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Protein

Phenazine biosynthesis-like domain-containing protein

Gene

PBLD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei46By similarity1

GO - Molecular functioni

GO - Biological processi

  • biosynthetic process Source: InterPro
  • maintenance of gastrointestinal epithelium Source: UniProtKB
  • negative regulation of epithelial cell migration Source: UniProtKB
  • negative regulation of epithelial cell proliferation Source: UniProtKB
  • negative regulation of epithelial to mesenchymal transition Source: UniProtKB
  • negative regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  • negative regulation of SMAD protein import into nucleus Source: UniProtKB
  • negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108187-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phenazine biosynthesis-like domain-containing protein (EC:5.1.-.-)
Alternative name(s):
MAWD-binding protein
Short name:
MAWDBP
Unknown protein 32 from 2D-page of liver tissue
Gene namesi
Name:PBLD
Synonyms:MAWBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23301. PBLD.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi64081.
OpenTargetsiENSG00000108187.
PharmGKBiPA162398821.

Polymorphism and mutation databases

BioMutaiPBLD.
DMDMi17380331.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001623831 – 288Phenazine biosynthesis-like domain-containing proteinAdd BLAST288

Proteomic databases

MaxQBiP30039.
PaxDbiP30039.
PeptideAtlasiP30039.
PRIDEiP30039.

2D gel databases

SWISS-2DPAGEP30039.

PTM databases

iPTMnetiP30039.
PhosphoSitePlusiP30039.

Expressioni

Gene expression databases

BgeeiENSG00000108187.
CleanExiHS_PBLD.
ExpressionAtlasiP30039. baseline and differential.
GenevisibleiP30039. HS.

Organism-specific databases

HPAiHPA038035.
HPA038036.

Interactioni

Subunit structurei

Interacts with UNRIP/MAWD.

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-750589,EBI-750589
CCDC184Q52MB25EBI-750589,EBI-10179526
EFHC2Q5JST65EBI-750589,EBI-2349927
LNX1Q8TBB13EBI-750589,EBI-739832
TCF4P158843EBI-750589,EBI-533224
TRIP13Q156454EBI-750589,EBI-358993

Protein-protein interaction databases

BioGridi122047. 12 interactors.
IntActiP30039. 6 interactors.
MINTiMINT-5000971.
STRINGi9606.ENSP00000308466.

Structurei

3D structure databases

ProteinModelPortaliP30039.
SMRiP30039.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PhzF family.Curated

Phylogenomic databases

eggNOGiKOG3033. Eukaryota.
COG0384. LUCA.
GeneTreeiENSGT00390000017595.
HOGENOMiHOG000251510.
HOVERGENiHBG018191.
InParanoidiP30039.
OMAiFNTRSGE.
OrthoDBiEOG091G1768.
PhylomeDBiP30039.
TreeFamiTF314596.

Family and domain databases

InterProiIPR003719. Phenazine_PhzF.
[Graphical view]
PfamiPF02567. PhzC-PhzF. 1 hit.
[Graphical view]
PIRSFiPIRSF016184. PhzC_PhzF. 1 hit.
TIGRFAMsiTIGR00654. PhzF_family. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P30039-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLPIFIADA FTARAFRGNP AAVCLLENEL DEDMHQKIAR EMNLSETAFI
60 70 80 90 100
RKLHPTDNFA QSSCFGLRWF TPASEVPLCG HATLASAAVL FHKIKNMNST
110 120 130 140 150
LTFVTLSGEL RARRAEDGIV LDLPLYPAHP QDFHEVEDLI KTAIGNTLVQ
160 170 180 190 200
DICYSPDTQK LLVRLSDVYN RSFLENLKVN TENLLQVENT GKVKGLILTL
210 220 230 240 250
KGEPGGQTQA FDFYSRYFAP WVGVAEDPVT GSAHAVLSSY WSQHLGKKEM
260 270 280
HAFQCSHRGG ELGISLRPDG RVDIRGGAAV VLEGTLTA
Length:288
Mass (Da):31,785
Last modified:September 26, 2001 - v2
Checksum:iAF79ECB704E6D62F
GO
Isoform 2 (identifier: P30039-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     252-288: AFQCSHRGGELGISLRPDGRVDIRGGAAVVLEGTLTA → GRTALYQFLFYLPNSKLVFLLICTIPLKM

Note: Gene prediction based on EST data.
Show »
Length:280
Mass (Da):31,409
Checksum:i04C2DF7A81DF1D62
GO

