Reviewed,
UniProtKB/Swiss-Prot P30046 (DOPD_HUMAN)
Last modified
June 16, 2009.
Version 95.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: D-dopachrome decarboxylase EC=4.1.1.84 Alternative name(s): D-dopachrome tautomerase Phenylpyruvate tautomerase II | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 118 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). |
| Catalytic activity | D-dopachrome = 5,6-dihydroxyindole + CO2. |
| Subunit structure | Homotrimer. Ref.12 |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the MIF family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Melanin biosynthesis |
| Cellular component | Cytoplasm |
| Molecular function | Lyase |
| PTM | Acetylation |
| Technical term | 3D-structure Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | melanin biosynthetic process from tyrosine Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | D-dopachrome decarboxylase activity Inferred from electronic annotation. Source: EC dopachrome isomerase activity Ref.2Traceable author statement. Source: ProtInc protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Ref.9 Ref.10 | ||||||||||||||||||||||||||||||
| Chain | 2 – 118 | 117 | D-dopachrome decarboxylase | PRO_0000158070 | |||||||||||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||||||||||||
| Modified residue | 2 | 1 | N-acetylproline By similarity | ||||||||||||||||||||||||||||||
Experimental info | |||||||||||||||||||||||||||||||||
| Sequence conflict | 3 | 1 | F → G AA sequence Ref.9 | ||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||
| Beta strand | 3 – 10 | 8 | |||||||||||||||||||||||||||||||
| Helix | 12 – 14 | 3 | |||||||||||||||||||||||||||||||
| Helix | 19 – 31 | 13 | |||||||||||||||||||||||||||||||
| Helix | 35 – 37 | 3 | |||||||||||||||||||||||||||||||
| Beta strand | 39 – 43 | 5 | |||||||||||||||||||||||||||||||
| Beta strand | 47 – 50 | 4 | |||||||||||||||||||||||||||||||
| Beta strand | 58 – 68 | 11 | |||||||||||||||||||||||||||||||
| Helix | 71 – 89 | 19 | |||||||||||||||||||||||||||||||
| Helix | 93 – 95 | 3 | |||||||||||||||||||||||||||||||
| Beta strand | 96 – 103 | 8 | |||||||||||||||||||||||||||||||
| Helix | 105 – 107 | 3 | |||||||||||||||||||||||||||||||
| Beta strand | 108 – 110 | 3 | |||||||||||||||||||||||||||||||
| Helix | 115 – 117 | 3 | |||||||||||||||||||||||||||||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | Thelin S., Panagopoulos I., Lassen C., Rosengren E., Aman P., Rorsman H. Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta. |
| [2] | "Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation." Nishihira J., Fujinaga M., Kuriyama T., Suzuki M., Sugimoto H., Nakagawa A., Tanaka I., Sakai M. Biochem. Biophys. Res. Commun. 243:538-544(1998) [PubMed: 9480844] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | Rorsman H. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [4] | "Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF." Esumi N., Budarf M., Ciccarelli L., Sellinger B., Kozak C.A., Wistow G. Mamm. Genome 9:753-757(1998) [PubMed: 9716662] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [5] | Board P.G., Coggan M.A. Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [6] | "A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [7] | "The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. Wright H.Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [8] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Pancreas. |
| [9] | "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J. Nat. Biotechnol. 21:566-569(2003) [PubMed: 12665801] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-22. Tissue: Platelet. |
| [10] | "Human liver protein map: a reference database established by microsequencing and gel comparison." Hochstrasser D.F., Frutiger S., Paquet N., Bairoch A., Ravier F., Pasquali C., Sanchez J.-C., Tissot J.-D., Bjellqvist B., Vargas R., Appel R.D., Hughes G.J. Electrophoresis 13:992-1001(1992) [PubMed: 1286669] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-12. Tissue: Liver. |
| [11] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [12] | "Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54-A resolution." Sugimoto H., Taniguchi M., Nakagawa A., Tanaka I., Suzuki M., Nishihira J. Biochemistry 38:3268-3279(1999) [PubMed: 10079069] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS), SUBUNIT. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| U49785 mRNA. Translation: AAB48546.1. U84143 mRNA. Translation: AAB41503.1. Y11151 Genomic DNA. Translation: CAA72037.1. AF012434, AF012432, AF012433 Genomic DNA. Translation: AAC77468.1. AF058293 Genomic DNA. Translation: AAC13717.1. CR456431 mRNA. Translation: CAG30317.1. Z84718 Genomic DNA. No translation available. BC005971 mRNA. Translation: AAH05971.1. BC015508 mRNA. Translation: AAH15508.1. | |||||||||||||
| IPI | IPI00293867. | ||||||||||||
| PIR | G02438. JE0162. | ||||||||||||
| RefSeq | NP_001077861.1. NP_001346.1. | ||||||||||||
| UniGene | Hs.656723 | ||||||||||||
3D structure databases | |||||||||||||
| |||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | P30046. 5 interactions. | ||||||||||||
2-D gel databases | |||||||||||||
| SWISS-2DPAGE | P30046. | ||||||||||||
Proteomic databases | |||||||||||||
| PeptideAtlas | P30046. | ||||||||||||
| PRIDE | P30046. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENSG00000099977. Homo sapiens. [Contig view] | ||||||||||||
| GeneID | 1652. | ||||||||||||
| KEGG | hsa:1652. | ||||||||||||
Organism-specific databases | |||||||||||||
| GeneCards | GC22M022638. | ||||||||||||
| H-InvDB | HIX0016303. HIX0027870. | ||||||||||||
| HGNC | HGNC:2732. DDT. | ||||||||||||
| MIM | 602750. gene. | ||||||||||||
| PharmGKB | PA27197. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | P30046. | ||||||||||||
| HOVERGEN | P30046. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| BRENDA | 4.1.1.84. 247. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | P30046. | ||||||||||||
| Bgee | P30046. | ||||||||||||
| CleanEx | HS_DDT. | ||||||||||||
| GermOnline | ENSG00000099977. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR001398. Macrophage_inhib_fac. IPR019829. Macrophage_inhib_fac_CS. IPR014347. Tautomerase. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:3.30.429.10. Tautomerase. 1 hit. | ||||||||||||
| PANTHER | PTHR11954. MIF. 1 hit. | ||||||||||||
| Pfam | PF01187. MIF. 1 hit. [Graphical view] | ||||||||||||
| ProDom | PD004816. MIF. 1 hit. [Graphical view] [Entries sharing at least one domain] | ||||||||||||
| PROSITE | PS01158. MIF. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 6800. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | DOPD_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P30046 Secondary accession number(s): O00774, O60787, Q13534 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 22 Human chromosome 22: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


