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Protein

Cytochrome P450 4C1

Gene

CYP4C1

Organism
Blaberus discoidalis (Tropical cockroach)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei314 – 3141Heme (covalent; via 1 link)By similarity
Metal bindingi452 – 4521Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4C1 (EC:1.14.14.1)
Alternative name(s):
CYPIVC1
Gene namesi
Name:CYP4C1
OrganismiBlaberus discoidalis (Tropical cockroach)
Taxonomic identifieri6981 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaDictyopteraBlattodeaBlaberoideaBlaberidaeBlaberinaeBlaberus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Cytochrome P450 4C1PRO_0000051823Add
BLAST

Expressioni

Inductioni

By hypertrehalosemic hormone and starvation.

Structurei

3D structure databases

ProteinModelPortaliP29981.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29981-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFITILLST ALFIVTFLFL FRQGAKRARF VYLVNKLPGP TAYPVVGNAI
60 70 80 90 100
EAIVPRNKLF QVFDRRAKLY GPLYRIWAGP IAQVGLTRPE HVELILRDTK
110 120 130 140 150
HIDKSLVYSF IRPWLGEGLL TGTGAKWHSH RKMITPTFHF KILDIFVDVF
160 170 180 190 200
VEKSEILVKK LQSKVGGKDF DIYPFITHCA LDIICETAMG IQMNAQEESE
210 220 230 240 250
SEYVKAVYEI SELTMQRSVR PWLHPKVIFD LTTMGKRYAE CLRILHGFTN
260 270 280 290 300
KVIQERKSLR QMTGMKPTIS NEEDELLGKK KRLAFLDLLL EASENGTKMS
310 320 330 340 350
DTDIREEVDT FMFEGHDTTS AGICWALFLL GSHPEIQDKV YEELDHIFQG
360 370 380 390 400
SDRSTTMRDL ADMKYLERVI KESLRLFPSV PFIGRVLKED TKIGDYLVPA
410 420 430 440 450
GCMMNLQIYH VHRNQDQYPN PEAFNPDNFL PERVAKRHPY AYVPFSAGPR
460 470 480 490 500
NCIGQKFATL EEKTVLSSIL RNFKVRSIEK REDLTLMNEL ILRPESGIKV
510
ELIPRLPADA C
Length:511
Mass (Da):58,754
Last modified:April 1, 1993 - v1
Checksum:iE857E9404C30F9AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63798 mRNA. Translation: AAA27819.1.
PIRiA39381.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63798 mRNA. Translation: AAA27819.1.
PIRiA39381.

3D structure databases

ProteinModelPortaliP29981.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cytochrome P450 family 4 in a cockroach: molecular cloning and regulation by regulation by hypertrehalosemic hormone."
    Bradfield J.Y., Lee Y.-H., Keeley L.L.
    Proc. Natl. Acad. Sci. U.S.A. 88:4558-4562(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCP4C1_BLADI
AccessioniPrimary (citable) accession number: P29981
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: January 7, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.