P29981 (CP4C1_BLADI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome P450 4C1
EC=1.14.14.1

Alternative name(s):
CYPIVC1

Gene names

Name:

CYP4C1

Organism

Blaberus discoidalis (Tropical cockroach)

Taxonomic identifier

6981 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Orthopteroidea › Dictyoptera › Blattodea › Blaberoidea › Blaberidae › Blaberinae › Blaberus

Protein attributes

Sequence length	511 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Induction	By hypertrehalosemic hormone and starvation.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 511	511	Cytochrome P450 4C1		PRO_0000051823
Sites
	Metal binding	452	1	Iron (heme axial ligand) By similarity
	Binding site	314	1	Heme (covalent; via 1 link) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P29981 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: E857E9404C30F9AD	FASTA	511	58,754
	10 20 30 40 50 60 MEFITILLST ALFIVTFLFL FRQGAKRARF VYLVNKLPGP TAYPVVGNAI EAIVPRNKLF 70 80 90 100 110 120 QVFDRRAKLY GPLYRIWAGP IAQVGLTRPE HVELILRDTK HIDKSLVYSF IRPWLGEGLL 130 140 150 160 170 180 TGTGAKWHSH RKMITPTFHF KILDIFVDVF VEKSEILVKK LQSKVGGKDF DIYPFITHCA 190 200 210 220 230 240 LDIICETAMG IQMNAQEESE SEYVKAVYEI SELTMQRSVR PWLHPKVIFD LTTMGKRYAE 250 260 270 280 290 300 CLRILHGFTN KVIQERKSLR QMTGMKPTIS NEEDELLGKK KRLAFLDLLL EASENGTKMS 310 320 330 340 350 360 DTDIREEVDT FMFEGHDTTS AGICWALFLL GSHPEIQDKV YEELDHIFQG SDRSTTMRDL 370 380 390 400 410 420 ADMKYLERVI KESLRLFPSV PFIGRVLKED TKIGDYLVPA GCMMNLQIYH VHRNQDQYPN 430 440 450 460 470 480 PEAFNPDNFL PERVAKRHPY AYVPFSAGPR NCIGQKFATL EEKTVLSSIL RNFKVRSIEK 490 500 510 REDLTLMNEL ILRPESGIKV ELIPRLPADA C

References

[1]	"Cytochrome P450 family 4 in a cockroach: molecular cloning and regulation by regulation by hypertrehalosemic hormone." Bradfield J.Y., Lee Y.-H., Keeley L.L. Proc. Natl. Acad. Sci. U.S.A. 88:4558-4562(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M63798 mRNA. Translation: AAA27819.1.
PIR	A39381.
3D structure databases
ProteinModelPortal	P29981.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP4C1_BLADI

Accession

Primary (citable) accession number: P29981

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	April 3, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)