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Protein

Aminoglycoside N(3')-acetyltransferase VII

Gene

aacC7

Organism
Streptomyces rimosus subsp. paromomycinus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Resistance to paromomycin.

Catalytic activityi

Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

GO - Molecular functioni

  1. aminoglycoside 3-N-acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Aminoglycoside N(3')-acetyltransferase VII (EC:2.3.1.81)
Alternative name(s):
ACC(3)-VII
Aminocyclitol 3-N-acetyltransferase type VII
Gene namesi
Name:aacC7
OrganismiStreptomyces rimosus subsp. paromomycinus
Taxonomic identifieri92743 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Aminoglycoside N(3')-acetyltransferase VIIPRO_0000068549Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP30180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamiPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30180-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDELALLKRS DGPVTRTRLA RDLTALGLGD GDTVMFHTRM SAVGYVAGGP
60 70 80 90 100
ETVIGALRDV VGERGTLMVT CGWNDAPPYD FTDWPQTWQD ARRAEHPAYD
110 120 130 140 150
PVLSEADHNN GRLPEALRRR PGAVRSRHPD ASFAALGAAA TALTADHPWD
160 170 180 190 200
DPHGPDSPLA RLVAMGGRVL LLGAPLEALT LLHHAEALAD APGKRFVDYE
210 220 230 240 250
QPILVDGERV WRRFHDIDSE DGAFDYSALV PEGTEAFEII GRDMRAAGIG
260 270 280
RRGTVGAADS HLFEARDVVD FGVAWMEEKL GRERGPGG
Length:288
Mass (Da):31,202
Last modified:April 1, 1993 - v1
Checksum:i430DCBBF30822382
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22999 Genomic DNA. Translation: AAA88552.1.
PIRiB32245.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22999 Genomic DNA. Translation: AAA88552.1.
PIRiB32245.

3D structure databases

ProteinModelPortaliP30180.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamiPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and nucleotide sequencing of an aminocyclitol acetyltransferase gene from Streptomyces rimosus forma paromomycinus."
    Lopez-Cabrera M., Perez-Gonzalez J.A., Heinzel P., Piepersberg W., Jimenez A.
    J. Bacteriol. 171:321-328(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 14827 / DSM 41429 / JCM 4541 / NBRC 15454 / NRRL 2455 / VKM Ac-605.

Entry informationi

Entry nameiAACC7_STRRY
AccessioniPrimary (citable) accession number: P30180
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.