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P29994

- ITPR1_RAT

UniProt

P29994 - ITPR1_RAT

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Protein
Inositol 1,4,5-trisphosphate receptor type 1
Gene
Itpr1, Insp3r
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways By similarity.

GO - Molecular functioni

  1. inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Source: UniProtKB
  2. intracellular ligand-gated calcium channel activity Source: UniProtKB
  3. phosphatidylinositol binding Source: UniProtKB
  4. protein C-terminus binding Source: RGD
  5. protein binding Source: RGD
  6. protein complex binding Source: RGD
  7. protein phosphatase binding Source: RGD

GO - Biological processi

  1. cellular response to cAMP Source: RGD
  2. cellular response to hypoxia Source: RGD
  3. inositol phosphate-mediated signaling Source: GOC
  4. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: UniProtKB
  5. negative regulation of neuron death Source: RGD
  6. positive regulation of calcium ion transport Source: RGD
  7. positive regulation of cytosolic calcium ion concentration Source: RGD
  8. release of sequestered calcium ion into cytosol Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Apoptosis, Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_194374. Role of phospholipids in phagocytosis.
REACT_194690. Ca2+ pathway.
REACT_203734. FCERI mediated Ca+2 mobilization.
REACT_211910. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_220575. DAG and IP3 signaling.
REACT_221588. PLC beta mediated events.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol 1,4,5-trisphosphate receptor type 1
Alternative name(s):
IP3 receptor isoform 1
Short name:
IP-3-R
Short name:
IP3R 1
Short name:
InsP3R1
Type 1 inositol 1,4,5-trisphosphate receptor
Short name:
Type 1 InsP3 receptor
Gene namesi
Name:Itpr1
Synonyms:Insp3r
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2933. Itpr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22742274Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei2275 – 229521Helical; Reviewed prediction
Add
BLAST
Topological domaini2296 – 230611Lumenal Reviewed prediction
Add
BLAST
Transmembranei2307 – 232721Helical; Reviewed prediction
Add
BLAST
Topological domaini2328 – 235326Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei2354 – 237421Helical; Reviewed prediction
Add
BLAST
Topological domaini2375 – 239723Lumenal Reviewed prediction
Add
BLAST
Transmembranei2398 – 241821Helical; Reviewed prediction
Add
BLAST
Topological domaini2419 – 244022Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei2441 – 246121Helical; Reviewed prediction
Add
BLAST
Topological domaini2462 – 2569108Lumenal Reviewed prediction
Add
BLAST
Transmembranei2570 – 259021Helical; Reviewed prediction
Add
BLAST
Topological domaini2591 – 2750160Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. dendrite Source: RGD
  3. endoplasmic reticulum membrane Source: RGD
  4. integral component of membrane Source: UniProtKB-KW
  5. intracellular membrane-bounded organelle Source: RGD
  6. membrane raft Source: RGD
  7. neuronal cell body Source: RGD
  8. nuclear envelope Source: RGD
  9. perinuclear region of cytoplasm Source: RGD
  10. plasma membrane Source: RGD
  11. postsynaptic density Source: RGD
  12. protein complex Source: RGD
  13. sarcoplasmic reticulum Source: RGD
  14. secretory granule membrane Source: RGD
  15. synaptic membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 27502750Inositol 1,4,5-trisphosphate receptor type 1
PRO_0000153922Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei482 – 4821Phosphotyrosine Reviewed prediction
Cross-linki916 – 916Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki962 – 962Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki1572 – 1572Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei1589 – 15891Phosphoserine By similarity
Modified residuei1756 – 17561Phosphoserine; by PKA Reviewed prediction
Cross-linki1772 – 1772Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki1885 – 1885Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki1886 – 1886Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki1887 – 1887Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki1902 – 1902Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki1925 – 1925Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki2119 – 2119Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki2258 – 2258Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei2656 – 26561Phosphotyrosine Reviewed prediction

Post-translational modificationi

Phosphorylated by cAMP kinase. Phosphorylation prevents the ligand-induced opening of the calcium channels.
Phosphorylated on tyrosine residues By similarity.
Ubiquitination at multiple lysines targets ITPR1 for proteasomal degradation. Approximately 40% of the ITPR1-associated ubiquitin is monoubiquitin, and polyubiquitins are both 'Lys-48'- and 'Lys-63'-linked.

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP29994.
PRIDEiP29994.

PTM databases

PhosphoSiteiP29994.

Expressioni

Tissue specificityi

Isoform 3 is found in the brain while isoform 7 is found in the fetal brain and peripheral tissues.

Gene expression databases

GenevestigatoriP29994.

Interactioni

Subunit structurei

Homotetramer. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Interacts with ERP44 in a pH-, redox state- and calcium-dependent manner which results in the inhibition the calcium channel activity. The strength of this interaction inversely correlates with calcium concentration. Interacts with CABP1. Interacts with AHCYL1 and MRVI1 By similarity. Interacts with TESPA1 By similarity.1 Publication

Protein-protein interaction databases

BioGridi247302. 11 interactions.
DIPiDIP-29715N.
IntActiP29994. 1 interaction.
MINTiMINT-5026585.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi14 – 2310
Beta strandi25 – 306
Beta strandi36 – 394
Turni41 – 433
Helixi53 – 564
Beta strandi57 – 615
Helixi67 – 748
Helixi87 – 10822
Turni109 – 1124
Beta strandi120 – 1256
Turni126 – 1294
Beta strandi130 – 13910
Beta strandi141 – 1433
Beta strandi147 – 1548
Helixi157 – 1593
Beta strandi161 – 1677
Beta strandi181 – 1899
Beta strandi193 – 1997
Beta strandi201 – 2033
Beta strandi207 – 2137
Beta strandi217 – 2248
Helixi226 – 2283
Beta strandi239 – 2446
Turni245 – 2484
Beta strandi249 – 2568
Beta strandi259 – 2657
Helixi278 – 2803
Beta strandi281 – 2866
Beta strandi302 – 3076
Turni308 – 3103
Beta strandi313 – 3186
Beta strandi353 – 3597
Helixi364 – 3663
Beta strandi368 – 3747
Beta strandi387 – 3926
Turni393 – 3953
Beta strandi398 – 4069
Beta strandi408 – 4125
Beta strandi415 – 4239
Beta strandi430 – 4345
Helixi437 – 46226
Helixi467 – 48317
Helixi504 – 5129
Helixi515 – 5228
Helixi552 – 56211
Turni563 – 5664
Helixi568 – 5758

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3T8SX-ray3.77A/B7-602[»]
3UJ0X-ray3.60A/B1-604[»]
3UJ4X-ray3.00A/B1-604[»]
ProteinModelPortaliP29994.
SMRiP29994. Positions 7-225, 236-602.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini112 – 16655MIR 1
Add
BLAST
Domaini173 – 22351MIR 2
Add
BLAST
Domaini231 – 28757MIR 3
Add
BLAST
Domaini294 – 37380MIR 4
Add
BLAST
Domaini379 – 43557MIR 5
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni265 – 2695Inositol 1,4,5-trisphosphate binding By similarity
Regioni508 – 5114Inositol 1,4,5-trisphosphate binding By similarity
Regioni567 – 5693Inositol 1,4,5-trisphosphate binding By similarity
Regioni2464 – 252966Interaction with ERP44
Add
BLAST

Domaini

The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

Sequence similaritiesi

Belongs to the InsP3 receptor family.
Contains 5 MIR domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG280601.
HOGENOMiHOG000007660.
HOVERGENiHBG052158.
InParanoidiP29994.
KOiK04958.
PhylomeDBiP29994.

