Reviewed, UniProtKB/Swiss-Prot P30152 (NGAL_RAT)

Names and origin

Protein names

Recommended name:
    Neutrophil gelatinase-associated lipocalin
      Short name=NGAL
Alternative name(s):
    p25
    Alpha-2-microglobulin-related protein
    Alpha-2U globulin-related protein
    Lipocalin-2

Gene names

Name:

Lcn2

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Secreted.
Sequence similarities	Belongs to the calycin superfamily. Lipocalin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	By similarity
	Chain	21 – 198	178	Neutrophil gelatinase-associated lipocalin		PRO_0000017935
Amino acid modifications
	Glycosylation	85	1	N-linked (GlcNAc...) Potential
	Disulfide bond	96 ↔ 195		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P30152-1 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 96C2F4ECFF26997B	FASTA	198	22,559
	10 20 30 40 50 60 MGLGVLCLAL VLLGVLQRQA QDSTQNLIPA PPLISVPLQP GFWTERFQGR WFVVGLAANA 70 80 90 100 110 120 VQKERQSRFT MYSTIYELQE DNSYNVTSIL VRGQGCRYWI RTFVPSSRPG QFTLGNIHSY 130 140 150 160 170 180 PQIQSYDVQV ADTDYDQFAM VFFQKTSENK QYFKVTLYGR TKGLSDELKE RFVSFAKSLG 190 LKDNNIVFSV PTDQCIDN

References

[1]	"The primary structure of rat alpha 2 mu globulin-related protein." Chan Y.-L., Paz V., Wool I.G. Nucleic Acids Res. 16:11368-11368(1988) [PubMed: 2462726] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBLGenBankDDBJ

X13295 mRNA. Translation: CAA31657.1.

IPI

IPI00205907.

PIR

S01989.

RefSeq

NP_570097.1.

UniGene

Rn.11303

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2K23	NMR	-	A	21-198	[»]

ModBase

Search...

Genome annotation databases

Ensembl

ENSRNOG00000013973. Rattus norvegicus. [Contig view]

GeneID

170496.

KEGG

rno:170496.

Organism-specific databases

RGD

69408. Lcn2.

Phylogenomic databases

HOVERGEN

P30152.

Gene expression databases

ArrayExpress

P30152.

GermOnline

ENSRNOG00000013973. Rattus norvegicus.

Family and domain databases

InterPro

IPR012674. Calycin.
IPR002345. Lipocalin.
IPR000566. Lipocln_cytFABP.
IPR003087. N_gelatinase.
[Graphical view]

Gene3D

G3DSA:2.40.128.20. Calycin. 1 hit.

Pfam

PF00061. Lipocalin. 1 hit.
[Graphical view]

PRINTS

PR00179. LIPOCALIN.
PR01275. NGELATINASE.

PROSITE

PS00213. LIPOCALIN. False negative.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

620993.

Entry information

Entry name

NGAL_RAT

Accession

Primary (citable) accession number: P30152

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	June 16, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)