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Protein

Vasoactive intestinal polypeptide receptor 1

Gene

Vipr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • vasoactive intestinal polypeptide receptor activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Vasoactive intestinal polypeptide receptor 1
Short name:
VIP-R-1
Alternative name(s):
Pituitary adenylate cyclase-activating polypeptide type II receptor
Short name:
PACAP type II receptor
Short name:
PACAP-R-2
Short name:
PACAP-R2
Gene namesi
Name:Vipr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3961. Vipr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 143113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei144 – 16825Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini169 – 1757CytoplasmicSequence Analysis
Transmembranei176 – 19520Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini196 – 21722ExtracellularSequence AnalysisAdd
BLAST
Transmembranei218 – 24124Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini242 – 25514CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei256 – 27722Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini278 – 29417ExtracellularSequence AnalysisAdd
BLAST
Transmembranei295 – 31824Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini319 – 34325CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei344 – 36320Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini364 – 37512ExtracellularSequence AnalysisAdd
BLAST
Transmembranei376 – 39520Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini396 – 45964CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 459429Vasoactive intestinal polypeptide receptor 1PRO_0000012858Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 72By similarity
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi63 ↔ 105By similarity
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi86 ↔ 122By similarity
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi216 ↔ 286By similarity
Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP30083.

PTM databases

PhosphoSiteiP30083.

Expressioni

Tissue specificityi

In liver, lung, intestines, thymus and brain (mostly in the cerebral cortex and hippocampus).1 Publication

Developmental stagei

Not expressed in the fetal lung, but is expressed at high levels 2 weeks after birth.1 Publication

Gene expression databases

GenevisibleiP30083. RN.

Interactioni

Protein-protein interaction databases

BioGridi246988. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP30083.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG008318.
InParanoidiP30083.
KOiK04589.
PhylomeDBiP30083.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR001571. GPCR_2_VIP_rcpt.
IPR001771. GPCR_2_VIP_rcpt_1.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00491. VASOACTVEIPR.
PR01154. VIP1RECEPTOR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30083-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPPSPPHVR WLCVLAGALA CALRPAGSQA ASPQHECEYL QLIEIQRQQC
60 70 80 90 100
LEEAQLENET TGCSKMWDNL TCWPTTPRGQ AVVLDCPLIF QLFAPIHGYN
110 120 130 140 150
ISRSCTEEGW SQLEPGPYHI ACGLNDRASS LDEQQQTKFY NTVKTGYTIG
160 170 180 190 200
YSLSLASLLV AMAILSLFRK LHCTRNYIHM HLFMSFILRA TAVFIKDMAL
210 220 230 240 250
FNSGEIDHCS EASVGCKAAV VFFQYCVMAN FFWLLVEGLY LYTLLAVSFF
260 270 280 290 300
SERKYFWGYI LIGWGVPSVF ITIWTVVRIY FEDFGCWDTI INSSLWWIIK
310 320 330 340 350
APILLSILVN FVLFICIIRI LVQKLRPPDI GKNDSSPYSR LAKSTLLLIP
360 370 380 390 400
LFGIHYVMFA FFPDNFKAQV KMVFELVVGS FQGFVVAILY CFLNGEVQAE
410 420 430 440 450
LRRKWRRWHL QGVLGWSSKS QHPWGGSNGA TCSTQVSMLT RVSPSARRSS

SFQAEVSLV
Length:459
Mass (Da):52,058
Last modified:April 1, 1993 - v1
Checksum:i99E8957DA86698D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86835 mRNA. Translation: AAA42331.1.
BC087136 mRNA. Translation: AAH87136.1.
U10635 Genomic DNA. Translation: AAB48185.1.
PIRiJH0594.
RefSeqiNP_036817.1. NM_012685.2.
UniGeneiRn.9973.

Genome annotation databases

GeneIDi24875.
KEGGirno:24875.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86835 mRNA. Translation: AAA42331.1.
BC087136 mRNA. Translation: AAH87136.1.
U10635 Genomic DNA. Translation: AAB48185.1.
PIRiJH0594.
RefSeqiNP_036817.1. NM_012685.2.
UniGeneiRn.9973.

3D structure databases

ProteinModelPortaliP30083.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246988. 1 interaction.

Chemistry

BindingDBiP30083.
ChEMBLiCHEMBL1955712.
GuidetoPHARMACOLOGYi371.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP30083.

Proteomic databases

PRIDEiP30083.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24875.
KEGGirno:24875.

Organism-specific databases

CTDi7433.
RGDi3961. Vipr1.

Phylogenomic databases

HOVERGENiHBG008318.
InParanoidiP30083.
KOiK04589.
PhylomeDBiP30083.

Miscellaneous databases

NextBioi604706.
PROiP30083.

Gene expression databases

GenevisibleiP30083. RN.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR001571. GPCR_2_VIP_rcpt.
IPR001771. GPCR_2_VIP_rcpt_1.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00491. VASOACTVEIPR.
PR01154. VIP1RECEPTOR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide."
    Ishihara T., Shigemoto R., Mori K., Takahashi K., Nagata S.
    Neuron 8:811-819(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. "Characterization of the rat vasoactive intestinal polypeptide receptor gene 5' region."
    Pei L., Melmed S.
    Biochem. J. 308:719-723(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-26, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiVIPR1_RAT
AccessioniPrimary (citable) accession number: P30083
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 24, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.