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P30083 (VIPR1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vasoactive intestinal polypeptide receptor 1

Short name=VIP-R-1
Alternative name(s):
Pituitary adenylate cyclase-activating polypeptide type II receptor
Short name=PACAP type II receptor
Short name=PACAP-R-2
Short name=PACAP-R2
Gene names
Name:Vipr1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

In liver, lung, intestines, thymus and brain (mostly in the cerebral cortex and hippocampus). Ref.3

Developmental stage

Not expressed in the fetal lung, but is expressed at high levels 2 weeks after birth. Ref.3

Sequence similarities

Belongs to the G-protein coupled receptor 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 459429Vasoactive intestinal polypeptide receptor 1
PRO_0000012858

Regions

Topological domain31 – 143113Extracellular Potential
Transmembrane144 – 16825Helical; Name=1; Potential
Topological domain169 – 1757Cytoplasmic Potential
Transmembrane176 – 19520Helical; Name=2; Potential
Topological domain196 – 21722Extracellular Potential
Transmembrane218 – 24124Helical; Name=3; Potential
Topological domain242 – 25514Cytoplasmic Potential
Transmembrane256 – 27722Helical; Name=4; Potential
Topological domain278 – 29417Extracellular Potential
Transmembrane295 – 31824Helical; Name=5; Potential
Topological domain319 – 34325Cytoplasmic Potential
Transmembrane344 – 36320Helical; Name=6; Potential
Topological domain364 – 37512Extracellular Potential
Transmembrane376 – 39520Helical; Name=7; Potential
Topological domain396 – 45964Cytoplasmic Potential

Amino acid modifications

Glycosylation581N-linked (GlcNAc...) Potential
Glycosylation691N-linked (GlcNAc...) Potential
Glycosylation1001N-linked (GlcNAc...) Potential
Glycosylation2921N-linked (GlcNAc...) Potential
Disulfide bond50 ↔ 72 By similarity
Disulfide bond63 ↔ 105 By similarity
Disulfide bond86 ↔ 122 By similarity
Disulfide bond216 ↔ 286 By similarity

Sequences

Sequence LengthMass (Da)Tools
P30083 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 99E8957DA86698D2

FASTA45952,058
        10         20         30         40         50         60 
MRPPSPPHVR WLCVLAGALA CALRPAGSQA ASPQHECEYL QLIEIQRQQC LEEAQLENET 

        70         80         90        100        110        120 
TGCSKMWDNL TCWPTTPRGQ AVVLDCPLIF QLFAPIHGYN ISRSCTEEGW SQLEPGPYHI 

       130        140        150        160        170        180 
ACGLNDRASS LDEQQQTKFY NTVKTGYTIG YSLSLASLLV AMAILSLFRK LHCTRNYIHM 

       190        200        210        220        230        240 
HLFMSFILRA TAVFIKDMAL FNSGEIDHCS EASVGCKAAV VFFQYCVMAN FFWLLVEGLY 

       250        260        270        280        290        300 
LYTLLAVSFF SERKYFWGYI LIGWGVPSVF ITIWTVVRIY FEDFGCWDTI INSSLWWIIK 

       310        320        330        340        350        360 
APILLSILVN FVLFICIIRI LVQKLRPPDI GKNDSSPYSR LAKSTLLLIP LFGIHYVMFA 

       370        380        390        400        410        420 
FFPDNFKAQV KMVFELVVGS FQGFVVAILY CFLNGEVQAE LRRKWRRWHL QGVLGWSSKS 

       430        440        450 
QHPWGGSNGA TCSTQVSMLT RVSPSARRSS SFQAEVSLV 

« Hide

References

« Hide 'large scale' references
[1]"Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide."
Ishihara T., Shigemoto R., Mori K., Takahashi K., Nagata S.
Neuron 8:811-819(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[3]"Characterization of the rat vasoactive intestinal polypeptide receptor gene 5' region."
Pei L., Melmed S.
Biochem. J. 308:719-723(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 1-26, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M86835 mRNA. Translation: AAA42331.1.
BC087136 mRNA. Translation: AAH87136.1.
U10635 Genomic DNA. Translation: AAB48185.1.
PIRJH0594.
RefSeqNP_036817.1. NM_012685.2.
UniGeneRn.9973.

3D structure databases

ProteinModelPortalP30083.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid246988. 1 interaction.

Chemistry

BindingDBP30083.
ChEMBLCHEMBL1955712.
GuidetoPHARMACOLOGY371.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP30083.

Proteomic databases

PRIDEP30083.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID24875.
KEGGrno:24875.

Organism-specific databases

CTD7433.
RGD3961. Vipr1.

Phylogenomic databases

HOVERGENHBG008318.
KOK04589.
PhylomeDBP30083.

Gene expression databases

GenevestigatorP30083.

Family and domain databases

InterProIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR001571. GPCR_2_VIP_rcpt.
IPR001771. GPCR_2_VIP_rcpt_1.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSPR00249. GPCRSECRETIN.
PR00491. VASOACTVEIPR.
PR01154. VIP1RECEPTOR.
SMARTSM00008. HormR. 1 hit.
[Graphical view]
PROSITEPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio604706.
PROP30083.

Entry information

Entry nameVIPR1_RAT
AccessionPrimary (citable) accession number: P30083
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries