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P29994

- ITPR1_RAT

UniProt

P29994 - ITPR1_RAT

Protein

Inositol 1,4,5-trisphosphate receptor type 1

Gene

Itpr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 2 (02 Nov 2001)
      Previous versions | rss
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    Functioni

    Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways By similarity.By similarity

    GO - Molecular functioni

    1. inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Source: UniProtKB
    2. intracellular ligand-gated calcium channel activity Source: UniProtKB
    3. phosphatidylinositol binding Source: UniProtKB
    4. protein binding Source: RGD
    5. protein complex binding Source: RGD
    6. protein C-terminus binding Source: RGD
    7. protein phosphatase binding Source: RGD

    GO - Biological processi

    1. cellular response to cAMP Source: RGD
    2. cellular response to hypoxia Source: RGD
    3. inositol phosphate-mediated signaling Source: GOC
    4. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: UniProtKB
    5. negative regulation of neuron death Source: RGD
    6. positive regulation of calcium ion transport Source: RGD
    7. positive regulation of cytosolic calcium ion concentration Source: RGD
    8. release of sequestered calcium ion into cytosol Source: BHF-UCL

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Apoptosis, Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_194374. Role of phospholipids in phagocytosis.
    REACT_194690. Ca2+ pathway.
    REACT_203734. FCERI mediated Ca+2 mobilization.
    REACT_211910. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_220575. DAG and IP3 signaling.
    REACT_221588. PLC beta mediated events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol 1,4,5-trisphosphate receptor type 1
    Alternative name(s):
    IP3 receptor isoform 1
    Short name:
    IP-3-R
    Short name:
    IP3R 1
    Short name:
    InsP3R1
    Type 1 inositol 1,4,5-trisphosphate receptor
    Short name:
    Type 1 InsP3 receptor
    Gene namesi
    Name:Itpr1
    Synonyms:Insp3r
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2933. Itpr1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. dendrite Source: RGD
    3. endoplasmic reticulum membrane Source: RGD
    4. integral component of membrane Source: UniProtKB-KW
    5. intracellular membrane-bounded organelle Source: RGD
    6. membrane raft Source: RGD
    7. neuronal cell body Source: RGD
    8. nuclear envelope Source: RGD
    9. perinuclear region of cytoplasm Source: RGD
    10. plasma membrane Source: RGD
    11. postsynaptic density Source: RGD
    12. protein complex Source: RGD
    13. sarcoplasmic reticulum Source: RGD
    14. secretory granule membrane Source: RGD
    15. synaptic membrane Source: RGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 27502750Inositol 1,4,5-trisphosphate receptor type 1PRO_0000153922Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei482 – 4821PhosphotyrosineSequence Analysis
    Cross-linki916 – 916Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Cross-linki962 – 962Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Cross-linki1572 – 1572Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Modified residuei1589 – 15891PhosphoserineBy similarity
    Modified residuei1756 – 17561Phosphoserine; by PKASequence Analysis
    Cross-linki1772 – 1772Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Cross-linki1885 – 1885Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Cross-linki1886 – 1886Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Cross-linki1887 – 1887Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Cross-linki1902 – 1902Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Cross-linki1925 – 1925Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Cross-linki2119 – 2119Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Cross-linki2258 – 2258Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Modified residuei2656 – 26561PhosphotyrosineSequence Analysis

    Post-translational modificationi

    Phosphorylated by cAMP kinase. Phosphorylation prevents the ligand-induced opening of the calcium channels.
    Phosphorylated on tyrosine residues.By similarity
    Ubiquitination at multiple lysines targets ITPR1 for proteasomal degradation. Approximately 40% of the ITPR1-associated ubiquitin is monoubiquitin, and polyubiquitins are both 'Lys-48'- and 'Lys-63'-linked.1 Publication

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiP29994.
    PRIDEiP29994.

    PTM databases

    PhosphoSiteiP29994.

    Expressioni

    Tissue specificityi

    Isoform 3 is found in the brain while isoform 7 is found in the fetal brain and peripheral tissues.

    Gene expression databases

    GenevestigatoriP29994.

