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Protein

Outer membrane usher protein FimD

Gene

fimD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the export and assembly of FimA fimbrial subunits across the outer membrane.

GO - Molecular functioni

  • fimbrial usher porin activity Source: EcoCyc

GO - Biological processi

  • pilus assembly Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Fimbrium biogenesis, Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG10311-MONOMER.
ECOL316407:JW5780-MONOMER.

Protein family/group databases

TCDBi1.B.11.3.9. the outer membrane fimbrial usher porin (fup) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane usher protein FimD
Gene namesi
Name:fimD
Ordered Locus Names:b4317, JW5780
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10311. fimD.

Subcellular locationi

GO - Cellular componenti

  • cell outer membrane Source: EcoCyc
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 45451 PublicationAdd
BLAST
Chaini46 – 878833Outer membrane usher protein FimDPRO_0000009312Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi855 ↔ 877Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP30130.

Interactioni

Protein-protein interaction databases

BioGridi4262748. 186 interactions.
DIPiDIP-9612N.
IntActiP30130. 7 interactions.
MINTiMINT-1292016.
STRINGi511145.b4317.

Structurei

Secondary structure

1
878
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi51 – 544Combined sources
Helixi60 – 689Combined sources
Beta strandi75 – 8410Combined sources
Beta strandi87 – 9812Combined sources
Beta strandi104 – 1074Combined sources
Helixi111 – 1166Combined sources
Helixi121 – 1233Combined sources
Helixi127 – 1293Combined sources
Helixi138 – 1414Combined sources
Turni142 – 1443Combined sources
Beta strandi146 – 1505Combined sources
Turni151 – 1544Combined sources
Beta strandi155 – 1595Combined sources
Helixi162 – 1643Combined sources
Helixi175 – 1773Combined sources
Beta strandi184 – 19815Combined sources
Turni199 – 2013Combined sources
Beta strandi202 – 21716Combined sources
Beta strandi220 – 23112Combined sources
Beta strandi243 – 25412Combined sources
Turni255 – 2584Combined sources
Beta strandi259 – 2679Combined sources
Beta strandi270 – 2734Combined sources
Beta strandi277 – 2859Combined sources
Helixi287 – 2893Combined sources
Helixi292 – 2943Combined sources
Beta strandi301 – 31515Combined sources
Beta strandi318 – 3258Combined sources
Beta strandi327 – 3326Combined sources
Turni338 – 3414Combined sources
Beta strandi344 – 3496Combined sources
Beta strandi351 – 3533Combined sources
Beta strandi355 – 3606Combined sources
Beta strandi374 – 38310Combined sources
Beta strandi394 – 40310Combined sources
Helixi405 – 4073Combined sources
Beta strandi408 – 41710Combined sources
Beta strandi420 – 43213Combined sources
Beta strandi435 – 44713Combined sources
Beta strandi453 – 46513Combined sources
Beta strandi471 – 48212Combined sources
Helixi489 – 4935Combined sources
Beta strandi494 – 4963Combined sources
Beta strandi525 – 53612Combined sources
Beta strandi538 – 55417Combined sources
Beta strandi560 – 57011Combined sources
Beta strandi573 – 58311Combined sources
Beta strandi585 – 5873Combined sources
Beta strandi591 – 60212Combined sources
Helixi603 – 6053Combined sources
Helixi613 – 6164Combined sources
Beta strandi617 – 6259Combined sources
Beta strandi627 – 6293Combined sources
Beta strandi631 – 64212Combined sources
Turni643 – 6464Combined sources
Beta strandi647 – 65812Combined sources
Turni659 – 6613Combined sources
Beta strandi664 – 67411Combined sources
Beta strandi679 – 6868Combined sources
Beta strandi691 – 70414Combined sources
Beta strandi707 – 7126Combined sources
Beta strandi716 – 7227Combined sources
Beta strandi743 – 7486Combined sources
Beta strandi756 – 7605Combined sources
Helixi762 – 7643Combined sources
Beta strandi769 – 7724Combined sources
Beta strandi774 – 7785Combined sources
Beta strandi785 – 7895Combined sources
Beta strandi792 – 80413Combined sources
Beta strandi814 – 8218Combined sources
Beta strandi823 – 8253Combined sources
Helixi828 – 8303Combined sources
Beta strandi831 – 8377Combined sources
Beta strandi839 – 8479Combined sources
Beta strandi856 – 8605Combined sources
Helixi863 – 8653Combined sources
Beta strandi871 – 8755Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZDVNMR-A70-184[»]
1ZDXNMR-A70-170[»]
1ZE3X-ray1.84D46-170[»]
3BWUX-ray1.76D46-170[»]
3OHNX-ray3.01A/B169-708[»]
3RFZX-ray2.80B/E46-878[»]
4J3OX-ray3.80D46-878[»]
ProteinModelPortaliP30130.
SMRiP30130. Positions 47-878.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30130.

