P29994 (ITPR1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 1,4,5-trisphosphate receptor type 1

Alternative name(s):
IP3 receptor isoform 1
Short name=IP-3-R
Short name=IP3R 1
Short name=InsP3R1
Type 1 inositol 1,4,5-trisphosphate receptor
Short name=Type 1 InsP3 receptor

Gene names

Name:	Itpr1
Synonyms:	Insp3r

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	2750 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways By similarity.
Subunit structure	Homotetramer. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Interacts with ERP44 in a pH-, redox state- and calcium-dependent manner which results in the inhibition the calcium channel activity. The strength of this interaction inversely correlates with calcium concentration. Interacts with CABP1. Interacts with AHCYL1 and MRVI1 By similarity. Ref.5
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue specificity	Isoform 3 is found in the brain while isoform 7 is found in the fetal brain and peripheral tissues.
Domain	The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
Post-translational modification	Phosphorylated by cAMP kinase. Phosphorylation prevents the ligand-induced opening of the calcium channels. Phosphorylated on tyrosine residues By similarity. Ubiquitination at multiple lysines targets ITPR1 for proteasomal degradation. Approximately 40% of the ITPR1-associated ubiquitin is monoubiquitin, and polyubiquitins are both 'Lys-48'- and 'Lys-63'-linked.
Miscellaneous	Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium-binding protein which then inhibits the receptor.
Sequence similarities	Belongs to the InsP3 receptor family. Contains 5 MIR domains.

Ontologies

Keywords
Biological process	Apoptosis Calcium transport Ion transport Transport
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Calcium channel Ion channel Ligand-gated ion channel Receptor
PTM	Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to hypoxia Inferred from expression pattern PubMed 17285299. Source: RGD intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of neuron death Inferred from mutant phenotype PubMed 20434434. Source: RGD positive regulation of calcium ion transport Inferred from direct assay PubMed 19036964. Source: RGD release of sequestered calcium ion into cytosol Inferred from mutant phenotype PubMed 16223735. Source: BHF-UCL
Cellular_component	endoplasmic reticulum membrane Inferred from direct assay PubMed 15533917PubMed 15911880. Source: RGD integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane raft Inferred from direct assay PubMed 15911880. Source: RGD neuronal cell body Inferred from direct assay PubMed 17471556. Source: RGD nuclear envelope Inferred from direct assay PubMed 16014380. Source: RGD perinuclear region of cytoplasm Inferred from direct assay PubMed 12615969. Source: RGD plasma membrane Inferred from direct assay PubMed 15911880. Source: RGD postsynaptic density Inferred from direct assay PubMed 1338970. Source: RGD protein complex Inferred from direct assay PubMed 12676536. Source: RGD sarcoplasmic reticulum Inferred from direct assay PubMed 16014380. Source: RGD secretory granule membrane Inferred from direct assay PubMed 15911880. Source: RGD synaptic membrane Inferred from direct assay PubMed 12676536. Source: RGD
Molecular_function	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Inferred from sequence or structural similarity. Source: UniProtKB intracellular ligand-gated calcium channel activity Inferred from sequence or structural similarity. Source: UniProtKB phosphatidylinositol binding Inferred from sequence or structural similarity. Source: UniProtKB protein complex binding Inferred from direct assay PubMed 15212990. Source: RGD protein phosphatase binding Inferred from direct assay PubMed 15212990. Source: RGD
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Note: There is a combination of two alternatively spliced domains at site SI and site SII (A, B and C). Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: P29994-1)

Also known as: SISIIABC;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P29994-2)

Also known as: SI-SIIABC;

The sequence of this isoform differs from the canonical sequence as follows:
     322-336: Missing.

Isoform 3 (identifier: P29994-3)

Also known as: SISIIAC;

The sequence of this isoform differs from the canonical sequence as follows:
     1716-1716: Missing.

Isoform 4 (identifier: P29994-4)

Also known as: SI-SIIAC;

The sequence of this isoform differs from the canonical sequence as follows:
     322-336: Missing.
     1716-1716: Missing.

Isoform 5 (identifier: P29994-5)

Also known as: SISIIA;

The sequence of this isoform differs from the canonical sequence as follows:
     1716-1716: Missing.
     1717-1732: Missing.

Isoform 6 (identifier: P29994-6)

Also known as: SI-SIIA;

The sequence of this isoform differs from the canonical sequence as follows:
     322-336: Missing.
     1716-1716: Missing.
     1717-1732: Missing.

Isoform 7 (identifier: P29994-7)

Also known as: SISII;

The sequence of this isoform differs from the canonical sequence as follows:
     1693-1715: Missing.
     1716-1716: Missing.
     1717-1732: Missing.

Isoform 8 (identifier: P29994-8)

Also known as: SI-SII;

The sequence of this isoform differs from the canonical sequence as follows:
     322-336: Missing.
     1693-1715: Missing.
     1716-1716: Missing.
     1717-1732: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2750

2750

Inositol 1,4,5-trisphosphate receptor type 1

PRO_0000153922

Regions

Topological domain

1 – 2274

2274

Cytoplasmic Potential

Transmembrane

2275 – 2295

21

Helical; Potential

Topological domain

2296 – 2306

11

Lumenal Potential

Transmembrane

2307 – 2327

21

Helical; Potential

Topological domain

2328 – 2353

26

Cytoplasmic Potential

Transmembrane

2354 – 2374

21

Helical; Potential

Topological domain

2375 – 2397

23

Lumenal Potential

Transmembrane

2398 – 2418

21

Helical; Potential

Topological domain

2419 – 2440

22

Cytoplasmic Potential

Transmembrane

2441 – 2461

21

Helical; Potential

Topological domain

2462 – 2569

108

Lumenal Potential

Transmembrane

2570 – 2590

21

Helical; Potential

Topological domain

2591 – 2750

160

Cytoplasmic Potential

Domain

112 – 166

55

MIR 1

Domain

173 – 223

51

MIR 2

Domain

231 – 287

57

MIR 3

Domain

294 – 373

80

MIR 4

Domain

379 – 435

57

MIR 5

Region

265 – 269

5

Inositol 1,4,5-trisphosphate binding By similarity

Region

508 – 511

4

Inositol 1,4,5-trisphosphate binding By similarity

Region

567 – 569

3

Inositol 1,4,5-trisphosphate binding By similarity

Region

2464 – 2529

66

Interaction with ERP44

Amino acid modifications

Modified residue

482

1

Phosphotyrosine Potential

Modified residue

1589

1

Phosphoserine By similarity

Modified residue

1756

1

Phosphoserine; by PKA Potential

Modified residue

2656

1

Phosphotyrosine Potential

Cross-link

916

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.6

Cross-link

962

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.6

Cross-link

1572

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.6

Cross-link

1772

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.6

Cross-link

1885

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.6

Cross-link

1886

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.6

Cross-link

1887

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.6

Cross-link

1902

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.6

Cross-link

1925

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.6

Cross-link

2119

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.6

Cross-link

2258

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.6

Natural variations

Alternative sequence

322 – 336

15

Missing in isoform 2, isoform 4, isoform 6 and isoform 8.

VSP_002695

Alternative sequence

1693 – 1715

23

Missing in isoform 7 and isoform 8.

VSP_002696

Alternative sequence

1716

1

Missing in isoform 3, isoform 4, isoform 5, isoform 6, isoform 7 and isoform 8.

VSP_002697

Alternative sequence

1717 – 1732

16

Missing in isoform 5, isoform 6, isoform 7 and isoform 8.

VSP_002698

Natural variant

1372

1

Missing in all but PI17 clones. Ref.1

Experimental info

Sequence conflict

1764

1

P → R in AAA41447. Ref.2

Sequence conflict

1764

1

P → R in AAA41448. Ref.2

Secondary structure

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2750

Helix Strand Turn

Details...

Beta strand

14 – 23

10

Beta strand

25 – 30

6

Beta strand

36 – 39

4

Turn

41 – 43

3

Helix

53 – 56

4

Beta strand

57 – 61

5

Helix

67 – 74

8

Helix

87 – 108

22

Turn

109 – 112

4

Beta strand

120 – 125

6

Turn

126 – 129

4

Beta strand

130 – 139

10

Beta strand

141 – 143

3

Beta strand

147 – 154

8

Helix

157 – 159

3

Beta strand

161 – 167

7

Beta strand

181 – 189

9

Beta strand

193 – 199

7

Beta strand

201 – 203

3

Beta strand

207 – 213

7

Beta strand

217 – 224

8

Helix

226 – 228

3

Beta strand

239 – 244

6

Turn

245 – 248

4

Beta strand

249 – 256

8

Beta strand

259 – 265

7

Helix

278 – 280

3

Beta strand

281 – 286

6

Beta strand

302 – 307

6

Turn

308 – 310

3

Beta strand

313 – 318

6

Beta strand

353 – 359

7

Helix

364 – 366

3

Beta strand

368 – 374

7

Beta strand

387 – 392

6

Turn

393 – 395

3

Beta strand

398 – 406

9

Beta strand

408 – 412

5

Beta strand

415 – 423

9

Beta strand

430 – 434

5

Helix

437 – 462

26

Helix

467 – 483

17

Helix

504 – 512

9

Helix

515 – 522

8

Helix

552 – 562

11

Turn

563 – 566

4

Helix

568 – 575

8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (SISIIABC) [UniParc]. Last modified November 2, 2001. Version 2. Checksum: 174BB77CBF6F21AC	FASTA	2,750	313,264
	10 20 30 40 50 60 MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PEAGDLNNPP KKFRDCLFKL 70 80 90 100 110 120 CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV 130 140 150 160 170 180 IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD 190 200 210 220 230 240 KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV 250 260 270 280 290 300 RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 310 320 330 340 350 360 SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVDPDQDAS RSRLRNAQEK MVYSLVSVPE 370 380 390 400 410 420 GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH STNIPIDKEE EKPVMLKIGT 430 440 450 460 470 480 SPLKEDKEAF AIVPVSPAEV RDLDFANDAS KVLGSIAGKL EKGTITQNER RSVTKLLEDL 490 500 510 520 530 540 VYFVTGGTNS GQDVLEVVFS KPNRERQKLM REQNILKQIF KLLQAPFTDC GDGPMLRLEE 550 560 570 580 590 600 LGDQRHAPFR HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH 610 620 630 640 650 660 NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE LICKAVLNPT 670 680 690 700 710 720 NADILIETKL VLSRFEFEGV STGENALEAG EDEEEVWLFW RDSNKEIRSK SVRELAQDAK 730 740 750 760 770 780 EGQKEDRDVL SYYRYQLNLF ARMCLDRQYL AINEISGQLD VDLILRCMSD ENLPYDLRAS 790 800 810 820 830 840 FCRLMLHMHV DRDPQEQVTP VKYARLWSEI PSEIAIDDYD SSGASKDEIK ERFAQTMEFV 850 860 870 880 890 900 EEYLRDVVCQ RFPFSDKEKN KLTFEVVNLA RNLIYFGFYN FSDLLRLTKI LLAILDCVHV 910 920 930 940 950 960 TTIFPISKMT KGEENKGSNV MRSIHGVGEL MTQVVLRGGG FLPMTPMAAA PEGNVKQAEP 970 980 990 1000 1010 1020 EKEDIMVMDT KLKIIEILQF ILNVRLDYRI SCLLCIFKRE FDESNSQSSE TSSGNSSQEG 1030 1040 1050 1060 1070 1080 PSNVPGALDF EHIEEQAEGI FGGSEENTPL DLDDHGGRTF LRVLLHLTMH DYPPLVSGAL 1090 1100 1110 1120 1130 1140 QLLFRHFSQR QEVLQAFKQV QLLVTSQDVD NYKQIKQDLD QLRSIVEKSE LWVYKGQGPD 1150 1160 1170 1180 1190 1200 EPMDGASGEN EHKKTEEGTS KPLKHESTSS YNYRVVKEIL IRLSKLCVQE SASVRKSRKQ 1210 1220 1230 1240 1250 1260 QQRLLRNMGA HAVVLELLQI PYEKAEDTKM QEIMRLAHEF LQNFCAGNQQ NQALLHKHIN 1270 1280 1290 1300 1310 1320 LFLNPGILEA VTMQHIFMNN FQLCSEINER VVQHFVHCIE THGRNVQYIK FLQTIVKAEG 1330 1340 1350 1360 1370 1380 KFIKKCQDMV MAELVNSGED VLVFYNDRAS FQTLIQMMRS ERDRMDENSP LFMYHIHLVE 1390 1400 1410 1420 1430 1440 LLAVCTEGKN VYTEIKCNSL LPLDDIVRVV THEDCIPEVK IAYINFLNHC YVDTEVEMKE 1450 1460 1470 1480 1490 1500 IYTSNHMWKL FENFLVDICR ACNNTSDRKH ADSVLEKYVT EIVMSIVTTF FSSPFSDQST 1510 1520 1530 1540 1550 1560 TLQTRQPVFV QLLQGVFRVY HCNWLMPSQK ASVESCIRVL SDVAKSRAIA IPVDLDSQVN 1570 1580 1590 1600 1610 1620 NLFLKSHNIV QKTAMNWRLS ARNAARRDSV LAASRDYRNI IERLQDIVSA LEDRLRPLVQ 1630 1640 1650 1660 1670 1680 AELSVLVDVL HRPELLFPEN TDARRKCESG GFICKLIKHT KQLLEENEEK LCIKVLQTLR 1690 1700 1710 1720 1730 1740 EMMTKDRGYG EKQISIDELE NAELPQPPEA ENSTEQELEP SPPLRQLEDH KRGEALRQIL 1750 1760 1770 1780 1790 1800 VNRYYGNIRP SGRRESLTSF GNGPLSPGGP SKPGGGGGGP GSGSTSRGEM SLAEVQCHLD 1810 1820 1830 1840 1850 1860 KEGASNLVID LIMNASSDRV FHESILLAIA LLEGGNTTIQ HSFFCRLTED KKSEKFFKVF 1870 1880 1890 1900 1910 1920 YDRMKVAQQE IKATVTVNTS DLGNKKKDDE VDRDAPSRKK AKEPTTQITE EVRDQLLEAS 1930 1940 1950 1960 1970 1980 AATRKAFTTF RREADPDDHY QSGEGTQATT DKAKDDLEMS AVITIMQPIL RFLQLLCENH 1990 2000 2010 2020 2030 2040 NRDLQNFLRC QNNKTNYNLV CETLQFLDCI CGSTTGGLGL LGLYINEKNV ALINQTLESL 2050 2060 2070 2080 2090 2100 TEYCQGPCHE NQNCIATHES NGIDIITALI LNDINPLGKK RMDLVLELKN NASKLLLAIM 2110 2120 2130 2140 2150 2160 ESRHDSENAE RILYNMRPKE LVEVIKKAYM QGEVEFEDGE NGEDGAASPR NVGHNIYILA 2170 2180 2190 2200 2210 2220 HQLARHNKEL QTMLKPGGQV DGDEALEFYA KHTAQIEIVR LDRTMEQIVF PVPSICEFLT 2230 2240 2250 2260 2270 2280 KESKLRIYYT TERDEQGSKI NDFFLRSEDL FNEMNWQKKL RAQPVLYWCA RNMSFWSSIS 2290 2300 2310 2320 2330 2340 FNLAVLMNLL VAFFYPFKGV RGGTLEPHWS GLLWTAMLIS LAIVIALPKP HGIRALIAST 2350 2360 2370 2380 2390 2400 ILRLIFSVGL QPTLFLLGAF NVCNKIIFLM SFVGNCGTFT RGYRAMVLDV EFLYHLLYLL 2410 2420 2430 2440 2450 2460 ICAMGLFVHE FFYSLLLFDL VYREETLLNV IKSVTRNGRP IILTAALALI LVYLFSIVGY 2470 2480 2490 2500 2510 2520 LFFKDDFILE VDRLPNETAG PETGESLAND FLYSDVCRVE TGENCTSPAP KEELLPVEET 2530 2540 2550 2560 2570 2580 EQDKEHTCET LLMCIVTVLS HGLRSGGGVG DVLRKPSKEE PLFAARVIYD LLFFFMVIII 2590 2600 2610 2620 2630 2640 VLNLIFGVII DTFADLRSEK QKKEEILKTT CFICGLERDK FDNKTVTFEE HIKEEHNMWH 2650 2660 2670 2680 2690 2700 YLCFIVLVKV KDSTEYTGPE SYVAEMIRER NLDWFPRMRA MSLVSSDSEG EQNELRNLQE 2710 2720 2730 2740 2750 KLESTMKLVT NLSGQLSELK DQMTEQRKQK QRIGLLGHPP HMNVNPQQPA
	Isoform 2 (SI-SIIABC) [UniParc]. Checksum: A80CC16884635058	FASTA	2,735	311,498
