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P30083

- VIPR1_RAT

UniProt

P30083 - VIPR1_RAT

Protein

Vasoactive intestinal polypeptide receptor 1

Gene

Vipr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

    GO - Molecular functioni

    1. vasoactive intestinal polypeptide receptor activity Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vasoactive intestinal polypeptide receptor 1
    Short name:
    VIP-R-1
    Alternative name(s):
    Pituitary adenylate cyclase-activating polypeptide type II receptor
    Short name:
    PACAP type II receptor
    Short name:
    PACAP-R-2
    Short name:
    PACAP-R2
    Gene namesi
    Name:Vipr1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3961. Vipr1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 459429Vasoactive intestinal polypeptide receptor 1PRO_0000012858Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi50 ↔ 72By similarity
    Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi63 ↔ 105By similarity
    Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi86 ↔ 122By similarity
    Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi216 ↔ 286By similarity
    Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP30083.

    PTM databases

    PhosphoSiteiP30083.

    Expressioni

    Tissue specificityi

    In liver, lung, intestines, thymus and brain (mostly in the cerebral cortex and hippocampus).1 Publication

    Developmental stagei

    Not expressed in the fetal lung, but is expressed at high levels 2 weeks after birth.1 Publication

    Gene expression databases

    GenevestigatoriP30083.

    Interactioni

    Protein-protein interaction databases

    BioGridi246988. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP30083.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini31 – 143113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini169 – 1757CytoplasmicSequence Analysis
    Topological domaini196 – 21722ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini242 – 25514CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini278 – 29417ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini319 – 34325CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini364 – 37512ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini396 – 45964CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei144 – 16825Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei176 – 19520Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei218 – 24124Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei256 – 27722Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei295 – 31824Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei344 – 36320Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei376 – 39520Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG008318.
    KOiK04589.
    PhylomeDBiP30083.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR001571. GPCR_2_VIP_rcpt.
    IPR001771. GPCR_2_VIP_rcpt_1.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    PR00491. VASOACTVEIPR.
    PR01154. VIP1RECEPTOR.
    SMARTiSM00008. HormR. 1 hit.
    [Graphical view]
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P30083-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPPSPPHVR WLCVLAGALA CALRPAGSQA ASPQHECEYL QLIEIQRQQC    50
    LEEAQLENET TGCSKMWDNL TCWPTTPRGQ AVVLDCPLIF QLFAPIHGYN 100
    ISRSCTEEGW SQLEPGPYHI ACGLNDRASS LDEQQQTKFY NTVKTGYTIG 150
    YSLSLASLLV AMAILSLFRK LHCTRNYIHM HLFMSFILRA TAVFIKDMAL 200
    FNSGEIDHCS EASVGCKAAV VFFQYCVMAN FFWLLVEGLY LYTLLAVSFF 250
    SERKYFWGYI LIGWGVPSVF ITIWTVVRIY FEDFGCWDTI INSSLWWIIK 300
    APILLSILVN FVLFICIIRI LVQKLRPPDI GKNDSSPYSR LAKSTLLLIP 350
    LFGIHYVMFA FFPDNFKAQV KMVFELVVGS FQGFVVAILY CFLNGEVQAE 400
    LRRKWRRWHL QGVLGWSSKS QHPWGGSNGA TCSTQVSMLT RVSPSARRSS 450
    SFQAEVSLV 459
    Length:459
    Mass (Da):52,058
    Last modified:April 1, 1993 - v1
    Checksum:i99E8957DA86698D2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M86835 mRNA. Translation: AAA42331.1.
    BC087136 mRNA. Translation: AAH87136.1.
    U10635 Genomic DNA. Translation: AAB48185.1.
    PIRiJH0594.
    RefSeqiNP_036817.1. NM_012685.2.
    UniGeneiRn.9973.

    Genome annotation databases

    GeneIDi24875.
    KEGGirno:24875.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M86835 mRNA. Translation: AAA42331.1 .
    BC087136 mRNA. Translation: AAH87136.1 .
    U10635 Genomic DNA. Translation: AAB48185.1 .
    PIRi JH0594.
    RefSeqi NP_036817.1. NM_012685.2.
    UniGenei Rn.9973.

    3D structure databases

    ProteinModelPortali P30083.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 246988. 1 interaction.

    Chemistry

    BindingDBi P30083.
    ChEMBLi CHEMBL1955712.
    GuidetoPHARMACOLOGYi 371.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P30083.

    Proteomic databases

    PRIDEi P30083.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 24875.
    KEGGi rno:24875.

    Organism-specific databases

    CTDi 7433.
    RGDi 3961. Vipr1.

    Phylogenomic databases

    HOVERGENi HBG008318.
    KOi K04589.
    PhylomeDBi P30083.

    Miscellaneous databases

    NextBioi 604706.
    PROi P30083.

    Gene expression databases

    Genevestigatori P30083.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR001571. GPCR_2_VIP_rcpt.
    IPR001771. GPCR_2_VIP_rcpt_1.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    PR00491. VASOACTVEIPR.
    PR01154. VIP1RECEPTOR.
    SMARTi SM00008. HormR. 1 hit.
    [Graphical view ]
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide."
      Ishihara T., Shigemoto R., Mori K., Takahashi K., Nagata S.
      Neuron 8:811-819(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    3. "Characterization of the rat vasoactive intestinal polypeptide receptor gene 5' region."
      Pei L., Melmed S.
      Biochem. J. 308:719-723(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 1-26, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiVIPR1_RAT
    AccessioniPrimary (citable) accession number: P30083
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3