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P29992

- GNA11_HUMAN

UniProt

P29992 - GNA11_HUMAN

Protein

Guanine nucleotide-binding protein subunit alpha-11

Gene

GNA11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi53 – 531MagnesiumBy similarity
    Metal bindingi186 – 1861MagnesiumBy similarity
    Binding sitei331 – 3311GTP; via amide nitrogenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi46 – 538GTPBy similarity
    Nucleotide bindingi180 – 1867GTPBy similarity
    Nucleotide bindingi205 – 2095GTPBy similarity
    Nucleotide bindingi274 – 2774GTPBy similarity

    GO - Molecular functioni

    1. G-protein beta/gamma-subunit complex binding Source: RefGenome
    2. GTPase activity Source: RefGenome
    3. GTP binding Source: UniProtKB-KW
    4. metal ion binding Source: UniProtKB-KW
    5. signal transducer activity Source: RefGenome
    6. type 2A serotonin receptor binding Source: RefGenome

    GO - Biological processi

    1. action potential Source: RefGenome
    2. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RefGenome
    3. blood coagulation Source: Reactome
    4. developmental pigmentation Source: Ensembl
    5. heart development Source: Ensembl
    6. phospholipase C-activating dopamine receptor signaling pathway Source: RefGenome
    7. platelet activation Source: Reactome
    8. regulation of melanocyte differentiation Source: Ensembl
    9. signal transduction Source: ProtInc
    10. skeletal system development Source: Ensembl

    Keywords - Molecular functioni

    Transducer

    Keywords - Ligandi

    GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_18283. G alpha (q) signalling events.
    REACT_18405. Acetylcholine regulates insulin secretion.
    REACT_19140. ADP signalling through P2Y purinoceptor 1.
    REACT_19193. Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion.
    REACT_20647. Thromboxane signalling through TP receptor.
    REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein subunit alpha-11
    Short name:
    G alpha-11
    Short name:
    G-protein subunit alpha-11
    Alternative name(s):
    Guanine nucleotide-binding protein G(y) subunit alpha
    Gene namesi
    Name:GNA11
    Synonyms:GA11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:4379. GNA11.

    Subcellular locationi

    Cell membrane 1 Publication; Lipid-anchor 1 Publication. Cytoplasm 1 Publication
    Note: In testicular cells, expressed exclusively in the cytoplasm.

    GO - Cellular componenti

    1. cytoplasm Source: ProtInc
    2. extracellular vesicular exosome Source: UniProt
    3. heterotrimeric G-protein complex Source: RefGenome
    4. lysosomal membrane Source: UniProtKB
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Hypocalciuric hypercalcemia, familial 2 (HHC2) [MIM:145981]: A form of hypocalciuric hypercalcemia, a disorder of mineral homeostasis that is transmitted as an autosomal dominant trait with a high degree of penetrance. It is characterized biochemically by lifelong elevation of serum calcium concentrations and is associated with inappropriately low urinary calcium excretion and a normal or mildly elevated circulating parathyroid hormone level. Hypermagnesemia is typically present. Affected individuals are usually asymptomatic and the disorder is considered benign. However, chondrocalcinosis and pancreatitis occur in some adults.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti135 – 1351L → Q in HHC2; induces a decrease in sensitivity to changes in extracellular calcium concentrations. 1 Publication
    VAR_070166
    Natural varianti200 – 2001Missing in HHC2; induces a decrease in sensitivity to changes in extracellular calcium concentrations. 1 Publication
    VAR_070168
    Hypocalcemia, autosomal dominant 2 (HYPOC2) [MIM:615361]: A form of hypocalcemia, a disorder of mineral homeostasis characterized by blood calcium levels below normal, and low or normal serum parathyroid hormone concentrations. Disease manifestations include hypocalcemia, paresthesias, carpopedal spasm, seizures, hypercalciuria with nephrocalcinosis or kidney stones, and ectopic and basal ganglia calcifications.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti60 – 601R → C in HYPOC2. 1 Publication
    VAR_070165
    Natural varianti181 – 1811R → Q in HYPOC2; induces an increase in sensitivity to changes in extracellular calcium concentrations. 1 Publication
    VAR_070167
    Natural varianti211 – 2111S → W in HYPOC2. 1 Publication
    VAR_070169
    Natural varianti341 – 3411F → L in HYPOC2; induces an increase in sensitivity to changes in extracellular calcium concentrations. 1 Publication
    VAR_070170

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi145981. phenotype.
    615361. phenotype.
    Orphaneti428. Autosomal dominant hypocalcemia.
    101049. Familial hypocalciuric hypercalcemia type 2.
    PharmGKBiPA28764.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Guanine nucleotide-binding protein subunit alpha-11PRO_0000203746Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi9 – 91S-palmitoyl cysteine1 Publication
    Lipidationi10 – 101S-palmitoyl cysteine1 Publication
    Modified residuei183 – 1831ADP-ribosylarginine; by cholera toxinBy similarity

    Keywords - PTMi

    ADP-ribosylation, Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiP29992.
    PaxDbiP29992.
    PRIDEiP29992.

    PTM databases

    PhosphoSiteiP29992.

    Expressioni

    Tissue specificityi

    Expressed in testis.1 Publication

    Gene expression databases

    ArrayExpressiP29992.
    BgeeiP29992.
    CleanExiHS_GNA11.
    GenevestigatoriP29992.

    Organism-specific databases

    HPAiHPA048886.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with RGS22. Interacts with NTSR1.2 Publications

    Protein-protein interaction databases

    BioGridi109029. 15 interactions.
    IntActiP29992. 2 interactions.
    MINTiMINT-4999662.
    STRINGi9606.ENSP00000078429.

    Structurei

    3D structure databases

    ProteinModelPortaliP29992.
    SMRiP29992. Positions 37-354.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-alpha family. G(q) subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG322962.
    HOGENOMiHOG000038729.
    HOVERGENiHBG063184.
    InParanoidiP29992.
    KOiK04635.
    OMAiKTLWDDP.
    OrthoDBiEOG7ZWD1W.
    PhylomeDBiP29992.
    TreeFamiTF300673.

    Family and domain databases

    Gene3Di1.10.400.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR000654. Gprotein_alpha_Q.
    IPR001019. Gprotein_alpha_su.
    IPR011025. GproteinA_insert.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR10218. PTHR10218. 1 hit.
    PfamiPF00503. G-alpha. 1 hit.
    [Graphical view]
    PRINTSiPR00318. GPROTEINA.
    PR00442. GPROTEINAQ.
    SMARTiSM00275. G_alpha. 1 hit.
    [Graphical view]
    SUPFAMiSSF47895. SSF47895. 1 hit.
    SSF52540. SSF52540. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    P29992-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLESMMACC LSDEVKESKR INAEIEKQLR RDKRDARREL KLLLLGTGES    50
    GKSTFIKQMR IIHGAGYSEE DKRGFTKLVY QNIFTAMQAM IRAMETLKIL 100
    YKYEQNKANA LLIREVDVEK VTTFEHQYVS AIKTLWEDPG IQECYDRRRE 150
    YQLSDSAKYY LTDVDRIATL GYLPTQQDVL RVRVPTTGII EYPFDLENII 200
    FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV ESDNENRMEE 250
    SKALFRTIIT YPWFQNSSVI LFLNKKDLLE DKILYSHLVD YFPEFDGPQR 300
    DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ 350
    LNLKEYNLV 359
    Length:359
    Mass (Da):42,123
    Last modified:July 15, 1998 - v2
    Checksum:iDD37176589E66046
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61M → I in AAB64303. 1 PublicationCurated
    Sequence conflicti266 – 2661N → H in AAA99949. (PubMed:7492305)Curated
    Sequence conflicti285 – 2851Y → H in AAA99949. (PubMed:7492305)Curated
    Sequence conflicti301 – 3022DA → EP in AAA58624. (PubMed:1902575)Curated
    Sequence conflicti310 – 3101L → P in AAB64303. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti60 – 601R → C in HYPOC2. 1 Publication
    VAR_070165
    Natural varianti135 – 1351L → Q in HHC2; induces a decrease in sensitivity to changes in extracellular calcium concentrations. 1 Publication
    VAR_070166
    Natural varianti181 – 1811R → Q in HYPOC2; induces an increase in sensitivity to changes in extracellular calcium concentrations. 1 Publication
    VAR_070167
    Natural varianti200 – 2001Missing in HHC2; induces a decrease in sensitivity to changes in extracellular calcium concentrations. 1 Publication
    VAR_070168
    Natural varianti211 – 2111S → W in HYPOC2. 1 Publication
    VAR_070169
    Natural varianti341 – 3411F → L in HYPOC2; induces an increase in sensitivity to changes in extracellular calcium concentrations. 1 Publication
    VAR_070170