	10 20 30 40 50 60 MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PEAGDLNNPP KKFRDCLFKL 70 80 90 100 110 120 CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV 130 140 150 160 170 180 IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD 190 200 210 220 230 240 KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV 250 260 270 280 290 300 RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 310 320 330 340 350 360 SLFRFKHLAT GHYLAAEVDP DQDASRSRLR NAQEKMVYSL VSVPEGNDIS SIFELDPTTL 370 380 390 400 410 420 RGGDSLVPRN SYVRLRHLCT NTWVHSTNIP IDKEEEKPVM LKIGTSPLKE DKEAFAIVPV 430 440 450 460 470 480 SPAEVRDLDF ANDASKVLGS IAGKLEKGTI TQNERRSVTK LLEDLVYFVT GGTNSGQDVL 490 500 510 520 530 540 EVVFSKPNRE RQKLMREQNI LKQIFKLLQA PFTDCGDGPM LRLEELGDQR HAPFRHICRL 550 560 570 580 590 600 CYRVLRHSQQ DYRKNQEYIA KQFGFMQKQI GYDVLAEDTI TALLHNNRKL LEKHITAAEI 610 620 630 640 650 660 DTFVSLVRKN REPRFLDYLS DLCVSMNKSI PVTQELICKA VLNPTNADIL IETKLVLSRF 670 680 690 700 710 720 EFEGVSTGEN ALEAGEDEEE VWLFWRDSNK EIRSKSVREL AQDAKEGQKE DRDVLSYYRY 730 740 750 760 770 780 QLNLFARMCL DRQYLAINEI SGQLDVDLIL RCMSDENLPY DLRASFCRLM LHMHVDRDPQ 790 800 810 820 830 840 EQVTPVKYAR LWSEIPSEIA IDDYDSSGAS KDEIKERFAQ TMEFVEEYLR DVVCQRFPFS 850 860 870 880 890 900 DKEKNKLTFE VVNLARNLIY FGFYNFSDLL RLTKILLAIL DCVHVTTIFP ISKMTKGEEN 910 920 930 940 950 960 KGSNVMRSIH GVGELMTQVV LRGGGFLPMT PMAAAPEGNV KQAEPEKEDI MVMDTKLKII 970 980 990 1000 1010 1020 EILQFILNVR LDYRISCLLC IFKREFDESN SQSSETSSGN SSQEGPSNVP GALDFEHIEE 1030 1040 1050 1060 1070 1080 QAEGIFGGSE ENTPLDLDDH GGRTFLRVLL HLTMHDYPPL VSGALQLLFR HFSQRQEVLQ 1090 1100 1110 1120 1130 1140 AFKQVQLLVT SQDVDNYKQI KQDLDQLRSI VEKSELWVYK GQGPDEPMDG ASGENEHKKT 1150 1160 1170 1180 1190 1200 EEGTSKPLKH ESTSSYNYRV VKEILIRLSK LCVQESASVR KSRKQQQRLL RNMGAHAVVL 1210 1220 1230 1240 1250 1260 ELLQIPYEKA EDTKMQEIMR LAHEFLQNFC AGNQQNQALL HKHINLFLNP GILEAVTMQH 1270 1280 1290 1300 1310 1320 IFMNNFQLCS EINERVVQHF VHCIETHGRN VQYIKFLQTI VKAEGKFIKK CQDMVMAELV 1330 1340 1350 1360 1370 1380 NSGEDVLVFY NDRASFQTLI QMMRSERDRM DENSPLFMYH IHLVELLAVC TEGKNVYTEI 1390 1400 1410 1420 1430 1440 KCNSLLPLDD IVRVVTHEDC IPEVKIAYIN FLNHCYVDTE VEMKEIYTSN HMWKLFENFL 1450 1460 1470 1480 1490 1500 VDICRACNNT SDRKHADSVL EKYVTEIVMS IVTTFFSSPF SDQSTTLQTR QPVFVQLLQG 1510 1520 1530 1540 1550 1560 VFRVYHCNWL MPSQKASVES CIRVLSDVAK SRAIAIPVDL DSQVNNLFLK SHNIVQKTAM 1570 1580 1590 1600 1610 1620 NWRLSARNAA RRDSVLAASR DYRNIIERLQ DIVSALEDRL RPLVQAELSV LVDVLHRPEL 1630 1640 1650 1660 1670 1680 LFPENTDARR KCESGGFICK LIKHTKQLLE ENEEKLCIKV LQTLREMMTK DRGYGEKQIS 1690 1700 1710 1720 1730 1740 IDELENAELP QPPEAENSTE QELEPSPPLR QLEDHKRGEA LRQILVNRYY GNIRPSGRRE 1750 1760 1770 1780 1790 1800 SLTSFGNGPL SPGGPSKPGG GGGGPGSGST SRGEMSLAEV QCHLDKEGAS NLVIDLIMNA 1810 1820 1830 1840 1850 1860 SSDRVFHESI LLAIALLEGG NTTIQHSFFC RLTEDKKSEK FFKVFYDRMK VAQQEIKATV 1870 1880 1890 1900 1910 1920 TVNTSDLGNK KKDDEVDRDA PSRKKAKEPT TQITEEVRDQ LLEASAATRK AFTTFRREAD 1930 1940 1950 1960 1970 1980 PDDHYQSGEG TQATTDKAKD DLEMSAVITI MQPILRFLQL LCENHNRDLQ NFLRCQNNKT 1990 2000 2010 2020 2030 2040 NYNLVCETLQ FLDCICGSTT GGLGLLGLYI NEKNVALINQ TLESLTEYCQ GPCHENQNCI 2050 2060 2070 2080 2090 2100 ATHESNGIDI ITALILNDIN PLGKKRMDLV LELKNNASKL LLAIMESRHD SENAERILYN 2110 2120 2130 2140 2150 2160 MRPKELVEVI KKAYMQGEVE FEDGENGEDG AASPRNVGHN IYILAHQLAR HNKELQTMLK 2170 2180 2190 2200 2210 2220 PGGQVDGDEA LEFYAKHTAQ IEIVRLDRTM EQIVFPVPSI CEFLTKESKL RIYYTTERDE 2230 2240 2250 2260 2270 2280 QGSKINDFFL RSEDLFNEMN WQKKLRAQPV LYWCARNMSF WSSISFNLAV LMNLLVAFFY 2290 2300 2310 2320 2330 2340 PFKGVRGGTL EPHWSGLLWT AMLISLAIVI ALPKPHGIRA LIASTILRLI FSVGLQPTLF 2350 2360 2370 2380 2390 2400 LLGAFNVCNK IIFLMSFVGN CGTFTRGYRA MVLDVEFLYH LLYLLICAMG LFVHEFFYSL 2410 2420 2430 2440 2450 2460 LLFDLVYREE TLLNVIKSVT RNGRPIILTA ALALILVYLF SIVGYLFFKD DFILEVDRLP 2470 2480 2490 2500 2510 2520 NETAGPETGE SLANDFLYSD VCRVETGENC TSPAPKEELL PVEETEQDKE HTCETLLMCI 2530 2540 2550 2560 2570 2580 VTVLSHGLRS GGGVGDVLRK PSKEEPLFAA RVIYDLLFFF MVIIIVLNLI FGVIIDTFAD 2590 2600 2610 2620 2630 2640 LRSEKQKKEE ILKTTCFICG LERDKFDNKT VTFEEHIKEE HNMWHYLCFI VLVKVKDSTE 2650 2660 2670 2680 2690 2700 YTGPESYVAE MIRERNLDWF PRMRAMSLVS SDSEGEQNEL RNLQEKLEST MKLVTNLSGQ 2710 2720 2730 LSELKDQMTE QRKQKQRIGL LGHPPHMNVN PQQPA
	Isoform 3 (SISIIAC) [UniParc]. Checksum: E80D784F7201E2C9	FASTA	2,749	313,136
	10 20 30 40 50 60 MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PEAGDLNNPP KKFRDCLFKL 70 80 90 100 110 120 CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV 130 140 150 160 170 180 IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD 190 200 210 220 230 240 KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV 250 260 270 280 290 300 RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 310 320 330 340 350 360 SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVDPDQDAS RSRLRNAQEK MVYSLVSVPE 370 380 390 400 410 420 GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH STNIPIDKEE EKPVMLKIGT 430 440 450 460 470 480 SPLKEDKEAF AIVPVSPAEV RDLDFANDAS KVLGSIAGKL EKGTITQNER RSVTKLLEDL 490 500 510 520 530 540 VYFVTGGTNS GQDVLEVVFS KPNRERQKLM REQNILKQIF KLLQAPFTDC GDGPMLRLEE 550 560 570 580 590 600 LGDQRHAPFR HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH 610 620 630 640 650 660 NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE LICKAVLNPT 670 680 690 700 710 720 NADILIETKL VLSRFEFEGV STGENALEAG EDEEEVWLFW RDSNKEIRSK SVRELAQDAK 730 740 750 760 770 780 EGQKEDRDVL SYYRYQLNLF ARMCLDRQYL AINEISGQLD VDLILRCMSD ENLPYDLRAS 790 800 810 820 830 840 FCRLMLHMHV DRDPQEQVTP VKYARLWSEI PSEIAIDDYD SSGASKDEIK ERFAQTMEFV 850 860 870 880 890 900 EEYLRDVVCQ RFPFSDKEKN KLTFEVVNLA RNLIYFGFYN FSDLLRLTKI LLAILDCVHV 910 920 930 940 950 960 TTIFPISKMT KGEENKGSNV MRSIHGVGEL MTQVVLRGGG FLPMTPMAAA PEGNVKQAEP 970 980 990 1000 1010 1020 EKEDIMVMDT KLKIIEILQF ILNVRLDYRI SCLLCIFKRE FDESNSQSSE TSSGNSSQEG 1030 1040 1050 1060 1070 1080 PSNVPGALDF EHIEEQAEGI FGGSEENTPL DLDDHGGRTF LRVLLHLTMH DYPPLVSGAL 1090 1100 1110 1120 1130 1140 QLLFRHFSQR QEVLQAFKQV QLLVTSQDVD NYKQIKQDLD QLRSIVEKSE LWVYKGQGPD 1150 1160 1170 1180 1190 1200 EPMDGASGEN EHKKTEEGTS KPLKHESTSS YNYRVVKEIL IRLSKLCVQE SASVRKSRKQ 1210 1220 1230 1240 1250 1260 QQRLLRNMGA HAVVLELLQI PYEKAEDTKM QEIMRLAHEF LQNFCAGNQQ NQALLHKHIN 1270 1280 1290 1300 1310 1320 