Reviewed,
UniProtKB/Swiss-Prot P29992 (GNA11_HUMAN)
Last modified
June 16, 2009.
Version 87.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Guanine nucleotide-binding protein subunit alpha-11 Short name=G-protein subunit alpha-11 Short name=G alpha-11 Alternative name(s): Guanine nucleotide-binding protein G(y) subunit alpha | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 359 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. |
| Subunit structure | G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. |
| Sequence similarities | Belongs to the G-alpha family. G(q) subfamily. |
Ontologies
| Keywords | |
|---|---|
| Ligand | GTP-binding Nucleotide-binding |
| Molecular function | Transducer |
| PTM | ADP-ribosylation |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | protein amino acid ADP-ribosylation Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Traceable author statement. Source: ProtInc plasma membraneTraceable author statement. Source: ProtInc |
| Molecular function | GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activityTraceable author statement. Source: ProtInc signal transducer activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 359 | 359 | Guanine nucleotide-binding protein subunit alpha-11 | PRO_0000203746 | |||||
Regions | |||||||||
| Nucleotide binding | 46 – 53 | 8 | GTP By similarity | ||||||
| Nucleotide binding | 205 – 209 | 5 | GTP By similarity | ||||||
| Nucleotide binding | 274 – 277 | 4 | GTP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 183 | 1 | ADP-ribosylarginine; by cholera toxin By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 6 | 1 | M → I in AAB64303. Ref.2 | ||||||
| Sequence conflict | 266 | 1 | N → H in AAA99949. Ref.8 | ||||||
| Sequence conflict | 285 | 1 | Y → H in AAA99949. Ref.8 | ||||||
| Sequence conflict | 301 – 302 | 2 | DA → EP in AAA58624. Ref.1 | ||||||
| Sequence conflict | 310 | 1 | L → P in AAB64303. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells." Jiang M., Pandey S., Tran V.T., Fong H.K.W. Proc. Natl. Acad. Sci. U.S.A. 88:3907-3911(1991) [PubMed: 1902575] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Retina. |
| [2] | Bai X.H., Acharya R., Bai Y.H., Murtagh J.J. Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. Lucas S.M.Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas. |
| [7] | Bienvenut W.V., Calvo F., Kolch W. Submitted (MAR-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 42-52 AND 159-166, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [8] | "Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways." Thomas C.P., Dunn M.J., Mattera R. Biochem. J. 312:151-158(1995) [PubMed: 7492305] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 244-337. Tissue: Hematopoietic. |
| [9] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| M69013 mRNA. Translation: AAA58624.1. AF011497 mRNA. Translation: AAB64303.1. AF493900 mRNA. Translation: AAM12614.1. CR457004 mRNA. Translation: CAG33285.1. AC005262 Genomic DNA. Translation: AAC25615.1. BC089041 mRNA. Translation: AAH89041.1. BC096225 mRNA. Translation: AAH96225.1. BC096226 mRNA. Translation: AAH96226.1. BC096227 mRNA. Translation: AAH96227.1. L40630 mRNA. Translation: AAA99949.1. | |
| IPI | IPI00305551. |
| PIR | RGHUGY. A39394. |
| RefSeq | NP_002058.2. |
| UniGene | Hs.650575 Hs.654784 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1CUL based on UniProtKB P04896. |
| SMR | P29992. Positions 38-354. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P29992. |
Proteomic databases | |
| PRIDE | P29992. |
Genome annotation databases | |
| Ensembl | ENSG00000088256. Homo sapiens. [Contig view] |
| GeneID | 2767. |
| KEGG | hsa:2767. |
Organism-specific databases | |
| GeneCards | GC19P003045. |
| H-InvDB | HIX0018695. HIX0034202. |
| HGNC | HGNC:4379. GNA11. |
| MIM | 139313. gene. |
| PharmGKB | PA28764. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P29992. |
| HOVERGEN | P29992. |
| OMA | P29992. VKESKRI. |
Enzyme and pathway databases | |
| Pathway_Interaction_DB | arf6cyclingpathway. Arf6 signaling events. endothelinpathway. Endothelins. lysophospholipid_pathway. LPA receptor mediated events. er_nongenomic_pathway. Plasma membrane estrogen receptor signaling. s1p_s1p2_pathway. S1P2 pathway. s1p_s1p3_pathway. S1P3 pathway. s1p_meta_pathway. Sphingosine 1-phosphate (S1P) pathway. txa2pathway. Thromboxane A2 receptor signaling. |
Gene expression databases | |
| ArrayExpress | P29992. |
| Bgee | P29992. |
| CleanEx | HS_GNA11. |
| GermOnline | ENSG00000088256. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001019. Gprotein_alph_bd. IPR000654. Gprotein_alpha_Q. [Graphical view] |
| PANTHER | PTHR10218. Gprotein_alph_bd. 1 hit. |
| Pfam | PF00503. G-alpha. 1 hit. [Graphical view] |
| PRINTS | PR00318. GPROTEINA. PR00442. GPROTEINAQ. |
| ProDom | PD000281. Gprotein_alpha. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 10884. |
| SOURCE | Search... |
Entry information
| Entry name | GNA11_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P29992 Secondary accession number(s): O15109, Q14350, Q6IB00 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


