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P30107 (GSTT1_DROTE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase 1-1

EC=2.5.1.18
EC=4.5.1.1
Alternative name(s):
DDT-dehydrochlorinase
GST class-theta
Gene names
Name:GstD1
Synonyms:GST, Gst1
OrganismDrosophila teissieri (Fruit fly)
Taxonomic identifier7243 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length200 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has DDT dehydrochlorinase activity By similarity.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride.

Subunit structure

Homodimer.

Sequence similarities

Belongs to the GST superfamily. Theta family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Molecular functionLyase
Transferase
Gene Ontology (GO)
   Molecular_functionDDT-dehydrochlorinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

glutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 200›200Glutathione S-transferase 1-1
PRO_0000185952

Regions

Domain‹1 – 73›73GST N-terminal
Domain79 – 200122GST C-terminal
Region43 – 453Glutathione binding By similarity
Region57 – 593Glutathione binding By similarity

Sites

Binding site21Glutathione By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P30107 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: C3169316B12D9FA1

FASTA20022,595
        10         20         30         40         50         60 
GSSPCRSVIM TAKAVGVELN KKLLNLQAGE HLKPEFVKIN PQHTIPTLVD NGFALWESRA 

        70         80         90        100        110        120 
IQVYLVEKYG KTDSLYPKCP KKRAVINQRL YFDMGTLYQS FANYYYPQVF AKAPADPEAF 

       130        140        150        160        170        180 
KKIEAAFEFL NTFLEGQEYA AGDSLTVADI ALVASVSTFE VAGFEISKYA NVNKWYENAK 

       190        200 
KVTPGWEENW AGCLEFKKYF 

« Hide

References

[1]"Sequence divergence of glutathione S-transferase coding regions among seven species in the melanogaster subgroup of Drosophila."
Hargis M.T., Cochrane B.J.
Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M84579 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalP30107.
SMRP30107. Positions 1-200.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

FlyBaseFBgn0013016. Dtei\GstD1.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTT1_DROTE
AccessionPrimary (citable) accession number: P30107
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase