 15, 2009. Version 3. Checksum: 59E6790E77FFBC42	FASTA	668	71,801
	10 20 30 40 50 60 MWLFFGITGL LTAALSGHPS PAPPDQLNTS SAESELWEPG ERLPVRLTNG SSSCSGTVEV 70 80 90 100 110 120 RLEASWEPAC GALWDSRAAE AVCRALGCGG AEAASQLAPP TPELPPPPAA GNTSVAANAT 130 140 150 160 170 180 LAGAPALLCS GAEWRLCEVV EHACRSDGRR ARVTCAENRA LRLVDGGGAC AGRVEMLEHG 190 200 210 220 230 240 EWGSVCDDTW DLEDAHVVCR QLGCGWAVQA LPGLHFTPGR GPIHRDQVNC SGAEAYLWDC 250 260 270 280 290 300 PGLPGQHYCG HKEDAGAVCS EHQSWRLTGG ADRCEGQVEV HFRGVWNTVC DSEWYPSEAK 310 320 330 340 350 360 VLCQSLGCGT AVERPKGLPH SLSGRMYYSC NGEELTLSNC SWRFNNSNLC SQSLAARVLC 370 380 390 400 410 420 SASRSLHNLS TPEVPASVQT VTIESSVTVK IENKESRELM LLIPSIVLGI LLLGSLIFIA 430 440 450 460 470 480 FILLRIKGKY ALPVMVNHQH LPTTIPAGSN SYQPVPITIP KEVFMLPIQV QAPPPEDSDS 490 500 510 520 530 540 GSDSDYEHYD FSAQPPVALT TFYNSQRHRV TDEEVQQSRF QMPPLEEGLE ELHASHIPTA 550 560 570 580 590 600 NPGHCITDPP SLGPQYHPRS NSESSTSSGE DYCNSPKSKL PPWNPQVFSS ERSSFLEQPP 610 620 630 640 650 660 NLELAGTQPA FSAGPPADDS SSTSSGEWYQ NFQPPPQPPS EEQFGCPGSP SPQPDSTDND DYDDISAA
	Isoform CD6B [UniParc]. Checksum: 8EC9117BF4AAD154	FASTA	636	68,368
	10 20 30 40 50 60 MWLFFGITGL LTAALSGHPS PAPPDQLNTS SAESELWEPG ERLPVRLTNG SSSCSGTVEV 70 80 90 100 110 120 RLEASWEPAC GALWDSRAAE AVCRALGCGG AEAASQLAPP TPELPPPPAA GNTSVAANAT 130 140 150 160 170 180 LAGAPALLCS GAEWRLCEVV EHACRSDGRR ARVTCAENRA LRLVDGGGAC AGRVEMLEHG 190 200 210 220 230 240 EWGSVCDDTW DLEDAHVVCR QLGCGWAVQA LPGLHFTPGR GPIHRDQVNC SGAEAYLWDC 250 260 270 280 290 300 PGLPGQHYCG HKEDAGAVCS EHQSWRLTGG ADRCEGQVEV HFRGVWNTVC DSEWYPSEAK 310 320 330 340 350 360 VLCQSLGCGT AVERPKGLPH SLSGRMYYSC NGEELTLSNC SWRFNNSNLC SQSLAARVLC 370 380 390 400 410 420 SASRSLHNLS TPEVPASVQT VTIESSVTVK IENKESRELM LLIPSIVLGI LLLGSLIFIA 430 440 450 460 470 480 FILLRIKGKY VFMLPIQVQA PPPEDSDSGS DSDYEHYDFS AQPPVALTTF YNSQRHRVTD 490 500 510 520 530 540 EEVQQSRFQM PPLEEGLEEL HASHIPTANP GHCITDPPSL GPQYHPRSNS ESSTSSGEDY 550 560 570 580 590 600 CNSPKSKLPP WNPQVFSSER SSFLEQPPNL ELAGTQPAFS AGPPADDSSS TSSGEWYQNF 610 620 630 QPPPQPPSEE QFGCPGSPSP QPDSTDNDDY DDISAA
	Isoform CD6C [UniParc]. Checksum: 04D85EE0DBB4A885	FASTA	595	63,824
	10 20 30 40 50 60 MWLFFGITGL LTAALSGHPS PAPPDQLNTS SAESELWEPG ERLPVRLTNG SSSCSGTVEV 70 80 90 100 110 120 RLEASWEPAC GALWDSRAAE AVCRALGCGG AEAASQLAPP TPELPPPPAA GNTSVAANAT 130 140 150 160 170 180 LAGAPALLCS GAEWRLCEVV EHACRSDGRR ARVTCAENRA LRLVDGGGAC AGRVEMLEHG 190 200 210 220 230 240 EWGSVCDDTW DLEDAHVVCR QLGCGWAVQA LPGLHFTPGR GPIHRDQVNC SGAEAYLWDC 250 260 270 280 290 300 PGLPGQHYCG HKEDAGAVCS EHQSWRLTGG ADRCEGQVEV HFRGVWNTVC DSEWYPSEAK 310 320 330 340 350 360 VLCQSLGCGT AVERPKGLPH SLSGRMYYSC NGEELTLSNC SWRFNNSNLC SQSLAARVLC 370 380 390 400 410 420 SASRSLHNLS TPEVPASVQT VTIESSVTVK IENKESRELM LLIPSIVLGI LLLGSLIFIA 430 440 450 460 470 480 FILLRIKGKY DSQRHRVTDE EVQQSRFQMP PLEEGLEELH ASHIPTANPG HCITDPPSLG 490 500 510 520 530 540 PQYHPRSNSE SSTSSGEDYC NSPKSKLPPW NPQVFSSERS SFLEQPPNLE LAGTQPAFSA 550 560 570 580 590 GPPADDSSST SSGEWYQNFQ PPPQPPSEEQ FGCPGSPSPQ PDSTDNDDYD DISAA
