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Protein

D-dopachrome decarboxylase

Gene

DDT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).

Catalytic activityi

D-dopachrome = 5,6-dihydroxyindole + CO2.

GO - Molecular functioni

  • D-dopachrome decarboxylase activity Source: UniProtKB-EC
  • dopachrome isomerase activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Melanin biosynthesis

Enzyme and pathway databases

BioCyciZFISH:HS01942-MONOMER.
BRENDAi4.1.1.84. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
D-dopachrome decarboxylase (EC:4.1.1.84)
Alternative name(s):
D-dopachrome tautomerase
Phenylpyruvate tautomerase II
Gene namesi
Name:DDT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:2732. DDT.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi100037417.
1652.
OpenTargetsiENSG00000099977.
ENSG00000275003.
PharmGKBiPA27197.

Polymorphism and mutation databases

DMDMi2828192.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity2 Publications
ChainiPRO_00001580702 – 118D-dopachrome decarboxylaseAdd BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylprolineBy similarity1
Modified residuei33N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP30046.
PaxDbiP30046.
PeptideAtlasiP30046.
PRIDEiP30046.
TopDownProteomicsiP30046-1. [P30046-1]

2D gel databases

SWISS-2DPAGEP30046.
UCD-2DPAGEP30046.

PTM databases

iPTMnetiP30046.
PhosphoSitePlusiP30046.
SwissPalmiP30046.

Expressioni

Gene expression databases

BgeeiENSG00000099977.
CleanExiHS_DDT.
ExpressionAtlasiP30046. baseline and differential.
GenevisibleiP30046. HS.

Organism-specific databases

HPAiHPA049871.

Interactioni

Subunit structurei

Homotrimer.1 Publication

Protein-protein interaction databases

BioGridi108018. 2 interactors.
755774. 4 interactors.
IntActiP30046. 1 interactor.
MINTiMINT-5000166.
STRINGi9606.ENSP00000215773.

Structurei

Secondary structure

1118
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 10Combined sources8
Helixi12 – 14Combined sources3
Helixi19 – 31Combined sources13
Helixi35 – 37Combined sources3
Beta strandi39 – 43Combined sources5
Beta strandi58 – 70Combined sources13
Helixi71 – 89Combined sources19
Helixi93 – 95Combined sources3
Beta strandi96 – 103Combined sources8
Helixi105 – 107Combined sources3
Helixi115 – 117Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DPTX-ray1.54A/B/C2-118[»]
3KANX-ray1.13A/B/C2-118[»]
4Q3FX-ray1.80A/B/C2-118[»]
ProteinModelPortaliP30046.
SMRiP30046.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30046.

Family & Domainsi

Sequence similaritiesi

Belongs to the MIF family.Curated

Phylogenomic databases

eggNOGiKOG1759. Eukaryota.
ENOG41122MF. LUCA.
GeneTreeiENSGT00840000129866.
HOGENOMiHOG000112325.
HOVERGENiHBG003240.
InParanoidiP30046.
KOiK10028.
PhylomeDBiP30046.
TreeFamiTF313853.

Family and domain databases

InterProiIPR001398. Macrophage_inhib_fac.
IPR019829. Macrophage_inhib_fac_CS.
IPR014347. Tautomerase/MIF_sf.
[Graphical view]
PANTHERiPTHR11954. PTHR11954. 1 hit.
PfamiPF01187. MIF. 1 hit.
[Graphical view]
ProDomiPD004816. Macrophage_inhib_fac. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55331. SSF55331. 1 hit.
PROSITEiPS01158. MIF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P30046-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPFLELDTNL PANRVPAGLE KRLCAAAASI LGKPADRVNV TVRPGLAMAL
60 70 80 90 100
SGSTEPCAQL SISSIGVVGT AEDNRSHSAH FFEFLTKELA LGQDRILIRF
110
FPLESWQIGK IGTVMTFL
Length:118
Mass (Da):12,712
Last modified:January 23, 2007 - v3
Checksum:i12FEF51908F342B7
GO
Isoform 2 (identifier: P30046-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-118: ILIRFFPLESWQIGKIGTVMTFL → QVPGEVHGRLTE

Note: No experimental confirmation available.
Show »
Length:107
Mass (Da):11,323
Checksum:i74E98DFC0FA5395A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3F → G AA sequence (PubMed:12665801).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05695396 – 118ILIRF…VMTFL → QVPGEVHGRLTE in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49785 mRNA. Translation: AAB48546.1.
U84143 mRNA. Translation: AAB41503.1.
Y11151 Genomic DNA. Translation: CAA72037.1.
AF012434, AF012432, AF012433 Genomic DNA. Translation: AAC77468.1.
AF058293 Genomic DNA. Translation: AAC13717.1.
CR456431 mRNA. Translation: CAG30317.1.
AK298326 mRNA. Translation: BAH12758.1.
AP000351 Genomic DNA. No translation available.
Z84718 Genomic DNA. No translation available.
CH471095 Genomic DNA. Translation: EAW59622.1.
BC005971 mRNA. Translation: AAH05971.1.
BC015508 mRNA. Translation: AAH15508.1.
CCDSiCCDS13820.1. [P30046-1]
PIRiG02438.
JE0162.
RefSeqiNP_001077861.1. NM_001084392.1. [P30046-1]
NP_001346.1. NM_001355.3. [P30046-1]
UniGeneiHs.656723.
Hs.744172.

