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P29981 (CP4C1_BLADI) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 4C1

EC=1.14.14.1
Alternative name(s):
CYPIVC1
Gene names
Name:CYP4C1
OrganismBlaberus discoidalis (Tropical cockroach)
Taxonomic identifier6981 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaDictyopteraBlattodeaBlaberoideaBlaberidaeBlaberinaeBlaberus

Protein attributes

Sequence length511 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

By hypertrehalosemic hormone and starvation.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 511511Cytochrome P450 4C1
PRO_0000051823

Sites

Metal binding4521Iron (heme axial ligand) By similarity
Binding site3141Heme (covalent; via 1 link) By similarity

Sequences

Sequence LengthMass (Da)Tools
P29981 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: E857E9404C30F9AD

FASTA51158,754
        10         20         30         40         50         60 
MEFITILLST ALFIVTFLFL FRQGAKRARF VYLVNKLPGP TAYPVVGNAI EAIVPRNKLF 

        70         80         90        100        110        120 
QVFDRRAKLY GPLYRIWAGP IAQVGLTRPE HVELILRDTK HIDKSLVYSF IRPWLGEGLL 

       130        140        150        160        170        180 
TGTGAKWHSH RKMITPTFHF KILDIFVDVF VEKSEILVKK LQSKVGGKDF DIYPFITHCA 

       190        200        210        220        230        240 
LDIICETAMG IQMNAQEESE SEYVKAVYEI SELTMQRSVR PWLHPKVIFD LTTMGKRYAE 

       250        260        270        280        290        300 
CLRILHGFTN KVIQERKSLR QMTGMKPTIS NEEDELLGKK KRLAFLDLLL EASENGTKMS 

       310        320        330        340        350        360 
DTDIREEVDT FMFEGHDTTS AGICWALFLL GSHPEIQDKV YEELDHIFQG SDRSTTMRDL 

       370        380        390        400        410        420 
ADMKYLERVI KESLRLFPSV PFIGRVLKED TKIGDYLVPA GCMMNLQIYH VHRNQDQYPN 

       430        440        450        460        470        480 
PEAFNPDNFL PERVAKRHPY AYVPFSAGPR NCIGQKFATL EEKTVLSSIL RNFKVRSIEK 

       490        500        510 
REDLTLMNEL ILRPESGIKV ELIPRLPADA C 

« Hide

References

[1]"Cytochrome P450 family 4 in a cockroach: molecular cloning and regulation by regulation by hypertrehalosemic hormone."
Bradfield J.Y., Lee Y.-H., Keeley L.L.
Proc. Natl. Acad. Sci. U.S.A. 88:4558-4562(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M63798 mRNA. Translation: AAA27819.1.
PIRA39381.

3D structure databases

ProteinModelPortalP29981.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP4C1_BLADI
AccessionPrimary (citable) accession number: P29981
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: December 11, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families