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P30107

- GSTT1_DROTE

UniProt

P30107 - GSTT1_DROTE

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Protein

Glutathione S-transferase 1-1

Gene

GstD1

Organism
Drosophila teissieri (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has DDT dehydrochlorinase activity (By similarity).By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.
1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei2 – 21GlutathioneBy similarity

GO - Molecular functioni

  1. DDT-dehydrochlorinase activity Source: UniProtKB-EC
  2. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Lyase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 1-1 (EC:2.5.1.18, EC:4.5.1.1)
Alternative name(s):
DDT-dehydrochlorinase
GST class-theta
Gene namesi
Name:GstD1
Synonyms:GST, Gst1
OrganismiDrosophila teissieri (Fruit fly)
Taxonomic identifieri7243 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0013016. Dtei\GstD1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 200›200Glutathione S-transferase 1-1PRO_0000185952Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP30107.
SMRiP30107. Positions 1-200.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini‹1 – 73›73GST N-terminalAdd
BLAST
Domaini79 – 200122GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni43 – 453Glutathione bindingBy similarity
Regioni57 – 593Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P30107-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
GSSPCRSVIM TAKAVGVELN KKLLNLQAGE HLKPEFVKIN PQHTIPTLVD
60 70 80 90 100
NGFALWESRA IQVYLVEKYG KTDSLYPKCP KKRAVINQRL YFDMGTLYQS
110 120 130 140 150
FANYYYPQVF AKAPADPEAF KKIEAAFEFL NTFLEGQEYA AGDSLTVADI
160 170 180 190 200
ALVASVSTFE VAGFEISKYA NVNKWYENAK KVTPGWEENW AGCLEFKKYF
Length:200
Mass (Da):22,595
Last modified:April 1, 1993 - v1
Checksum:iC3169316B12D9FA1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84579 Genomic DNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84579 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali P30107.
SMRi P30107. Positions 1-200.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

FlyBasei FBgn0013016. Dtei\GstD1.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence divergence of glutathione S-transferase coding regions among seven species in the melanogaster subgroup of Drosophila."
    Hargis M.T., Cochrane B.J.
    Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGSTT1_DROTE
AccessioniPrimary (citable) accession number: P30107
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 1, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3