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P30108 (GSTT1_DROYA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase 1-1

EC=2.5.1.18
Alternative name(s):
GST class-theta
Gene names
Name:GstD1
Synonyms:GST, Gst1
ORF Names:GE24527
OrganismDrosophila yakuba (Fruit fly) [Complete proteome]
Taxonomic identifier7245 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer.

Sequence similarities

Belongs to the GST superfamily. Theta family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 209209Glutathione S-transferase 1-1
PRO_0000185953

Regions

Domain1 – 8181GST N-terminal
Domain87 – 209123GST C-terminal
Region51 – 533Glutathione binding By similarity
Region65 – 673Glutathione binding By similarity

Experimental info

Sequence conflict1951E → S in M84580. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P30108 [UniParc].

Last modified February 22, 2012. Version 2.
Checksum: 5FAF3267E4F1410D

FASTA20923,725
        10         20         30         40         50         60 
MADFYYLPGS SPCRSVIMTA KAVGVELNKK LLNLQAGEHL KPEFLKINPQ HTIPTLVDNG 

        70         80         90        100        110        120 
FALWESRAIQ VYLVEKYGKT DSLYPKCPKK RAVINQRLYF DMGTLYQSFA NYYYPQVFAK 

       130        140        150        160        170        180 
APADPEAFKK IEAAFEFLNT FLEGQDYAAG DSLTVADIAL VASVSTFEVA GFEISKYANV 

       190        200 
NKWYENAKKV TPGWEENWAG CLEFKKYFE 

« Hide

References

« Hide 'large scale' references
[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tai18E2 / Tucson 14021-0261.01.
[2]"Sequence divergence of glutathione S-transferase coding regions among seven species in the melanogaster subgroup of Drosophila."
Hargis M.T., Cochrane B.J.
Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-208.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM000160 Genomic DNA. Translation: EDW97076.1.
M84580 Genomic DNA. No translation available.
RefSeqXP_002097364.1. XM_002097328.1.

3D structure databases

ProteinModelPortalP30108.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7245.FBpp0269537.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0271045; FBpp0269537; FBgn0013168.
GeneID6536794.
KEGGdya:Dyak_GE24527.

Organism-specific databases

FlyBaseFBgn0013168. Dyak\GstD1.

Phylogenomic databases

eggNOGCOG0625.
KOK00799.
OrthoDBEOG7V1FRJ.
PhylomeDBP30108.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTT1_DROYA
AccessionPrimary (citable) accession number: P30108
Secondary accession number(s): B4PNR1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: February 22, 2012
Last modified: July 9, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase