Reviewed, UniProtKB/Swiss-Prot P29992 (GNA11_HUMAN)

Names and origin

Protein names

Recommended name:
    Guanine nucleotide-binding protein subunit alpha-11
      Short name=G-protein subunit alpha-11
      Short name=G alpha-11
Alternative name(s):
    Guanine nucleotide-binding protein G(y) subunit alpha

Gene names

Name:	GNA11
Synonyms:	GA11

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.
Subunit structure	G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Sequence similarities	Belongs to the G-alpha family. G(q) subfamily.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding
Molecular function	Transducer
PTM	ADP-ribosylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	protein amino acid ADP-ribosylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Traceable author statement. Source: ProtInc plasma membrane Traceable author statement. Source: ProtInc
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Traceable author statement. Source: ProtInc signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Guanine nucleotide-binding protein subunit alpha-11		PRO_0000203746
Regions
	Nucleotide binding	46 – 53	8	GTP By similarity
	Nucleotide binding	205 – 209	5	GTP By similarity
	Nucleotide binding	274 – 277	4	GTP By similarity
Amino acid modifications
	Modified residue	183	1	ADP-ribosylarginine; by cholera toxin By similarity
Experimental info
	Sequence conflict	6	1	M → I in AAB64303. Ref.2
	Sequence conflict	266	1	N → H in AAA99949. Ref.8
	Sequence conflict	285	1	Y → H in AAA99949. Ref.8
	Sequence conflict	301 – 302	2	DA → EP in AAA58624. Ref.1
	Sequence conflict	310	1	L → P in AAB64303. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P29992-1 [UniParc]. Last modified July 15, 1998. Version 2. Checksum: DD37176589E66046	FASTA	359	42,123
	10 20 30 40 50 60 MTLESMMACC LSDEVKESKR INAEIEKQLR RDKRDARREL KLLLLGTGES GKSTFIKQMR 70 80 90 100 110 120 IIHGAGYSEE DKRGFTKLVY QNIFTAMQAM IRAMETLKIL YKYEQNKANA LLIREVDVEK 130 140 150 160 170 180 VTTFEHQYVS AIKTLWEDPG IQECYDRRRE YQLSDSAKYY LTDVDRIATL GYLPTQQDVL 190 200 210 220 230 240 RVRVPTTGII EYPFDLENII FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV 250 260 270 280 290 300 ESDNENRMEE SKALFRTIIT YPWFQNSSVI LFLNKKDLLE DKILYSHLVD YFPEFDGPQR 310 320 330 340 350 DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ LNLKEYNLV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells." Jiang M., Pandey S., Tran V.T., Fong H.K.W. Proc. Natl. Acad. Sci. U.S.A. 88:3907-3911(1991) [PubMed: 1902575] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Retina.
[2]	Bai X.H., Acharya R., Bai Y.H., Murtagh J.J. Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
[7]	Bienvenut W.V., Calvo F., Kolch W. Submitted (MAR-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 42-52 AND 159-166, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways." Thomas C.P., Dunn M.J., Mattera R. Biochem. J. 312:151-158(1995) [PubMed: 7492305] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 244-337. Tissue: Hematopoietic.
[9]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M69013 mRNA. Translation: AAA58624.1. AF011497 mRNA. Translation: AAB64303.1. AF493900 mRNA. Translation: AAM12614.1. CR457004 mRNA. Translation: CAG33285.1. AC005262 Genomic DNA. Translation: AAC25615.1. BC089041 mRNA. Translation: AAH89041.1. BC096225 mRNA. Translation: AAH96225.1. BC096226 mRNA. Translation: AAH96226.1. BC096227 mRNA. Translation: AAH96227.1. L40630 mRNA. Translation: AAA99949.1.
IPI	IPI00305551.
PIR	RGHUGY. A39394.
RefSeq	NP_002058.2.
UniGene	Hs.650575 Hs.654784
3D structure databases
HSSP	HSSP built from PDB template 1CUL based on UniProtKB P04896.
SMR	P29992. Positions 38-354.
ModBase	Search...
PTM databases
PhosphoSite	P29992.
Proteomic databases
PRIDE	P29992.
Genome annotation databases
Ensembl	ENSG00000088256. Homo sapiens. [Contig view]
GeneID	2767.
KEGG	hsa:2767.
Organism-specific databases
GeneCards	GC19P003045.
H-InvDB	HIX0018695. HIX0034202.
HGNC	HGNC:4379. GNA11.
MIM	139313. gene.
PharmGKB	PA28764.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P29992.
HOVERGEN	P29992.
OMA	P29992. VKESKRI.
Enzyme and pathway databases
Pathway_Interaction_DB	arf6cyclingpathway. Arf6 signaling events. endothelinpathway. Endothelins. lysophospholipid_pathway. LPA receptor mediated events. er_nongenomic_pathway. Plasma membrane estrogen receptor signaling. s1p_s1p2_pathway. S1P2 pathway. s1p_s1p3_pathway. S1P3 pathway. s1p_meta_pathway. Sphingosine 1-phosphate (S1P) pathway. txa2pathway. Thromboxane A2 receptor signaling.
Gene expression databases
ArrayExpress	P29992.
Bgee	P29992.
CleanEx	HS_GNA11.
GermOnline	ENSG00000088256. Homo sapiens.
Family and domain databases
InterPro	IPR001019. Gprotein_alph_bd. IPR000654. Gprotein_alpha_Q. [Graphical view]
PANTHER	PTHR10218. Gprotein_alph_bd. 1 hit.
Pfam	PF00503. G-alpha. 1 hit. [Graphical view]
PRINTS	PR00318. GPROTEINA. PR00442. GPROTEINAQ.
ProDom	PD000281. Gprotein_alpha. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other Resources
NextBio	10884.
SOURCE	Search...

Entry information

Entry name

GNA11_HUMAN

Accession

Primary (citable) accession number: P29992
Secondary accession number(s): O15109, Q14350, Q6IB00

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	July 15, 1998
Last modified:	June 16, 2009
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)