	Isoform CD6D [UniParc]. Checksum: 0D8DCC42B53BDA2E	FASTA	601	64,663
	10 20 30 40 50 60 MWLFFGITGL LTAALSGHPS PAPPDQLNTS SAESELWEPG ERLPVRLTNG SSSCSGTVEV 70 80 90 100 110 120 RLEASWEPAC GALWDSRAAE AVCRALGCGG AEAASQLAPP TPELPPPPAA GNTSVAANAT 130 140 150 160 170 180 LAGAPALLCS GAEWRLCEVV EHACRSDGRR ARVTCAENRA LRLVDGGGAC AGRVEMLEHG 190 200 210 220 230 240 EWGSVCDDTW DLEDAHVVCR QLGCGWAVQA LPGLHFTPGR GPIHRDQVNC SGAEAYLWDC 250 260 270 280 290 300 PGLPGQHYCG HKEDAGAVCS EHQSWRLTGG ADRCEGQVEV HFRGVWNTVC DSEWYPSEAK 310 320 330 340 350 360 VLCQSLGCGT AVERPKGLPH SLSGRMYYSC NGEELTLSNC SWRFNNSNLC SQSLAARVLC 370 380 390 400 410 420 SASRSLHNLS TPEVPASVQT VTIESSVTVK IENKESRELM LLIPSIVLGI LLLGSLIFIA 430 440 450 460 470 480 FILLRIKGKY VFMLPIQVQA PPPEDSDSGS DSDYEHYDFS AQPPVALTTF YNSQRHRVTD 490 500 510 520 530 540 EEVQQSRFQM PPLEEGLEEL HASHIPTANP GHCITDPPSL GPQYHPRSNS ESSTSSGEDY 550 560 570 580 590 600 CNSPKSKLPP WNPQVFSSER SSFLEQPPNL ELAGTQPAFS GSPSPQPDST DNDDYDDISA A
	Isoform CD6E [UniParc]. Checksum: 504C102257DA7B3C	FASTA	592	63,552
	10 20 30 40 50 60 MWLFFGITGL LTAALSGHPS PAPPDQLNTS SAESELWEPG ERLPVRLTNG SSSCSGTVEV 70 80 90 100 110 120 RLEASWEPAC GALWDSRAAE AVCRALGCGG AEAASQLAPP TPELPPPPAA GNTSVAANAT 130 140 150 160 170 180 LAGAPALLCS GAEWRLCEVV EHACRSDGRR ARVTCAENRA LRLVDGGGAC AGRVEMLEHG 190 200 210 220 230 240 EWGSVCDDTW DLEDAHVVCR QLGCGWAVQA LPGLHFTPGR GPIHRDQVNC SGAEAYLWDC 250 260 270 280 290 300 PGLPGQHYCG HKEDAGAVCS EHQSWRLTGG ADRCEGQVEV HFRGVWNTVC DSEWYPSEAK 310 320 330 340 350 360 VLCQSLGCGT AVERPKGLPH SLSGRMYYSC NGEELTLSNC SWRFNNSNLC SQSLAARVLC 370 380 390 400 410 420 SASRSLHNLS TPEVPASVQT VTIESSVTVK IENKESRELM LLIPSIVLGI LLLGSLIFIA 430 440 450 460 470 480 FILLRIKGKY ALPVMVNHQH LPTTIPAGSN SYQPVPITIP KEDSQRHRVT DEEVQQSRFQ 490 500 510 520 530 540 MPPLEEGLEE LHASHIPTAN PGHCITDPPS LGPQYHPRSN SESSTSSGED YCNSPKSKLP 550 560 570 580 590 PWNPQVFSSE RSSFLEQPPN LELAGTQPAF SGSPSPQPDS TDNDDYDDIS AA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms." Bowen M.A., Whitney G.S., Neubauer M., Starling G.C., Palmer D., Zhang J., Nowak N.J., Shows T.B., Aruffo A. J. Immunol. 158:1149-1156(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING, VARIANT VAL-257.
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins." Aruffo A., Melnick M.B., Linsley P.S., Seed B. J. Exp. Med. 174:949-952(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-468, VARIANT VAL-257.
[4]	"Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule." Swack J.A., Mier J.W., Romain P.L., Hull S.R., Rudd C.E. J. Biol. Chem. 266:7137-7143(1991) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT SERINE RESIDUES, DISULFIDE BONDS, GLYCOSYLATION.
