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P30104 (GSTT1_DROER) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase 1-1

EC=2.5.1.18
EC=4.5.1.1
Alternative name(s):
DDT-dehydrochlorinase
GST class-theta
Gene names
Name:GstD1
Synonyms:GST, Gst1
ORF Names:GG17135
OrganismDrosophila erecta (Fruit fly) [Complete proteome]
Taxonomic identifier7220 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has DDT dehydrochlorinase activity By similarity.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride.

Subunit structure

Homodimer.

Sequence similarities

Belongs to the GST superfamily. Theta family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Molecular functionLyase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionDDT-dehydrochlorinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

glutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 209209Glutathione S-transferase 1-1
PRO_0000185948

Regions

Domain1 – 8181GST N-terminal
Domain87 – 209123GST C-terminal
Region51 – 533Glutathione binding By similarity
Region65 – 673Glutathione binding By similarity

Sites

Binding site101Glutathione By similarity

Experimental info

Sequence conflict38 – 392DQ → EH in M84576. Ref.2
Sequence conflict1711G → R in M84576. Ref.2
Sequence conflict1821R → K in M84576. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P30104 [UniParc].

Last modified February 22, 2012. Version 2.
Checksum: B9B1400B96F5C338

FASTA20923,716
        10         20         30         40         50         60 
MADFYYLPGS SPCRSVIMTA KAVGVELNKK LLNLQAGDQL KPEFVKINPQ HTVPTLVDNG 

        70         80         90        100        110        120 
FALWESRAIQ VYLVEKYGKT DSLYPKCPKK RAVINQRLYF DMGTLYQSFA NYYYPQVFAK 

       130        140        150        160        170        180 
APADPEAFKK IEAAFEFLNT FLEGQEYAAG DSLTVADIAL VASVSTFEVA GFEISKYANV 

       190        200 
NRWYENAKKV TPGWEENWAG CLEFKKYFE 

« Hide

References

« Hide 'large scale' references
[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 14021-0224.01.
[2]"Sequence divergence of glutathione S-transferase coding regions among seven species in the melanogaster subgroup of Drosophila."
Hargis M.T., Cochrane B.J.
Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-208.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH954181 Genomic DNA. Translation: EDV49389.1.
M84576 Genomic DNA. No translation available.
RefSeqXP_001980431.1. XM_001980395.1.

3D structure databases

ProteinModelPortalP30104.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0137189; FBpp0135681; FBgn0012266.
GeneID6553974.
KEGGder:Dere_GG17135.

Organism-specific databases

FlyBaseFBgn0012266. Dere\GstD1.

Phylogenomic databases

KOK00799.
OrthoDBEOG7V1FRJ.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTT1_DROER
AccessionPrimary (citable) accession number: P30104
Secondary accession number(s): B3P1D0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: February 22, 2012
Last modified: April 16, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase