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Protein

Large delta antigen

Gene
N/A
Organism
Hepatitis delta virus genotype I (isolate D380) (HDV)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. Needs co-infection with hepatitis B virus to provide surface proteins, otherwise there is no packaging or budding. Packages the HDV ribonucleoprotein in hepatitis B virus empty particles. Interacts with both HDV genomic RNA and cytoplasmic tail of HBsAg. May inhibit viral RNA replication.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Viral penetration into host nucleus, Virus entry into host cell

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Large delta antigen
Short name:
L-HDAg
Alternative name(s):
p27
OrganismiHepatitis delta virus genotype I (isolate D380) (HDV)
Taxonomic identifieri31762 [NCBI]
Taxonomic lineageiVirusesDeltavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000006675 Componenti: Genome

Subcellular locationi

  • Virion 1 Publication
  • Host nucleushost nucleolus 1 Publication

  • Note: isoprenylated in the cytoplasm, and translocates in the nucleus possibly after phosphorylation. Translocates after to nuclear speckle, then to the ER membrane where interaction with Hepatitis B virus antigene takes place.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000381301 – 211Large delta antigenAdd BLAST211
PropeptideiPRO_0000396787212 – 214Removed in mature formCurated3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2Phosphoserine; by host1 Publication1
Modified residuei13Omega-N-methylated arginine; by hostCurated1
Modified residuei72N6-acetyllysine; by hostCurated1
Modified residuei123Phosphoserine; by host1 Publication1
Modified residuei177Phosphoserine; by host1 Publication1
Modified residuei211Cysteine methyl ester; by hostCurated1
Lipidationi211S-farnesyl cysteine; by host2 Publications1

Post-translational modificationi

Prenylated by host farnesyl-transferase in the cytoplasm prior to nucleus translocation.2 Publications
Phosphorylated at serines by host CK2 and other kinases. phosphorylation does not seem to be important for its function.1 Publication

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

PTM databases

iPTMnetiP29996.

Interactioni

Subunit structurei

Homodimer. Homooctamer. Interacts with HBV HBsAg. May interact with clathrin to induce virion budding.2 Publications

Protein-protein interaction databases

MINTiMINT-196884.

Structurei

3D structure databases

ProteinModelPortaliP29996.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 60DimerizationSequence analysisAdd BLAST49
Regioni97 – 107RNA-bindingSequence analysisAdd BLAST11
Regioni136 – 146RNA-bindingSequence analysisAdd BLAST11

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi66 – 75Nuclear localization signalBy similarity10

Sequence similaritiesi

Belongs to the hepatitis delta antigen family.Curated

Family and domain databases

Gene3Di4.10.220.40. 1 hit.
InterProiIPR027403. Delta_antigen_N.
IPR002506. HDV_ag.
[Graphical view]
PfamiPF01517. HDV_ag. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29996-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPEGRKNR GGREEVLEQW VSGRKKLEEL ERDLRKVKKK IKKLEDEHPW
60 70 80 90 100
LGNIKGILGK KDKDGEGAPP AKRARTDQME VDSGPRKRPS RGGFTDKERQ
110 120 130 140 150
DHRRRKALEN KRKQLSAGGK NLSKEEEEEL RRLTEEDERR ERRIAGPQVG
160 170 180 190 200
GVNPLEGGTR GAPGGGFVPS MQGVPESPFT RTGEGLDIRG SQGFPWDILF
210
PADPPSSPQS CRPQ
Length:214
Mass (Da):24,060
Last modified:March 1, 2004 - v2
Checksum:i4A4C6AAAF90A388E
GO

RNA editingi

Edited at position 196.By similarity
Partially edited. RNA editing at this position occurs on the antigenomic strand and consists of a conversion of A to G catalyzed by the cellular enzyme ADAR1. The unedited RNA version gives rise to the small delta antigen (AC P0C6L3), which ends with a nonsense codon at position 196. In the edited version, this amber codon is modified to a tryptophan codon and gives rise to the large delta antigen protein. S-HDAg suppresses editing of non-replicating antigenomic RNA, thereby regulating the extent of editing (By similarity).By similarity

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D01075 Genomic RNA. Translation: BAA00874.1. Different termination.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D01075 Genomic RNA. Translation: BAA00874.1. Different termination.

3D structure databases

ProteinModelPortaliP29996.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-196884.

PTM databases

iPTMnetiP29996.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di4.10.220.40. 1 hit.
InterProiIPR027403. Delta_antigen_N.
IPR002506. HDV_ag.
[Graphical view]
PfamiPF01517. HDV_ag. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLHDAG_HDVD3
AccessioniPrimary (citable) accession number: P29996
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: March 1, 2004
Last modified: November 30, 2016
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.