Reviewed,
UniProtKB/Swiss-Prot P30184 (AMPL1_ARATH)
Last modified
February 9, 2010.
Version 90.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Leucine aminopeptidase 1 EC=3.4.11.1 Alternative name(s): Leucyl aminopeptidase 1 Short name=LAP 1 Proline aminopeptidase 1 EC=3.4.11.5 Prolyl aminopeptidase 1 | ||||||
| Gene names |
| ||||||
| Organism | Arabidopsis thaliana (Mouse-ear cress) [Complete proteome] | ||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Arabidopsis |
Protein attributes
| Sequence length | 520 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. |
| Catalytic activity | Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low. Release of N-terminal proline from a peptide. |
| Cofactor | Binds 2 zinc ions per subunit By similarity. |
| Subunit structure | Homohexamer Probable. |
| Subcellular location | |
| Sequence similarities | Belongs to the peptidase M17 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | Metal-binding Zinc |
| Molecular function | Aminopeptidase Hydrolase Protease |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | proteolysis Inferred from electronic annotation. Source: InterPro response to cadmium ionInferred from expression pattern. Source: TAIR |
| Cellular component | vacuole Inferred from direct assay. Source: TAIR |
| Molecular function | aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion bindingInferred from electronic annotation. Source: InterPro metalloexopeptidase activityInferred from electronic annotation. Source: InterPro zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 520 | 520 | Leucine aminopeptidase 1 | PRO_0000165823 | |||||
Sites | |||||||||
| Active site | 300 | 1 | Potential | ||||||
| Active site | 377 | 1 | Potential | ||||||
| Metal binding | 288 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 293 | 1 | Zinc 1 By similarity | ||||||
| Metal binding | 293 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 313 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 373 | 1 | Zinc 1 By similarity | ||||||
| Metal binding | 375 | 1 | Zinc 1 By similarity | ||||||
| Metal binding | 375 | 1 | Zinc 2 By similarity | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X63444 mRNA. Translation: CAA45040.1. AC005967 Genomic DNA. Translation: AAD03381.1. AY062105 mRNA. Translation: AAL32980.1. BT006345 mRNA. Translation: AAP21153.1. |
| IPI | IPI00538374. |
| PIR | S22399. |
| RefSeq | NP_001118375.1. NP_179997.1. |
| UniGene | At.24655 Rsa.25407 |
3D structure databases | |
| SMR | P30184. Positions 20-518. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P30184. |
Protein family/group databases | |
| MEROPS | M17.A03. |
Proteomic databases | |
| PRIDE | P30184. |
| ProMEX | P30184. |
Genome annotation databases | |
| GeneID | 816954. |
| GenomeReviews | Gene locus AT2G24200 in contig CT485783_GR. |
| KEGG | ath:AT2G24200. |
| NMPDR | fig|3702.1.peg.9442. |
Organism-specific databases | |
| GeneFarm | 1931. 195. |
| TAIR | At2g24200. |
Phylogenomic databases | |
| eggNOG | KOG2597. |
| HOGENOM | HBG742580. |
| InParanoid | P30184. |
| OMA | GVIFGRE. |
| PhylomeDB | P30184. |
Enzyme and pathway databases | |
| BRENDA | 3.4.11.1. 302. 3.4.11.5. 302. |
Gene expression databases | |
| ArrayExpress | P30184. |
| Genevestigator | P30184. |
| GermOnline | AT2G24200. Arabidopsis thaliana. |
Family and domain databases | |
| InterPro | IPR011356. Peptidase_M17. IPR000819. Peptidase_M17_C. IPR008283. Peptidase_M17_N. [Graphical view] |
| PANTHER | PTHR11963:SF3. Peptidase_M17. 1 hit. |
| Pfam | PF00883. Peptidase_M17. 1 hit. PF02789. Peptidase_M17_N. 1 hit. [Graphical view] |
| PRINTS | PR00481. LAMNOPPTDASE. |
| PROSITE | PS00631. CYTOSOL_AP. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | AMPL1_ARATH | ||||||||
| Accession | Primary (citable) accession number: P30184 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


