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P30051

- TEAD1_MOUSE

UniProt

P30051 - TEAD1_MOUSE

Protein

Transcriptional enhancer factor TEF-1

Gene

Tead1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi30 – 9768TEAPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. protein binding Source: MGI
    3. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. embryonic heart tube morphogenesis Source: MGI
    2. heart development Source: MGI
    3. hippo signaling Source: MGI
    4. lateral mesoderm development Source: MGI
    5. notochord development Source: MGI
    6. paraxial mesoderm development Source: MGI
    7. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    8. regulation of cell proliferation Source: MGI
    9. regulation of transcription, DNA-templated Source: MGI
    10. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_196516. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
    REACT_198602. PPARA activates gene expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional enhancer factor TEF-1
    Alternative name(s):
    NTEF-1
    Protein GT-IIC
    TEA domain family member 1
    Short name:
    TEAD-1
    Transcription factor 13
    Short name:
    TCF-13
    Gene namesi
    Name:Tead1
    Synonyms:Tcf13, Tef-1, Tef1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:101876. Tead1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 426426Transcriptional enhancer factor TEF-1PRO_0000205931Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP30051.
    PRIDEiP30051.

    PTM databases

    PhosphoSiteiP30051.

    Expressioni

    Tissue specificityi

    In developing skeletal muscle and myocardium, in mitotic neuroblasts both in the brain and spinal cord. At later stages of embryogenesis expressed in several developing structures such as the olfactory system, the intestine, and the kidney.

    Gene expression databases

    ArrayExpressiP30051.
    BgeeiP30051.
    CleanExiMM_TEAD1.
    GenevestigatoriP30051.

    Interactioni

    Subunit structurei

    Interacts with YAP1 and WWTR1/TAZ.By similarity

    Protein-protein interaction databases

    BioGridi204098. 3 interactions.
    DIPiDIP-41748N.
    IntActiP30051. 2 interactions.
    MINTiMINT-1514648.

    Structurei

    3D structure databases

    ProteinModelPortaliP30051.
    SMRiP30051. Positions 27-105, 209-425.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni167 – 426260Transcriptional activationSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi143 – 20462Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 TEA DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG246992.
    HOGENOMiHOG000253933.
    HOVERGENiHBG056905.
    KOiK09448.
    PhylomeDBiP30051.

    Family and domain databases

    InterProiIPR000818. TEA/ATTS.
    IPR016361. TEF.
    [Graphical view]
    PANTHERiPTHR11834. PTHR11834. 1 hit.
    PfamiPF01285. TEA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002603. TEF. 1 hit.
    PRINTSiPR00065. TEADOMAIN.
    SMARTiSM00426. TEA. 1 hit.
    [Graphical view]
    PROSITEiPS00554. TEA_1. 1 hit.
    PS51088. TEA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30051-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPSSWSGSE SPAENMERMS DSADKPIDND AEGVWSPDIE QSFQEALAIY    50
    PPCGRRKIIL SDEGKMYGRN ELIARYIKLR TGKTRTRKQV SSHIQVLARR 100
    KSRDFHSKLK DQTAKDKALQ HMAAMSSAQI VSATAIHNKL GLPGIPRPTF 150
    PGGPGFWPGM IQTGQPGSSQ DVKPFVQQAY PIQPAVTAPI PGFEPTSAPA 200
    PSVPAWQGRS IGTTKLRLVE FSAFLEQQRD PDSYNKHLFV HIGHANHSYS 250
    DPLLESVDIR QIYDKFPEKK GGLKELFGKG PQNAFFLVKF WADLNCNIQD 300
    DAGAFYGVSS QYESSENMTV TCSTKVCSFG KQVVEKVETE YARFENGRFV 350
    YRINRSPMCE YMINFIHKLK HLPEKYMMNS VLENFTILLV VTNRDTQETL 400
    LCMACVFEVS NSEHGAQHHI YRLVKD 426
    Length:426
    Mass (Da):47,948
    Last modified:July 15, 1998 - v2
    Checksum:iAEC83DAD2DDAF07A
    GO

