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P30079 (CHSY_PINSY) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase
Gene names
Name:CHS
OrganismPinus sylvestris (Scots pine)
Taxonomic identifier3349 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaPinidaePinalesPinaceaePinusPinus

Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 396396Chalcone synthase
PRO_0000216042

Sites

Active site1691 By similarity

Sequences

Sequence LengthMass (Da)Tools
P30079 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 5B5CFAEE888173B4

FASTA39643,294
        10         20         30         40         50         60 
MAAGMMKDLE AFRKAQRADG PATILAIGTA TPPNAVDQSS YPDYYFKITN SEHMTELKEK 

        70         80         90        100        110        120 
FRRMCDKSAI KKRYMYLTEE ILKENPKVCE YMAPSLDARQ DMVVVEVPRL GKEAAAKAIK 

       130        140        150        160        170        180 
EWGQPKSKIT HVIFCTTSGV DMPGADYQLT KLLGLRPSVK RVMMYQQGCF AGGTVLRVAK 

       190        200        210        220        230        240 
DLAENNRGAR VLVVCSEITA VTFRGPSDTH LDSMVGQALF GDGAAALIVG ADPVPEVEKP 

       250        260        270        280        290        300 
CFELMWTAQT ILPDSDGAID GHLREVGLTF HLLKDVPGLI SKNIEKSLVE AFQQFGISDW 

       310        320        330        340        350        360 
NQLFWIAHPG GPAILDQVEA KLNLDPKKLS ATRQVLSDYG NMSSACVHFI LDEMRKSSKE 

       370        380        390 
KGCSTTGEGL DVGVLFGFGP GLTVETVVLK SVPLLD 

« Hide

References

[1]"Molecular analysis of chalcone and dihydropinosylvin synthase from Scots pine (Pinus sylvestris), and differential regulation of these and related enzyme activities in stressed plants."
Fliegmann J., Schroeder G., Schanz S., Britsch L., Schroeder J.
Plant Mol. Biol. 18:489-503(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X60754 Genomic DNA. Translation: CAA43166.1.
PIRS20515.

3D structure databases

ProteinModelPortalP30079.
SMRP30079. Positions 13-394.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-11832.
UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHSY_PINSY
AccessionPrimary (citable) accession number: P30079
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: March 19, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways