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P30078 (CHSY_MALDO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase

EC=2.3.1.74
Alternative name(s):
Naregenin-chalcone synthase
Gene names
Name:CHS
OrganismMalus domestica (Apple) (Pyrus malus)
Taxonomic identifier3750 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsRosalesRosaceaeMaloideaeMaleaeMalus

Protein attributes

Sequence length232 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 232›232Chalcone synthase
PRO_0000216015

Sites

Active site71 By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P30078 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 12D6113C80A9E86B

FASTA23224,616
        10         20         30         40         50         60 
MMYQQGCFAG GTVLRLAKDL AENNKGARVL VVCSEITAVT FRGPSDTHLD SLVGQALFGD 

        70         80         90        100        110        120 
GAAAVIIGAD PVPEVEKPLF ELVSAAQTVL PDSDGAIDGH LREVGLTFHL LKDVPGLISK 

       130        140        150        160        170        180 
NIEKSLNEAL KPIGISDWNS LFWIAHPGGP AILDQVEAKL ALKPEKLEAT RQVLSDYGNM 

       190        200        210        220        230 
SSACVLFILD EVRRKSAEKG LETTGEGLEW GVLFGFGPGL TVETVVLHSV AA 

« Hide

References

[1]Podivinsky E., Bradley J.M., Davis K.M.
Submitted (AUG-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Leaf.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X68977 mRNA. Translation: CAA48773.1.
PIRS29556.

3D structure databases

ProteinModelPortalP30078.
SMRP30078. Positions 1-231.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR001099. Chalcone/stilbene_synthase_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
SUPFAMSSF53901. SSF53901. 2 hits.
ProtoNetSearch...

Entry information

Entry nameCHSY_MALDO
AccessionPrimary (citable) accession number: P30078
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: February 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways