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Protein

Vasoactive intestinal polypeptide receptor 1

Gene

Vipr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • vasoactive intestinal polypeptide receptor activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Vasoactive intestinal polypeptide receptor 1
Short name:
VIP-R-1
Alternative name(s):
Pituitary adenylate cyclase-activating polypeptide type II receptor
Short name:
PACAP type II receptor
Short name:
PACAP-R-2
Short name:
PACAP-R2
Gene namesi
Name:Vipr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3961 Vipr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 143ExtracellularSequence analysisAdd BLAST113
Transmembranei144 – 168Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini169 – 175CytoplasmicSequence analysis7
Transmembranei176 – 195Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini196 – 217ExtracellularSequence analysisAdd BLAST22
Transmembranei218 – 241Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini242 – 255CytoplasmicSequence analysisAdd BLAST14
Transmembranei256 – 277Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini278 – 294ExtracellularSequence analysisAdd BLAST17
Transmembranei295 – 318Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini319 – 343CytoplasmicSequence analysisAdd BLAST25
Transmembranei344 – 363Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini364 – 375ExtracellularSequence analysisAdd BLAST12
Transmembranei376 – 395Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini396 – 459CytoplasmicSequence analysisAdd BLAST64

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1955712
GuidetoPHARMACOLOGYi371

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001285831 – 459Vasoactive intestinal polypeptide receptor 1Add BLAST429

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 72By similarity
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi63 ↔ 105By similarity
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi86 ↔ 122By similarity
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi216 ↔ 286By similarity
Glycosylationi292N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP30083

PTM databases

iPTMnetiP30083
PhosphoSitePlusiP30083

Expressioni

Tissue specificityi

In liver, lung, intestines, thymus and brain (mostly in the cerebral cortex and hippocampus).1 Publication

Developmental stagei

Not expressed in the fetal lung, but is expressed at high levels 2 weeks after birth.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi246988, 1 interactor

Chemistry databases

BindingDBiP30083

Structurei

3D structure databases

ProteinModelPortaliP30083
SMRiP30083
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG008318
InParanoidiP30083
KOiK04589
PhylomeDBiP30083

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR001571 GPCR_2_VIP_rcpt
IPR001771 GPCR_2_VIP_rcpt_1
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR00249 GPCRSECRETIN
PR00491 VASOACTVEIPR
PR01154 VIP1RECEPTOR
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30083-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPPSPPHVR WLCVLAGALA CALRPAGSQA ASPQHECEYL QLIEIQRQQC
60 70 80 90 100
LEEAQLENET TGCSKMWDNL TCWPTTPRGQ AVVLDCPLIF QLFAPIHGYN
110 120 130 140 150
ISRSCTEEGW SQLEPGPYHI ACGLNDRASS LDEQQQTKFY NTVKTGYTIG
160 170 180 190 200
YSLSLASLLV AMAILSLFRK LHCTRNYIHM HLFMSFILRA TAVFIKDMAL
210 220 230 240 250
FNSGEIDHCS EASVGCKAAV VFFQYCVMAN FFWLLVEGLY LYTLLAVSFF
260 270 280 290 300
SERKYFWGYI LIGWGVPSVF ITIWTVVRIY FEDFGCWDTI INSSLWWIIK
310 320 330 340 350
APILLSILVN FVLFICIIRI LVQKLRPPDI GKNDSSPYSR LAKSTLLLIP
360 370 380 390 400
LFGIHYVMFA FFPDNFKAQV KMVFELVVGS FQGFVVAILY CFLNGEVQAE
410 420 430 440 450
LRRKWRRWHL QGVLGWSSKS QHPWGGSNGA TCSTQVSMLT RVSPSARRSS

SFQAEVSLV
Length:459
Mass (Da):52,058
Last modified:April 1, 1993 - v1
Checksum:i99E8957DA86698D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86835 mRNA Translation: AAA42331.1
BC087136 mRNA Translation: AAH87136.1
U10635 Genomic DNA Translation: AAB48185.1
PIRiJH0594
RefSeqiNP_036817.1, NM_012685.2
UniGeneiRn.9973

Genome annotation databases

GeneIDi24875
KEGGirno:24875

Similar proteinsi

Entry informationi

Entry nameiVIPR1_RAT
AccessioniPrimary (citable) accession number: P30083
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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