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M69013 mRNA. Translation: AAA58624.1.
    AF011497 mRNA. Translation: AAB64303.1.
    AF493900 mRNA. Translation: AAM12614.1.
    CR457004 mRNA. Translation: CAG33285.1.
    AC005262 Genomic DNA. Translation: AAC25615.1.
    BC089041 mRNA. Translation: AAH89041.1.
    BC096225 mRNA. Translation: AAH96225.1.
    BC096226 mRNA. Translation: AAH96226.1.
    BC096227 mRNA. Translation: AAH96227.1.
    L40630 mRNA. Translation: AAA99949.1.
    CCDSiCCDS12103.1.
    PIRiA39394. RGHUGY.
    RefSeqiNP_002058.2. NM_002067.4.
    UniGeneiHs.650575.
    Hs.654784.

    Genome annotation databases

    EnsembliENST00000078429; ENSP00000078429; ENSG00000088256.
    GeneIDi2767.
    KEGGihsa:2767.
    UCSCiuc002lxd.3. human.

    Polymorphism databases

    DMDMi3041682.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M69013 mRNA. Translation: AAA58624.1 .
    AF011497 mRNA. Translation: AAB64303.1 .
    AF493900 mRNA. Translation: AAM12614.1 .
    CR457004 mRNA. Translation: CAG33285.1 .
    AC005262 Genomic DNA. Translation: AAC25615.1 .
    BC089041 mRNA. Translation: AAH89041.1 .
    BC096225 mRNA. Translation: AAH96225.1 .
    BC096226 mRNA. Translation: AAH96226.1 .
    BC096227 mRNA. Translation: AAH96227.1 .
    L40630 mRNA. Translation: AAA99949.1 .
    CCDSi CCDS12103.1.
    PIRi A39394. RGHUGY.
    RefSeqi NP_002058.2. NM_002067.4.
    UniGenei Hs.650575.
    Hs.654784.

    3D structure databases

    ProteinModelPortali P29992.
    SMRi P29992. Positions 37-354.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109029. 15 interactions.
    IntActi P29992. 2 interactions.
    MINTi MINT-4999662.
    STRINGi 9606.ENSP00000078429.

    PTM databases

    PhosphoSitei P29992.

    Polymorphism databases

    DMDMi 3041682.

    Proteomic databases

    MaxQBi P29992.
    PaxDbi P29992.
    PRIDEi P29992.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000078429 ; ENSP00000078429 ; ENSG00000088256 .
    GeneIDi 2767.
    KEGGi hsa:2767.
    UCSCi uc002lxd.3. human.

