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P30108

- GSTT1_DROYA

UniProt

P30108 - GSTT1_DROYA

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Protein

Glutathione S-transferase 1-1

Gene

GstD1

Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 1-1 (EC:2.5.1.18)
Alternative name(s):
GST class-theta
Gene namesi
Name:GstD1
Synonyms:GST, Gst1
ORF Names:GE24527
OrganismiDrosophila yakuba (Fruit fly)
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000002282: Chromosome 3R, UP000002282: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0013168. Dyak\GstD1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Glutathione S-transferase 1-1PRO_0000185953Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi7245.FBpp0269537.

Structurei

3D structure databases

ProteinModelPortaliP30108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8181GST N-terminalAdd
BLAST
Domaini87 – 209123GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 533Glutathione bindingBy similarity
Regioni65 – 673Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG0625.
KOiK00799.
OrthoDBiEOG7V1FRJ.
PhylomeDBiP30108.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30108-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADFYYLPGS SPCRSVIMTA KAVGVELNKK LLNLQAGEHL KPEFLKINPQ
60 70 80 90 100
HTIPTLVDNG FALWESRAIQ VYLVEKYGKT DSLYPKCPKK RAVINQRLYF
110 120 130 140 150
DMGTLYQSFA NYYYPQVFAK APADPEAFKK IEAAFEFLNT FLEGQDYAAG
160 170 180 190 200
DSLTVADIAL VASVSTFEVA GFEISKYANV NKWYENAKKV TPGWEENWAG

CLEFKKYFE
Length:209
Mass (Da):23,725
Last modified:February 22, 2012 - v2
Checksum:i5FAF3267E4F1410D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti195 – 1951E → S in M84580. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000160 Genomic DNA. Translation: EDW97076.1.
M84580 Genomic DNA. No translation available.
RefSeqiXP_002097364.1. XM_002097328.1.

Genome annotation databases

EnsemblMetazoaiFBtr0271045; FBpp0269537; FBgn0013168.
GeneIDi6536794.
KEGGidya:Dyak_GE24527.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000160 Genomic DNA. Translation: EDW97076.1 .
M84580 Genomic DNA. No translation available.
RefSeqi XP_002097364.1. XM_002097328.1.

3D structure databases

ProteinModelPortali P30108.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7245.FBpp0269537.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0271045 ; FBpp0269537 ; FBgn0013168 .
GeneIDi 6536794.
KEGGi dya:Dyak_GE24527.

Organism-specific databases

FlyBasei FBgn0013168. Dyak\GstD1.

Phylogenomic databases

eggNOGi COG0625.
KOi K00799.
OrthoDBi EOG7V1FRJ.
PhylomeDBi P30108.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tai18E2 / Tucson 14021-0261.01.
  2. "Sequence divergence of glutathione S-transferase coding regions among seven species in the melanogaster subgroup of Drosophila."
    Hargis M.T., Cochrane B.J.
    Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-208.

Entry informationi

Entry nameiGSTT1_DROYA
AccessioniPrimary (citable) accession number: P30108
Secondary accession number(s): B4PNR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: February 22, 2012
Last modified: October 1, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3