Family and domain databases

Gene3Di1.25.10.30. 2 hits.
InterProiIPR016024. ARM-type_fold.
IPR014821. Ins145_P3_rcpt.
IPR000493. InsP3_rcpt-bd.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 1 hit.
PfamiPF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
[Graphical view]
PRINTSiPR00779. INSP3RECEPTR.
SMARTiSM00472. MIR. 4 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF48371. SSF48371. 4 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50919. MIR. 5 hits.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. Align

Note: There is a combination of two alternatively spliced domains at site SI and site SII (A, B and C). Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: P29994-1) [UniParc]FASTAAdd to Basket

Also known as: SISIIABC

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PEAGDLNNPP     50
KKFRDCLFKL CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK 100
KQNETENRKL LGTVIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT 150
LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD KVVLNPVNAG QPLHASSHQL 200
VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV RLFHAEQEKF 250
LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 300
SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVDPDQDAS RSRLRNAQEK 350
MVYSLVSVPE GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH 400
STNIPIDKEE EKPVMLKIGT SPLKEDKEAF AIVPVSPAEV RDLDFANDAS 450
KVLGSIAGKL EKGTITQNER RSVTKLLEDL VYFVTGGTNS GQDVLEVVFS 500
KPNRERQKLM REQNILKQIF KLLQAPFTDC GDGPMLRLEE LGDQRHAPFR 550
HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH 600
NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE 650
LICKAVLNPT NADILIETKL VLSRFEFEGV STGENALEAG EDEEEVWLFW 700
RDSNKEIRSK SVRELAQDAK EGQKEDRDVL SYYRYQLNLF ARMCLDRQYL 750
AINEISGQLD VDLILRCMSD ENLPYDLRAS FCRLMLHMHV DRDPQEQVTP 800
VKYARLWSEI PSEIAIDDYD SSGASKDEIK ERFAQTMEFV EEYLRDVVCQ 850
RFPFSDKEKN KLTFEVVNLA RNLIYFGFYN FSDLLRLTKI LLAILDCVHV 900
TTIFPISKMT KGEENKGSNV MRSIHGVGEL MTQVVLRGGG FLPMTPMAAA 950
PEGNVKQAEP EKEDIMVMDT KLKIIEILQF ILNVRLDYRI SCLLCIFKRE 1000
FDESNSQSSE TSSGNSSQEG PSNVPGALDF EHIEEQAEGI FGGSEENTPL 1050
DLDDHGGRTF LRVLLHLTMH DYPPLVSGAL QLLFRHFSQR QEVLQAFKQV 1100