LFLNPGILEA VTMQHIFMNN FQLCSEINER VVQHFVHCIE THGRNVQYIK FLQTIVKAEG 1330 1340 1350 1360 1370 1380 KFIKKCQDMV MAELVNSGED VLVFYNDRAS FQTLIQMMRS ERDRMDENSP LFMYHIHLVE 1390 1400 1410 1420 1430 1440 LLAVCTEGKN VYTEIKCNSL LPLDDIVRVV THEDCIPEVK IAYINFLNHC YVDTEVEMKE 1450 1460 1470 1480 1490 1500 IYTSNHMWKL FENFLVDICR ACNNTSDRKH ADSVLEKYVT EIVMSIVTTF FSSPFSDQST 1510 1520 1530 1540 1550 1560 TLQTRQPVFV QLLQGVFRVY HCNWLMPSQK ASVESCIRVL SDVAKSRAIA IPVDLDSQVN 1570 1580 1590 1600 1610 1620 NLFLKSHNIV QKTAMNWRLS ARNAARRDSV LAASRDYRNI IERLQDIVSA LEDRLRPLVQ 1630 1640 1650 1660 1670 1680 AELSVLVDVL HRPELLFPEN TDARRKCESG GFICKLIKHT KQLLEENEEK LCIKVLQTLR 1690 1700 1710 1720 1730 1740 EMMTKDRGYG EKQISIDELE NAELPQPPEA ENSTEELEPS PPLRQLEDHK RGEALRQILV 1750 1760 1770 1780 1790 1800 NRYYGNIRPS GRRESLTSFG NGPLSPGGPS KPGGGGGGPG SGSTSRGEMS LAEVQCHLDK 1810 1820 1830 1840 1850 1860 EGASNLVIDL IMNASSDRVF HESILLAIAL LEGGNTTIQH SFFCRLTEDK KSEKFFKVFY 1870 1880 1890 1900 1910 1920 DRMKVAQQEI KATVTVNTSD LGNKKKDDEV DRDAPSRKKA KEPTTQITEE VRDQLLEASA 1930 1940 1950 1960 1970 1980 ATRKAFTTFR READPDDHYQ SGEGTQATTD KAKDDLEMSA VITIMQPILR FLQLLCENHN 1990 2000 2010 2020 2030 2040 RDLQNFLRCQ NNKTNYNLVC ETLQFLDCIC GSTTGGLGLL GLYINEKNVA LINQTLESLT 2050 2060 2070 2080 2090 2100 EYCQGPCHEN QNCIATHESN GIDIITALIL NDINPLGKKR MDLVLELKNN ASKLLLAIME 2110 2120 2130 2140 2150 2160 SRHDSENAER ILYNMRPKEL VEVIKKAYMQ GEVEFEDGEN GEDGAASPRN VGHNIYILAH 2170 2180 2190 2200 2210 2220 QLARHNKELQ TMLKPGGQVD GDEALEFYAK HTAQIEIVRL DRTMEQIVFP VPSICEFLTK 2230 2240 2250 2260 2270 2280 ESKLRIYYTT ERDEQGSKIN DFFLRSEDLF NEMNWQKKLR AQPVLYWCAR NMSFWSSISF 2290 2300 2310 2320 2330 2340 NLAVLMNLLV AFFYPFKGVR GGTLEPHWSG LLWTAMLISL AIVIALPKPH GIRALIASTI 2350 2360 2370 2380 2390 2400 LRLIFSVGLQ PTLFLLGAFN VCNKIIFLMS FVGNCGTFTR GYRAMVLDVE FLYHLLYLLI 2410 2420 2430 2440 2450 2460 CAMGLFVHEF FYSLLLFDLV YREETLLNVI KSVTRNGRPI ILTAALALIL VYLFSIVGYL 2470 2480 2490 2500 2510 2520 FFKDDFILEV DRLPNETAGP ETGESLANDF LYSDVCRVET GENCTSPAPK EELLPVEETE 2530 2540 2550 2560 2570 2580 QDKEHTCETL LMCIVTVLSH GLRSGGGVGD VLRKPSKEEP LFAARVIYDL LFFFMVIIIV 2590 2600 2610 2620 2630 2640 LNLIFGVIID TFADLRSEKQ KKEEILKTTC FICGLERDKF DNKTVTFEEH IKEEHNMWHY 2650 2660 2670 2680 2690 2700 LCFIVLVKVK DSTEYTGPES YVAEMIRERN LDWFPRMRAM SLVSSDSEGE QNELRNLQEK 2710 2720 2730 2740 LESTMKLVTN LSGQLSELKD QMTEQRKQKQ RIGLLGHPPH MNVNPQQPA
	Isoform 4 (SI-SIIAC) [UniParc]. Checksum: EF7B6C747E701605	FASTA	2,734	311,370
	10 20 30 40 50 60 MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PEAGDLNNPP KKFRDCLFKL 70 80 90 100 110 120 CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV 130 140 150 160 170 180 IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD 190 200 210 220 230 240 KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV 250 260 270 280 290 300 RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 310 320 330 340 350 360 SLFRFKHLAT GHYLAAEVDP DQDASRSRLR NAQEKMVYSL VSVPEGNDIS SIFELDPTTL 370 380 390 400 410 420 RGGDSLVPRN SYVRLRHLCT NTWVHSTNIP IDKEEEKPVM LKIGTSPLKE DKEAFAIVPV 430 440 450 460 470 480 SPAEVRDLDF ANDASKVLGS IAGKLEKGTI TQNERRSVTK LLEDLVYFVT GGTNSGQDVL 490 500 510 520 530 540 EVVFSKPNRE RQKLMREQNI LKQIFKLLQA PFTDCGDGPM LRLEELGDQR HAPFRHICRL 550 560 570 580 590 600 CYRVLRHSQQ DYRKNQEYIA KQFGFMQKQI GYDVLAEDTI TALLHNNRKL LEKHITAAEI 610 620 630 640 650 660 DTFVSLVRKN REPRFLDYLS DLCVSMNKSI PVTQELICKA VLNPTNADIL IETKLVLSRF 670 680 690 700 710 720 EFEGVSTGEN ALEAGEDEEE VWLFWRDSNK EIRSKSVREL AQDAKEGQKE DRDVLSYYRY 730 740 750 760 770 780 QLNLFARMCL DRQYLAINEI SGQLDVDLIL RCMSDENLPY DLRASFCRLM LHMHVDRDPQ 790 800 810 820 830 840 EQVTPVKYAR LWSEIPSEIA IDDYDSSGAS KDEIKERFAQ TMEFVEEYLR DVVCQRFPFS 850 860 870 880 890 900 DKEKNKLTFE VVNLARNLIY FGFYNFSDLL RLTKILLAIL DCVHVTTIFP ISKMTKGEEN 910 920 930 940 950 960 KGSNVMRSIH GVGELMTQVV LRGGGFLPMT PMAAAPEGNV KQAEPEKEDI MVMDTKLKII 970 980 990 1000 1010 1020 EILQFILNVR LDYRISCLLC IFKREFDESN SQSSETSSGN SSQEGPSNVP GALDFEHIEE 1030 1040 1050 1060 1070 1080 QAEGIFGGSE ENTPLDLDDH GGRTFLRVLL HLTMHDYPPL VSGALQLLFR HFSQRQEVLQ 1090 1100 1110 1120 1130 1140 AFKQVQLLVT SQDVDNYKQI KQDLDQLRSI VEKSELWVYK GQGPDEPMDG ASGENEHKKT 1150 1160 1170 1180 1190 1200 EEGTSKPLKH ESTSSYNYRV VKEILIRLSK LCVQESASVR KSRKQQQRLL RNMGAHAVVL 1210 1220 1230 1240 1250 1260 ELLQIPYEKA EDTKMQEIMR LAHEFLQNFC AGNQQNQALL HKHINLFLNP GILEAVTMQH 1270 1280 1290 1300 1310 1320 IFMNNFQLCS EINERVVQHF VHCIETHGRN VQYIKFLQTI VKAEGKFIKK CQDMVMAELV 1330 1340 1350 1360 1370 1380 NSGEDVLVFY NDRASFQTLI QMMRSERDRM DENSPLFMYH IHLVELLAVC TEGKNVYTEI 1390 1400 1410 1420 1430 1440 KCNSLLPLDD IVRVVTHEDC IPEVKIAYIN FLNHCYVDTE VEMKEIYTSN HMWKLFENFL 1450 1460 1470 1480 1490 1500 VDICRACNNT SDRKHADSVL EKYVTEIVMS IVTTFFSSPF SDQSTTLQTR QPVFVQLLQG 1510 1520 1530 1540 1550 1560 VFRVYHCNWL MPSQKASVES CIRVLSDVAK SRAIAIPVDL DSQVNNLFLK SHNIVQKTAM 1570 1580 1590 1600 1610 1620 NWRLSARNAA RRDSVLAASR DYRNIIERLQ DIVSALEDRL RPLVQAELSV LVDVLHRPEL 1630 1640 1650 1660 1670 1680 LFPENTDARR KCESGGFICK LIKHTKQLLE ENEEKLCIKV LQTLREMMTK DRGYGEKQIS 1690 1700 1710 1720 1730 1740 IDELENAELP QPPEAENSTE ELEPSPPLRQ LEDHKRGEAL RQILVNRYYG NIRPSGRRES 1750 1760 1770 1780 1790 1800 LTSFGNGPLS PGGPSKPGGG GGGPGSGSTS RGEMSLAEVQ CHLDKEGASN LVIDLIMNAS 1810 1820 1830 1840 1850 1860 SDRVFHESIL LAIALLEGGN TTIQHSFFCR LTEDKKSEKF FKVFYDRMKV AQQEIKATVT 1870 1880 1890 1900 1910 1920 VNTSDLGNKK KDDEVDRDAP SRKKAKEPTT QITEEVRDQL LEASAATRKA FTTFRREADP 1930 1940 1950 1960 1970 1980 DDHYQSGEGT QATTDKAKDD LEMSAVITIM QPILRFLQLL CENHNRDLQN FLRCQNNKTN 1990 2000 2010 2020 2030 2040 YNLVCETLQF LDCICGSTTG GLGLLGLYIN EKNVALINQT LESLTEYCQG PCHENQNCIA 2050 2060 2070 2080 2090 2100 THESNGIDII TALILNDINP LGKKRMDLVL ELKNNASKLL LAIMESRHDS ENAERILYNM 2110 2120 2130 2140 2150 2160 RPKELVEVIK KAYMQGEVEF EDGENGEDGA ASPRNVGHNI YILAHQLARH NKELQTMLKP 2170 2180 2190 2200 2210 2220 GGQVDGDEAL EFYAKHTAQI EIVRLDRTME QIVFPVPSIC EFLTKESKLR IYYTTERDEQ 2230 2240 2250 2260 2270 2280 GSKINDFFLR SEDLFNEMNW QKKLRAQPVL YWCARNMSFW SSISFNLAVL MNLLVAFFYP 2290 2300 2310 2320 2330 2340 FKGVRGGTLE PHWSGLLWTA MLISLAIVIA LPKPHGIRAL IASTILRLIF SVGLQPTLFL 2350 2360 2370 2380 2390 2400 LGAFNVCNKI IFLMSFVGNC GTFTRGYRAM VLDVEFLYHL LYLLICAMGL FVHEFFYSLL 2410 2420 2430 2440 2450 2460 LFDLVYREET LLNVIKSVTR NGRPIILTAA LALILVYLFS IVGYLFFKDD FILEVDRLPN 2470 2480 2490 2500 2510 2520 ETAGPETGES LANDFLYSDV CRVETGENCT SPAPKEELLP VEETEQDKEH TCETLLMCIV 2530 2540 2550 2560 2570 2580 TVLSHGLRSG GGVGDVLRKP SKEEPLFAAR VIYDLLFFFM VIIIVLNLIF GVIIDTFADL 2590 2600 2610 2620 2630 2640 RSEKQKKEEI LKTTCFICGL ERDKFDNKTV TFEEHIKEEH NMWHYLCFIV LVKVKDSTEY 2650 2660 2670 2680 2690 2700 TGPESYVAEM IRERNLDWFP RMRAMSLVSS DSEGEQNELR NLQEKLESTM KLVTNLSGQL 2710 2720 2730 SELKDQMTEQ RKQKQRIGLL GHPPHMNVNP QQPA