    Interactioni

    Subunit structurei

    Homotetramer. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Interacts with ERP44 in a pH-, redox state- and calcium-dependent manner which results in the inhibition the calcium channel activity. The strength of this interaction inversely correlates with calcium concentration. Interacts with CABP1. Interacts with AHCYL1 and MRVI1 By similarity. Interacts with TESPA1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi247302. 11 interactions.
    DIPiDIP-29715N.
    IntActiP29994. 1 interaction.
    MINTiMINT-5026585.

    Structurei

    Secondary structure

    1
    2750
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi14 – 2310
    Beta strandi25 – 306
    Beta strandi36 – 394
    Turni41 – 433
    Helixi53 – 564
    Beta strandi57 – 615
    Helixi67 – 748
    Helixi87 – 10822
    Turni109 – 1124
    Beta strandi120 – 1256
    Turni126 – 1294
    Beta strandi130 – 13910
    Beta strandi141 – 1433
    Beta strandi147 – 1548
    Helixi157 – 1593
    Beta strandi161 – 1677
    Beta strandi181 – 1899
    Beta strandi193 – 1997
    Beta strandi201 – 2033
    Beta strandi207 – 2137
    Beta strandi217 – 2248
    Helixi226 – 2283
    Beta strandi239 – 2446
    Turni245 – 2484
    Beta strandi249 – 2568
    Beta strandi259 – 2657
    Helixi278 – 2803
    Beta strandi281 – 2866
    Beta strandi302 – 3076
    Turni308 – 3103
    Beta strandi313 – 3186
    Beta strandi353 – 3597
    Helixi364 – 3663
    Beta strandi368 – 3747
    Beta strandi387 – 3926
    Turni393 – 3953
    Beta strandi398 – 4069
    Beta strandi408 – 4125
    Beta strandi415 – 4239
    Beta strandi430 – 4345
    Helixi437 – 46226
    Helixi467 – 48317
    Helixi504 – 5129
    Helixi515 – 5228
    Helixi552 – 56211
    Turni563 – 5664
    Helixi568 – 5758

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3T8SX-ray3.77A/B7-602[»]
    3UJ0X-ray3.60A/B1-604[»]
    3UJ4X-ray3.00A/B1-604[»]
    ProteinModelPortaliP29994.
    SMRiP29994. Positions 7-225, 236-602.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 22742274CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini2296 – 230611LumenalSequence AnalysisAdd
    BLAST
    Topological domaini2328 – 235326CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini2375 – 239723LumenalSequence AnalysisAdd
    BLAST
    Topological domaini2419 – 244022CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini2462 – 2569108LumenalSequence AnalysisAdd
    BLAST
    Topological domaini2591 – 2750160CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2275 – 229521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei2307 – 232721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei2354 – 237421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei2398 – 241821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei2441 – 246121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei2570 – 259021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini112 – 16655MIR 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini173 – 22351MIR 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini231 – 28757MIR 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini294 – 37380MIR 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini379 – 43557MIR 5PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni265 – 2695Inositol 1,4,5-trisphosphate bindingBy similarity
    Regioni508 – 5114Inositol 1,4,5-trisphosphate bindingBy similarity
    Regioni567 – 5693Inositol 1,4,5-trisphosphate bindingBy similarity
    Regioni2464 – 252966Interaction with ERP44Add
    BLAST

    Domaini

    The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

    Sequence similaritiesi

    Belongs to the InsP3 receptor family.Curated
    Contains 5 MIR domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG280601.
    HOGENOMiHOG000007660.
    HOVERGENiHBG052158.
    InParanoidiP29994.
    KOiK04958.
    PhylomeDBiP29994.

    Family and domain databases

    Gene3Di1.25.10.30. 2 hits.
    InterProiIPR016024. ARM-type_fold.
    IPR014821. Ins145_P3_rcpt.
    IPR000493. InsP3_rcpt-bd.
    IPR005821. Ion_trans_dom.
    IPR016093. MIR_motif.
    IPR013662. RIH_assoc-dom.
    IPR000699. RIH_dom.
    IPR015925. Ryanodine_recept-rel.
    [Graphical view]
    PANTHERiPTHR13715. PTHR13715. 1 hit.
    PfamiPF08709. Ins145_P3_rec. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF02815. MIR. 1 hit.
    PF08454. RIH_assoc. 1 hit.
    PF01365. RYDR_ITPR. 2 hits.
    [Graphical view]
    PRINTSiPR00779. INSP3RECEPTR.
    SMARTiSM00472. MIR. 4 hits.
    [Graphical view]
    SUPFAMiSSF100909. SSF100909. 2 hits.
    SSF48371. SSF48371. 4 hits.
    SSF82109. SSF82109. 2 hits.
    PROSITEiPS50919. MIR. 5 hits.
    [Graphical view]

    Sequences (8)i

    Sequence statusi: Complete.

    This entry describes 8 isoformsi produced by alternative splicing. Align

    Note: There is a combination of two alternatively spliced domains at site SI and site SII (A, B and C). Experimental confirmation may be lacking for some isoforms.

    Isoform 1 (identifier: P29994-1) [UniParc]FASTAAdd to Basket

    Also known as: SISIIABC

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PEAGDLNNPP     50
    KKFRDCLFKL CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK 100
    KQNETENRKL LGTVIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT 150
    LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD KVVLNPVNAG QPLHASSHQL 200
    VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV RLFHAEQEKF 250
    LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 300
    SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVDPDQDAS RSRLRNAQEK 350
    MVYSLVSVPE GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH 400
    STNIPIDKEE EKPVMLKIGT SPLKEDKEAF AIVPVSPAEV RDLDFANDAS 450
    KVLGSIAGKL EKGTITQNER RSVTKLLEDL VYFVTGGTNS GQDVLEVVFS 500
    KPNRERQKLM REQNILKQIF KLLQAPFTDC GDGPMLRLEE LGDQRHAPFR 550
    HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH 600
    NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE 650
    LICKAVLNPT NADILIETKL VLSRFEFEGV STGENALEAG EDEEEVWLFW 700
    RDSNKEIRSK SVRELAQDAK EGQKEDRDVL SYYRYQLNLF ARMCLDRQYL 750
    AINEISGQLD VDLILRCMSD ENLPYDLRAS FCRLMLHMHV DRDPQEQVTP 800
    VKYARLWSEI PSEIAIDDYD SSGASKDEIK ERFAQTMEFV EEYLRDVVCQ 850
    RFPFSDKEKN KLTFEVVNLA RNLIYFGFYN FSDLLRLTKI LLAILDCVHV 900
    TTIFPISKMT KGEENKGSNV MRSIHGVGEL MTQVVLRGGG FLPMTPMAAA 950
    PEGNVKQAEP EKEDIMVMDT KLKIIEILQF ILNVRLDYRI SCLLCIFKRE 1000
    FDESNSQSSE TSSGNSSQEG PSNVPGALDF EHIEEQAEGI FGGSEENTPL 1050
    DLDDHGGRTF LRVLLHLTMH DYPPLVSGAL QLLFRHFSQR QEVLQAFKQV 1100
    QLLVTSQDVD NYKQIKQDLD QLRSIVEKSE LWVYKGQGPD EPMDGASGEN 1150
    EHKKTEEGTS KPLKHESTSS YNYRVVKEIL IRLSKLCVQE SASVRKSRKQ 1200
    QQRLLRNMGA HAVVLELLQI PYEKAEDTKM QEIMRLAHEF LQNFCAGNQQ 1250
    NQALLHKHIN LFLNPGILEA VTMQHIFMNN FQLCSEINER VVQHFVHCIE 1300
