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P29981

- CP4C1_BLADI

UniProt

P29981 - CP4C1_BLADI

Protein

Cytochrome P450 4C1

Gene

CYP4C1

Organism
Blaberus discoidalis (Tropical cockroach)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei314 – 3141Heme (covalent; via 1 link)By similarity
    Metal bindingi452 – 4521Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 4C1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIVC1
    Gene namesi
    Name:CYP4C1
    OrganismiBlaberus discoidalis (Tropical cockroach)
    Taxonomic identifieri6981 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaDictyopteraBlattodeaBlaberoideaBlaberidaeBlaberinaeBlaberus

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 511511Cytochrome P450 4C1PRO_0000051823Add
    BLAST

    Expressioni

    Inductioni

    By hypertrehalosemic hormone and starvation.

    Structurei

    3D structure databases

    ProteinModelPortaliP29981.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P29981-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFITILLST ALFIVTFLFL FRQGAKRARF VYLVNKLPGP TAYPVVGNAI    50
    EAIVPRNKLF QVFDRRAKLY GPLYRIWAGP IAQVGLTRPE HVELILRDTK 100
    HIDKSLVYSF IRPWLGEGLL TGTGAKWHSH RKMITPTFHF KILDIFVDVF 150
    VEKSEILVKK LQSKVGGKDF DIYPFITHCA LDIICETAMG IQMNAQEESE 200
    SEYVKAVYEI SELTMQRSVR PWLHPKVIFD LTTMGKRYAE CLRILHGFTN 250
    KVIQERKSLR QMTGMKPTIS NEEDELLGKK KRLAFLDLLL EASENGTKMS 300
    DTDIREEVDT FMFEGHDTTS AGICWALFLL GSHPEIQDKV YEELDHIFQG 350
    SDRSTTMRDL ADMKYLERVI KESLRLFPSV PFIGRVLKED TKIGDYLVPA 400
    GCMMNLQIYH VHRNQDQYPN PEAFNPDNFL PERVAKRHPY AYVPFSAGPR 450
    NCIGQKFATL EEKTVLSSIL RNFKVRSIEK REDLTLMNEL ILRPESGIKV 500
    ELIPRLPADA C 511
    Length:511
    Mass (Da):58,754
    Last modified:April 1, 1993 - v1
    Checksum:iE857E9404C30F9AD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M63798 mRNA. Translation: AAA27819.1.
    PIRiA39381.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M63798 mRNA. Translation: AAA27819.1 .
    PIRi A39381.

    3D structure databases

    ProteinModelPortali P29981.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cytochrome P450 family 4 in a cockroach: molecular cloning and regulation by regulation by hypertrehalosemic hormone."
      Bradfield J.Y., Lee Y.-H., Keeley L.L.
      Proc. Natl. Acad. Sci. U.S.A. 88:4558-4562(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCP4C1_BLADI
    AccessioniPrimary (citable) accession number: P29981
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3