Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P30051

- TEAD1_MOUSE

UniProt

P30051 - TEAD1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Transcriptional enhancer factor TEF-1

Gene

Tead1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi30 – 9768TEAPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. embryonic heart tube morphogenesis Source: MGI
  2. heart development Source: MGI
  3. hippo signaling Source: MGI
  4. lateral mesoderm development Source: MGI
  5. notochord development Source: MGI
  6. paraxial mesoderm development Source: MGI
  7. positive regulation of stem cell maintenance Source: MGI
  8. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  9. regulation of cell proliferation Source: MGI
  10. regulation of transcription, DNA-templated Source: MGI
  11. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_196516. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
REACT_198602. PPARA activates gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional enhancer factor TEF-1
Alternative name(s):
NTEF-1
Protein GT-IIC
TEA domain family member 1
Short name:
TEAD-1
Transcription factor 13
Short name:
TCF-13
Gene namesi
Name:Tead1
Synonyms:Tcf13, Tef-1, Tef1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:101876. Tead1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Transcriptional enhancer factor TEF-1PRO_0000205931Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP30051.
PaxDbiP30051.
PRIDEiP30051.

PTM databases

PhosphoSiteiP30051.

Expressioni

Tissue specificityi

In developing skeletal muscle and myocardium, in mitotic neuroblasts both in the brain and spinal cord. At later stages of embryogenesis expressed in several developing structures such as the olfactory system, the intestine, and the kidney.

Gene expression databases

BgeeiP30051.
CleanExiMM_TEAD1.
ExpressionAtlasiP30051. baseline and differential.
GenevestigatoriP30051.

Interactioni

Subunit structurei

Interacts with YAP1 and WWTR1/TAZ.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Yap1P469382EBI-3953905,EBI-1211949

Protein-protein interaction databases

BioGridi204098. 3 interactions.
DIPiDIP-41748N.
IntActiP30051. 2 interactions.
MINTiMINT-1514648.

Structurei

3D structure databases

ProteinModelPortaliP30051.
SMRiP30051. Positions 27-105, 209-425.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni167 – 426260Transcriptional activationSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi143 – 20462Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 TEA DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG246992.
HOGENOMiHOG000253933.
HOVERGENiHBG056905.
InParanoidiP30051.
KOiK09448.
PhylomeDBiP30051.

Family and domain databases

InterProiIPR000818. TEA/ATTS.
IPR016361. TEF.
[Graphical view]
PANTHERiPTHR11834. PTHR11834. 1 hit.
PfamiPF01285. TEA. 1 hit.
[Graphical view]
PIRSFiPIRSF002603. TEF. 1 hit.
PRINTSiPR00065. TEADOMAIN.
SMARTiSM00426. TEA. 1 hit.
[Graphical view]
PROSITEiPS00554. TEA_1. 1 hit.
PS51088. TEA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30051-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPSSWSGSE SPAENMERMS DSADKPIDND AEGVWSPDIE QSFQEALAIY
60 70 80 90 100
PPCGRRKIIL SDEGKMYGRN ELIARYIKLR TGKTRTRKQV SSHIQVLARR
110 120 130 140 150
KSRDFHSKLK DQTAKDKALQ HMAAMSSAQI VSATAIHNKL GLPGIPRPTF
160 170 180 190 200
PGGPGFWPGM IQTGQPGSSQ DVKPFVQQAY PIQPAVTAPI PGFEPTSAPA
210 220 230 240 250
PSVPAWQGRS IGTTKLRLVE FSAFLEQQRD PDSYNKHLFV HIGHANHSYS
260 270 280 290 300
DPLLESVDIR QIYDKFPEKK GGLKELFGKG PQNAFFLVKF WADLNCNIQD
310 320 330 340 350
DAGAFYGVSS QYESSENMTV TCSTKVCSFG KQVVEKVETE YARFENGRFV
360 370 380 390 400
YRINRSPMCE YMINFIHKLK HLPEKYMMNS VLENFTILLV VTNRDTQETL
410 420
LCMACVFEVS NSEHGAQHHI YRLVKD
Length:426
Mass (Da):47,948
Last modified:July 15, 1998 - v2
Checksum:iAEC83DAD2DDAF07A
GO