Genome annotation databases

EnsembliENST00000350608; ENSP00000215773; ENSG00000099977. [P30046-1]
ENST00000398344; ENSP00000381386; ENSG00000099977. [P30046-1]
ENST00000430101; ENSP00000399768; ENSG00000099977. [P30046-2]
ENST00000615721; ENSP00000481175; ENSG00000275003. [P30046-1]
ENST00000626871; ENSP00000486829; ENSG00000275003. [P30046-1]
ENST00000629401; ENSP00000486384; ENSG00000275003. [P30046-2]
GeneIDi1652.
KEGGihsa:1652.
UCSCiuc062cik.1. human. [P30046-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49785 mRNA. Translation: AAB48546.1.
U84143 mRNA. Translation: AAB41503.1.
Y11151 Genomic DNA. Translation: CAA72037.1.
AF012434, AF012432, AF012433 Genomic DNA. Translation: AAC77468.1.
AF058293 Genomic DNA. Translation: AAC13717.1.
CR456431 mRNA. Translation: CAG30317.1.
AK298326 mRNA. Translation: BAH12758.1.
AP000351 Genomic DNA. No translation available.
Z84718 Genomic DNA. No translation available.
CH471095 Genomic DNA. Translation: EAW59622.1.
BC005971 mRNA. Translation: AAH05971.1.
BC015508 mRNA. Translation: AAH15508.1.
CCDSiCCDS13820.1. [P30046-1]
PIRiG02438.
JE0162.
RefSeqiNP_001077861.1. NM_001084392.1. [P30046-1]
NP_001346.1. NM_001355.3. [P30046-1]
UniGeneiHs.656723.
Hs.744172.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DPTX-ray1.54A/B/C2-118[»]
3KANX-ray1.13A/B/C2-118[»]
4Q3FX-ray1.80A/B/C2-118[»]
ProteinModelPortaliP30046.
SMRiP30046.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108018. 2 interactors.
755774. 4 interactors.
IntActiP30046. 1 interactor.
MINTiMINT-5000166.
STRINGi9606.ENSP00000215773.

PTM databases

iPTMnetiP30046.
PhosphoSitePlusiP30046.
SwissPalmiP30046.

Polymorphism and mutation databases

DMDMi2828192.

2D gel databases

SWISS-2DPAGEP30046.
UCD-2DPAGEP30046.

Proteomic databases

EPDiP30046.
PaxDbiP30046.
PeptideAtlasiP30046.
PRIDEiP30046.
TopDownProteomicsiP30046-1. [P30046-1]

Protocols and materials databases

DNASUi1652.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350608; ENSP00000215773; ENSG00000099977. [P30046-1]
ENST00000398344; ENSP00000381386; ENSG00000099977. [P30046-1]
ENST00000430101; ENSP00000399768; ENSG00000099977. [P30046-2]
ENST00000615721; ENSP00000481175; ENSG00000275003. [P30046-1]
ENST00000626871; ENSP00000486829; ENSG00000275003. [P30046-1]
ENST00000629401; ENSP00000486384; ENSG00000275003. [P30046-2]
GeneIDi1652.
KEGGihsa:1652.
UCSCiuc062cik.1. human. [P30046-1]

Organism-specific databases

CTDi1652.
DisGeNETi100037417.
1652.
GeneCardsiDDT.
HGNCiHGNC:2732. DDT.
HPAiHPA049871.
MIMi602750. gene.
neXtProtiNX_P30046.
OpenTargetsiENSG00000099977.
ENSG00000275003.
PharmGKBiPA27197.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1759. Eukaryota.
ENOG41122MF. LUCA.
GeneTreeiENSGT00840000129866.
HOGENOMiHOG000112325.
HOVERGENiHBG003240.
InParanoidiP30046.
KOiK10028.
PhylomeDBiP30046.
TreeFamiTF313853.

Enzyme and pathway databases

BioCyciZFISH:HS01942-MONOMER.
BRENDAi4.1.1.84. 2681.

Miscellaneous databases

ChiTaRSiDDT. human.
EvolutionaryTraceiP30046.
GeneWikiiDDT_(gene).
GenomeRNAii1652.
PROiP30046.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099977.
CleanExiHS_DDT.
ExpressionAtlasiP30046. baseline and differential.
GenevisibleiP30046. HS.

Family and domain databases

InterProiIPR001398. Macrophage_inhib_fac.
IPR019829. Macrophage_inhib_fac_CS.
IPR014347. Tautomerase/MIF_sf.
[Graphical view]
PANTHERiPTHR11954. PTHR11954. 1 hit.
PfamiPF01187. MIF. 1 hit.
[Graphical view]
ProDomiPD004816. Macrophage_inhib_fac. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55331. SSF55331. 1 hit.
PROSITEiPS01158. MIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDOPD_HUMAN
AccessioniPrimary (citable) accession number: P30046
Secondary accession number(s): B7Z522
, O00774, O60787, Q13534
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 166 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.