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial export usher family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105CW0. Bacteria.
COG3188. LUCA.
HOGENOMiHOG000111414.
InParanoidiP30130.
KOiK07347.
OMAiVPQAFMG.
PhylomeDBiP30130.

Family and domain databases

InterProiIPR000015. Fimb_usher.
IPR018030. Fimbrial_membr_usher_CS.
IPR025949. PapC-like_C.
IPR025885. PapC_N.
[Graphical view]
PANTHERiPTHR30451. PTHR30451. 1 hit.
PfamiPF13953. PapC_C. 1 hit.
PF13954. PapC_N. 1 hit.
PF00577. Usher. 1 hit.
[Graphical view]
PROSITEiPS01151. FIMBRIAL_USHER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30130-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYLNLRLYQ RNTQCLHIRK HRLAGFFVRL VVACAFAAQA PLSSADLYFN
60 70 80 90 100
PRFLADDPQA VADLSRFENG QELPPGTYRV DIYLNNGYMA TRDVTFNTGD
110 120 130 140 150
SEQGIVPCLT RAQLASMGLN TASVAGMNLL ADDACVPLTT MVQDATAHLD
160 170 180 190 200
VGQQRLNLTI PQAFMSNRAR GYIPPELWDP GINAGLLNYN FSGNSVQNRI
210 220 230 240 250
GGNSHYAYLN LQSGLNIGAW RLRDNTTWSY NSSDRSSGSK NKWQHINTWL
260 270 280 290 300
ERDIIPLRSR LTLGDGYTQG DIFDGINFRG AQLASDDNML PDSQRGFAPV
310 320 330 340 350
IHGIARGTAQ VTIKQNGYDI YNSTVPPGPF TINDIYAAGN SGDLQVTIKE
360 370 380 390 400
ADGSTQIFTV PYSSVPLLQR EGHTRYSITA GEYRSGNAQQ EKTRFFQSTL
410 420 430 440 450
LHGLPAGWTI YGGTQLADRY RAFNFGIGKN MGALGALSVD MTQANSTLPD
460 470 480 490 500
DSQHDGQSVR FLYNKSLNES GTNIQLVGYR YSTSGYFNFA DTTYSRMNGY
510 520 530 540 550
NIETQDGVIQ VKPKFTDYYN LAYNKRGKLQ LTVTQQLGRT STLYLSGSHQ
560 570 580 590 600
TYWGTSNVDE QFQAGLNTAF EDINWTLSYS LTKNAWQKGR DQMLALNVNI
610 620 630 640 650
PFSHWLRSDS KSQWRHASAS YSMSHDLNGR MTNLAGVYGT LLEDNNLSYS
660 670 680 690 700
VQTGYAGGGD GNSGSTGYAT LNYRGGYGNA NIGYSHSDDI KQLYYGVSGG
710 720 730 740 750
VLAHANGVTL GQPLNDTVVL VKAPGAKDAK VENQTGVRTD WRGYAVLPYA
760 770 780 790 800
TEYRENRVAL DTNTLADNVD LDNAVANVVP TRGAIVRAEF KARVGIKLLM
810 820 830 840 850
TLTHNNKPLP FGAMVTSESS QSSGIVADNG QVYLSGMPLA GKVQVKWGEE
860 870
ENAHCVANYQ LPPESQQQLL TQLSAECR
Length:878
Mass (Da):96,482
Last modified:February 1, 1995 - v2
Checksum:iB2B86CC44FAB7B0F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti143 – 1486QDATAH → RTLLRT in CAA35968 (PubMed:1970114).Curated
Sequence conflicti352 – 40251DGSTQ…STLLH → VLAARRFLPYPIRTFPLLNV KAYSLFHYGRRIPYESRSRK KPAFSRVHYSN (PubMed:1970114).CuratedAdd
BLAST
Sequence conflicti658 – 67013GGDGN…TGYAT → EAMEIAEVQATP (PubMed:1970114).CuratedAdd
BLAST
Sequence conflicti723 – 74220APGAK…RTDWR → RLAQKMQKSKTRRGAYRLA in CAA35968 (PubMed:1970114).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51655 Genomic DNA. Translation: CAA35968.1.
U14003 Genomic DNA. Translation: AAA97213.1.
U00096 Genomic DNA. Translation: AAC77273.1.
AP009048 Genomic DNA. Translation: BAE78310.1.
PIRiS56542.
RefSeqiNP_418737.1. NC_000913.3.
WP_000121005.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77273; AAC77273; b4317.
BAE78310; BAE78310; BAE78310.
GeneIDi948844.
KEGGiecj:JW5780.
eco:b4317.
PATRICi32124230. VBIEscCol129921_4458.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51655 Genomic DNA. Translation: CAA35968.1.
U14003 Genomic DNA. Translation: AAA97213.1.
U00096 Genomic DNA. Translation: AAC77273.1.
AP009048 Genomic DNA. Translation: BAE78310.1.
PIRiS56542.
RefSeqiNP_418737.1. NC_000913.3.
WP_000121005.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZDVNMR-A70-184[»]
1ZDXNMR-A70-170[»]
1ZE3X-ray1.84D46-170[»]
3BWUX-ray1.76D46-170[»]
3OHNX-ray3.01A/B169-708[»]
3RFZX-ray2.80B/E46-878[»]
4J3OX-ray3.80D46-878[»]
ProteinModelPortaliP30130.
SMRiP30130. Positions 47-878.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262748. 186 interactions.
DIPiDIP-9612N.
IntActiP30130. 7 interactions.
MINTiMINT-1292016.
STRINGi511145.b4317.