Sequence cautioni

The sequence AAA40410.1 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical ATT isoleucine codon.Curated
The sequence AAA40411.1 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical ATT isoleucine codon.Curated
The sequence AAB32420.1 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical ATT isoleucine codon.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 102SE → RR in AAB32420. (PubMed:7958896)Curated
Sequence conflicti110 – 1101K → KVTSM in AAA40411. (PubMed:8396764)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06865 mRNA. Translation: AAA40410.1. Sequence problems.
L13853 mRNA. Translation: AAA40411.1. Sequence problems.
S74227 mRNA. Translation: AAB32420.1. Sequence problems.
PIRiA54882.
S40779.
S41767.
RefSeqiNP_033372.1. NM_009346.3.
UniGeneiMm.24685.
Mm.398985.

Genome annotation databases

GeneIDi21676.
KEGGimmu:21676.
UCSCiuc009jgz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06865 mRNA. Translation: AAA40410.1 . Sequence problems.
L13853 mRNA. Translation: AAA40411.1 . Sequence problems.
S74227 mRNA. Translation: AAB32420.1 . Sequence problems.
PIRi A54882.
S40779.
S41767.
RefSeqi NP_033372.1. NM_009346.3.
UniGenei Mm.24685.
Mm.398985.

3D structure databases

ProteinModelPortali P30051.
SMRi P30051. Positions 27-105, 209-425.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204098. 3 interactions.
DIPi DIP-41748N.
IntActi P30051. 2 interactions.
MINTi MINT-1514648.

PTM databases

PhosphoSitei P30051.

Proteomic databases

MaxQBi P30051.
PaxDbi P30051.
PRIDEi P30051.

Protocols and materials databases

DNASUi 21676.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 21676.
KEGGi mmu:21676.
UCSCi uc009jgz.2. mouse.

Organism-specific databases

CTDi 7003.
MGIi MGI:101876. Tead1.

Phylogenomic databases

eggNOGi NOG246992.
HOGENOMi HOG000253933.
HOVERGENi HBG056905.
InParanoidi P30051.
KOi K09448.
PhylomeDBi P30051.

Enzyme and pathway databases

Reactomei REACT_196516. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
REACT_198602. PPARA activates gene expression.

Miscellaneous databases

ChiTaRSi Tead1. mouse.
NextBioi 300968.
PROi P30051.
SOURCEi Search...

Gene expression databases

Bgeei P30051.
CleanExi MM_TEAD1.
ExpressionAtlasi P30051. baseline and differential.
Genevestigatori P30051.

Family and domain databases

InterProi IPR000818. TEA/ATTS.
IPR016361. TEF.
[Graphical view ]
PANTHERi PTHR11834. PTHR11834. 1 hit.
Pfami PF01285. TEA. 1 hit.
[Graphical view ]
PIRSFi PIRSF002603. TEF. 1 hit.
PRINTSi PR00065. TEADOMAIN.
SMARTi SM00426. TEA. 1 hit.
[Graphical view ]
PROSITEi PS00554. TEA_1. 1 hit.
PS51088. TEA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Striking homology between mouse and human transcription enhancer factor-1 (TEF-1)."
    Blatt C., Depamphilis M.L.
    Nucleic Acids Res. 21:747-748(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Both a ubiquitous factor mTEF-1 and a distinct muscle-specific factor bind to the M-CAT motif of the myosin heavy chain beta gene."
    Shimizu N.N., Smith G., Izumo S.
    Nucleic Acids Res. 21:4103-4110(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Heart.
  3. "Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice."
    Chen Z., Friedrich G.A., Soriano P.
    Genes Dev. 8:2293-2301(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTEAD1_MOUSE
AccessioniPrimary (citable) accession number: P30051
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: July 15, 1998
Last modified: November 26, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3