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Protein

Chalcone synthase 6

Gene

CHS6

Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathway: flavonoid biosynthesis

This protein is involved in the pathway flavonoid biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway flavonoid biosynthesis and in Secondary metabolite biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei164 – 1641PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

BRENDAi2.3.1.74. 2483.
UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 6 (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase 6
Gene namesi
Name:CHS6
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
ProteomesiUP000008827 Componenti: Chromosome 9

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Chalcone synthase 6PRO_0000216066Add
BLAST

Proteomic databases

PRIDEiP30080.

Interactioni

Protein-protein interaction databases

STRINGi3847.GLYMA09G08780.1.

Structurei

3D structure databases

ProteinModelPortaliP30080.
SMRiP30080. Positions 3-388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Phylogenomic databases

InParanoidiP30080.
KOiK00660.
OMAiYESEAPV.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30080-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSVEEIRKA QRAEGPATVM AIGTATPPNC VDQSTYPDYY FRITNSDHMN
60 70 80 90 100
ELKEKFKRMC DKSMIKKRYM YLNEEILKEN PSVCAYMEPS LDARQDMVVV
110 120 130 140 150
EVPKLGKEAA TKAIKEWGQP KSKITHLIFC TTSGVDMPGA DYQLTKLLGL
160 170 180 190 200
RPSVKRYMMY QQGCFAGGTV LRLAKDLAEN NTGARVLVVC SEITAVTFRG
210 220 230 240 250
PSDTHLDSLV GQALFGDGAA AVIVGSDPLP AEKPLFELVW TAQTILPDSE
260 270 280 290 300
GAIDGHLREV GLTFHLLKDV PGLISKNIQK ALVEAFQPLG IDDYNSIFWI
310 320 330 340 350
AHPGGPAILD QVEAKLGLKP EKMEATRHVL SEYGNMSSAC VLFILDQMRK
360 370 380
KSIENGLGTT GEGLEWGVLF GFGPGLTVET VVLRSVTV
Length:388
Mass (Da):42,532
Last modified:April 1, 1993 - v1
Checksum:i77062AE778734BAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03352 Genomic DNA. Translation: AAA33951.1.
PIRiJQ2259.
RefSeqiXP_003533807.1. XM_003533759.2.

Genome annotation databases

EnsemblPlantsiGLYMA09G08780.1; GLYMA09G08780.1; GLYMA09G08780.
GeneIDi100809433.
KEGGigmx:100809433.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03352 Genomic DNA. Translation: AAA33951.1.
PIRiJQ2259.
RefSeqiXP_003533807.1. XM_003533759.2.

3D structure databases

ProteinModelPortaliP30080.
SMRiP30080. Positions 3-388.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3847.GLYMA09G08780.1.

Proteomic databases

PRIDEiP30080.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiGLYMA09G08780.1; GLYMA09G08780.1; GLYMA09G08780.
GeneIDi100809433.
KEGGigmx:100809433.

Phylogenomic databases

InParanoidiP30080.
KOiK00660.
OMAiYESEAPV.

Enzyme and pathway databases

UniPathwayiUPA00154.
BRENDAi2.3.1.74. 2483.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of a soybean chalcone synthase gene with a possible role in ultraviolet-B sensitivity, Gmchs6."
    Akada S., Kung S.D., Dube S.K.
    Plant Physiol. 102:699-701(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Williams.

Entry informationi

Entry nameiCHS6_SOYBN
AccessioniPrimary (citable) accession number: P30080
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 24, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.