    THGRNVQYIK FLQTIVKAEG KFIKKCQDMV MAELVNSGED VLVFYNDRAS 1350
    FQTLIQMMRS ERDRMDENSP LFMYHIHLVE LLAVCTEGKN VYTEIKCNSL 1400
    LPLDDIVRVV THEDCIPEVK IAYINFLNHC YVDTEVEMKE IYTSNHMWKL 1450
    FENFLVDICR ACNNTSDRKH ADSVLEKYVT EIVMSIVTTF FSSPFSDQST 1500
    TLQTRQPVFV QLLQGVFRVY HCNWLMPSQK ASVESCIRVL SDVAKSRAIA 1550
    IPVDLDSQVN NLFLKSHNIV QKTAMNWRLS ARNAARRDSV LAASRDYRNI 1600
    IERLQDIVSA LEDRLRPLVQ AELSVLVDVL HRPELLFPEN TDARRKCESG 1650
    GFICKLIKHT KQLLEENEEK LCIKVLQTLR EMMTKDRGYG EKQISIDELE 1700
    NAELPQPPEA ENSTEQELEP SPPLRQLEDH KRGEALRQIL VNRYYGNIRP 1750
    SGRRESLTSF GNGPLSPGGP SKPGGGGGGP GSGSTSRGEM SLAEVQCHLD 1800
    KEGASNLVID LIMNASSDRV FHESILLAIA LLEGGNTTIQ HSFFCRLTED 1850
    KKSEKFFKVF YDRMKVAQQE IKATVTVNTS DLGNKKKDDE VDRDAPSRKK 1900
    AKEPTTQITE EVRDQLLEAS AATRKAFTTF RREADPDDHY QSGEGTQATT 1950
    DKAKDDLEMS AVITIMQPIL RFLQLLCENH NRDLQNFLRC QNNKTNYNLV 2000
    CETLQFLDCI CGSTTGGLGL LGLYINEKNV ALINQTLESL TEYCQGPCHE 2050
    NQNCIATHES NGIDIITALI LNDINPLGKK RMDLVLELKN NASKLLLAIM 2100
    ESRHDSENAE RILYNMRPKE LVEVIKKAYM QGEVEFEDGE NGEDGAASPR 2150
    NVGHNIYILA HQLARHNKEL QTMLKPGGQV DGDEALEFYA KHTAQIEIVR 2200
    LDRTMEQIVF PVPSICEFLT KESKLRIYYT TERDEQGSKI NDFFLRSEDL 2250
    FNEMNWQKKL RAQPVLYWCA RNMSFWSSIS FNLAVLMNLL VAFFYPFKGV 2300
    RGGTLEPHWS GLLWTAMLIS LAIVIALPKP HGIRALIAST ILRLIFSVGL 2350
    QPTLFLLGAF NVCNKIIFLM SFVGNCGTFT RGYRAMVLDV EFLYHLLYLL 2400
    ICAMGLFVHE FFYSLLLFDL VYREETLLNV IKSVTRNGRP IILTAALALI 2450
    LVYLFSIVGY LFFKDDFILE VDRLPNETAG PETGESLAND FLYSDVCRVE 2500
    TGENCTSPAP KEELLPVEET EQDKEHTCET LLMCIVTVLS HGLRSGGGVG 2550
    DVLRKPSKEE PLFAARVIYD LLFFFMVIII VLNLIFGVII DTFADLRSEK 2600
    QKKEEILKTT CFICGLERDK FDNKTVTFEE HIKEEHNMWH YLCFIVLVKV 2650
    KDSTEYTGPE SYVAEMIRER NLDWFPRMRA MSLVSSDSEG EQNELRNLQE 2700
    KLESTMKLVT NLSGQLSELK DQMTEQRKQK QRIGLLGHPP HMNVNPQQPA 2750
    Length:2,750
    Mass (Da):313,264
    Last modified:November 2, 2001 - v2
    Checksum:i174BB77CBF6F21AC
    GO
    Isoform 2 (identifier: P29994-2) [UniParc]FASTAAdd to Basket

    Also known as: SI-SIIABC

    The sequence of this isoform differs from the canonical sequence as follows:
         322-336: Missing.

    Show »
    Length:2,735
    Mass (Da):311,498
    Checksum:iA80CC16884635058
    GO
    Isoform 3 (identifier: P29994-3) [UniParc]FASTAAdd to Basket

    Also known as: SISIIAC

    The sequence of this isoform differs from the canonical sequence as follows:
         1716-1716: Missing.

    Show »
    Length:2,749
    Mass (Da):313,136
    Checksum:iE80D784F7201E2C9
    GO
    Isoform 4 (identifier: P29994-4) [UniParc]FASTAAdd to Basket

    Also known as: SI-SIIAC

    The sequence of this isoform differs from the canonical sequence as follows:
         322-336: Missing.
         1716-1716: Missing.

    Show »
    Length:2,734
    Mass (Da):311,370
    Checksum:iEF7B6C747E701605
    GO
    Isoform 5 (identifier: P29994-5) [UniParc]FASTAAdd to Basket

    Also known as: SISIIA

    The sequence of this isoform differs from the canonical sequence as follows:
         1716-1716: Missing.
         1717-1732: Missing.

    Show »
    Length:2,733
    Mass (Da):311,210
    Checksum:i3BE4A15DD99264F5
    GO
    Isoform 6 (identifier: P29994-6) [UniParc]FASTAAdd to Basket

    Also known as: SI-SIIA

    The sequence of this isoform differs from the canonical sequence as follows:
         322-336: Missing.
         1716-1716: Missing.
         1717-1732: Missing.

    Show »
    Length:2,718
    Mass (Da):309,444
    Checksum:iFBE35154A6AF0190
    GO
    Isoform 7 (identifier: P29994-7) [UniParc]FASTAAdd to Basket

    Also known as: SISII

    The sequence of this isoform differs from the canonical sequence as follows:
         1693-1715: Missing.
         1716-1716: Missing.
         1717-1732: Missing.

    Show »
    Length:2,710
    Mass (Da):308,674
    Checksum:i6A7FF31BC8448BFD
    GO
    Isoform 8 (identifier: P29994-8) [UniParc]FASTAAdd to Basket

    Also known as: SI-SII

    The sequence of this isoform differs from the canonical sequence as follows:
         322-336: Missing.
         1693-1715: Missing.
         1716-1716: Missing.
         1717-1732: Missing.

    Show »
    Length:2,695
    Mass (Da):306,909
    Checksum:i81B8B4551AB0814F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1764 – 17641P → R in AAA41447. (PubMed:1849282)Curated
    Sequence conflicti1764 – 17641P → R in AAA41448. (PubMed:1849282)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1372 – 13721Missing in all but PI17 clones. 1 Publication

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei322 – 33615Missing in isoform 2, isoform 4, isoform 6 and isoform 8. 1 PublicationVSP_002695Add
    BLAST
    Alternative sequencei1693 – 171523Missing in isoform 7 and isoform 8. CuratedVSP_002696Add
    BLAST
    Alternative sequencei1716 – 17161Missing in isoform 3, isoform 4, isoform 5, isoform 6, isoform 7 and isoform 8. 1 PublicationVSP_002697
    Alternative sequencei1717 – 173216Missing in isoform 5, isoform 6, isoform 7 and isoform 8. CuratedVSP_002698Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05510 mRNA. Translation: AAA41358.1.
    J05510 mRNA. Translation: AAA41357.1.
    M64699 mRNA. Translation: AAA41447.1.
    M64698 mRNA. Translation: AAA41448.1.
    U38653 mRNA. Translation: AAC53099.1.
    U38812 mRNA. Translation: AAC53100.1.
    U38665 mRNA. Translation: AAB51330.1.
    PIRiA36579.
    B36579.
    RefSeqiNP_001257526.1. NM_001270597.1.
    UniGeneiRn.2135.

    Genome annotation databases

    GeneIDi25262.
    KEGGirno:25262.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05510 mRNA. Translation: AAA41358.1 .
    J05510 mRNA. Translation: AAA41357.1 .
    M64699 mRNA. Translation: AAA41447.1 .
    M64698 mRNA. Translation: AAA41448.1 .
    U38653 mRNA. Translation: AAC53099.1 .
    U38812 mRNA. Translation: AAC53100.1 .
    U38665 mRNA. Translation: AAB51330.1 .
    PIRi A36579.
    B36579.
    RefSeqi NP_001257526.1. NM_001270597.1.
    UniGenei Rn.2135.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3T8S X-ray 3.77 A/B 7-602 [» ]
    3UJ0 X-ray 3.60 A/B 1-604 [» ]
    3UJ4 X-ray 3.00 A/B 1-604 [» ]
    ProteinModelPortali P29994.
    SMRi P29994. Positions 7-225, 236-602.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 247302. 11 interactions.
    DIPi DIP-29715N.
    IntActi P29994. 1 interaction.
    MINTi MINT-5026585.

    Chemistry

    BindingDBi P29994.
    ChEMBLi CHEMBL2804.

    PTM databases

    PhosphoSitei P29994.

    Proteomic databases

    PaxDbi P29994.
    PRIDEi P29994.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 25262.
    KEGGi rno:25262.

    Organism-specific databases

    CTDi 3708.
    RGDi 2933. Itpr1.

    Phylogenomic databases

    eggNOGi NOG280601.
    HOGENOMi HOG000007660.
    HOVERGENi HBG052158.
    InParanoidi P29994.
    KOi K04958.
    PhylomeDBi P29994.

    Enzyme and pathway databases

    Reactomei REACT_194374. Role of phospholipids in phagocytosis.
    REACT_194690. Ca2+ pathway.
    REACT_203734. FCERI mediated Ca+2 mobilization.
    REACT_211910. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_220575. DAG and IP3 signaling.
    REACT_221588. PLC beta mediated events.

    Miscellaneous databases

    NextBioi 605915.
    PROi P29994.

    Gene expression databases

    Genevestigatori P29994.

    Family and domain databases

    Gene3Di 1.25.10.30. 2 hits.
    InterProi IPR016024. ARM-type_fold.
    IPR014821. Ins145_P3_rcpt.
    IPR000493. InsP3_rcpt-bd.
    IPR005821. Ion_trans_dom.
    IPR016093. MIR_motif.
    IPR013662. RIH_assoc-dom.
    IPR000699. RIH_dom.
    IPR015925. Ryanodine_recept-rel.
    [Graphical view ]
    PANTHERi PTHR13715. PTHR13715. 1 hit.
    Pfami PF08709. Ins145_P3_rec. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF02815. MIR. 1 hit.
    PF08454. RIH_assoc. 1 hit.
    PF01365. RYDR_ITPR. 2 hits.
    [Graphical view ]
    PRINTSi PR00779. INSP3RECEPTR.
    SMARTi SM00472. MIR. 4 hits.
    [Graphical view ]
    SUPFAMi SSF100909. SSF100909. 2 hits.
    SSF48371. SSF48371. 4 hits.
    SSF82109. SSF82109. 2 hits.
    PROSITEi PS50919. MIR. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression of the rat inositol 1,4,5-trisphosphate receptor."
      Mignery G.A., Newton C.L., Archer B.T. III, Suedhof T.C.
      J. Biol. Chem. 265:12679-12685(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), VARIANT PHE-1372 DEL.
    2. "Inositol 1,4,5-trisphosphate receptors: distinct neuronal and nonneuronal forms derived by alternative splicing differ in phosphorylation."
      Danoff S.K., Ferris C.D., Donath C., Fischer G.A., Munemitsu S., Ullrich A., Snyder S.H., Ross C.A.
      Proc. Natl. Acad. Sci. U.S.A. 88:2951-2955(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 7).
      Tissue: Brain.
    3. "Inositol 1,4,5-trisphosphate receptor expression in mammalian olfactory tissue."
      Smutzer G., Zimmerman J.E., Hahn C.-G., Ruscheinsky D.D., Rodriguez A., Han L.-Y., Arnold S.E.
      Brain Res. Mol. Brain Res. 44:347-354(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4; 7 AND 8).
      Strain: Sprague-Dawley.
    4. "Subunit oligomerization, and topology of the inositol 1,4, 5-trisphosphate receptor."
      Galvan D.L., Borrego-Diaz E., Perez P.J., Mignery G.A.
      J. Biol. Chem. 274:29483-29492(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    5. "Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels."
      Yang J., McBride S., Mak D.-O.D., Vardi N., Palczewski K., Haeseleer F., Foskett J.K.
      Proc. Natl. Acad. Sci. U.S.A. 99:7711-7716(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CABP1.
    6. "Mass spectrometric analysis of type 1 inositol 1,4,5-trisphosphate receptor ubiquitination."
      Sliter D.A., Kubota K., Kirkpatrick D.S., Alzayady K.J., Gygi S.P., Wojcikiewicz R.J.
      J. Biol. Chem. 283:35319-35328(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION AT LYS-916; LYS-962; LYS-1572; LYS-1772; LYS-1885; LYS-1886; LYS-1887; LYS-1902; LYS-1925; LYS-2119 AND LYS-2258.

    Entry informationi

    Entry nameiITPR1_RAT
    AccessioniPrimary (citable) accession number: P29994
    Secondary accession number(s): Q62869
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: November 2, 2001
    Last modified: October 1, 2014
    This is version 145 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium-binding protein which then inhibits the receptor.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3