    Organism-specific databases

    CTDi 2767.
    GeneCardsi GC19P003094.
    HGNCi HGNC:4379. GNA11.
    HPAi HPA048886.
    MIMi 139313. gene.
    145981. phenotype.
    615361. phenotype.
    neXtProti NX_P29992.
    Orphaneti 428. Autosomal dominant hypocalcemia.
    101049. Familial hypocalciuric hypercalcemia type 2.
    PharmGKBi PA28764.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG322962.
    HOGENOMi HOG000038729.
    HOVERGENi HBG063184.
    InParanoidi P29992.
    KOi K04635.
    OMAi KTLWDDP.
    OrthoDBi EOG7ZWD1W.
    PhylomeDBi P29992.
    TreeFami TF300673.

    Enzyme and pathway databases

    Reactomei REACT_18283. G alpha (q) signalling events.
    REACT_18405. Acetylcholine regulates insulin secretion.
    REACT_19140. ADP signalling through P2Y purinoceptor 1.
    REACT_19193. Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion.
    REACT_20647. Thromboxane signalling through TP receptor.
    REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).

    Miscellaneous databases

    ChiTaRSi GNA11. human.
    GeneWikii GNA11.
    GenomeRNAii 2767.
    NextBioi 10884.
    PROi P29992.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P29992.
    Bgeei P29992.
    CleanExi HS_GNA11.
    Genevestigatori P29992.

    Family and domain databases

    Gene3Di 1.10.400.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR000654. Gprotein_alpha_Q.
    IPR001019. Gprotein_alpha_su.
    IPR011025. GproteinA_insert.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR10218. PTHR10218. 1 hit.
    Pfami PF00503. G-alpha. 1 hit.
    [Graphical view ]
    PRINTSi PR00318. GPROTEINA.
    PR00442. GPROTEINAQ.
    SMARTi SM00275. G_alpha. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47895. SSF47895. 1 hit.
    SSF52540. SSF52540. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells."
      Jiang M., Pandey S., Tran V.T., Fong H.K.W.
      Proc. Natl. Acad. Sci. U.S.A. 88:3907-3911(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Retina.
    2. Bai X.H., Acharya R., Bai Y.H., Murtagh J.J.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.
    7. Bienvenut W.V., Calvo F., Kolch W.
      Submitted (MAR-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 42-52 AND 159-166, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Cervix carcinoma.
    8. "Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways."
      Thomas C.P., Dunn M.J., Mattera R.
      Biochem. J. 312:151-158(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 244-337.
      Tissue: Hematopoietic.
    9. "RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits."
      Hu Y., Xing J., Chen L., Guo X., Du Y., Zhao C., Zhu Y., Lin M., Zhou Z., Sha J.
      Biol. Reprod. 79:1021-1029(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RGS22, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Testis.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains."
      Heakal Y., Woll M.P., Fox T., Seaton K., Levenson R., Kester M.
      Cancer Biol. Ther. 12:427-435(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NTSR1.
    12. "Site-specific analysis of protein S-acylation by resin-assisted capture."
      Forrester M.T., Hess D.T., Thompson J.W., Hultman R., Moseley M.A., Stamler J.S., Casey P.J.
      J. Lipid Res. 52:393-398(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PALMITOYLATION AT CYS-9 AND CYS-10.
    13. "A rude awakening--the perioperative sleep apnea epidemic."
      Memtsoudis S.G., Besculides M.C., Mazumdar M.
      N. Engl. J. Med. 368:2352-2353(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS HYPOC2 CYS-60 AND TRP-211.
    14. Cited for: VARIANTS HHC2 GLN-135 AND ILE-200 DEL, VARIANTS HYPOC2 GLN-181 AND LEU-341, CHARACTERIZATION OF VARIANTS HHC2 GLN-135 AND ILE-200 DEL, CHARACTERIZATION OF VARIANTS HYPOC2 GLN-181 AND LEU-341.

    Entry informationi

    Entry nameiGNA11_HUMAN
    AccessioniPrimary (citable) accession number: P29992
    Secondary accession number(s): O15109, Q14350, Q6IB00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 144 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3