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Protein

Phosphatidylethanolamine-binding protein 1

Gene

PEBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.By similarity1 Publication
HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).By similarity

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • enzyme binding Source: UniProtKB
  • phosphatidylethanolamine binding Source: ProtInc
  • protein kinase binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
LigandATP-binding, Lipid-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-5674135 MAP2K and MAPK activation
R-HSA-5675221 Negative regulation of MAPK pathway
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
SignaLinkiP30086
SIGNORiP30086

Protein family/group databases

MEROPSiI51.002

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylethanolamine-binding protein 1
Short name:
PEBP-1
Alternative name(s):
HCNPpp
Neuropolypeptide h3
Prostatic-binding protein
Raf kinase inhibitor protein
Short name:
RKIP
Cleaved into the following chain:
Gene namesi
Name:PEBP1
Synonyms:PBP, PEBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000089220.4
HGNCiHGNC:8630 PEBP1
MIMi604591 gene
neXtProtiNX_P30086

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi5037
OpenTargetsiENSG00000089220
PharmGKBiPA32968

Polymorphism and mutation databases

BioMutaiPEBP1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000232712 – 187Phosphatidylethanolamine-binding protein 1Add BLAST186
PeptideiPRO_00000232722 – 12Hippocampal cholinergic neurostimulating peptideAdd BLAST11

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineCombined sources1
Modified residuei13PhosphoserineBy similarity1
Modified residuei42PhosphothreonineCombined sources1
Modified residuei52PhosphoserineCombined sources1
Modified residuei54PhosphoserineCombined sources1
Modified residuei98PhosphoserineCombined sources1
Modified residuei153PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiP30086
MaxQBiP30086
PaxDbiP30086
PeptideAtlasiP30086
PRIDEiP30086
ProteomicsDBi54634
TopDownProteomicsiP30086

2D gel databases

DOSAC-COBS-2DPAGEiP30086
OGPiP30086
REPRODUCTION-2DPAGEiIPI00219446
P30086
SWISS-2DPAGEiP30086
UCD-2DPAGEiP30086

PTM databases

iPTMnetiP30086
PhosphoSitePlusiP30086
SwissPalmiP30086

Expressioni

Gene expression databases

BgeeiENSG00000089220
CleanExiHS_PEBP1
ExpressionAtlasiP30086 baseline and differential
GenevisibleiP30086 HS

Organism-specific databases

HPAiCAB013493
HPA008819
HPA063904

Interactioni

Subunit structurei

Has a tendency to form dimers by disulfide cross-linking (By similarity). Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues 'Ser-338', 'Ser-339', 'Tyr-340' and 'Tyr-341'. Interacts with ALOX15; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade.By similarity3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi111076, 41 interactors
DIPiDIP-44269N
IntActiP30086, 12 interactors
MINTiP30086
STRINGi9606.ENSP00000261313

Structurei

Secondary structure

1187
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 7Combined sources3
Turni8 – 12Combined sources5
Helixi14 – 16Combined sources3
Beta strandi22 – 24Combined sources3
Beta strandi26 – 28Combined sources3
Beta strandi32 – 34Combined sources3
Turni43 – 46Combined sources4
Beta strandi51 – 54Combined sources4
Beta strandi62 – 71Combined sources10
Beta strandi76 – 78Combined sources3
Beta strandi84 – 93Combined sources10
Helixi97 – 99Combined sources3
Beta strandi100 – 104Combined sources5
Beta strandi118 – 129Combined sources12
Beta strandi140 – 142Combined sources3
Turni144 – 146Combined sources3
Helixi151 – 157Combined sources7
Beta strandi164 – 171Combined sources8
Helixi177 – 183Combined sources7
Turni184 – 186Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BD9X-ray2.05A/B1-187[»]
1BEHX-ray1.75A/B1-187[»]
2L7WNMR-A1-187[»]
2QYQX-ray1.95A1-187[»]
ProteinModelPortaliP30086
SMRiP30086
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30086

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni93 – 134Interaction with RAF11 PublicationAdd BLAST42

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3346 Eukaryota
COG1881 LUCA
GeneTreeiENSGT00900000141013
HOGENOMiHOG000237655
HOVERGENiHBG008165
InParanoidiP30086
OMAiCFQAEWD
OrthoDBiEOG091G0KH6
PhylomeDBiP30086
TreeFamiTF315074

Family and domain databases

CDDicd00866 PEBP_euk, 1 hit
Gene3Di3.90.280.10, 1 hit
InterProiView protein in InterPro
IPR008914 PEBP
IPR036610 PEBP-like_sf
IPR035810 PEBP_euk
IPR001858 Phosphotidylethanolamine-bd_CS
PANTHERiPTHR11362 PTHR11362, 1 hit
PfamiView protein in Pfam
PF01161 PBP, 1 hit
SUPFAMiSSF49777 SSF49777, 1 hit
PROSITEiView protein in PROSITE
PS01220 PBP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30086-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVDLSKWSG PLSLQEVDEQ PQHPLHVTYA GAAVDELGKV LTPTQVKNRP
60 70 80 90 100
TSISWDGLDS GKLYTLVLTD PDAPSRKDPK YREWHHFLVV NMKGNDISSG
110 120 130 140 150
TVLSDYVGSG PPKGTGLHRY VWLVYEQDRP LKCDEPILSN RSGDHRGKFK
160 170 180
VASFRKKYEL RAPVAGTCYQ AEWDDYVPKL YEQLSGK
Length:187
Mass (Da):21,057
Last modified:January 23, 2007 - v3
Checksum:iF1E9F17E2CD11C36
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8W → K (PubMed:7637590).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0060489S → N. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16111 mRNA Translation: BAA03684.1
X75252 mRNA Translation: CAA53031.1
X85033 mRNA Translation: CAA59404.1
AK311927 mRNA Translation: BAG34868.1
CH471054 Genomic DNA Translation: EAW98122.1
BC008714 mRNA Translation: AAH08714.1
BC017396 mRNA Translation: AAH17396.1
BC031102 mRNA Translation: AAH31102.1
S76773 mRNA Translation: AAD14234.1
CCDSiCCDS9187.1
PIRiI53745
RefSeqiNP_002558.1, NM_002567.3
UniGeneiHs.433863

Genome annotation databases

EnsembliENST00000261313; ENSP00000261313; ENSG00000089220
GeneIDi5037
KEGGihsa:5037
UCSCiuc001twu.2 human

Similar proteinsi

Entry informationi

Entry nameiPEBP1_HUMAN
AccessioniPrimary (citable) accession number: P30086
Secondary accession number(s): B2R4S1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 191 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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