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Protein

Gamma-aminobutyric acid receptor subunit alpha-6

Gene

Gabra6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

  • chloride channel activity Source: RGD
  • drug binding Source: RGD
  • GABA-A receptor activity Source: InterPro
  • inhibitory extracellular ligand-gated ion channel activity Source: RGD

GO - Biological processi

  • gamma-aminobutyric acid signaling pathway Source: InterPro
  • synaptic transmission, GABAergic Source: RGD

Keywordsi

Molecular functionChloride channel, Ion channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandChloride

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit alpha-6
Alternative name(s):
GABA(A) receptor subunit alpha-6
Gene namesi
Name:Gabra6
Synonyms:Gabra-6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61861 Gabra6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 242ExtracellularCuratedAdd BLAST223
Transmembranei243 – 264HelicalCuratedAdd BLAST22
Transmembranei269 – 290HelicalCuratedAdd BLAST22
Transmembranei301 – 324HelicalCuratedAdd BLAST24
Topological domaini325 – 419CytoplasmicCuratedAdd BLAST95
Transmembranei420 – 441HelicalCuratedAdd BLAST22

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL293

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000000044920 – 453Gamma-aminobutyric acid receptor subunit alpha-6Add BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi156 ↔ 170By similarity
Modified residuei375PhosphoserineBy similarity1
Modified residuei403PhosphothreonineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP30191
PRIDEiP30191

PTM databases

iPTMnetiP30191
PhosphoSitePlusiP30191

Expressioni

Tissue specificityi

Only found in cerebellar granule cells.

Interactioni

Subunit structurei

Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004877

Chemistry databases

BindingDBiP30191

Structurei

3D structure databases

ProteinModelPortaliP30191
SMRiP30191
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3642 Eukaryota
ENOG410XNQG LUCA
HOGENOMiHOG000231337
HOVERGENiHBG051707
InParanoidiP30191
KOiK05175
PhylomeDBiP30191

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR001390 GABAAa_rcpt
IPR005436 GABBAa6_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR01079 GABAARALPHA
PR01619 GABAARALPHA6
PR00253 GABAARECEPTR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30191-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLLPWLFS LLWIENAQAQ LEDEGNFYSE NVSRILDNLL EGYDNRLRPG
60 70 80 90 100
FGGAVTEVKT DIYVTSFGPV SDVEMEYTMD VFFRQTWTDE RLKFKGPAEI
110 120 130 140 150
LSLNNLMVSK IWTPDTFFRN GKKSIAHNMT TPNKLFRLMH NGTILYTMRL
160 170 180 190 200
TINADCPMRL VNFPMDGHAC PLKFGSYAYP KSEIIYTWKK GPLYSVEVPE
210 220 230 240 250
ESSSLLQYDL IGQTVSSETI KSNTGEYVIM TVYFHLQRKM GYFMIQIYTP
260 270 280 290 300
CIMTVILSQV SFWINKESVP ARTVFGITTV LTMTTLSISA RHSLPKVSYA
310 320 330 340 350
TAMDWFIAVC FAFVFSALIE FAAVNYFTNL QSQKAERQAQ TAAKPPVAKS
360 370 380 390 400
KTTESLEAEI VVHSDSKYHL KKRISSLTLP IVPSSEASKV LSRTPILPST
410 420 430 440 450
PVTPPLLLPA IGGTSKIDQY SRILFPVAFA GFNLVYWIVY LSKDTMEVSS

TVE
Length:453
Mass (Da):51,184
Last modified:April 1, 1993 - v1
Checksum:i77EF2636A8B116F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08495 Genomic DNA Translation: AAC42034.1
X55742 Genomic DNA Translation: CAA39273.1
PIRiS11087
RefSeqiNP_068613.1, NM_021841.1
UniGeneiRn.29890

Genome annotation databases

GeneIDi29708
KEGGirno:29708
UCSCiRGD:61861 rat

Similar proteinsi

Entry informationi

Entry nameiGBRA6_RAT
AccessioniPrimary (citable) accession number: P30191
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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