QLLVTSQDVD NYKQIKQDLD QLRSIVEKSE LWVYKGQGPD EPMDGASGEN 1150
EHKKTEEGTS KPLKHESTSS YNYRVVKEIL IRLSKLCVQE SASVRKSRKQ 1200
QQRLLRNMGA HAVVLELLQI PYEKAEDTKM QEIMRLAHEF LQNFCAGNQQ 1250
NQALLHKHIN LFLNPGILEA VTMQHIFMNN FQLCSEINER VVQHFVHCIE 1300
THGRNVQYIK FLQTIVKAEG KFIKKCQDMV MAELVNSGED VLVFYNDRAS 1350
FQTLIQMMRS ERDRMDENSP LFMYHIHLVE LLAVCTEGKN VYTEIKCNSL 1400
LPLDDIVRVV THEDCIPEVK IAYINFLNHC YVDTEVEMKE IYTSNHMWKL 1450
FENFLVDICR ACNNTSDRKH ADSVLEKYVT EIVMSIVTTF FSSPFSDQST 1500
TLQTRQPVFV QLLQGVFRVY HCNWLMPSQK ASVESCIRVL SDVAKSRAIA 1550
IPVDLDSQVN NLFLKSHNIV QKTAMNWRLS ARNAARRDSV LAASRDYRNI 1600
IERLQDIVSA LEDRLRPLVQ AELSVLVDVL HRPELLFPEN TDARRKCESG 1650
GFICKLIKHT KQLLEENEEK LCIKVLQTLR EMMTKDRGYG EKQISIDELE 1700
NAELPQPPEA ENSTEQELEP SPPLRQLEDH KRGEALRQIL VNRYYGNIRP 1750
SGRRESLTSF GNGPLSPGGP SKPGGGGGGP GSGSTSRGEM SLAEVQCHLD 1800
KEGASNLVID LIMNASSDRV FHESILLAIA LLEGGNTTIQ HSFFCRLTED 1850
KKSEKFFKVF YDRMKVAQQE IKATVTVNTS DLGNKKKDDE VDRDAPSRKK 1900
AKEPTTQITE EVRDQLLEAS AATRKAFTTF RREADPDDHY QSGEGTQATT 1950
DKAKDDLEMS AVITIMQPIL RFLQLLCENH NRDLQNFLRC QNNKTNYNLV 2000
CETLQFLDCI CGSTTGGLGL LGLYINEKNV ALINQTLESL TEYCQGPCHE 2050
NQNCIATHES NGIDIITALI LNDINPLGKK RMDLVLELKN NASKLLLAIM 2100
ESRHDSENAE RILYNMRPKE LVEVIKKAYM QGEVEFEDGE NGEDGAASPR 2150
NVGHNIYILA HQLARHNKEL QTMLKPGGQV DGDEALEFYA KHTAQIEIVR 2200
LDRTMEQIVF PVPSICEFLT KESKLRIYYT TERDEQGSKI NDFFLRSEDL 2250
FNEMNWQKKL RAQPVLYWCA RNMSFWSSIS FNLAVLMNLL VAFFYPFKGV 2300
RGGTLEPHWS GLLWTAMLIS LAIVIALPKP HGIRALIAST ILRLIFSVGL 2350
QPTLFLLGAF NVCNKIIFLM SFVGNCGTFT RGYRAMVLDV EFLYHLLYLL 2400
ICAMGLFVHE FFYSLLLFDL VYREETLLNV IKSVTRNGRP IILTAALALI 2450
LVYLFSIVGY LFFKDDFILE VDRLPNETAG PETGESLAND FLYSDVCRVE 2500
TGENCTSPAP KEELLPVEET EQDKEHTCET LLMCIVTVLS HGLRSGGGVG 2550
DVLRKPSKEE PLFAARVIYD LLFFFMVIII VLNLIFGVII DTFADLRSEK 2600
QKKEEILKTT CFICGLERDK FDNKTVTFEE HIKEEHNMWH YLCFIVLVKV 2650
KDSTEYTGPE SYVAEMIRER NLDWFPRMRA MSLVSSDSEG EQNELRNLQE 2700
KLESTMKLVT NLSGQLSELK DQMTEQRKQK QRIGLLGHPP HMNVNPQQPA 2750
Length:2,750
Mass (Da):313,264
Last modified:November 2, 2001 - v2
Checksum:i174BB77CBF6F21AC
GO
Isoform 2 (identifier: P29994-2) [UniParc]FASTAAdd to Basket

Also known as: SI-SIIABC

The sequence of this isoform differs from the canonical sequence as follows:
     322-336: Missing.

Show »
Length:2,735
Mass (Da):311,498
Checksum:iA80CC16884635058
GO
Isoform 3 (identifier: P29994-3) [UniParc]FASTAAdd to Basket

Also known as: SISIIAC

The sequence of this isoform differs from the canonical sequence as follows:
     1716-1716: Missing.

Show »
Length:2,749
Mass (Da):313,136
Checksum:iE80D784F7201E2C9
GO
Isoform 4 (identifier: P29994-4) [UniParc]FASTAAdd to Basket

Also known as: SI-SIIAC

The sequence of this isoform differs from the canonical sequence as follows:
     322-336: Missing.
     1716-1716: Missing.

Show »
Length:2,734
Mass (Da):311,370
Checksum:iEF7B6C747E701605
GO
Isoform 5 (identifier: P29994-5) [UniParc]FASTAAdd to Basket

Also known as: SISIIA

The sequence of this isoform differs from the canonical sequence as follows:
     1716-1716: Missing.
     1717-1732: Missing.

Show »
Length:2,733
Mass (Da):311,210
Checksum:i3BE4A15DD99264F5
GO
Isoform 6 (identifier: P29994-6) [UniParc]FASTAAdd to Basket

Also known as: SI-SIIA

The sequence of this isoform differs from the canonical sequence as follows:
     322-336: Missing.
     1716-1716: Missing.
     1717-1732: Missing.

Show »
Length:2,718
Mass (Da):309,444
Checksum:iFBE35154A6AF0190
GO
Isoform 7 (identifier: P29994-7) [UniParc]FASTAAdd to Basket

Also known as: SISII

The sequence of this isoform differs from the canonical sequence as follows:
     1693-1715: Missing.
     1716-1716: Missing.
     1717-1732: Missing.

Show »
Length:2,710
Mass (Da):308,674
Checksum:i6A7FF31BC8448BFD
GO
Isoform 8 (identifier: P29994-8) [UniParc]FASTAAdd to Basket

Also known as: SI-SII

The sequence of this isoform differs from the canonical sequence as follows:
     322-336: Missing.
     1693-1715: Missing.
     1716-1716: Missing.
     1717-1732: Missing.

Show »
Length:2,695
Mass (Da):306,909
Checksum:i81B8B4551AB0814F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1372 – 13721Missing in all but PI17 clones. 1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei322 – 33615Missing in isoform 2, isoform 4, isoform 6 and isoform 8.
VSP_002695Add
BLAST
Alternative sequencei1693 – 171523Missing in isoform 7 and isoform 8.
VSP_002696Add
BLAST
Alternative sequencei1716 – 17161Missing in isoform 3, isoform 4, isoform 5, isoform 6, isoform 7 and isoform 8.
VSP_002697
Alternative sequencei1717 – 173216Missing in isoform 5, isoform 6, isoform 7 and isoform 8.
VSP_002698Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1764 – 17641P → R in AAA41447. 1 Publication
Sequence conflicti1764 – 17641P → R in AAA41448. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05510 mRNA. Translation: AAA41358.1.
J05510 mRNA. Translation: AAA41357.1.
M64699 mRNA. Translation: AAA41447.1.
M64698 mRNA. Translation: AAA41448.1.
U38653 mRNA. Translation: AAC53099.1.
U38812 mRNA. Translation: AAC53100.1.
U38665 mRNA. Translation: AAB51330.1.
PIRiA36579.
B36579.
RefSeqiNP_001257526.1. NM_001270597.1.
UniGeneiRn.2135.

Genome annotation databases

GeneIDi25262.
KEGGirno:25262.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05510 mRNA. Translation: AAA41358.1 .
J05510 mRNA. Translation: AAA41357.1 .
M64699 mRNA. Translation: AAA41447.1 .
M64698 mRNA. Translation: AAA41448.1 .
U38653 mRNA. Translation: AAC53099.1 .
U38812 mRNA. Translation: AAC53100.1 .
U38665 mRNA. Translation: AAB51330.1 .
PIRi A36579.
B36579.
RefSeqi NP_001257526.1. NM_001270597.1.
UniGenei Rn.2135.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3T8S X-ray 3.77 A/B 7-602 [» ]
3UJ0 X-ray 3.60 A/B 1-604 [» ]
3UJ4 X-ray 3.00 A/B 1-604 [» ]
ProteinModelPortali P29994.
SMRi P29994. Positions 7-225, 236-602.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 247302. 11 interactions.
DIPi DIP-29715N.
IntActi P29994. 1 interaction.
MINTi MINT-5026585.

Chemistry

BindingDBi P29994.
ChEMBLi CHEMBL2804.

PTM databases

PhosphoSitei P29994.

Proteomic databases

PaxDbi P29994.
PRIDEi P29994.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 25262.
KEGGi rno:25262.

Organism-specific databases

CTDi 3708.
RGDi 2933. Itpr1.

Phylogenomic databases

eggNOGi NOG280601.
HOGENOMi HOG000007660.
HOVERGENi HBG052158.
InParanoidi P29994.
KOi K04958.
PhylomeDBi P29994.

Enzyme and pathway databases

Reactomei REACT_194374. Role of phospholipids in phagocytosis.
REACT_194690. Ca2+ pathway.
REACT_203734. FCERI mediated Ca+2 mobilization.
REACT_211910. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_220575. DAG and IP3 signaling.
REACT_221588. PLC beta mediated events.

Miscellaneous databases

NextBioi 605915.
PROi P29994.

Gene expression databases

Genevestigatori P29994.

Family and domain databases

Gene3Di 1.25.10.30. 2 hits.
InterProi IPR016024. ARM-type_fold.
IPR014821. Ins145_P3_rcpt.
IPR000493. InsP3_rcpt-bd.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view ]
PANTHERi PTHR13715. PTHR13715. 1 hit.
Pfami PF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
[Graphical view ]
PRINTSi PR00779. INSP3RECEPTR.
SMARTi SM00472. MIR. 4 hits.
[Graphical view ]
SUPFAMi SSF100909. SSF100909. 2 hits.
SSF48371. SSF48371. 4 hits.
SSF82109. SSF82109. 2 hits.
PROSITEi PS50919. MIR. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and expression of the rat inositol 1,4,5-trisphosphate receptor."
    Mignery G.A., Newton C.L., Archer B.T. III, Suedhof T.C.
    J. Biol. Chem. 265:12679-12685(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), VARIANT PHE-1372 DEL.
  2. "Inositol 1,4,5-trisphosphate receptors: distinct neuronal and nonneuronal forms derived by alternative splicing differ in phosphorylation."
    Danoff S.K., Ferris C.D., Donath C., Fischer G.A., Munemitsu S., Ullrich A., Snyder S.H., Ross C.A.
    Proc. Natl. Acad. Sci. U.S.A. 88:2951-2955(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 7).
    Tissue: Brain.
  3. "Inositol 1,4,5-trisphosphate receptor expression in mammalian olfactory tissue."
    Smutzer G., Zimmerman J.E., Hahn C.-G., Ruscheinsky D.D., Rodriguez A., Han L.-Y., Arnold S.E.
    Brain Res. Mol. Brain Res. 44:347-354(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4; 7 AND 8).
    Strain: Sprague-Dawley.
  4. "Subunit oligomerization, and topology of the inositol 1,4, 5-trisphosphate receptor."
    Galvan D.L., Borrego-Diaz E., Perez P.J., Mignery G.A.
    J. Biol. Chem. 274:29483-29492(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  5. "Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels."
    Yang J., McBride S., Mak D.-O.D., Vardi N., Palczewski K., Haeseleer F., Foskett J.K.
    Proc. Natl. Acad. Sci. U.S.A. 99:7711-7716(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CABP1.
  6. "Mass spectrometric analysis of type 1 inositol 1,4,5-trisphosphate receptor ubiquitination."
    Sliter D.A., Kubota K., Kirkpatrick D.S., Alzayady K.J., Gygi S.P., Wojcikiewicz R.J.
    J. Biol. Chem. 283:35319-35328(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION AT LYS-916; LYS-962; LYS-1572; LYS-1772; LYS-1885; LYS-1886; LYS-1887; LYS-1902; LYS-1925; LYS-2119 AND LYS-2258.

Entry informationi

Entry nameiITPR1_RAT
AccessioniPrimary (citable) accession number: P29994
Secondary accession number(s): Q62869
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 2, 2001
Last modified: September 3, 2014
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium-binding protein which then inhibits the receptor.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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