	Isoform 5 (SISIIA) [UniParc]. Checksum: 3BE4A15DD99264F5	FASTA	2,733	311,210
	10 20 30 40 50 60 MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PEAGDLNNPP KKFRDCLFKL 70 80 90 100 110 120 CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV 130 140 150 160 170 180 IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD 190 200 210 220 230 240 KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV 250 260 270 280 290 300 RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 310 320 330 340 350 360 SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVDPDQDAS RSRLRNAQEK MVYSLVSVPE 370 380 390 400 410 420 GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH STNIPIDKEE EKPVMLKIGT 430 440 450 460 470 480 SPLKEDKEAF AIVPVSPAEV RDLDFANDAS KVLGSIAGKL EKGTITQNER RSVTKLLEDL 490 500 510 520 530 540 VYFVTGGTNS GQDVLEVVFS KPNRERQKLM REQNILKQIF KLLQAPFTDC GDGPMLRLEE 550 560 570 580 590 600 LGDQRHAPFR HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH 610 620 630 640 650 660 NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE LICKAVLNPT 670 680 690 700 710 720 NADILIETKL VLSRFEFEGV STGENALEAG EDEEEVWLFW RDSNKEIRSK SVRELAQDAK 730 740 750 760 770 780 EGQKEDRDVL SYYRYQLNLF ARMCLDRQYL AINEISGQLD VDLILRCMSD ENLPYDLRAS 790 800 810 820 830 840 FCRLMLHMHV DRDPQEQVTP VKYARLWSEI PSEIAIDDYD SSGASKDEIK ERFAQTMEFV 850 860 870 880 890 900 EEYLRDVVCQ RFPFSDKEKN KLTFEVVNLA RNLIYFGFYN FSDLLRLTKI LLAILDCVHV 910 920 930 940 950 960 TTIFPISKMT KGEENKGSNV MRSIHGVGEL MTQVVLRGGG FLPMTPMAAA PEGNVKQAEP 970 980 990 1000 1010 1020 EKEDIMVMDT KLKIIEILQF ILNVRLDYRI SCLLCIFKRE FDESNSQSSE TSSGNSSQEG 1030 1040 1050 1060 1070 1080 PSNVPGALDF EHIEEQAEGI FGGSEENTPL DLDDHGGRTF LRVLLHLTMH DYPPLVSGAL 1090 1100 1110 1120 1130 1140 QLLFRHFSQR QEVLQAFKQV QLLVTSQDVD NYKQIKQDLD QLRSIVEKSE LWVYKGQGPD 1150 1160 1170 1180 1190 1200 EPMDGASGEN EHKKTEEGTS KPLKHESTSS YNYRVVKEIL IRLSKLCVQE SASVRKSRKQ 1210 1220 1230 1240 1250 1260 QQRLLRNMGA HAVVLELLQI PYEKAEDTKM QEIMRLAHEF LQNFCAGNQQ NQALLHKHIN 1270 1280 1290 1300 1310 1320 LFLNPGILEA VTMQHIFMNN FQLCSEINER VVQHFVHCIE THGRNVQYIK FLQTIVKAEG 1330 1340 1350 1360 1370 1380 KFIKKCQDMV MAELVNSGED VLVFYNDRAS FQTLIQMMRS ERDRMDENSP LFMYHIHLVE 1390 1400 1410 1420 1430 1440 LLAVCTEGKN VYTEIKCNSL LPLDDIVRVV THEDCIPEVK IAYINFLNHC YVDTEVEMKE 1450 1460 1470 1480 1490 1500 IYTSNHMWKL FENFLVDICR ACNNTSDRKH ADSVLEKYVT EIVMSIVTTF FSSPFSDQST 1510 1520 1530 1540 1550 1560 TLQTRQPVFV QLLQGVFRVY HCNWLMPSQK ASVESCIRVL SDVAKSRAIA IPVDLDSQVN 1570 1580 1590 1600 1610 1620 NLFLKSHNIV QKTAMNWRLS ARNAARRDSV LAASRDYRNI IERLQDIVSA LEDRLRPLVQ 1630 1640 1650 1660 1670 1680 AELSVLVDVL HRPELLFPEN TDARRKCESG GFICKLIKHT KQLLEENEEK LCIKVLQTLR 1690 1700 1710 1720 1730 1740 EMMTKDRGYG EKQISIDELE NAELPQPPEA ENSTEGEALR QILVNRYYGN IRPSGRRESL 1750 1760 1770 1780 1790 1800 TSFGNGPLSP GGPSKPGGGG GGPGSGSTSR GEMSLAEVQC HLDKEGASNL VIDLIMNASS 1810 1820 1830 1840 1850 1860 DRVFHESILL AIALLEGGNT TIQHSFFCRL TEDKKSEKFF KVFYDRMKVA QQEIKATVTV 1870 1880 1890 1900 1910 1920 NTSDLGNKKK DDEVDRDAPS RKKAKEPTTQ ITEEVRDQLL EASAATRKAF TTFRREADPD 1930 1940 1950 1960 1970 1980 DHYQSGEGTQ ATTDKAKDDL EMSAVITIMQ PILRFLQLLC ENHNRDLQNF LRCQNNKTNY 1990 2000 2010 2020 2030 2040 NLVCETLQFL DCICGSTTGG LGLLGLYINE KNVALINQTL ESLTEYCQGP CHENQNCIAT 2050 2060 2070 2080 2090 2100 HESNGIDIIT ALILNDINPL GKKRMDLVLE LKNNASKLLL AIMESRHDSE NAERILYNMR 2110 2120 2130 2140 2150 2160 PKELVEVIKK AYMQGEVEFE DGENGEDGAA SPRNVGHNIY ILAHQLARHN KELQTMLKPG 2170 2180 2190 2200 2210 2220 GQVDGDEALE FYAKHTAQIE IVRLDRTMEQ IVFPVPSICE FLTKESKLRI YYTTERDEQG 2230 2240 2250 2260 2270 2280 SKINDFFLRS EDLFNEMNWQ KKLRAQPVLY WCARNMSFWS SISFNLAVLM NLLVAFFYPF 2290 2300 2310 2320 2330 2340 KGVRGGTLEP HWSGLLWTAM LISLAIVIAL PKPHGIRALI ASTILRLIFS VGLQPTLFLL 2350 2360 2370 2380 2390 2400 GAFNVCNKII FLMSFVGNCG TFTRGYRAMV LDVEFLYHLL YLLICAMGLF VHEFFYSLLL 2410 2420 2430 2440 2450 2460 FDLVYREETL LNVIKSVTRN GRPIILTAAL ALILVYLFSI VGYLFFKDDF ILEVDRLPNE 2470 2480 2490 2500 2510 2520 TAGPETGESL ANDFLYSDVC RVETGENCTS PAPKEELLPV EETEQDKEHT CETLLMCIVT 2530 2540 2550 2560 2570 2580 VLSHGLRSGG GVGDVLRKPS KEEPLFAARV IYDLLFFFMV IIIVLNLIFG VIIDTFADLR 2590 2600 2610 2620 2630 2640 SEKQKKEEIL KTTCFICGLE RDKFDNKTVT FEEHIKEEHN MWHYLCFIVL VKVKDSTEYT 2650 2660 2670 2680 2690 2700 GPESYVAEMI RERNLDWFPR MRAMSLVSSD SEGEQNELRN LQEKLESTMK LVTNLSGQLS 2710 2720 2730 ELKDQMTEQR KQKQRIGLLG HPPHMNVNPQ QPA
	Isoform 6 (SI-SIIA) [UniParc]. Checksum: FBE35154A6AF0190	FASTA	2,718	309,444
