Glutathione S-transferase 1-1 - Drosophila teissieri (Fruit fly)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Glutathione S-transferase 1-1
EC=2.5.1.18
EC=4.5.1.1

Alternative name(s):
DDT-dehydrochlorinase
GST class-theta

Gene names

Name:	GstD1
Synonyms:	GST, Gst1

Organism

Drosophila teissieri (Fruit fly)

Taxonomic identifier

7243 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›

Protein attributes

Sequence length	200 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has DDT dehydrochlorinase activity By similarity.
Catalytic activity	RX + glutathione = HX + R-S-glutathione. 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the GST superfamily. Theta family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Lyase Transferase
Gene Ontology (GO)
Molecular_function	DDT-dehydrochlorinase activity Inferred from electronic annotation. Source: EC glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

‹1 – 200

›200

Glutathione S-transferase 1-1

PRO_0000185952

Regions

Domain

‹1 – 73

›73

GST N-terminal

Domain

79 – 200

122

GST C-terminal

Region

43 – 45

3

Glutathione binding By similarity

Region

57 – 59

3

Glutathione binding By similarity

Sites

Binding site

2

1

Glutathione By similarity

Experimental info

Non-terminal residue

1

Sequences

Sequence

Length

Mass (Da)

Tools

P30107 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: C3169316B12D9FA1
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FASTA

200

22,595

        10         20         30         40         50         60 
GSSPCRSVIM TAKAVGVELN KKLLNLQAGE HLKPEFVKIN PQHTIPTLVD NGFALWESRA 

        70         80         90        100        110        120 
IQVYLVEKYG KTDSLYPKCP KKRAVINQRL YFDMGTLYQS FANYYYPQVF AKAPADPEAF 

       130        140        150        160        170        180 
KKIEAAFEFL NTFLEGQEYA AGDSLTVADI ALVASVSTFE VAGFEISKYA NVNKWYENAK 

       190        200 
KVTPGWEENW AGCLEFKKYF

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References

[1]	"Sequence divergence of glutathione S-transferase coding regions among seven species in the melanogaster subgroup of Drosophila." Hargis M.T., Cochrane B.J. Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M84579 Genomic DNA. No translation available.
3D structure databases
ProteinModelPortal	P30107.
SMR	P30107. Positions 1-200.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
FlyBase	FBgn0013016. Dtei\GstD1.
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSTT1_DROTE

Accession

Primary (citable) accession number: P30107

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	March 6, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families