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Protein

Tegument protein UL47

Gene

UL47

Organism
Bovine herpesvirus 1.1 (strain P8-2) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Tegument protein that can bind to various RNA transcripts. Plays a role in the attenuation of selective viral and cellular mRNA degradation by modulating the activity of host shutoff RNase UL41/VHS. Plays also a role in the primary envelopement of virions in the perinuclear space, probably by interacting with two nuclear egress proteins UL31 and UL34.By similarity

Miscellaneous

Expressed in late in the infection.By similarity

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Tegument protein UL47
Gene namesi
ORF Names:UL47
OrganismiBovine herpesvirus 1.1 (strain P8-2) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Taxonomic identifieri10324 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]

Subcellular locationi

  • Virion tegument By similarity
  • Host nucleus By similarity
  • Host cytoplasm By similarity

  • Note: Major tegument protein of the virion. Undergoes nucleocytoplasmic shuttling during infection. Localizes to the major sites of transcription in the infected cell nucleus.By similarity

GO - Cellular componenti

  • host cell cytoplasm Source: UniProtKB-SubCell
  • host cell nucleoplasm Source: AgBase
  • viral tegument Source: UniProtKB-SubCell

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001160761 – 742Tegument protein UL47Add BLAST742

Post-translational modificationi

Phosphorylated by US3. This phosphorylation is required for proper nuclear localization.By similarity

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Interacts with US3 kinase. Interacts with UL31 and UL34; these interactions seem important for efficient virion nuclear egress. Interacts with UL41/VHS.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
DDB1A1A4K37EBI-11301368,EBI-11296420From Bos taurus.

Protein-protein interaction databases

IntActiP30021. 2 interactors.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 30Nuclear localization signalSequence analysisAdd BLAST21
Motifi95 – 122Nuclear export signalSequence analysisAdd BLAST28
Motifi485 – 495Nuclear export signalSequence analysisAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi182 – 186Poly-Gly5
Compositional biasi231 – 236Poly-Ala6

Domaini

The nuclear export signal is CRM1-dependent.By similarity

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR005029. Herpes_UL47.
PfamiView protein in Pfam
PF03362. Herpes_UL47. 1 hit.

Sequencei

Sequence statusi: Complete.

P30021-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAARDGRPE RRPRRSGTYR THPFQRPSAR RSLLDALRAA DAEAAERPRV
60 70 80 90 100
RRPRPDFQRP PDEDTSEDEN VYDYIDGDSS DSADDYDSDY FTANRGPNHG
110 120 130 140 150
AGDAMDTDAP PERAPEGGAP QDYLTAHLRA IEALPESAPH RSLLERTART
160 170 180 190 200
VYAHEFPPRD LSAGSRAPAQ RARRSLRGFP RGGGGGQEPG PDDEGDDAAD
210 220 230 240 250
LREDLVPDEA YAHLERDERL SEGPPLLNME AAAAAAGERS VVEELFTYAP
260 270 280 290 300
AQPQVEVPLP RILEGRVRPS AFFAQMPLDA LCRTPPNDQR VVRERRAWDM
310 320 330 340 350
AGTPHGLLIT TWSTVDPEFS IGGMYVGAPE GTRPRLVWRR AMKQAMALQY
360 370 380 390 400
RLGVGGLCRA VDGARMPPTE ALLFLAARAA ARSAQLPFFV AAGARGRRRA
410 420 430 440 450
APARGGGWAA GSHAVHATGR VPHATLFRGS MGSLIYWHEL RVMLTAVPAL
460 470 480 490 500
CARYAGAGLQ SAELYLLALR HSEAPGYTAN ERYALSAYLT LFVALAERAV
510 520 530 540 550
RWLYLAGAHL LGPHPTAAAF REVRAKIPYE RLPLGSATLH DAEVETVDSA
560 570 580 590 600
TFQEALAFSA LAHVYGEAYV AVRTATTLLM AEYAAHAERR DVREMTAAFL
610 620 630 640 650
GVGLIAQRLM GSLEPAAELR SRRSGVRGPA CPTVREGTLA RYSLLADAAL
660 670 680 690 700
PLVRPVSLVE FWEARDGVMR ELRLRPVASP PLAGKRRVME LYLSLDSIEA
710 720 730 740
LVGREPLGSR PVLGPLVDIA EALADHPHLV TGDGRGPRLG GR
Length:742
Mass (Da):80,744
Last modified:April 1, 1993 - v1
Checksum:i85979D8C2C953C89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10327 Genomic DNA. Translation: BAA01170.1.
Z11610 Genomic DNA. Translation: CAA77683.1.
PIRiJQ1435. TNBEB1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTEG5_BHV1P
AccessioniPrimary (citable) accession number: P30021
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: September 7, 2016
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families