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Protein

Probable ATP-dependent helicase lhr

Gene

lhr

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi51 – 58ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG11548-MONOMER.
ECOL316407:JW1645-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent helicase lhr (EC:3.6.4.-)
Alternative name(s):
Large helicase-related protein
Gene namesi
Name:lhr
Synonyms:rhlF
Ordered Locus Names:b1653, JW1645
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11548. lhr.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001021931 – 1538Probable ATP-dependent helicase lhrAdd BLAST1538

Proteomic databases

PaxDbiP30015.
PRIDEiP30015.

Interactioni

Protein-protein interaction databases

BioGridi4260268. 62 interactors.
DIPiDIP-10097N.
IntActiP30015. 9 interactors.
MINTiMINT-1293547.
STRINGi511145.b1653.

Structurei

3D structure databases

ProteinModelPortaliP30015.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 235Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST198
Domaini284 – 462Helicase C-terminalPROSITE-ProRule annotationAdd BLAST179

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi179 – 182DEVH box4

Sequence similaritiesi

Belongs to the helicase family.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4107QRT. Bacteria.
COG1201. LUCA.
HOGENOMiHOG000238716.
InParanoidiP30015.
KOiK03724.
OMAiRYGVVFW.
PhylomeDBiP30015.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR013701. DEAD/DEAH_assoc.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF08494. DEAD_assoc. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30015-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADNPDPSSL LPDVFSPATR DWFLRAFKQP TAVQPQTWHV AARSEHALVI
60 70 80 90 100
APTGSGKTLA AFLYALDRLF REGGEDTREA HKRKTSRILY ISPIKALGTD
110 120 130 140 150
VQRNLQIPLK GIADERRRRG ETEVNLRVGI RTGDTPAQER SKLTRNPPDI
160 170 180 190 200
LITTPESLYL MLTSRARETL RGVETVIIDE VHAVAGSKRG AHLALSLERL
210 220 230 240 250
DALLHTSAQR IGLSATVRSA SDVAAFLGGD RPVTVVNPPA MRHPQIRIVV
260 270 280 290 300
PVANMDDVSS VASGTGEDSH AGREGSIWPY IETGILDEVL RHRSTIVFTN
310 320 330 340 350
SRGLAEKLTA RLNELYAARL QRSPSIAVDA AHFESTSGAT SNRVQSSDVF
360 370 380 390 400
IARSHHGSVS KEQRAITEQA LKSGELRCVV ATSSLELGID MGAVDLVIQV
410 420 430 440 450
ATPLSVASGL QRIGRAGHQV GGVSKGLFFP RTRRDLVDSA VIVECMFAGR
460 470 480 490 500
LENLTPPHNP LDVLAQQTVA AAAMDALQVD EWYSRVRRAA PWKDLPRRVF
510 520 530 540 550
DATLDMLSGR YPSGDFSAFR PKLVWNRETG ILTARPGAQL LAVTSGGTIP
560 570 580 590 600
DRGMYSVLLP EGEEKAGSRR VGELDEEMVY ESRVNDIITL GATSWRIQQI
610 620 630 640 650
TRDQVIVTPA PGRSARLPFW RGEGNGRPAE LGEMIGDFLH LLADGAFFSG
660 670 680 690 700
TIPPWLAEEN TIANIQGLIE EQRNATGIVP GSRHLVLERC RDEIGDWRII
710 720 730 740 750
LHSPYGRRVH EPWAVAIAGR IHALWGADAS VVASDDGIVA RIPDTDGKLP
760 770 780 790 800
DAAIFLFEPE KLLQIVREAV GSSALFAARF RECAARALLM PGRTPGHRTP
810 820 830 840 850
LWQQRLRASQ LLEIAQGYPD FPVILETLRE CLQDVYDLPA LERLMRRLNG
860 870 880 890 900
GEIQISDVTT TTPSPFATSL LFGYVAEFMY QSDAPLAERR ASVLSLDSEL
910 920 930 940 950
LRNLLGQVDP GELLDPQVIR QVEEELQRLA PGRRAKGEEG LFDLLRELGP
960 970 980 990 1000
MTVEDLAQRH TGSSEEVASY LENLLAVKRI FPAMISGQER LACMDDAARL
1010 1020 1030 1040 1050
RDALGVRLPE SLPEIYLHRV SYPLRDLFLR YLRAHALVTA EQLAHEFSLG
1060 1070 1080 1090 1100
IAIVEEQLQQ LREQGLVMNL QQDIWVSDEV FRRLRLRSLQ AAREATRPVA
1110 1120 1130 1140 1150
ATTYARLLLE RQGVLPATDG SPALFASTSP GVYEGVDGVM RVIEQLAGVG
1160 1170 1180 1190 1200
LPASLWESQI LPARVRDYSS EMLDELLATG AVIWSGQKKL GEDDGLVALH
1210 1220 1230 1240 1250
LQEYAAESFT PAEADQANRS ALQQAIVAVL ADGGAWFAQQ ISQRIRDKIG
1260 1270 1280 1290 1300
ESVDLSALQE ALWALVWQGV ITSDIWAPLR ALTRSSSNAR TSTRRSHRAR
1310 1320 1330 1340 1350
RGRPVYAQPV SPRVSYNTPN LAGRWSLLQV EPLNDTERML ALAENMLDRY
1360 1370 1380 1390 1400
GIISRQAVIA ENIPGGFPSM QTLCRSMEDS GRIMRGRFVE GLGGAQFAER
1410 1420 1430 1440 1450
LTIDRLRDLA TQATQTRHYT PVALSANDPA NVWGNLLPWP AHPATLVPTR
1460 1470 1480 1490 1500
RAGALVVVSG GKLLLYLAQG GKKMLVWQEK EELLAPEVFH ALTTALRREP
1510 1520 1530
RLRFTLTEVN DLPVRQTPMF TLLREAGFSS SPQGLDWG
Length:1,538
Mass (Da):169,381
Last modified:June 1, 1994 - v2
Checksum:i563172B5FE3D826E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01622 Genomic DNA. Translation: AAC37009.1.
U00096 Genomic DNA. Translation: AAC74725.1.
AP009048 Genomic DNA. Translation: BAA15419.1.
PIRiG64922.
RefSeqiNP_416170.1. NC_000913.3.
WP_001310858.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74725; AAC74725; b1653.
BAA15419; BAA15419; BAA15419.
GeneIDi946156.
KEGGiecj:JW1645.
eco:b1653.
PATRICi32118608. VBIEscCol129921_1724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01622 Genomic DNA. Translation: AAC37009.1.
U00096 Genomic DNA. Translation: AAC74725.1.
AP009048 Genomic DNA. Translation: BAA15419.1.
PIRiG64922.
RefSeqiNP_416170.1. NC_000913.3.
WP_001310858.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP30015.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260268. 62 interactors.
DIPiDIP-10097N.
IntActiP30015. 9 interactors.
MINTiMINT-1293547.
STRINGi511145.b1653.

Proteomic databases

PaxDbiP30015.
PRIDEiP30015.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74725; AAC74725; b1653.
BAA15419; BAA15419; BAA15419.
GeneIDi946156.
KEGGiecj:JW1645.
eco:b1653.
PATRICi32118608. VBIEscCol129921_1724.

Organism-specific databases

EchoBASEiEB1510.
EcoGeneiEG11548. lhr.

Phylogenomic databases

eggNOGiENOG4107QRT. Bacteria.
COG1201. LUCA.
HOGENOMiHOG000238716.
InParanoidiP30015.
KOiK03724.
OMAiRYGVVFW.
PhylomeDBiP30015.

Enzyme and pathway databases

BioCyciEcoCyc:EG11548-MONOMER.
ECOL316407:JW1645-MONOMER.

Miscellaneous databases

PROiP30015.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR013701. DEAD/DEAH_assoc.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF08494. DEAD_assoc. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLHR_ECOLI
AccessioniPrimary (citable) accession number: P30015
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.