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Protein

Inositol 1,4,5-trisphosphate receptor

Gene

Itp-r83A

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. May be involved in visual and olfactory transduction, and myoblast proliferation.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular calcium ion homeostasis Source: FlyBase
  • fatty acid homeostasis Source: FlyBase
  • flight behavior Source: FlyBase
  • larval feeding behavior Source: FlyBase
  • molting cycle, chitin-based cuticle Source: FlyBase
  • mushroom body development Source: FlyBase
  • nuclear division Source: FlyBase
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: FlyBase
  • positive regulation of ecdysteroid secretion Source: FlyBase
  • regulation of feeding behavior Source: FlyBase
  • release of sequestered calcium ion into cytosol Source: FlyBase
  • response to oxidative stress Source: FlyBase
  • response to starvation Source: FlyBase
  • salivary gland cell autophagic cell death Source: FlyBase
  • sensory perception of smell Source: UniProtKB-KW
  • sensory perception of taste Source: FlyBase
  • stabilization of membrane potential Source: FlyBase
  • visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Developmental protein, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Calcium transport, Ion transport, Olfaction, Sensory transduction, Transport, Vision

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-DME-114508. Effects of PIP2 hydrolysis.
R-DME-139853. Elevation of cytosolic Ca2+ levels.
R-DME-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-DME-5578775. Ion homeostasis.
R-DME-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Protein family/group databases

TCDBi1.A.3.2.2. the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol 1,4,5-trisphosphate receptor
Alternative name(s):
InsP3 receptor
Short name:
IP3R
Short name:
InsP3R
Gene namesi
Name:Itp-r83A
Synonyms:dip, InsP3R, itpr
ORF Names:CG1063
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0010051. Itp-r83A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 23662366CytoplasmicSequence analysisAdd
BLAST
Transmembranei2367 – 238721HelicalSequence analysisAdd
BLAST
Topological domaini2388 – 239811ExtracellularSequence analysisAdd
BLAST
Transmembranei2399 – 241921HelicalSequence analysisAdd
BLAST
Topological domaini2420 – 243415CytoplasmicSequence analysisAdd
BLAST
Transmembranei2435 – 245521HelicalSequence analysisAdd
BLAST
Topological domaini2456 – 248732ExtracellularSequence analysisAdd
BLAST
Transmembranei2488 – 250821HelicalSequence analysisAdd
BLAST
Topological domaini2509 – 253123CytoplasmicSequence analysisAdd
BLAST
Transmembranei2532 – 255221HelicalSequence analysisAdd
BLAST
Topological domaini2553 – 2659107ExtracellularSequence analysisAdd
BLAST
Transmembranei2660 – 268021HelicalSequence analysisAdd
BLAST
Topological domaini2681 – 2838158CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 28382838Inositol 1,4,5-trisphosphate receptorPRO_0000153931Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP29993.
PRIDEiP29993.

Expressioni

Tissue specificityi

Segmental expression of isoform B is first detected in stage 13 embryos in lateral and posterior epidermis. Expression extends to head region during stages 13-17: gnathal buds, clypeolabrum, procephalic lobe, labial organ and anterior sense organs. Adults exhibit high expression in antenna and lower expression in retina, head, legs and thorax.2 Publications

Developmental stagei

Isoform A is expressed only in early embryos. Isoform B is expressed from mid-late embryos to adults. Predominant expression is in the adult.1 Publication

Gene expression databases

BgeeiP29993.
GenevisibleiP29993. DM.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

BioGridi65871. 2 interactions.
IntActiP29993. 5 interactions.
STRINGi7227.FBpp0078336.

Structurei

3D structure databases

ProteinModelPortaliP29993.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini115 – 17056MIR 1PROSITE-ProRule annotationAdd
BLAST
Domaini177 – 22953MIR 2PROSITE-ProRule annotationAdd
BLAST
Domaini237 – 29357MIR 3PROSITE-ProRule annotationAdd
BLAST
Domaini300 – 35960MIR 4PROSITE-ProRule annotationAdd
BLAST
Domaini398 – 45457MIR 5PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni272 – 2765Inositol 1,4,5-trisphosphate bindingBy similarity
Regioni530 – 5334Inositol 1,4,5-trisphosphate bindingBy similarity
Regioni591 – 5933Inositol 1,4,5-trisphosphate bindingBy similarity

Domaini

The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

Sequence similaritiesi

Belongs to the InsP3 receptor family.Curated
Contains 5 MIR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3533. Eukaryota.
ENOG410XR97. LUCA.
InParanoidiP29993.
KOiK04958.
OrthoDBiEOG76HQ0M.
PhylomeDBiP29993.

Family and domain databases

Gene3Di1.25.10.30. 2 hits.
InterProiIPR014821. Ins145_P3_rcpt.
IPR000493. InsP3_rcpt-bd.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 5 hits.
PfamiPF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
[Graphical view]
PRINTSiPR00779. INSP3RECEPTR.
SMARTiSM00472. MIR. 4 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50919. MIR. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B (identifier: P29993-1) [UniParc]FASTAAdd to basket

Also known as: Head

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDNIIGSAS FLHLGDIVSL YAEGSVCGFL STLGLVDDRT VVCPEAGDLS
60 70 80 90 100
CPPKKFRDCL IKICPMNRYS AQKQFWKAAK QSASSNTDPN LLKRLHHAAE
110 120 130 140 150
IEKKQNETEN KKLLGTSIQY GRAVVQLLHL KSNKYLTVNK RLPSLLEKNA
160 170 180 190 200
MRVYLDANGN EGSWFYIKPF YKLRSIGDYV VVVGDKVILS PVNADQQNLH
210 220 230 240 250
VAANYELPDN PGCKEVNVLN SSTSWKISLF MEHKENQEHI LKGGDVVRLF
260 270 280 290 300
HAEQEKFLTM DEYKKQYHVF LRTTGRTSAT AATSSKALWE IEVVQHDSCR
310 320 330 340 350
GGAGDWNSLY RFKHLATGHY LAAEAEIDVS AGAMSATSAS GHDLHLGDCS
360 370 380 390 400
KDSGLSCSTM NSTINDKPKG KQYRLVSVPY SADIASVFVL DATTMARPDS
410 420 430 440 450
LVPQSSYVRL QHICSNTWVH ATSIPIDADD DKPVMSMVCC SPIKEDKEAF
460 470 480 490 500
ALIPVSPVEV RDLDFANDAC KVLATVTSKL DNGSISINER RALISLLQDI
510 520 530 540 550
VYFIAGMENE QNKTKALEFT IKNPIRDRQK LLREQYILKQ LFKILQGPFQ
560 570 580 590 600
EHTAGDGPFL RLDELSDPKN SPYKNIFRLC YRILRLSQQD YRKNQEYIAK
610 620 630 640 650
HFGLMQKQIG YDILAEDTIT ALLHNNRKLL EKHITAAEIE TFVGLVRKNM
660 670 680 690 700
HNWDSRFLDY LSDLCVSNRK AIAVTQELIC KSVLSDKNKD ILIETQVKAL
710 720 730 740 750
RTGSGPVRCY KGNSEDVCLA TLAEDPGDDE DRSDVQSTST TTTWDSASLN
760 770 780 790 800
EDDGTPSTGD KYEIHLKWTG QPTSRSMADL ASCDGGELEA AILNYYRHQL
810 820 830 840 850
NLFSNMCLNR QYLALNELSP RLDIDLILKC MSDETMPYEL RASFCRLMLH
860 870 880 890 900
LHVDRDPQEP VTPVKYARLW SEIPSKMSIQ DYDGKNQQPD QNKQACRAKF
910 920 930 940 950
NTTIAFVENY LCNVATKVWL FTDQEQNKLT FEVVKLARDL IYFGFYSFSD
960 970 980 990 1000
LLRLTKTLLS ILDCVSDTSS GEFASTDIDS VEEETNAEAE GGVLRSIGDI
1010 1020 1030 1040 1050
NTVMTSLALG SVGQAIAAPT ISLQQRKSVS QLMKEYPLVM DTKLKIIEIL
1060 1070 1080 1090 1100
QFILDVRLDY RISCLLSIFK REFDESEVAA SAASNEASQQ QSQQQEPQTP
1110 1120 1130 1140 1150
GSSNETDPLD SAESVAAGAA AAAATTARQK NIDLESIGVQ AEGIFDCERS
1160 1170 1180 1190 1200
DAANLDLDGQ GGRTFLRVLL HLIMHDYAPL VSGALHLLFR HFSQRQEVLQ
1210 1220 1230 1240 1250
AFRQVQLLVS DSDVESYKQI KSDLDILRQS VEKSELWVYK AKATDELGAT
1260 1270 1280 1290 1300
DAGGDAVSLE YNAALSQEQR NEYRKVKEIL IRMNKFCVTA SGPGSVVKPR
1310 1320 1330 1340 1350
KHEQRLLRNV GVHTVVLDLL QNPYDEKDDE LMKELMCLAH EFLQNFCLGN
1360 1370 1380 1390 1400
QQNQVLLHNH LDLFLNPGIL EAKTVCAIFK DNLALCNEVT DKVVQHFVHC
1410 1420 1430 1440 1450
IEIHGRHVAY LQFLQTVVAA ENQFIRRCQD MVMQELINSG EDVLVFYNDK
1460 1470 1480 1490 1500
GSFNHFVQMM QQQMLGMEKL SDDSPLKYHV ELVKLLACCT MGKNVYTEIK
1510 1520 1530 1540 1550
CNNLLSLDDI VTIICHPLCM PEVKEAYVDF LNHCYIDTEV EMKEIYASGH
1560 1570 1580 1590 1600
MWSLFEKSFL VDINQLITNP AAASNKTLQA YVLNGVTNLL GSFFASPFSD
1610 1620 1630 1640 1650
QSAIVQSRQL IFVQLLQAAH RITQCRWLSL GDRFNVENCI RTLTESAKMR
1660 1670 1680 1690 1700
SIALPPELEQ QVATMSSKTA MLTRQTTKWL LASKQPKYEA QQAASLMRWD
1710 1720 1730 1740 1750
RSIIEGLQDI VSLLEDQLKP VVEAELSLLV DILYRSELLF PAGTEARKRC
1760 1770 1780 1790 1800
ESGGFIRKLI KHTEKLLEEK EERMCVKVLR TLREMMAIDV NYGEKGDALR
1810 1820 1830 1840 1850
QTLLLRYFQT KSTPRLPEDE VPLLAAPLMD PAKQNHLVTH GPGAKYLQRA
1860 1870 1880 1890 1900
GKTLHEMQNH LDREGASDLV VELVIKSVHS PNIFVEAVEL GIALLEGGNP
1910 1920 1930 1940 1950
IIQKGMFQKF LSDDLNQAFF KVFFEKMKDA QQEIKSTVTV NTTDIAAKAH
1960 1970 1980 1990 2000
EHKQDTNLEL DKIARKHGLK SNGVVITEEL KRELHNAGLA TARAYGNARN
2010 2020 2030 2040 2050
IHSGEESSAI SVNSPLEDIL AEKLEKHKDS RDQRNQLSNK VLVMQPILRF
2060 2070 2080 2090 2100
LQLLCENHNP DMQNLLRNQN NKTNNNLVSE TLMFLDCICG STTGGLGLLG
2110 2120 2130 2140 2150
LYINEHNLAL INQTLEALTE YCQGPCHENQ NCIATHESNG LDIITALILN
2160 2170 2180 2190 2200
NINPLGENRM DLVLELKNNA SKLLLAIMES RGDSENAERI LYNMNPKQLV
2210 2220 2230 2240 2250
EVACKAYHQE ELIDEQDDGD EPDAGSDDDD ATVSPREVGH NIYILCHQLA
2260 2270 2280 2290 2300
QHNKELAGLL KASEDPQSAS FDAKTSQALM YYATHTAQIE IVRNDRTLEQ
2310 2320 2330 2340 2350
IVFPIPEICE YLTTDTKIKI LNTAERDDQG SKLADFFDKA EEMFNEMKWQ
2360 2370 2380 2390 2400
KKLRSQPLLF WISSYMSLWS NILFNCVVVI NMIVAFFYPF DNTVPELSSH
2410 2420 2430 2440 2450
ISLLFWIITI FSLVIVLALP RESGIRTFIG SVILRFIFLL GPESTLCLLG
2460 2470 2480 2490 2500
VVTVTLKSVH IVSIMGNKGT LEKQLIKIIT DFQLLYHCIY IAFCFCGLIF
2510 2520 2530 2540 2550
HPFFYSLLLF DVVYREETLV NVIRSVTRNG RSIVLTAVLA LILVYLFSII
2560 2570 2580 2590 2600
GYMFFKDDFL VSVDFEEQDN APPPSVPLTL SVPVSGDSCS APDDLGNCQA
2610 2620 2630 2640 2650
AKEVAPPSAG GGEVKERSCD SLVMCIVTTL NQGLRNGGGI GDILRAPSSK
2660 2670 2680 2690 2700
EGLFVARVIY DLLFFFIVII IVLNLIFGVI IDTFADLRSE KQQKEAILKT
2710 2720 2730 2740 2750
TCFICSLNRS AFDNKTVSFE EHIKSEHNMW HYLYFIVLVK VKDPTEFTGP
2760 2770 2780 2790 2800
ESYVYAMVKA GILEWFPRLR AMSLAAVDAD GEQIELRSMQ AQLLDTQLLI
2810 2820 2830
KNLSTQLHEL KDHMTEQRKQ KQRLGLLNTT ANSLLPFQ
Length:2,838
Mass (Da):319,107
Last modified:March 1, 2004 - v3
Checksum:i0718F04D15BE00BB
GO
Isoform A (identifier: P29993-2) [UniParc]FASTAAdd to basket

Also known as: Embryo

The sequence of this isoform differs from the canonical sequence as follows:
     981-989: Missing.

Show »
Length:2,829
Mass (Da):318,134
Checksum:iE35B33428F803680
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti183 – 1831Missing in AAF52015 (PubMed:10731132).Curated
Sequence conflicti183 – 1831Missing in AAN13240 (PubMed:10731132).Curated
Sequence conflicti551 – 5511E → Q in AAF52015 (PubMed:10731132).Curated
Sequence conflicti551 – 5511E → Q in AAN13240 (PubMed:10731132).Curated
Sequence conflicti726 – 7261P → A in AAF52015 (PubMed:10731132).Curated
Sequence conflicti726 – 7261P → A in AAN13240 (PubMed:10731132).Curated
Sequence conflicti1079 – 112042AASAA…AAGAA → PLRPLAMRQVSSSRNNRNRR RLAAPMRLIPSTVPSLWPPR C (PubMed:1322910).CuratedAdd
BLAST
Sequence conflicti1079 – 112042AASAA…AAGAA → PLRPLAMRQVSSSRNNRNRR RLAAPMRLIPSTVPSLWPPR C (PubMed:10375644).CuratedAdd
BLAST
Sequence conflicti1150 – 11523SDA → TP in BAA14399 (PubMed:1322910).Curated
Sequence conflicti1394 – 13974VQHF → GVGHSV in CAB51853 (PubMed:10375644).Curated
Sequence conflicti1395 – 13951Missing in BAA14399 (PubMed:1322910).Curated
Sequence conflicti1419 – 14191A → R in AAF52015 (PubMed:10731132).Curated
Sequence conflicti1419 – 14191A → R in AAN13240 (PubMed:10731132).Curated
Sequence conflicti1466 – 14661G → R in AAF52015 (PubMed:10731132).Curated
Sequence conflicti1466 – 14661G → R in AAN13240 (PubMed:10731132).Curated
Sequence conflicti2108 – 21081L → V in AAF52015 (PubMed:10731132).Curated
Sequence conflicti2108 – 21081L → V in AAN13240 (PubMed:10731132).Curated
Sequence conflicti2333 – 23331L → V in AAF52015 (PubMed:10731132).Curated
Sequence conflicti2333 – 23331L → V in AAN13240 (PubMed:10731132).Curated
Sequence conflicti2452 – 24521V → I (PubMed:1338312).Curated
Sequence conflicti2483 – 249715QLLYH…FCFCG → STYTALYSVLLLR (PubMed:1322910).CuratedAdd
BLAST
Sequence conflicti2483 – 249715QLLYH…FCFCG → STYTALYSVLLLR (PubMed:10375644).CuratedAdd
BLAST
Sequence conflicti2511 – 25111D → H (PubMed:1338312).Curated
Sequence conflicti2802 – 28021N → F in BAA14399 (PubMed:1322910).Curated
Sequence conflicti2807 – 28071L → V (PubMed:1338312).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei981 – 9899Missing in isoform A. 1 PublicationVSP_002703

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90403 mRNA. Translation: BAA14399.1.
AJ238949 mRNA. Translation: CAB51853.1.
AE014297 Genomic DNA. Translation: AAF52015.2.
AE014297 Genomic DNA. Translation: AAN13240.1.
Z18535 mRNA. Translation: CAA79220.1.
PIRiA43360.
RefSeqiNP_001287180.1. NM_001300251.1.
NP_730941.1. NM_169060.2.
NP_730942.1. NM_169061.2.
UniGeneiDm.4462.

Genome annotation databases

GeneIDi40664.
KEGGidme:Dmel_CG1063.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90403 mRNA. Translation: BAA14399.1.
AJ238949 mRNA. Translation: CAB51853.1.
AE014297 Genomic DNA. Translation: AAF52015.2.
AE014297 Genomic DNA. Translation: AAN13240.1.
Z18535 mRNA. Translation: CAA79220.1.
PIRiA43360.
RefSeqiNP_001287180.1. NM_001300251.1.
NP_730941.1. NM_169060.2.
NP_730942.1. NM_169061.2.
UniGeneiDm.4462.

3D structure databases

ProteinModelPortaliP29993.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi65871. 2 interactions.
IntActiP29993. 5 interactions.
STRINGi7227.FBpp0078336.

Protein family/group databases

TCDBi1.A.3.2.2. the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family.

Proteomic databases

PaxDbiP29993.
PRIDEiP29993.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi40664.
KEGGidme:Dmel_CG1063.

Organism-specific databases

CTDi40664.
FlyBaseiFBgn0010051. Itp-r83A.

Phylogenomic databases

eggNOGiKOG3533. Eukaryota.
ENOG410XR97. LUCA.
InParanoidiP29993.
KOiK04958.
OrthoDBiEOG76HQ0M.
PhylomeDBiP29993.

Enzyme and pathway databases

ReactomeiR-DME-114508. Effects of PIP2 hydrolysis.
R-DME-139853. Elevation of cytosolic Ca2+ levels.
R-DME-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-DME-5578775. Ion homeostasis.
R-DME-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Miscellaneous databases

ChiTaRSiItp-r83A. fly.
GenomeRNAii40664.
PROiP29993.

Gene expression databases

BgeeiP29993.
GenevisibleiP29993. DM.

Family and domain databases

Gene3Di1.25.10.30. 2 hits.
InterProiIPR014821. Ins145_P3_rcpt.
IPR000493. InsP3_rcpt-bd.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 5 hits.
PfamiPF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
[Graphical view]
PRINTSiPR00779. INSP3RECEPTR.
SMARTiSM00472. MIR. 4 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50919. MIR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of the inositol 1,4,5-trisphosphate receptor in Drosophila melanogaster."
    Yoshikawa S., Tanimura T., Miyawaki A., Nakamura M., Yuzaki M., Furuichi T., Mikoshiba K.
    J. Biol. Chem. 267:16613-16619(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), FUNCTION, TISSUE SPECIFICITY.
    Strain: Oregon-R.
    Tissue: Head.
  2. "Sequencing and exon mapping of the inositol 1,4,5-trisphosphate receptor cDNA from Drosophila embryos suggests the presence of differentially regulated forms of RNA and protein."
    Sinha M., Hasan G.
    Gene 233:271-276(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
    Tissue: Embryo.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  5. "Drosophila homologs of two mammalian intracellular Ca(2+)-release channels: identification and expression patterns of the inositol 1,4,5-triphosphate and the ryanodine receptor genes."
    Hasan G., Rosbash M.
    Development 116:967-975(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 2370-2837, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Brain.

Entry informationi

Entry nameiITPR_DROME
AccessioniPrimary (citable) accession number: P29993
Secondary accession number(s): Q24309, Q9U981, Q9VNC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: March 1, 2004
Last modified: July 6, 2016
This is version 157 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.