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P30007

- DUT_HHV6G

UniProt

P30007 - DUT_HHV6G

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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene
U45, RF5
Organism
Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Magnesium By similarity.

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:U45
Synonyms:RF5
OrganismiHuman herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)
Taxonomic identifieri10369 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182958Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP30007.

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.

Family and domain databases

InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 2 hits.

Sequencei

Sequence statusi: Complete.

P30007-1 [UniParc]FASTAAdd to Basket

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MYSAISEKIS ETITLQRQTS SRYIEFFVFR NVDINELWTT DISEDKTHDV    50
WPAVNKKSFK KFLENELTSY QRPIPLLGIP QNGTVSKTCK KEKQRETDCV 100
NYERKHGNPV TFYPRHRAKR NANTDTCISE EPSILVSHHR NSKMDVFMDT 150
NKITLVNREL IWVPHDQVRI VKLDISLYIP DGFFGVITGH SNDVFCECVT 200
EIITDETDIS VFLMNLSEHS LMLLPGDVEF SINFLPCYIP EPWEMINLSP 250
PEFAIFHLKA SREFIAKPNS YTIQYFDAMY VCADELKALM IPSKEIAKLG 300
LLIETYIWNK DTIPSIKIFN STRKTIYIPT GICIARIIFT CGHFCLSLMP 350
ERAINRLQVL DANSSFLFHY ATSNNA 376
Length:376
Mass (Da):43,408
Last modified:April 1, 1993 - v1
Checksum:iB967E545601E1683
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S57509 Genomic DNA. Translation: AAB19782.1.
PIRiD40511.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S57509 Genomic DNA. Translation: AAB19782.1 .
PIRi D40511.

3D structure databases

ProteinModelPortali P30007.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Identification of the human herpesvirus 6 glycoprotein H and putative large tegument protein genes."
    Josephs S.F., Ablashi D.V., Salahuddin S.Z., Jagodzinski L.L., Wong-Staal F., Gallo R.C.
    J. Virol. 65:5597-5604(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiDUT_HHV6G
AccessioniPrimary (citable) accession number: P30007
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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