    Sequence cautioni

    The sequence AAA40410.1 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical ATT isoleucine codon.
    The sequence AAA40411.1 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical ATT isoleucine codon.
    The sequence AAB32420.1 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical ATT isoleucine codon.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 102SE → RR in AAB32420. (PubMed:7958896)Curated
    Sequence conflicti110 – 1101K → KVTSM in AAA40411. (PubMed:8396764)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L06865 mRNA. Translation: AAA40410.1. Sequence problems.
    L13853 mRNA. Translation: AAA40411.1. Sequence problems.
    S74227 mRNA. Translation: AAB32420.1. Sequence problems.
    PIRiA54882.
    S40779.
    S41767.
    RefSeqiNP_033372.1. NM_009346.3.
    UniGeneiMm.24685.
    Mm.398985.

    Genome annotation databases

    GeneIDi21676.
    KEGGimmu:21676.
    UCSCiuc009jgz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L06865 mRNA. Translation: AAA40410.1 . Sequence problems.
    L13853 mRNA. Translation: AAA40411.1 . Sequence problems.
    S74227 mRNA. Translation: AAB32420.1 . Sequence problems.
    PIRi A54882.
    S40779.
    S41767.
    RefSeqi NP_033372.1. NM_009346.3.
    UniGenei Mm.24685.
    Mm.398985.

    3D structure databases

    ProteinModelPortali P30051.
    SMRi P30051. Positions 27-105, 209-425.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204098. 3 interactions.
    DIPi DIP-41748N.
    IntActi P30051. 2 interactions.
    MINTi MINT-1514648.

    PTM databases

    PhosphoSitei P30051.

    Proteomic databases

    PaxDbi P30051.
    PRIDEi P30051.

    Protocols and materials databases

    DNASUi 21676.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 21676.
    KEGGi mmu:21676.
    UCSCi uc009jgz.2. mouse.

    Organism-specific databases

    CTDi 7003.
    MGIi MGI:101876. Tead1.

    Phylogenomic databases

    eggNOGi NOG246992.
    HOGENOMi HOG000253933.
    HOVERGENi HBG056905.
    KOi K09448.
    PhylomeDBi P30051.

    Enzyme and pathway databases

    Reactomei REACT_196516. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
    REACT_198602. PPARA activates gene expression.

    Miscellaneous databases

    ChiTaRSi TEAD1. mouse.
    NextBioi 300968.
    PROi P30051.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P30051.
    Bgeei P30051.
    CleanExi MM_TEAD1.
    Genevestigatori P30051.

    Family and domain databases

    InterProi IPR000818. TEA/ATTS.
    IPR016361. TEF.
    [Graphical view ]
    PANTHERi PTHR11834. PTHR11834. 1 hit.
    Pfami PF01285. TEA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002603. TEF. 1 hit.
    PRINTSi PR00065. TEADOMAIN.
    SMARTi SM00426. TEA. 1 hit.
    [Graphical view ]
    PROSITEi PS00554. TEA_1. 1 hit.
    PS51088. TEA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Striking homology between mouse and human transcription enhancer factor-1 (TEF-1)."
      Blatt C., Depamphilis M.L.
      Nucleic Acids Res. 21:747-748(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Both a ubiquitous factor mTEF-1 and a distinct muscle-specific factor bind to the M-CAT motif of the myosin heavy chain beta gene."
      Shimizu N.N., Smith G., Izumo S.
      Nucleic Acids Res. 21:4103-4110(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Heart.
    3. "Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice."
      Chen Z., Friedrich G.A., Soriano P.
      Genes Dev. 8:2293-2301(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiTEAD1_MOUSE
    AccessioniPrimary (citable) accession number: P30051
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-16 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3