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P30180 (AACC7_STRRY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aminoglycoside N(3')-acetyltransferase VII

EC=2.3.1.81
Alternative name(s):
ACC(3)-VII
Aminocyclitol 3-N-acetyltransferase type VII
Gene names
Name:aacC7
OrganismStreptomyces rimosus subsp. paromomycinus
Taxonomic identifier92743 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Resistance to paromomycin.

Catalytic activity

Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

Sequence similarities

Belongs to the antibiotic N-acetyltransferase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processresponse to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionaminoglycoside 3-N-acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Aminoglycoside N(3')-acetyltransferase VII
PRO_0000068549

Sequences

Sequence LengthMass (Da)Tools
P30180 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 430DCBBF30822382

FASTA28831,202
        10         20         30         40         50         60 
MDELALLKRS DGPVTRTRLA RDLTALGLGD GDTVMFHTRM SAVGYVAGGP ETVIGALRDV 

        70         80         90        100        110        120 
VGERGTLMVT CGWNDAPPYD FTDWPQTWQD ARRAEHPAYD PVLSEADHNN GRLPEALRRR 

       130        140        150        160        170        180 
PGAVRSRHPD ASFAALGAAA TALTADHPWD DPHGPDSPLA RLVAMGGRVL LLGAPLEALT 

       190        200        210        220        230        240 
LLHHAEALAD APGKRFVDYE QPILVDGERV WRRFHDIDSE DGAFDYSALV PEGTEAFEII 

       250        260        270        280 
GRDMRAAGIG RRGTVGAADS HLFEARDVVD FGVAWMEEKL GRERGPGG 

« Hide

References

[1]"Isolation and nucleotide sequencing of an aminocyclitol acetyltransferase gene from Streptomyces rimosus forma paromomycinus."
Lopez-Cabrera M., Perez-Gonzalez J.A., Heinzel P., Piepersberg W., Jimenez A.
J. Bacteriol. 171:321-328(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 14827 / DSM 41429 / JCM 4541 / NBRC 15454 / NRRL 2455 / VKM Ac-605.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M22999 Genomic DNA. Translation: AAA88552.1.
PIRB32245.

3D structure databases

ProteinModelPortalP30180.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAACC7_STRRY
AccessionPrimary (citable) accession number: P30180
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families