ID   CHS6_SOYBN              Reviewed;         388 AA.
AC   P30080;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   27-MAR-2024, entry version 119.
DE   RecName: Full=Chalcone synthase 6;
DE            EC=2.3.1.74;
DE   AltName: Full=Naringenin-chalcone synthase 6;
GN   Name=CHS6;
OS   Glycine max (Soybean) (Glycine hispida).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Glycine;
OC   Glycine subgen. Soja.
OX   NCBI_TaxID=3847;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cv. Williams;
RX   PubMed=8108524; DOI=10.1104/pp.102.2.699;
RA   Akada S., Kung S.D., Dube S.K.;
RT   "Nucleotide sequence of a soybean chalcone synthase gene with a possible
RT   role in ultraviolet-B sensitivity, Gmchs6.";
RL   Plant Physiol. 102:699-701(1993).
CC   -!- FUNCTION: The primary product of this enzyme is 4,2',4',6'-
CC       tetrahydroxychalcone (also termed naringenin-chalcone or chalcone)
CC       which can under specific conditions spontaneously isomerize into
CC       naringenin.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA = 2',4,4',6'-
CC         tetrahydroxychalcone + 3 CO2 + 4 CoA; Xref=Rhea:RHEA:11128,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57355, ChEBI:CHEBI:57384, ChEBI:CHEBI:77645; EC=2.3.1.74;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10023};
CC   -!- PATHWAY: Secondary metabolite biosynthesis; flavonoid biosynthesis.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC       synthases family. {ECO:0000305}.
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DR   EMBL; L03352; AAA33951.1; -; Genomic_DNA.
DR   PIR; JQ2259; JQ2259.
DR   RefSeq; XP_003533807.1; XM_003533759.3.
DR   AlphaFoldDB; P30080; -.
DR   SMR; P30080; -.
DR   STRING; 3847.P30080; -.
DR   PaxDb; 3847-GLYMA09G08780-1; -.
DR   EnsemblPlants; KRH37579; KRH37579; GLYMA_09G075200.
DR   GeneID; 100809433; -.
DR   Gramene; KRH37579; KRH37579; GLYMA_09G075200.
DR   KEGG; gmx:100809433; -.
DR   eggNOG; ENOG502QRSY; Eukaryota.
DR   HOGENOM; CLU_034992_2_0_1; -.
DR   InParanoid; P30080; -.
DR   OMA; PRCKITH; -.
DR   OrthoDB; 883077at2759; -.
DR   BRENDA; 2.3.1.74; 2483.
DR   UniPathway; UPA00154; -.
DR   Proteomes; UP000008827; Chromosome 9.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IBA:GO_Central.
DR   GO; GO:0102128; F:chalcone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016210; F:naringenin-chalcone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0030639; P:polyketide biosynthetic process; IBA:GO_Central.
DR   CDD; cd00831; CHS_like; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR   InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR   InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11877:SF14; CHALCONE SYNTHASE; 1.
DR   PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS00441; CHALCONE_SYNTH; 1.
DR   Genevisible; P30080; GM.
PE   3: Inferred from homology;
KW   Acyltransferase; Flavonoid biosynthesis; Reference proteome; Transferase.
FT   CHAIN           1..388
FT                   /note="Chalcone synthase 6"
FT                   /id="PRO_0000216066"
FT   ACT_SITE        164
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10023"
SQ   SEQUENCE   388 AA;  42532 MW;  77062AE778734BAF CRC64;
     MVSVEEIRKA QRAEGPATVM AIGTATPPNC VDQSTYPDYY FRITNSDHMN ELKEKFKRMC
     DKSMIKKRYM YLNEEILKEN PSVCAYMEPS LDARQDMVVV EVPKLGKEAA TKAIKEWGQP
     KSKITHLIFC TTSGVDMPGA DYQLTKLLGL RPSVKRYMMY QQGCFAGGTV LRLAKDLAEN
     NTGARVLVVC SEITAVTFRG PSDTHLDSLV GQALFGDGAA AVIVGSDPLP AEKPLFELVW
     TAQTILPDSE GAIDGHLREV GLTFHLLKDV PGLISKNIQK ALVEAFQPLG IDDYNSIFWI
     AHPGGPAILD QVEAKLGLKP EKMEATRHVL SEYGNMSSAC VLFILDQMRK KSIENGLGTT
     GEGLEWGVLF GFGPGLTVET VVLRSVTV
//