	10 20 30 40 50 60 MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PEAGDLNNPP KKFRDCLFKL 70 80 90 100 110 120 CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV 130 140 150 160 170 180 IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD 190 200 210 220 230 240 KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV 250 260 270 280 290 300 RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 310 320 330 340 350 360 SLFRFKHLAT GHYLAAEVDP DQDASRSRLR NAQEKMVYSL VSVPEGNDIS SIFELDPTTL 370 380 390 400 410 420 RGGDSLVPRN SYVRLRHLCT NTWVHSTNIP IDKEEEKPVM LKIGTSPLKE DKEAFAIVPV 430 440 450 460 470 480 SPAEVRDLDF ANDASKVLGS IAGKLEKGTI TQNERRSVTK LLEDLVYFVT GGTNSGQDVL 490 500 510 520 530 540 EVVFSKPNRE RQKLMREQNI LKQIFKLLQA PFTDCGDGPM LRLEELGDQR HAPFRHICRL 550 560 570 580 590 600 CYRVLRHSQQ DYRKNQEYIA KQFGFMQKQI GYDVLAEDTI TALLHNNRKL LEKHITAAEI 610 620 630 640 650 660 DTFVSLVRKN REPRFLDYLS DLCVSMNKSI PVTQELICKA VLNPTNADIL IETKLVLSRF 670 680 690 700 710 720 EFEGVSTGEN ALEAGEDEEE VWLFWRDSNK EIRSKSVREL AQDAKEGQKE DRDVLSYYRY 730 740 750 760 770 780 QLNLFARMCL DRQYLAINEI SGQLDVDLIL RCMSDENLPY DLRASFCRLM LHMHVDRDPQ 790 800 810 820 830 840 EQVTPVKYAR LWSEIPSEIA IDDYDSSGAS KDEIKERFAQ TMEFVEEYLR DVVCQRFPFS 850 860 870 880 890 900 DKEKNKLTFE VVNLARNLIY FGFYNFSDLL RLTKILLAIL DCVHVTTIFP ISKMTKGEEN 910 920 930 940 950 960 KGSNVMRSIH GVGELMTQVV LRGGGFLPMT PMAAAPEGNV KQAEPEKEDI MVMDTKLKII 970 980 990 1000 1010 1020 EILQFILNVR LDYRISCLLC IFKREFDESN SQSSETSSGN SSQEGPSNVP GALDFEHIEE 1030 1040 1050 1060 1070 1080 QAEGIFGGSE ENTPLDLDDH GGRTFLRVLL HLTMHDYPPL VSGALQLLFR HFSQRQEVLQ 1090 1100 1110 1120 1130 1140 AFKQVQLLVT SQDVDNYKQI KQDLDQLRSI VEKSELWVYK GQGPDEPMDG ASGENEHKKT 1150 1160 1170 1180 1190 1200 EEGTSKPLKH ESTSSYNYRV VKEILIRLSK LCVQESASVR KSRKQQQRLL RNMGAHAVVL 1210 1220 1230 1240 1250 1260 ELLQIPYEKA EDTKMQEIMR LAHEFLQNFC AGNQQNQALL HKHINLFLNP GILEAVTMQH 1270 1280 1290 1300 1310 1320 IFMNNFQLCS EINERVVQHF VHCIETHGRN VQYIKFLQTI VKAEGKFIKK CQDMVMAELV 1330 1340 1350 1360 1370 1380 NSGEDVLVFY NDRASFQTLI QMMRSERDRM DENSPLFMYH IHLVELLAVC TEGKNVYTEI 1390 1400 1410 1420 1430 1440 KCNSLLPLDD IVRVVTHEDC IPEVKIAYIN FLNHCYVDTE VEMKEIYTSN HMWKLFENFL 1450 1460 1470 1480 1490 1500 VDICRACNNT SDRKHADSVL EKYVTEIVMS IVTTFFSSPF SDQSTTLQTR QPVFVQLLQG 1510 1520 1530 1540 1550 1560 VFRVYHCNWL MPSQKASVES CIRVLSDVAK SRAIAIPVDL DSQVNNLFLK SHNIVQKTAM 1570 1580 1590 1600 1610 1620 NWRLSARNAA RRDSVLAASR DYRNIIERLQ DIVSALEDRL RPLVQAELSV LVDVLHRPEL 1630 1640 1650 1660 1670 1680 LFPENTDARR KCESGGFICK LIKHTKQLLE ENEEKLCIKV LQTLREMMTK DRGYGEKQIS 1690 1700 1710 1720 1730 1740 IDELENAELP QPPEAENSTE GEALRQILVN RYYGNIRPSG RRESLTSFGN GPLSPGGPSK 1750 1760 1770 1780 1790 1800 PGGGGGGPGS GSTSRGEMSL AEVQCHLDKE GASNLVIDLI MNASSDRVFH ESILLAIALL 1810 1820 1830 1840 1850 1860 EGGNTTIQHS FFCRLTEDKK SEKFFKVFYD RMKVAQQEIK ATVTVNTSDL GNKKKDDEVD 1870 1880 1890 1900 1910 1920 RDAPSRKKAK EPTTQITEEV RDQLLEASAA TRKAFTTFRR EADPDDHYQS GEGTQATTDK 1930 1940 1950 1960 1970 1980 AKDDLEMSAV ITIMQPILRF LQLLCENHNR DLQNFLRCQN NKTNYNLVCE TLQFLDCICG 1990 2000 2010 2020 2030 2040 STTGGLGLLG LYINEKNVAL INQTLESLTE YCQGPCHENQ NCIATHESNG IDIITALILN 2050 2060 2070 2080 2090 2100 DINPLGKKRM DLVLELKNNA SKLLLAIMES RHDSENAERI LYNMRPKELV EVIKKAYMQG 2110 2120 2130 2140 2150 2160 EVEFEDGENG EDGAASPRNV GHNIYILAHQ LARHNKELQT MLKPGGQVDG DEALEFYAKH 2170 2180 2190 2200 2210 2220 TAQIEIVRLD RTMEQIVFPV PSICEFLTKE SKLRIYYTTE RDEQGSKIND FFLRSEDLFN 2230 2240 2250 2260 2270 2280 EMNWQKKLRA QPVLYWCARN MSFWSSISFN LAVLMNLLVA FFYPFKGVRG GTLEPHWSGL 2290 2300 2310 2320 2330 2340 LWTAMLISLA IVIALPKPHG IRALIASTIL RLIFSVGLQP TLFLLGAFNV CNKIIFLMSF 2350 2360 2370 2380 2390 2400 VGNCGTFTRG YRAMVLDVEF LYHLLYLLIC AMGLFVHEFF YSLLLFDLVY REETLLNVIK 2410 2420 2430 2440 2450 2460 SVTRNGRPII LTAALALILV YLFSIVGYLF FKDDFILEVD RLPNETAGPE TGESLANDFL 2470 2480 2490 2500 2510 2520 YSDVCRVETG ENCTSPAPKE ELLPVEETEQ DKEHTCETLL MCIVTVLSHG LRSGGGVGDV 2530 2540 2550 2560 2570 2580 LRKPSKEEPL FAARVIYDLL FFFMVIIIVL NLIFGVIIDT FADLRSEKQK KEEILKTTCF 2590 2600 2610 2620 2630 2640 ICGLERDKFD NKTVTFEEHI KEEHNMWHYL CFIVLVKVKD STEYTGPESY VAEMIRERNL 2650 2660 2670 2680 2690 2700 DWFPRMRAMS LVSSDSEGEQ NELRNLQEKL ESTMKLVTNL SGQLSELKDQ MTEQRKQKQR 2710 IGLLGHPPHM NVNPQQPA
	Isoform 7 (SISII) [UniParc]. Checksum: 6A7FF31BC8448BFD	FASTA	2,710	308,674
	10 20 30 40 50 60 MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PEAGDLNNPP KKFRDCLFKL 70 80 90 100 110 120 CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV 130 140 150 160 170 180 IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD 190 200 210 220 230 240 KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV 250 260 270 280 290 300 RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 310 320 330 340 350 360 SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVDPDQDAS RSRLRNAQEK MVYSLVSVPE 370 380 390 400 410 420 GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH STNIPIDKEE EKPVMLKIGT 430 440 450 460 470 480 SPLKEDKEAF AIVPVSPAEV RDLDFANDAS KVLGSIAGKL EKGTITQNER RSVTKLLEDL 490 500 510 520 530 540 VYFVTGGTNS GQDVLEVVFS KPNRERQKLM REQNILKQIF KLLQAPFTDC GDGPMLRLEE 550 560 570 580 590 600 LGDQRHAPFR HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH 610 620 630 640 650 660 NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE LICKAVLNPT 670 680 690 700 710 720 NADILIETKL VLSRFEFEGV STGENALEAG EDEEEVWLFW RDSNKEIRSK SVRELAQDAK 730 740 750 760 770 780 EGQKEDRDVL SYYRYQLNLF ARMCLDRQYL AINEISGQLD VDLILRCMSD ENLPYDLRAS 790 800 810 820 830 840 FCRLMLHMHV DRDPQEQVTP VKYARLWSEI PSEIAIDDYD SSGASKDEIK ERFAQTMEFV 850 860 870 880 890 900 EEYLRDVVCQ RFPFSDKEKN KLTFEVVNLA RNLIYFGFYN FSDLLRLTKI LLAILDCVHV 910 920 930 940 950 960 TTIFPISKMT KGEENKGSNV MRSIHGVGEL MTQVVLRGGG FLPMTPMAAA PEGNVKQAEP 970 980 990 1000 1010 1020 EKEDIMVMDT KLKIIEILQF ILNVRLDYRI SCLLCIFKRE FDESNSQSSE TSSGNSSQEG 1030 1040 1050 1060 1070 1080 PSNVPGALDF EHIEEQAEGI FGGSEENTPL DLDDHGGRTF LRVLLHLTMH DYPPLVSGAL 1090 1100 1110 1120 1130 1140 QLLFRHFSQR QEVLQAFKQV QLLVTSQDVD NYKQIKQDLD QLRSIVEKSE LWVYKGQGPD 1150 1160 1170 1180 1190 1200 EPMDGASGEN EHKKTEEGTS KPLKHESTSS YNYRVVKEIL IRLSKLCVQE SASVRKSRKQ 1210 1220 1230 1240 1250 1260 QQRLLRNMGA HAVVLELLQI PYEKAEDTKM QEIMRLAHEF LQNFCAGNQQ NQALLHKHIN 1270 1280 1290 1300 1310 1320 LFLNPGILEA VTMQHIFMNN FQLCSEINER VVQHFVHCIE THGRNVQYIK FLQTIVKAEG 1330 1340 1350 1360 1370 1380 KFIKKCQDMV MAELVNSGED VLVFYNDRAS FQTLIQMMRS ERDRMDENSP LFMYHIHLVE 1390 1400 1410 1420 1430 1440 LLAVCTEGKN VYTEIKCNSL LPLDDIVRVV THEDCIPEVK IAYINFLNHC YVDTEVEMKE 1450 1460 1470 1480 1490 1500 IYTSNHMWKL FENFLVDICR ACNNTSDRKH ADSVLEKYVT EIVMSIVTTF FSSPFSDQST 1510 1520 1530 1540 1550 1560 TLQTRQPVFV QLLQGVFRVY HCNWLMPSQK ASVESCIRVL SDVAKSRAIA IPVDLDSQVN 1570 1580 1590 1600 1610 1620 NLFLKSHNIV QKTAMNWRLS ARNAARRDSV LAASRDYRNI IERLQDIVSA LEDRLRPLVQ 1630 1640 1650 1660 1670 1680 AELSVLVDVL HRPELLFPEN TDARRKCESG GFICKLIKHT KQLLEENEEK LCIKVLQTLR 1690 1700 1710 1720 1730 1740 EMMTKDRGYG EKGEALRQIL VNRYYGNIRP SGRRESLTSF GNGPLSPGGP SKPGGGGGGP 1750 1760 1770 1780 1790 1800 GSGSTSRGEM SLAEVQCHLD KEGASNLVID LIMNASSDRV FHESILLAIA LLEGGNTTIQ 1810 1820 1830 1840 1850 1860 HSFFCRLTED KKSEKFFKVF YDRMKVAQQE IKATVTVNTS DLGNKKKDDE VDRDAPSRKK 1870 1880 1890 1900 1910 1920 AKEPTTQITE EVRDQLLEAS AATRKAFTTF RREADPDDHY QSGEGTQATT DKAKDDLEMS 1930 1940 1950 1960 1970 1980 AVITIMQPIL RFLQLLCENH NRDLQNFLRC QNNKTNYNLV CETLQFLDCI CGSTTGGLGL 1990 2000 2010 2020 2030 2040 LGLYINEKNV ALINQTLESL TEYCQGPCHE NQNCIATHES NGIDIITALI LNDINPLGKK 2050 2060 2070 2080 2090 2100 RMDLVLELKN NASKLLLAIM ESRHDSENAE RILYNMRPKE LVEVIKKAYM QGEVEFEDGE 2110 2120 2130 2140 2150 2160 NGEDGAASPR NVGHNIYILA HQLARHNKEL QTMLKPGGQV DGDEALEFYA KHTAQIEIVR 2170 2180 2190 2200 2210 2220 LDRTMEQIVF PVPSICEFLT KESKLRIYYT TERDEQGSKI NDFFLRSEDL FNEMNWQKKL 2230 2240 2250 2260 2270 2280 RAQPVLYWCA RNMSFWSSIS FNLAVLMNLL VAFFYPFKGV RGGTLEPHWS GLLWTAMLIS 2290 2300 2310 2320 2330 2340 LAIVIALPKP HGIRALIAST ILRLIFSVGL QPTLFLLGAF NVCNKIIFLM SFVGNCGTFT 2350 2360 2370 2380 2390 2400 RGYRAMVLDV EFLYHLLYLL ICAMGLFVHE FFYSLLLFDL VYREETLLNV IKSVTRNGRP 2410 2420 2430 2440 2450 2460 IILTAALALI LVYLFSIVGY LFFKDDFILE VDRLPNETAG PETGESLAND FLYSDVCRVE 2470 2480 2490 2500 2510 2520 TGENCTSPAP KEELLPVEET EQDKEHTCET LLMCIVTVLS HGLRSGGGVG DVLRKPSKEE 2530 2540 2550 2560 2570 2580 PLFAARVIYD LLFFFMVIII VLNLIFGVII DTFADLRSEK QKKEEILKTT CFICGLERDK 2590 2600 2610 2620 2630 2640 FDNKTVTFEE HIKEEHNMWH YLCFIVLVKV KDSTEYTGPE SYVAEMIRER NLDWFPRMRA 2650 2660 2670 2680 2690 2700 MSLVSSDSEG EQNELRNLQE KLESTMKLVT NLSGQLSELK DQMTEQRKQK QRIGLLGHPP 2710 HMNVNPQQPA
	Isoform 8 (SI-SII) [UniParc]. Checksum: 81B8B4551AB0814F	FASTA	2,695	306,909
	10 20 30 40 50 60 MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PEAGDLNNPP KKFRDCLFKL 70 80 90 100 110 120 CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV 130 140 150 160 170 180 IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD 190 200 210 220 230 240 KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV 250 260 270 280 290 300 RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 310 320 330 340 350 360 SLFRFKHLAT GHYLAAEVDP DQDASRSRLR NAQEKMVYSL VSVPEGNDIS SIFELDPTTL 370 380 390 400 410 420 RGGDSLVPRN SYVRLRHLCT NTWVHSTNIP IDKEEEKPVM LKIGTSPLKE DKEAFAIVPV 430 440 450 460 470 480 SPAEVRDLDF ANDASKVLGS IAGKLEKGTI TQNERRSVTK LLEDLVYFVT GGTNSGQDVL 490 500 510 520 530 540 EVVFSKPNRE RQKLMREQNI LKQIFKLLQA PFTDCGDGPM LRLEELGDQR HAPFRHICRL 550 560 570 580 590 600 CYRVLRHSQQ DYRKNQEYIA KQFGFMQKQI GYDVLAEDTI TALLHNNRKL LEKHITAAEI 610 620 630 640 650 660 DTFVSLVRKN REPRFLDYLS DLCVSMNKSI PVTQELICKA VLNPTNADIL IETKLVLSRF 670 680 690 700 710 720 EFEGVSTGEN ALEAGEDEEE VWLFWRDSNK EIRSKSVREL AQDAKEGQKE DRDVLSYYRY 730 740 750 760 770 780 QLNLFARMCL DRQYLAINEI SGQLDVDLIL RCMSDENLPY DLRASFCRLM LHMHVDRDPQ 790 800 810 820 830 840 EQVTPVKYAR LWSEIPSEIA IDDYDSSGAS KDEIKERFAQ TMEFVEEYLR DVVCQRFPFS 850 860 870 880 890 900 DKEKNKLTFE VVNLARNLIY FGFYNFSDLL RLTKILLAIL DCVHVTTIFP ISKMTKGEEN 910 920 930 940 950 960 KGSNVMRSIH GVGELMTQVV LRGGGFLPMT PMAAAPEGNV KQAEPEKEDI MVMDTKLKII 970 980 990 1000 1010 1020 EILQFILNVR LDYRISCLLC IFKREFDESN SQSSETSSGN SSQEGPSNVP GALDFEHIEE 1030 1040 1050 1060 1070 1080 QAEGIFGGSE ENTPLDLDDH GGRTFLRVLL HLTMHDYPPL VSGALQLLFR HFSQRQEVLQ 1090 1100 1110 1120 1130 1140 AFKQVQLLVT SQDVDNYKQI KQDLDQLRSI VEKSELWVYK GQGPDEPMDG ASGENEHKKT 1150 1160 1170 1180 1190 1200 EEGTSKPLKH ESTSSYNYRV VKEILIRLSK LCVQESASVR KSRKQQQRLL RNMGAHAVVL 1210 1220 1230 1240 1250 1260 ELLQIPYEKA EDTKMQEIMR LAHEFLQNFC AGNQQNQALL HKHINLFLNP GILEAVTMQH 1270 1280 1290 1300 1310 1320 IFMNNFQLCS EINERVVQHF VHCIETHGRN VQYIKFLQTI VKAEGKFIKK CQDMVMAELV 1330 1340 1350 1360 1370 1380 NSGEDVLVFY NDRASFQTLI QMMRSERDRM DENSPLFMYH IHLVELLAVC TEGKNVYTEI 1390 1400 1410 1420 1430 1440 KCNSLLPLDD IVRVVTHEDC IPEVKIAYIN FLNHCYVDTE VEMKEIYTSN HMWKLFENFL 1450 1460 1470 1480 1490 1500 VDICRACNNT SDRKHADSVL EKYVTEIVMS IVTTFFSSPF SDQSTTLQTR QPVFVQLLQG 1510 1520 1530 1540 1550 1560 VFRVYHCNWL MPSQKASVES CIRVLSDVAK SRAIAIPVDL DSQVNNLFLK SHNIVQKTAM 1570 1580 1590 1600 1610 1620 NWRLSARNAA RRDSVLAASR DYRNIIERLQ DIVSALEDRL RPLVQAELSV LVDVLHRPEL 1630 1640 1650 1660 1670 1680 LFPENTDARR KCESGGFICK LIKHTKQLLE ENEEKLCIKV LQTLREMMTK DRGYGEKGEA 1690 1700 1710 1720 1730 1740 LRQILVNRYY GNIRPSGRRE SLTSFGNGPL SPGGPSKPGG GGGGPGSGST SRGEMSLAEV 1750 1760 1770 1780 1790 1800 QCHLDKEGAS NLVIDLIMNA SSDRVFHESI LLAIALLEGG NTTIQHSFFC RLTEDKKSEK 1810 1820 1830 1840 1850 1860 FFKVFYDRMK VAQQEIKATV TVNTSDLGNK KKDDEVDRDA PSRKKAKEPT TQITEEVRDQ 1870 1880 1890 1900 1910 1920 LLEASAATRK AFTTFRREAD PDDHYQSGEG TQATTDKAKD DLEMSAVITI MQPILRFLQL 1930 1940 1950 1960 1970 1980 LCENHNRDLQ NFLRCQNNKT NYNLVCETLQ FLDCICGSTT GGLGLLGLYI NEKNVALINQ 1990 2000 2010 2020 2030 2040 TLESLTEYCQ GPCHENQNCI ATHESNGIDI ITALILNDIN PLGKKRMDLV LELKNNASKL 2050 2060 2070 2080 2090 2100 LLAIMESRHD SENAERILYN MRPKELVEVI KKAYMQGEVE FEDGENGEDG AASPRNVGHN 2110 2120 2130 2140 2150 2160 IYILAHQLAR HNKELQTMLK PGGQVDGDEA LEFYAKHTAQ IEIVRLDRTM EQIVFPVPSI 2170 2180 2190 2200 2210 2220 CEFLTKESKL RIYYTTERDE QGSKINDFFL RSEDLFNEMN WQKKLRAQPV LYWCARNMSF 2230 2240 2250 2260 2270 2280 WSSISFNLAV LMNLLVAFFY PFKGVRGGTL EPHWSGLLWT AMLISLAIVI ALPKPHGIRA 2290 2300 2310 2320 2330 2340 LIASTILRLI FSVGLQPTLF LLGAFNVCNK IIFLMSFVGN CGTFTRGYRA MVLDVEFLYH 2350 2360 2370 2380 2390 2400 LLYLLICAMG LFVHEFFYSL LLFDLVYREE TLLNVIKSVT RNGRPIILTA ALALILVYLF 2410 2420 2430 2440 2450 2460 SIVGYLFFKD DFILEVDRLP NETAGPETGE SLANDFLYSD VCRVETGENC TSPAPKEELL 2470 2480 2490 2500 2510 2520 PVEETEQDKE HTCETLLMCI VTVLSHGLRS GGGVGDVLRK PSKEEPLFAA RVIYDLLFFF 2530 2540 2550 2560 2570 2580 MVIIIVLNLI FGVIIDTFAD LRSEKQKKEE ILKTTCFICG LERDKFDNKT VTFEEHIKEE 2590 2600 2610 2620 2630 2640 HNMWHYLCFI VLVKVKDSTE YTGPESYVAE MIRERNLDWF PRMRAMSLVS SDSEGEQNEL 2650 2660 2670 2680 2690 RNLQEKLEST MKLVTNLSGQ LSELKDQMTE QRKQKQRIGL LGHPPHMNVN PQQPA

References

[1]	"Structure and expression of the rat inositol 1,4,5-trisphosphate receptor." Mignery G.A., Newton C.L., Archer B.T. III, Suedhof T.C. J. Biol. Chem. 265:12679-12685(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), VARIANT PHE-1372 DEL.
[2]	"Inositol 1,4,5-trisphosphate receptors: distinct neuronal and nonneuronal forms derived by alternative splicing differ in phosphorylation." Danoff S.K., Ferris C.D., Donath C., Fischer G.A., Munemitsu S., Ullrich A., Snyder S.H., Ross C.A. Proc. Natl. Acad. Sci. U.S.A. 88:2951-2955(1991) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 7). Tissue: Brain.
[3]	"Inositol 1,4,5-trisphosphate receptor expression in mammalian olfactory tissue." Smutzer G., Zimmerman J.E., Hahn C.-G., Ruscheinsky D.D., Rodriguez A., Han L.-Y., Arnold S.E. Brain Res. Mol. Brain Res. 44:347-354(1997) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4; 7 AND 8). Strain: Sprague-Dawley.
[4]	"Subunit oligomerization, and topology of the inositol 1,4, 5-trisphosphate receptor." Galvan D.L., Borrego-Diaz E., Perez P.J., Mignery G.A. J. Biol. Chem. 274:29483-29492(1999) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[5]	"Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels." Yang J., McBride S., Mak D.-O.D., Vardi N., Palczewski K., Haeseleer F., Foskett J.K. Proc. Natl. Acad. Sci. U.S.A. 99:7711-7716(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CABP1.
[6]	"Mass spectrometric analysis of type 1 inositol 1,4,5-trisphosphate receptor ubiquitination." Sliter D.A., Kubota K., Kirkpatrick D.S., Alzayady K.J., Gygi S.P., Wojcikiewicz R.J. J. Biol. Chem. 283:35319-35328(2008) [PubMed] [Europe PMC] [Abstract] Cited for: UBIQUITINATION AT LYS-916; LYS-962; LYS-1572; LYS-1772; LYS-1885; LYS-1886; LYS-1887; LYS-1902; LYS-1925; LYS-2119 AND LYS-2258.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

J05510 mRNA. Translation: AAA41358.1.
J05510 mRNA. Translation: AAA41357.1.
M64699 mRNA. Translation: AAA41447.1.
M64698 mRNA. Translation: AAA41448.1.
U38653 mRNA. Translation: AAC53099.1.
U38812 mRNA. Translation: AAC53100.1.
U38665 mRNA. Translation: AAB51330.1.

IPI

IPI00230873.
IPI00230877.
IPI00230879.
IPI00230881.
IPI00944825.
IPI00947857.
IPI00949472.
IPI00950591.

PIR

A36579.
B36579.

RefSeq

NP_001257526.1. NM_001270597.1.

UniGene

Rn.170703.
Rn.2135.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3T8S	X-ray	3.77	A/B	7-602	[»]
3UJ0	X-ray	3.60	A/B	1-604	[»]
3UJ4	X-ray	3.00	A/B	1-604	[»]

ProteinModelPortal

P29994.

SMR

P29994. Positions 7-225, 236-602.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-29715N.

PTM databases

PhosphoSite

P29994.

Proteomic databases

PaxDb

P29994.

PRIDE

P29994.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

25262.

KEGG

rno:25262.

Organism-specific databases

CTD

3708.

RGD

2933. Itpr1.

Phylogenomic databases

eggNOG

NOG280601.

HOGENOM

HOG000007660.

HOVERGEN

HBG052158.

InParanoid

P29994.

KO

K04958.

Enzyme and pathway databases

Reactome

REACT_109781. Immune System.
REACT_110573. Disease.
REACT_111984. Signal Transduction.
REACT_113568. Metabolism.

Gene expression databases

ArrayExpress

P29994.

Genevestigator

P29994.

GermOnline

ENSRNOG00000007104. Rattus norvegicus.

Family and domain databases

InterPro

IPR000699. Ca-rel_channel.
IPR014821. Ins145_P3_rcpt.
IPR000493. InsP3_rcpt-bd.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view]

PANTHER

PTHR13715. PTHR13715. 1 hit.

Pfam

PF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
[Graphical view]

PRINTS

PR00779. INSP3RECEPTR.

SMART

SM00472. MIR. 4 hits.
[Graphical view]

SUPFAM

SSF82109. MIR. 2 hits.

PROSITE

PS50919. MIR. 5 hits.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

P29994.

ChEMBL

CHEMBL2804.

NextBio

605915.

Entry information

Entry name

ITPR1_RAT

Accession

Primary (citable) accession number: P29994
Secondary accession number(s): Q62869

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	November 2, 2001
Last modified:	April 3, 2013
This is version 131 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program