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Protein

Vasoactive intestinal polypeptide receptor 1

Gene

Vipr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • vasoactive intestinal polypeptide receptor activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Vasoactive intestinal polypeptide receptor 1
Short name:
VIP-R-1
Alternative name(s):
Pituitary adenylate cyclase-activating polypeptide type II receptor
Short name:
PACAP type II receptor
Short name:
PACAP-R-2
Short name:
PACAP-R2
Gene namesi
Name:Vipr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3961. Vipr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 143ExtracellularSequence analysisAdd BLAST113
Transmembranei144 – 168Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini169 – 175CytoplasmicSequence analysis7
Transmembranei176 – 195Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini196 – 217ExtracellularSequence analysisAdd BLAST22
Transmembranei218 – 241Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini242 – 255CytoplasmicSequence analysisAdd BLAST14
Transmembranei256 – 277Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini278 – 294ExtracellularSequence analysisAdd BLAST17
Transmembranei295 – 318Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini319 – 343CytoplasmicSequence analysisAdd BLAST25
Transmembranei344 – 363Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini364 – 375ExtracellularSequence analysisAdd BLAST12
Transmembranei376 – 395Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini396 – 459CytoplasmicSequence analysisAdd BLAST64

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1955712.
GuidetoPHARMACOLOGYi371.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001285831 – 459Vasoactive intestinal polypeptide receptor 1Add BLAST429

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 72By similarity
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi63 ↔ 105By similarity
Glycosylationi69N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi86 ↔ 122By similarity
Glycosylationi100N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi216 ↔ 286By similarity
Glycosylationi292N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP30083.

PTM databases

iPTMnetiP30083.
PhosphoSitePlusiP30083.

Expressioni

Tissue specificityi

In liver, lung, intestines, thymus and brain (mostly in the cerebral cortex and hippocampus).1 Publication

Developmental stagei

Not expressed in the fetal lung, but is expressed at high levels 2 weeks after birth.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi246988. 1 interactor.

Chemistry databases

BindingDBiP30083.

Structurei

3D structure databases

ProteinModelPortaliP30083.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG008318.
InParanoidiP30083.
KOiK04589.
PhylomeDBiP30083.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR001571. GPCR_2_VIP_rcpt.
IPR001771. GPCR_2_VIP_rcpt_1.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00491. VASOACTVEIPR.
PR01154. VIP1RECEPTOR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30083-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPPSPPHVR WLCVLAGALA CALRPAGSQA ASPQHECEYL QLIEIQRQQC
60 70 80 90 100
LEEAQLENET TGCSKMWDNL TCWPTTPRGQ AVVLDCPLIF QLFAPIHGYN
110 120 130 140 150
ISRSCTEEGW SQLEPGPYHI ACGLNDRASS LDEQQQTKFY NTVKTGYTIG
160 170 180 190 200
YSLSLASLLV AMAILSLFRK LHCTRNYIHM HLFMSFILRA TAVFIKDMAL
210 220 230 240 250
FNSGEIDHCS EASVGCKAAV VFFQYCVMAN FFWLLVEGLY LYTLLAVSFF
260 270 280 290 300
SERKYFWGYI LIGWGVPSVF ITIWTVVRIY FEDFGCWDTI INSSLWWIIK
310 320 330 340 350
APILLSILVN FVLFICIIRI LVQKLRPPDI GKNDSSPYSR LAKSTLLLIP
360 370 380 390 400
LFGIHYVMFA FFPDNFKAQV KMVFELVVGS FQGFVVAILY CFLNGEVQAE
410 420 430 440 450
LRRKWRRWHL QGVLGWSSKS QHPWGGSNGA TCSTQVSMLT RVSPSARRSS

SFQAEVSLV
Length:459
Mass (Da):52,058
Last modified:April 1, 1993 - v1
Checksum:i99E8957DA86698D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86835 mRNA. Translation: AAA42331.1.
BC087136 mRNA. Translation: AAH87136.1.
U10635 Genomic DNA. Translation: AAB48185.1.
PIRiJH0594.
RefSeqiNP_036817.1. NM_012685.2.
UniGeneiRn.9973.

Genome annotation databases

GeneIDi24875.
KEGGirno:24875.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86835 mRNA. Translation: AAA42331.1.
BC087136 mRNA. Translation: AAH87136.1.
U10635 Genomic DNA. Translation: AAB48185.1.
PIRiJH0594.
RefSeqiNP_036817.1. NM_012685.2.
UniGeneiRn.9973.

3D structure databases

ProteinModelPortaliP30083.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246988. 1 interactor.

Chemistry databases

BindingDBiP30083.
ChEMBLiCHEMBL1955712.
GuidetoPHARMACOLOGYi371.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP30083.
PhosphoSitePlusiP30083.

Proteomic databases

PRIDEiP30083.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24875.
KEGGirno:24875.

Organism-specific databases

CTDi7433.
RGDi3961. Vipr1.

Phylogenomic databases

HOVERGENiHBG008318.
InParanoidiP30083.
KOiK04589.
PhylomeDBiP30083.

Miscellaneous databases

PROiP30083.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR001571. GPCR_2_VIP_rcpt.
IPR001771. GPCR_2_VIP_rcpt_1.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00491. VASOACTVEIPR.
PR01154. VIP1RECEPTOR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVIPR1_RAT
AccessioniPrimary (citable) accession number: P30083
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.