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P30108

- GSTT1_DROYA

UniProt

P30108 - GSTT1_DROYA

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Protein
Glutathione S-transferase 1-1
Gene
GstD1, GST, Gst1, GE24527
Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 1-1 (EC:2.5.1.18)
Alternative name(s):
GST class-theta
Gene namesi
Name:GstD1
Synonyms:GST, Gst1
ORF Names:GE24527
OrganismiDrosophila yakuba (Fruit fly)
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000002282: Chromosome 3R, UP000002282: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0013168. Dyak\GstD1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Glutathione S-transferase 1-1
PRO_0000185953Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi7245.FBpp0269537.

Structurei

3D structure databases

ProteinModelPortaliP30108.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8181GST N-terminal
Add
BLAST
Domaini87 – 209123GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 533Glutathione binding By similarity
Regioni65 – 673Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.

Phylogenomic databases

eggNOGiCOG0625.
KOiK00799.
OrthoDBiEOG7V1FRJ.
PhylomeDBiP30108.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30108-1 [UniParc]FASTAAdd to Basket

« Hide

MADFYYLPGS SPCRSVIMTA KAVGVELNKK LLNLQAGEHL KPEFLKINPQ    50
HTIPTLVDNG FALWESRAIQ VYLVEKYGKT DSLYPKCPKK RAVINQRLYF 100
DMGTLYQSFA NYYYPQVFAK APADPEAFKK IEAAFEFLNT FLEGQDYAAG 150
DSLTVADIAL VASVSTFEVA GFEISKYANV NKWYENAKKV TPGWEENWAG 200
CLEFKKYFE 209
Length:209
Mass (Da):23,725
Last modified:February 22, 2012 - v2
Checksum:i5FAF3267E4F1410D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti195 – 1951E → S in M84580. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000160 Genomic DNA. Translation: EDW97076.1.
M84580 Genomic DNA. No translation available.
RefSeqiXP_002097364.1. XM_002097328.1.

Genome annotation databases

EnsemblMetazoaiFBtr0271045; FBpp0269537; FBgn0013168.
GeneIDi6536794.
KEGGidya:Dyak_GE24527.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000160 Genomic DNA. Translation: EDW97076.1 .
M84580 Genomic DNA. No translation available.
RefSeqi XP_002097364.1. XM_002097328.1.

3D structure databases

ProteinModelPortali P30108.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7245.FBpp0269537.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0271045 ; FBpp0269537 ; FBgn0013168 .
GeneIDi 6536794.
KEGGi dya:Dyak_GE24527.

Organism-specific databases

FlyBasei FBgn0013168. Dyak\GstD1.

Phylogenomic databases

eggNOGi COG0625.
KOi K00799.
OrthoDBi EOG7V1FRJ.
PhylomeDBi P30108.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tai18E2 / Tucson 14021-0261.01.
  2. "Sequence divergence of glutathione S-transferase coding regions among seven species in the melanogaster subgroup of Drosophila."
    Hargis M.T., Cochrane B.J.
    Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-208.

Entry informationi

Entry nameiGSTT1_DROYA
AccessioniPrimary (citable) accession number: P30108
Secondary accession number(s): B4PNR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: February 22, 2012
Last modified: July 9, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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