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Protein

Phospho-2-dehydro-3-deoxyheptonate aldolase 1, chloroplastic

Gene

DHS1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.

Pathwayi: chorismate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase, Phospho-2-dehydro-3-deoxyheptonate aldolase 2, chloroplastic (DHS2), Phospho-2-dehydro-3-deoxyheptonate aldolase (At4g33510), Phospho-2-dehydro-3-deoxyheptonate aldolase (At4g33510), Phospho-2-dehydro-3-deoxyheptonate aldolase (At1g22410), Phospho-2-dehydro-3-deoxyheptonate aldolase (AXX17_At1g23540), Phospho-2-dehydro-3-deoxyheptonate aldolase, Phospho-2-dehydro-3-deoxyheptonate aldolase (DHS2), Phospho-2-dehydro-3-deoxyheptonate aldolase (AXX17_At4g38330), Phospho-2-dehydro-3-deoxyheptonate aldolase (AXX17_At4g45420), Phospho-2-dehydro-3-deoxyheptonate aldolase 1, chloroplastic (DHS1)
  2. 3-dehydroquinate synthase, chloroplastic (DHQS), Uncharacterized protein (AXX17_At5g66050)
  3. Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic (EMB3004)
  4. Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic (EMB3004)
  5. Shikimate kinase 2, chloroplastic (SK2), Shikimate kinase 1, chloroplastic (SK1)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (F27K7.11), 3-phosphoshikimate 1-carboxyvinyltransferase (At2g45300), 3-phosphoshikimate 1-carboxyvinyltransferase, 3-phosphoshikimate 1-carboxyvinyltransferase (AXX17_At2g42890), 3-phosphoshikimate 1-carboxyvinyltransferase (AXX17_At1g42980), 3-phosphoshikimate 1-carboxyvinyltransferase, chloroplastic (At2g45300)
  7. Chorismate synthase (At1g48850), Chorismate synthase, chloroplastic (EMB1144), Chorismate synthase (AXX17_At1g42970), Chorismate synthase (EMB1144), Chorismate synthase (EMB1144)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

  • 3-deoxy-7-phosphoheptulonate synthase activity Source: TAIR

GO - Biological processi

  • aromatic amino acid family biosynthetic process Source: TAIR
  • chorismate biosynthetic process Source: TAIR
  • response to wounding Source: TAIR

Keywordsi

Molecular functionTransferase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis

Enzyme and pathway databases

BRENDAi2.5.1.54 399
UniPathwayiUPA00053; UER00084

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolase 1, chloroplastic (EC:2.5.1.54)
Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase 1
DAHP synthase 1
Phospho-2-keto-3-deoxyheptonate aldolase 1
Gene namesi
Name:DHS1
Ordered Locus Names:At4g39980
ORF Names:T5J17.150
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G39980
TAIRilocus:2005525 AT4G39980

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 52ChloroplastSequence analysisAdd BLAST52
ChainiPRO_000000229853 – 525Phospho-2-dehydro-3-deoxyheptonate aldolase 1, chloroplasticAdd BLAST473

Proteomic databases

PaxDbiP29976
PRIDEiP29976

Expressioni

Inductioni

By pathogen infection and wounding.

Gene expression databases

ExpressionAtlasiP29976 baseline and differential
GenevisibleiP29976 AT

Interactioni

Protein-protein interaction databases

BioGridi15439, 2 interactors
IntActiP29976, 1 interactor
STRINGi3702.AT4G39980.1

Structurei

3D structure databases

ProteinModelPortaliP29976
SMRiP29976
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II DAHP synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IGEI Eukaryota
COG3200 LUCA
HOGENOMiHOG000242917
InParanoidiP29976
KOiK01626
OMAiHAWNQDF
OrthoDBiEOG093607BP
PhylomeDBiP29976

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR002480 DAHP_synth_2
PANTHERiPTHR21337 PTHR21337, 1 hit
PfamiView protein in Pfam
PF01474 DAHP_synth_2, 1 hit
TIGRFAMsiTIGR01358 DAHP_synth_II, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29976-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSNASSLS TRSIYGGDLS HRPSNRQSSF TFHPAVNTKP KSVNLVTAVH
60 70 80 90 100
AAEPARNAVS VKESVASSSS GALKWTPESW KLKKALQLPD YPNANELESV
110 120 130 140 150
LKTIEAFPPI VFAGEARNLE ERLADAAVGK AFLLQGGDCA ESFKEFNATN
160 170 180 190 200
IRDTFRVLLQ MSIVLTFGGQ VPVIKVGRMA GQFAKPRSDA FEEKDGVKLP
210 220 230 240 250
SYKGDNINGD TFDEKSRIPD PNRMIRAYTQ SAATLNLLRA FATGGYAAIQ
260 270 280 290 300
RVTQWNLDFV EQSEQADRYQ ELANRVDEAL GFMSACGLGT DHPLMTTTDF
310 320 330 340 350
YTSHECLLLP YEQSLTRLDS TSGLYYDCSA HMVWCGERTR QLDGAHVEFL
360 370 380 390 400
RGIANPLGIK VSNKMDPFEL VKLVEILNPN NKPGRITVIV RMGAENMRVK
410 420 430 440 450
LPHLIRAVRR SGQIVTWVCD PMHGNTIKAP CGLKTRAFDS ILAEVRAFLD
460 470 480 490 500
VHEQEGSHAG GIHLEMTGQN VTECIGGSRT VTYDDLSSRY HTHCDPRLNA
510 520
SQSLELAFIV AERLRKRRTG SQRVS
Length:525
Mass (Da):57,979
Last modified:January 23, 2002 - v2
Checksum:i13CA141A3C71D9E6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti429 – 430AP → ST in AAA32784 (PubMed:1681544).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74819 mRNA Translation: AAA32784.1
AL035708 Genomic DNA Translation: CAB38911.1
AL161596 Genomic DNA Translation: CAB80661.1
CP002687 Genomic DNA Translation: AEE87148.1
AY090349 mRNA Translation: AAL91255.1
AY140052 mRNA Translation: AAM98193.1
BT000821 mRNA Translation: AAN33196.1
PIRiA41370
T06104
RefSeqiNP_195708.1, NM_120162.5
UniGeneiAt.23161

Genome annotation databases

EnsemblPlantsiAT4G39980.1; AT4G39980.1; AT4G39980
GeneIDi830159
GrameneiAT4G39980.1; AT4G39980.1; AT4G39980
KEGGiath:AT4G39980

Similar proteinsi

Entry informationi

Entry nameiAROF_ARATH
AccessioniPrimary (citable) accession number: P29976
Secondary accession number(s): Q9SMQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2002
Last modified: April 25, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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