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Protein

Glutathione S-transferase 1-1

Gene

GstD1

Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 1-1 (EC:2.5.1.18)
Alternative name(s):
GST class-theta
Gene namesi
Name:GstD1
Synonyms:GST, Gst1
ORF Names:GE24527
OrganismiDrosophila yakuba (Fruit fly)
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000002282 Componentsi: Chromosome 3R, Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0013168. Dyak\GstD1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859531 – 209Glutathione S-transferase 1-1Add BLAST209

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi7245.FBpp0269537.

Structurei

3D structure databases

ProteinModelPortaliP30108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 81GST N-terminalAdd BLAST81
Domaini87 – 209GST C-terminalAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 53Glutathione bindingBy similarity3
Regioni65 – 67Glutathione bindingBy similarity3

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
COG0625. LUCA.
KOiK00799.
OMAiFARIFTT.
OrthoDBiEOG091G0MS3.
PhylomeDBiP30108.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30108-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADFYYLPGS SPCRSVIMTA KAVGVELNKK LLNLQAGEHL KPEFLKINPQ
60 70 80 90 100
HTIPTLVDNG FALWESRAIQ VYLVEKYGKT DSLYPKCPKK RAVINQRLYF
110 120 130 140 150
DMGTLYQSFA NYYYPQVFAK APADPEAFKK IEAAFEFLNT FLEGQDYAAG
160 170 180 190 200
DSLTVADIAL VASVSTFEVA GFEISKYANV NKWYENAKKV TPGWEENWAG

CLEFKKYFE
Length:209
Mass (Da):23,725
Last modified:February 22, 2012 - v2
Checksum:i5FAF3267E4F1410D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195E → S in M84580 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000160 Genomic DNA. Translation: EDW97076.1.
M84580 Genomic DNA. No translation available.
RefSeqiXP_002097364.1. XM_002097328.2.

Genome annotation databases

EnsemblMetazoaiFBtr0271045; FBpp0269537; FBgn0013168.
GeneIDi6536794.
KEGGidya:Dyak_GE24527.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000160 Genomic DNA. Translation: EDW97076.1.
M84580 Genomic DNA. No translation available.
RefSeqiXP_002097364.1. XM_002097328.2.

3D structure databases

ProteinModelPortaliP30108.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7245.FBpp0269537.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0271045; FBpp0269537; FBgn0013168.
GeneIDi6536794.
KEGGidya:Dyak_GE24527.

Organism-specific databases

FlyBaseiFBgn0013168. Dyak\GstD1.

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
COG0625. LUCA.
KOiK00799.
OMAiFARIFTT.
OrthoDBiEOG091G0MS3.
PhylomeDBiP30108.

Miscellaneous databases

ChiTaRSiGstS1. fly.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSTT1_DROYA
AccessioniPrimary (citable) accession number: P30108
Secondary accession number(s): B4PNR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: February 22, 2012
Last modified: September 7, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.