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P30079

- CHSY_PINSY

UniProt

P30079 - CHSY_PINSY

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Protein

Chalcone synthase

Gene

CHS

Organism
Pinus sylvestris (Scots pine)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei169 – 1691PROSITE-ProRule annotation

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-11832.
UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase
Gene namesi
Name:CHS
OrganismiPinus sylvestris (Scots pine)
Taxonomic identifieri3349 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaPinidaePinalesPinaceaePinusPinus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Chalcone synthasePRO_0000216042Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP30079.
SMRiP30079. Positions 13-394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30079-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAGMMKDLE AFRKAQRADG PATILAIGTA TPPNAVDQSS YPDYYFKITN
60 70 80 90 100
SEHMTELKEK FRRMCDKSAI KKRYMYLTEE ILKENPKVCE YMAPSLDARQ
110 120 130 140 150
DMVVVEVPRL GKEAAAKAIK EWGQPKSKIT HVIFCTTSGV DMPGADYQLT
160 170 180 190 200
KLLGLRPSVK RVMMYQQGCF AGGTVLRVAK DLAENNRGAR VLVVCSEITA
210 220 230 240 250
VTFRGPSDTH LDSMVGQALF GDGAAALIVG ADPVPEVEKP CFELMWTAQT
260 270 280 290 300
ILPDSDGAID GHLREVGLTF HLLKDVPGLI SKNIEKSLVE AFQQFGISDW
310 320 330 340 350
NQLFWIAHPG GPAILDQVEA KLNLDPKKLS ATRQVLSDYG NMSSACVHFI
360 370 380 390
LDEMRKSSKE KGCSTTGEGL DVGVLFGFGP GLTVETVVLK SVPLLD
Length:396
Mass (Da):43,294
Last modified:April 1, 1993 - v1
Checksum:i5B5CFAEE888173B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60754 Genomic DNA. Translation: CAA43166.1.
PIRiS20515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60754 Genomic DNA. Translation: CAA43166.1 .
PIRi S20515.

3D structure databases

ProteinModelPortali P30079.
SMRi P30079. Positions 13-394.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00154 .
BioCyci MetaCyc:MONOMER-11832.

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000451. PKS_III. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular analysis of chalcone and dihydropinosylvin synthase from Scots pine (Pinus sylvestris), and differential regulation of these and related enzyme activities in stressed plants."
    Fliegmann J., Schroeder G., Schanz S., Britsch L., Schroeder J.
    Plant Mol. Biol. 18:489-503(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCHSY_PINSY
AccessioniPrimary (citable) accession number: P30079
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 1, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3