Protein family/group databases

TCDBi1.B.11.3.9. the outer membrane fimbrial usher porin (fup) family.

Proteomic databases

PaxDbiP30130.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77273; AAC77273; b4317.
BAE78310; BAE78310; BAE78310.
GeneIDi948844.
KEGGiecj:JW5780.
eco:b4317.
PATRICi32124230. VBIEscCol129921_4458.

Organism-specific databases

EchoBASEiEB0307.
EcoGeneiEG10311. fimD.

Phylogenomic databases

eggNOGiENOG4105CW0. Bacteria.
COG3188. LUCA.
HOGENOMiHOG000111414.
InParanoidiP30130.
KOiK07347.
OMAiVPQAFMG.
PhylomeDBiP30130.

Enzyme and pathway databases

BioCyciEcoCyc:EG10311-MONOMER.
ECOL316407:JW5780-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP30130.
PROiP30130.

Family and domain databases

InterProiIPR000015. Fimb_usher.
IPR018030. Fimbrial_membr_usher_CS.
IPR025949. PapC-like_C.
IPR025885. PapC_N.
[Graphical view]
PANTHERiPTHR30451. PTHR30451. 1 hit.
PfamiPF13953. PapC_C. 1 hit.
PF13954. PapC_N. 1 hit.
PF00577. Usher. 1 hit.
[Graphical view]
PROSITEiPS01151. FIMBRIAL_USHER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFIMD_ECOLI
AccessioniPrimary (citable) accession number: P30130
Secondary accession number(s): Q2M5Z6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.