[5]	"Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors." Wee S., Schieven G.L., Kirihara J.M., Tsu T.T., Ledbetter J.A., Aruffo A. J. Exp. Med. 177:219-223(1993) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT TYROSINE RESIDUES.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U66142 mRNA. Translation: AAC51161.1. U66143 Genomic DNA. Translation: AAC51162.1. U66144 Genomic DNA. Translation: AAC51163.1. U66145 mRNA. Translation: AAC51164.1. U66146 mRNA. Translation: AAC51165.1. AP003721 Genomic DNA. No translation available. X60992 mRNA. Translation: CAA43306.1.
IPI	IPI00025700. IPI00218871. IPI00218872. IPI00218873. IPI00374647.
PIR	S26741.
RefSeq	NP_001241679.1. NM_001254750.1. NP_001241680.1. NM_001254751.1. NP_006716.3. NM_006725.4.
UniGene	Hs.643167.
3D structure databases
ProteinModelPortal	P30203.
SMR	P30203. Positions 161-361.
ModBase	Search...
Protein-protein interaction databases
IntAct	P30203. 3 interactions.
MINT	MINT-1351620.
STRING	9606.ENSP00000323280.
PTM databases
PhosphoSite	P30203.
Polymorphism databases
DMDM	281185506.
Proteomic databases
PaxDb	P30203.
PRIDE	P30203.
Protocols and materials databases
DNASU	923.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000313421; ENSP00000323280; ENSG00000013725. ENST00000344028; ENSP00000344108; ENSG00000013725. ENST00000346437; ENSP00000345566; ENSG00000013725. ENST00000352009; ENSP00000340628; ENSG00000013725. ENST00000452451; ENSP00000390676; ENSG00000013725.
GeneID	923.
KEGG	hsa:923.
UCSC	uc001nqq.3. human. uc001nqr.3. human. uc001nqt.3. human.
Organism-specific databases
CTD	923.
GeneCards	GC11P060743.
H-InvDB	HIX0009678.
HGNC	HGNC:1691. CD6.
HPA	CAB002489. CAB016252.
MIM	186720. gene.
neXtProt	NX_P30203.
PharmGKB	PA26230.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG76003.
HOGENOM	HOG000137917.
HOVERGEN	HBG005289.
InParanoid	P30203.
KO	K06456.
OMA	TCAENRA.
PhylomeDB	P30203.
Gene expression databases
ArrayExpress	P30203.
Bgee	P30203.
CleanEx	HS_CD6.
Genevestigator	P30203.
GermOnline	ENSG00000013725. Homo sapiens.
Family and domain databases
InterPro	IPR001190. Srcr_rcpt. IPR017448. Srcr_rcpt-rel. [Graphical view]
Pfam	PF00530. SRCR. 3 hits. [Graphical view]
PRINTS	PR00258. SPERACTRCPTR.
SMART	SM00202. SR. 3 hits. [Graphical view]
SUPFAM	SSF56487. Srcr_receptor. 3 hits.
PROSITE	PS00420. SRCR_1. 1 hit. PS50287. SRCR_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	923.
NextBio	3818.
SOURCE	Search...

Entry information

Entry name

CD6_HUMAN

Accession

Primary (citable) accession number: P30203
Secondary accession number(s): Q9UMF2 , Q9Y4K7, Q9Y4K8, Q9Y4K9, Q9Y4L0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	December 15, 2009
Last modified:	May 1, 2013
This is version 113 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.