Sequence cautioni

The sequence BAB55285 differs from that shown. Reason: Frameshift at position 232.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12 – 13TA → NV AA sequence (PubMed:1286669).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02268417R → C.1 PublicationCorresponds to variant rs12359690dbSNPEnsembl.1
Natural variantiVAR_07240362S → I.1 PublicationCorresponds to variant rs756247151dbSNPEnsembl.1
Natural variantiVAR_022685257H → R.1 PublicationCorresponds to variant rs4142048dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053822252 – 288AFQCS…GTLTA → GRTALYQFLFYLPNSKLVFL LICTIPLKM in isoform 2. CuratedAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027673 mRNA. Translation: BAB55285.1. Frameshift.
AC016395 Genomic DNA. No translation available.
CH471083 Genomic DNA. Translation: EAW54274.1.
CH471083 Genomic DNA. Translation: EAW54273.1.
BC009738 mRNA. Translation: AAH09738.1.
AB049758 mRNA. Translation: BAB16606.1.
CCDSiCCDS44413.1. [P30039-2]
CCDS7277.2. [P30039-1]
RefSeqiNP_001028255.1. NM_001033083.1. [P30039-2]
NP_071412.2. NM_022129.3. [P30039-1]
XP_005270085.1. XM_005270028.3. [P30039-1]
UniGeneiHs.198158.

Genome annotation databases

EnsembliENST00000309049; ENSP00000308466; ENSG00000108187. [P30039-1]
ENST00000358769; ENSP00000351619; ENSG00000108187. [P30039-1]
ENST00000495025; ENSP00000476306; ENSG00000108187. [P30039-2]
GeneIDi64081.
KEGGihsa:64081.
UCSCiuc001jnr.1. human. [P30039-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027673 mRNA. Translation: BAB55285.1. Frameshift.
AC016395 Genomic DNA. No translation available.
CH471083 Genomic DNA. Translation: EAW54274.1.
CH471083 Genomic DNA. Translation: EAW54273.1.
BC009738 mRNA. Translation: AAH09738.1.
AB049758 mRNA. Translation: BAB16606.1.
CCDSiCCDS44413.1. [P30039-2]
CCDS7277.2. [P30039-1]
RefSeqiNP_001028255.1. NM_001033083.1. [P30039-2]
NP_071412.2. NM_022129.3. [P30039-1]
XP_005270085.1. XM_005270028.3. [P30039-1]
UniGeneiHs.198158.

3D structure databases

ProteinModelPortaliP30039.
SMRiP30039.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122047. 12 interactors.
IntActiP30039. 6 interactors.
MINTiMINT-5000971.
STRINGi9606.ENSP00000308466.

PTM databases

iPTMnetiP30039.
PhosphoSitePlusiP30039.

Polymorphism and mutation databases

BioMutaiPBLD.
DMDMi17380331.

2D gel databases

SWISS-2DPAGEP30039.

Proteomic databases

MaxQBiP30039.
PaxDbiP30039.
PeptideAtlasiP30039.
PRIDEiP30039.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309049; ENSP00000308466; ENSG00000108187. [P30039-1]
ENST00000358769; ENSP00000351619; ENSG00000108187. [P30039-1]
ENST00000495025; ENSP00000476306; ENSG00000108187. [P30039-2]
GeneIDi64081.
KEGGihsa:64081.
UCSCiuc001jnr.1. human. [P30039-1]

Organism-specific databases

CTDi64081.
DisGeNETi64081.
GeneCardsiPBLD.
HGNCiHGNC:23301. PBLD.
HPAiHPA038035.
HPA038036.
MIMi612189. gene.
neXtProtiNX_P30039.
OpenTargetsiENSG00000108187.
PharmGKBiPA162398821.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3033. Eukaryota.
COG0384. LUCA.
GeneTreeiENSGT00390000017595.
HOGENOMiHOG000251510.
HOVERGENiHBG018191.
InParanoidiP30039.
OMAiFNTRSGE.
OrthoDBiEOG091G1768.
PhylomeDBiP30039.
TreeFamiTF314596.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108187-MONOMER.

Miscellaneous databases

ChiTaRSiPBLD. human.
GenomeRNAii64081.
PROiP30039.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108187.
CleanExiHS_PBLD.
ExpressionAtlasiP30039. baseline and differential.
GenevisibleiP30039. HS.

Family and domain databases

InterProiIPR003719. Phenazine_PhzF.
[Graphical view]
PfamiPF02567. PhzC-PhzF. 1 hit.
[Graphical view]
PIRSFiPIRSF016184. PhzC_PhzF. 1 hit.
TIGRFAMsiTIGR00654. PhzF_family. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPBLD_HUMAN
AccessioniPrimary (citable) accession number: P30039
Secondary accession number(s): A8MZJ3, C9JIM0, Q9HCC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: September 26, 2001
Last modified: November 30, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.