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P30106

- GSTT1_DROSE

UniProt

P30106 - GSTT1_DROSE

Protein

Glutathione S-transferase 1-1

Gene

GstD1

Organism
Drosophila sechellia (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (22 Feb 2012)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has DDT dehydrochlorinase activity By similarity.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.
    1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei10 – 101GlutathioneBy similarity

    GO - Molecular functioni

    1. DDT-dehydrochlorinase activity Source: UniProtKB-EC
    2. glutathione transferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Lyase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase 1-1 (EC:2.5.1.18, EC:4.5.1.1)
    Alternative name(s):
    DDT-dehydrochlorinase
    GST class-theta
    Gene namesi
    Name:GstD1
    Synonyms:GST, Gst1
    ORF Names:GM26019
    OrganismiDrosophila sechellia (Fruit fly)
    Taxonomic identifieri7238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000001292: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0012785. Dsec\GstD1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 209209Glutathione S-transferase 1-1PRO_0000185950Add
    BLAST

    Proteomic databases

    PRIDEiP30106.

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    3D structure databases

    ProteinModelPortaliP30106.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8181GST N-terminalAdd
    BLAST
    Domaini87 – 209123GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni51 – 533Glutathione bindingBy similarity
    Regioni65 – 673Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Theta family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    KOiK00799.
    OrthoDBiEOG7V1FRJ.
    PhylomeDBiP30106.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30106-1 [UniParc]FASTAAdd to Basket

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    MADFYYLPGS SPCRSVIMTA KAVGVELNKK LLNLRAGEHL KPEFLKINPQ    50
    HTIPTLVDNG FALWESRAIQ VYLVEKYGKT DSLYPKCPKK RAVINQRLYF 100
    DMGTLYQSFA NYYYPQVFAK APADPEAFKK IESAFEFLNT FLEGQEYAAG 150
    DSLTVADIAL VASVSTFEVA GFEISKYANV NKWYENAKKV TPGWEENWAG 200
    CLEFKKFFE 209
    Length:209
    Mass (Da):23,767
    Last modified:February 22, 2012 - v2
    Checksum:iCD023FF2D076F716
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti195 – 1951E → S in M84578. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH480815 Genomic DNA. Translation: EDW42478.1.
    M84578 Genomic DNA. No translation available.
    RefSeqiXP_002031492.1. XM_002031456.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0209004; FBpp0207496; FBgn0012785.
    GeneIDi6606692.
    KEGGidse:Dsec_GM26019.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH480815 Genomic DNA. Translation: EDW42478.1 .
    M84578 Genomic DNA. No translation available.
    RefSeqi XP_002031492.1. XM_002031456.1.

    3D structure databases

    ProteinModelPortali P30106.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P30106.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0209004 ; FBpp0207496 ; FBgn0012785 .
    GeneIDi 6606692.
    KEGGi dse:Dsec_GM26019.

    Organism-specific databases

    FlyBasei FBgn0012785. Dsec\GstD1.

    Phylogenomic databases

    KOi K00799.
    OrthoDBi EOG7V1FRJ.
    PhylomeDBi P30106.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Rob3c / Tucson 14021-0248.25.
    2. "Sequence divergence of glutathione S-transferase coding regions among seven species in the melanogaster subgroup of Drosophila."
      Hargis M.T., Cochrane B.J.
      Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-208.

    Entry informationi

    Entry nameiGSTT1_DROSE
    AccessioniPrimary (citable) accession number: P30106
    Secondary accession number(s): B4HHD9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: February 22, 2012
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3