Reviewed, UniProtKB/Swiss-Prot P30051 (TEAD1_MOUSE)

Names and origin

Protein names

Recommended name:
    Transcriptional enhancer factor TEF-1
Alternative name(s):
    TEA domain family member 1
      Short name=TEAD-1
    Protein GT-IIC
    Transcription factor 13
    NTEF-1

Gene names

Name:	Tead1
Synonyms:	Tcf13, Tef-1, Tef1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	426 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Binds specifically and cooperatively to the SPH and GT-IIC "enhansons" (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.
Subcellular location	Nucleus.
Tissue specificity	In developing skeletal muscle and myocardium, in mitotic neuroblasts both in the brain and spinal cord. At later stages of embryogenesis expressed in several developing structures such as the olfactory system, the intestine, and the kidney.
Sequence similarities	Contains 1 TEA DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Activator
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	heart development Ref.3 Inferred from mutant phenotype. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from genetic interaction. Source: MGI transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	transcription factor complex Inferred from direct assay. Source: MGI
Molecular function	protein binding Inferred from physical interaction. Source: MGI transcription activator activity Inferred from genetic interaction. Source: MGI transcription factor activity Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 426	426	Transcriptional enhancer factor TEF-1		PRO_0000205931
Regions
	DNA binding	30 – 97	68	TEA
	Region	167 – 426	260	Transcriptional activation Potential
	Compositional bias	143 – 204	62	Pro-rich
Amino acid modifications
	Modified residue	7	1	Phosphoserine By similarity
	Modified residue	9	1	Phosphoserine By similarity
	Modified residue	11	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	9 – 10	2	SE → RR in AAB32420. Ref.3
	Sequence conflict	110	1	K → KVTSM in AAA40411. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P30051-1 [UniParc]. Last modified July 15, 1998. Version 2. Checksum: AEC83DAD2DDAF07A	FASTA	426	47,948
	10 20 30 40 50 60 MEPSSWSGSE SPAENMERMS DSADKPIDND AEGVWSPDIE QSFQEALAIY PPCGRRKIIL 70 80 90 100 110 120 SDEGKMYGRN ELIARYIKLR TGKTRTRKQV SSHIQVLARR KSRDFHSKLK DQTAKDKALQ 130 140 150 160 170 180 HMAAMSSAQI VSATAIHNKL GLPGIPRPTF PGGPGFWPGM IQTGQPGSSQ DVKPFVQQAY 190 200 210 220 230 240 PIQPAVTAPI PGFEPTSAPA PSVPAWQGRS IGTTKLRLVE FSAFLEQQRD PDSYNKHLFV 250 260 270 280 290 300 HIGHANHSYS DPLLESVDIR QIYDKFPEKK GGLKELFGKG PQNAFFLVKF WADLNCNIQD 310 320 330 340 350 360 DAGAFYGVSS QYESSENMTV TCSTKVCSFG KQVVEKVETE YARFENGRFV YRINRSPMCE 370 380 390 400 410 420 YMINFIHKLK HLPEKYMMNS VLENFTILLV VTNRDTQETL LCMACVFEVS NSEHGAQHHI YRLVKD

References

[1]	"Striking homology between mouse and human transcription enhancer factor-1 (TEF-1)." Blatt C., Depamphilis M.L. Nucleic Acids Res. 21:747-748(1993) [PubMed: 8441689] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Both a ubiquitous factor mTEF-1 and a distinct muscle-specific factor bind to the M-CAT motif of the myosin heavy chain beta gene." Shimizu N.N., Smith G., Izumo S. Nucleic Acids Res. 21:4103-4110(1993) [PubMed: 8396764] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Heart.
[3]	"Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice." Chen Z., Friedrich G.A., Soriano P. Genes Dev. 8:2293-2301(1994) [PubMed: 7958896] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L06865 mRNA. Translation: AAA40410.1. Different initiation. L13853 mRNA. Translation: AAA40411.1. Different initiation. S74227 mRNA. Translation: AAB32420.1. Different initiation.
IPI	IPI00331222.
PIR	A54882. S40779. S41767.
UniGene	Mm.28081
3D structure databases
SMR	P30051. Positions 27-105.
ModBase	Search...
PTM databases
PhosphoSite	P30051.
Proteomic databases
PRIDE	P30051.
Genome annotation databases
Ensembl	ENSMUSG00000055320. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:101876. Tead1.
Phylogenomic databases
HOVERGEN	P30051.
Gene expression databases
ArrayExpress	P30051.
Bgee	P30051.
CleanEx	MM_TEAD1.
GermOnline	ENSMUSG00000055320. Mus musculus.
Family and domain databases
InterPro	IPR000818. TEA/ATTS. IPR016361. TEF. [Graphical view]
PANTHER	PTHR11834. TEA/ATTS. 1 hit.
Pfam	PF01285. TEA. 1 hit. [Graphical view]
PIRSF	PIRSF002603. TEF. 1 hit.
PRINTS	PR00065. TEADOMAIN.
SMART	SM00426. TEA. 1 hit. [Graphical view]
PROSITE	PS00554. TEA_1. 1 hit. PS51088. TEA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

TEAD1_MOUSE

Accession

Primary (citable) accession number: P30051

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	July 15, 1998
Last modified:	June 16, 2009
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)