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Protein

Interferon gamma

Gene

IFNG

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense, Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma
Short name:
IFN-gamma
Gene namesi
Name:IFNG
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000001645624 – 167Interferon gammaAdd BLAST144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acidBy similarity1
Glycosylationi41N-linked (GlcNAc...)Sequence analysis1
Glycosylationi108N-linked (GlcNAc...)Sequence analysis1
Glycosylationi117N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Released primarily from activated T lymphocytes.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000021866.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RIGX-ray2.30A24-167[»]
ProteinModelPortaliP30123.
SMRiP30123.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30123.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWSY. Eukaryota.
ENOG410Z8I5. LUCA.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP30123.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG091G0ZH0.
TreeFamiTF336308.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30123-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYTSYILAF QLCLILGSYG CYCQDTLTRE TEHLKAYLKA NTSDVANGGP
60 70 80 90 100
LFLNILRNWK EESDNKIIQS QIVSFYFKLF DNLKDHEVIK KSMESIKEDI
110 120 130 140 150
FVKFFNSNLT KMDDFQNLTR ISVDDRLVQR KAVSELSNVL NFLSPKSNLK
160
KRKRSQTLFR GRRASKY
Length:167
Mass (Da):19,516
Last modified:April 1, 1993 - v1
Checksum:i96D1CAD2A5163850
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123Missing in BAA20884 (PubMed:8753862).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010386 mRNA. Translation: BAA24439.1.
AF244933 mRNA. Translation: AAF64188.1.
DQ680162 mRNA. Translation: ABG73601.1.
DQ852341 mRNA. Translation: ABH10826.1.
D84216 mRNA. Translation: BAA20884.1.
RefSeqiNP_001075460.1. NM_001081991.1.
UniGeneiOcu.2149.

Genome annotation databases

EnsembliENSOCUT00000030109; ENSOCUP00000021866; ENSOCUG00000024937.
GeneIDi100008602.
KEGGiocu:100008602.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010386 mRNA. Translation: BAA24439.1.
AF244933 mRNA. Translation: AAF64188.1.
DQ680162 mRNA. Translation: ABG73601.1.
DQ852341 mRNA. Translation: ABH10826.1.
D84216 mRNA. Translation: BAA20884.1.
RefSeqiNP_001075460.1. NM_001081991.1.
UniGeneiOcu.2149.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RIGX-ray2.30A24-167[»]
ProteinModelPortaliP30123.
SMRiP30123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000021866.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000030109; ENSOCUP00000021866; ENSOCUG00000024937.
GeneIDi100008602.
KEGGiocu:100008602.

Organism-specific databases

CTDi3458.

Phylogenomic databases

eggNOGiENOG410IWSY. Eukaryota.
ENOG410Z8I5. LUCA.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP30123.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG091G0ZH0.
TreeFamiTF336308.

Miscellaneous databases

EvolutionaryTraceiP30123.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIFNG_RABIT
AccessioniPrimary (citable) accession number: P30123
Secondary accession number(s): P79215, Q0PW35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.