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Protein

Endoplasmic reticulum resident protein 29

Gene

ERP29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER.

GO - Molecular functioni

GO - Biological processi

  • activation of MAPK activity Source: ParkinsonsUK-UCL
  • intracellular protein transport Source: GO_Central
  • negative regulation of gene expression Source: ParkinsonsUK-UCL
  • negative regulation of protein secretion Source: ParkinsonsUK-UCL
  • positive regulation of gene expression Source: ParkinsonsUK-UCL
  • positive regulation of protein phosphorylation Source: ParkinsonsUK-UCL
  • protein folding Source: GO_Central
  • protein secretion Source: InterPro
  • protein unfolding Source: ParkinsonsUK-UCL
  • regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: Ensembl

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum resident protein 29
Short name:
ERp29
Alternative name(s):
Endoplasmic reticulum resident protein 28
Short name:
ERp28
Endoplasmic reticulum resident protein 31
Short name:
ERp31
Gene namesi
Name:ERP29
Synonyms:C12orf8, ERP28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000089248.6
HGNCiHGNC:13799 ERP29
MIMi602287 gene
neXtProtiNX_P30040

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi10961
OpenTargetsiENSG00000089248
PharmGKBiPA25509

Polymorphism and mutation databases

BioMutaiERP29
DMDMi6015110

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Combined sources1 PublicationAdd BLAST32
ChainiPRO_000002119733 – 261Endoplasmic reticulum resident protein 29Add BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64Phosphotyrosine; by PKDCC1 Publication1
Modified residuei66Phosphotyrosine; by PKDCC1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP30040
PaxDbiP30040
PeptideAtlasiP30040
PRIDEiP30040
TopDownProteomicsiP30040-1 [P30040-1]

2D gel databases

OGPiP30040
REPRODUCTION-2DPAGEIPI00024911
SWISS-2DPAGEP30040

PTM databases

iPTMnetiP30040
PhosphoSitePlusiP30040
SwissPalmiP30040

Expressioni

Tissue specificityi

Ubiquitous. Mostly expressed in secretory tissues.

Gene expression databases

BgeeiENSG00000089248
CleanExiHS_ERP29
ExpressionAtlasiP30040 baseline and differential
GenevisibleiP30040 HS

Organism-specific databases

HPAiHPA039363
HPA039456

Interactioni

Subunit structurei

Homodimer. Part of a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116160, 20 interactors
IntActiP30040, 15 interactors
STRINGi9606.ENSP00000261735

Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi45 – 49Combined sources5
Helixi50 – 52Combined sources3
Beta strandi54 – 60Combined sources7
Helixi68 – 80Combined sources13
Beta strandi86 – 91Combined sources6
Beta strandi96 – 98Combined sources3
Helixi102 – 107Combined sources6
Helixi112 – 114Combined sources3
Beta strandi116 – 122Combined sources7
Helixi138 – 147Combined sources10
Helixi159 – 170Combined sources12
Helixi174 – 187Combined sources14
Helixi188 – 190Combined sources3
Helixi193 – 195Combined sources3
Helixi196 – 212Combined sources17
Helixi216 – 230Combined sources15
Helixi235 – 249Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QC7X-ray2.90A/B34-261[»]
5V8ZX-ray2.10A/C158-261[»]
5V90X-ray3.25A/C158-261[»]
ProteinModelPortaliP30040
SMRiP30040
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30040

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi258 – 261Prevents secretion from ERPROSITE-ProRule annotation4

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX2F Eukaryota
ENOG4111I8S LUCA
GeneTreeiENSGT00390000018566
HOGENOMiHOG000169611
HOVERGENiHBG051508
InParanoidiP30040
KOiK09586
OMAiDGCIKEF
OrthoDBiEOG091G0NH4
PhylomeDBiP30040
TreeFamiTF324701

Family and domain databases

CDDicd00238 ERp29c, 1 hit
cd03007 PDI_a_ERp29_N, 1 hit
Gene3Di1.20.1150.12, 1 hit
InterProiView protein in InterPro
IPR016855 ERp29
IPR011679 ERp29_C
IPR036356 ERp29_C_sf
IPR012883 ERp29_N
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF07749 ERp29, 1 hit
PF07912 ERp29_N, 1 hit
PIRSFiPIRSF027352 ER_p29, 1 hit
SUPFAMiSSF47933 SSF47933, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P30040-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAVPRAAF LSPLLPLLLG FLLLSAPHGG SGLHTKGALP LDTVTFYKVI
60 70 80 90 100
PKSKFVLVKF DTQYPYGEKQ DEFKRLAENS ASSDDLLVAE VGISDYGDKL
110 120 130 140 150
NMELSEKYKL DKESYPVFYL FRDGDFENPV PYTGAVKVGA IQRWLKGQGV
160 170 180 190 200
YLGMPGCLPV YDALAGEFIR ASGVEARQAL LKQGQDNLSS VKETQKKWAE
210 220 230 240 250
QYLKIMGKIL DQGEDFPASE MTRIARLIEK NKMSDGKKEE LQKSLNILTA
260
FQKKGAEKEE L
Length:261
Mass (Da):28,993
Last modified:December 15, 1998 - v4
Checksum:i76145006433A1983
GO
Isoform 2 (identifier: P30040-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-53: VIPKS → IMVTS
     54-261: Missing.

Note: No experimental confirmation available.
Show »
Length:53
Mass (Da):5,477
Checksum:i67DE41DE8CA1F165
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04568049 – 53VIPKS → IMVTS in isoform 2. 1 Publication5
Alternative sequenceiVSP_04568154 – 261Missing in isoform 2. 1 PublicationAdd BLAST208

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94910 mRNA Translation: CAA64397.1
AA412124 mRNA No translation available.
CR541667 mRNA Translation: CAG46468.1
AC073575 Genomic DNA No translation available.
BC101493 mRNA Translation: AAI01494.1
BC101495 mRNA Translation: AAI01496.1
CCDSiCCDS44977.1 [P30040-2]
CCDS9158.1 [P30040-1]
PIRiT09549
RefSeqiNP_001029197.1, NM_001034025.1 [P30040-2]
NP_006808.1, NM_006817.3 [P30040-1]
UniGeneiHs.75841

Genome annotation databases

EnsembliENST00000261735; ENSP00000261735; ENSG00000089248 [P30040-1]
ENST00000455836; ENSP00000412083; ENSG00000089248 [P30040-2]
GeneIDi10961
KEGGihsa:10961
UCSCiuc001ttl.1 human [P30040-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiERP29_HUMAN
AccessioniPrimary (citable) accession number: P30040
Secondary accession number(s): C9J183, Q3MJC3, Q6FHT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: December 15, 1998
Last modified: May 23, 2018
This is version 189 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health