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P29974

- CNGA1_MOUSE

UniProt

P29974 - CNGA1_MOUSE

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Protein

cGMP-gated cation channel alpha-1

Gene
Cnga1, Cncg, Cncg1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei538 – 5381cGMP Reviewed prediction
Binding sitei553 – 5531cGMP Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi479 – 601123cGMP Reviewed predictionAdd
BLAST

GO - Molecular functioni

  1. cGMP binding Source: RefGenome
  2. intracellular cAMP activated cation channel activity Source: RefGenome
  3. intracellular cGMP activated cation channel activity Source: RefGenome
  4. voltage-gated potassium channel activity Source: RefGenome

GO - Biological processi

  1. phototransduction, visible light Source: RefGenome
  2. potassium ion transmembrane transport Source: RefGenome
  3. regulation of membrane potential Source: RefGenome
  4. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel

Keywords - Biological processi

Ion transport, Sensory transduction, Transport, Vision

Keywords - Ligandi

cGMP, cGMP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_188252. Activation of the phototransduction cascade.
REACT_188266. Inactivation, recovery and regulation of the phototransduction cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-gated cation channel alpha-1
Alternative name(s):
Cyclic nucleotide-gated cation channel 1
Cyclic nucleotide-gated channel alpha-1
Short name:
CNG channel alpha-1
Short name:
CNG-1
Short name:
CNG1
Cyclic nucleotide-gated channel, photoreceptor
Rod photoreceptor cGMP-gated channel subunit alpha
Gene namesi
Name:Cnga1
Synonyms:Cncg, Cncg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:88436. Cnga1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 156156Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei157 – 17721Helical; Name=H1; Reviewed predictionAdd
BLAST
Topological domaini178 – 19013Extracellular Reviewed predictionAdd
BLAST
Transmembranei191 – 20919Helical; Name=H2; Reviewed predictionAdd
BLAST
Topological domaini210 – 23324Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei234 – 25320Helical; Name=H3; Reviewed predictionAdd
BLAST
Topological domaini254 – 29138Extracellular Reviewed predictionAdd
BLAST
Transmembranei292 – 31423Helical; Name=H4; Reviewed predictionAdd
BLAST
Topological domaini315 – 36652Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei367 – 38620Helical; Name=H5; Reviewed predictionAdd
BLAST
Topological domaini387 – 47084Extracellular Reviewed predictionAdd
BLAST
Transmembranei471 – 49121Helical; Name=H6; Reviewed predictionAdd
BLAST
Topological domaini492 – 684193Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: RefGenome
  2. membrane Source: MGI
  3. photoreceptor outer segment Source: MGI
  4. photoreceptor outer segment membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 684684cGMP-gated cation channel alpha-1PRO_0000219309Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi417 – 4171N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP29974.

PTM databases

PhosphoSiteiP29974.

Expressioni

Tissue specificityi

Rod cells in the retina and inner medulla of kidney.

Gene expression databases

BgeeiP29974.
CleanExiMM_CNGA1.
GenevestigatoriP29974.

Interactioni

Subunit structurei

Tetramer formed of three CNGA1 and one CNGB1 modulatory subunits By similarity.

Structurei

3D structure databases

ProteinModelPortaliP29974.
SMRiP29974. Positions 340-588, 615-664.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili615 – 65844 By similarityAdd
BLAST

Domaini

The C-terminal coiled-coil domain mediates homotrimerization of CNGA subunits By similarity.

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG300025.
GeneTreeiENSGT00550000074376.
HOGENOMiHOG000007898.
HOVERGENiHBG000281.
InParanoidiP29974.
KOiK04948.
OMAiWTMVIAR.
OrthoDBiEOG771268.
PhylomeDBiP29974.
TreeFamiTF319048.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29974-1 [UniParc]FASTAAdd to Basket

« Hide

MKTNIINTWH SFVNIPNVIV PAIEKEIRRM ENGACSSFSD DDNGSLSEES    50
ENEDSFFRSN SYKRRGPSQR EQHLPGTMAL FNVNNSSNKD QEPKEKKKKK 100
KEKKSKADDK NENKKDPEKK KKKEKEKEKK KKEEKTKEKK EEEKKEVVVI 150
DPSGNTYYNW LFCITLPVMY NWTMIIARAC FDELQSDYLE YWLIFDYVSD 200
VVYLADMFVR TRTGYLEQGL LVKDRMKLIE KYKANLQFKL DVLSVIPTDL 250
LYIKFGWNYP EIRLNRLLRI SRMFEFFQRT ETRTNYPNIF RISNLVMYIV 300
IIIHWNACVY YSISKAIGFG NDTWVYPDVN DPEFGRLARK YVYSLYWSTL 350
TLTTIGETPP PVLDSEYIFV VVDFLIGVLI FATIVGNIGS MISNMNAARA 400
EFQSRVDAIK QYMNFRNVSK DMEKRVIKWF DYLWTNKKTV DEREVLRYLP 450
DKLRAEIAIN VHLDTLKKVR IFADCEAGLL VELVLKLQPQ VYSPGDYICK 500
KGDIGREMYI IKEGKLAVVA DDGITQFVVL SDGSYFGEIS ILNIKGSKAG 550
NRRTANIKSI GYSDLFCLSK DDLMEALTEY PDAKTMLEEK GRQILMKDGL 600
LDINIANMGS DPKDLEEKVT RMEGSVDLLQ TRFARILAEY ESMQQKLKQR 650
LTKVEKFLKP LIETEFSALE EPGGESELTE SLQD 684
Length:684
Mass (Da):79,460
Last modified:November 1, 1997 - v2
Checksum:i13EC2A405B6B8CBF
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti113 – 1142NK → I in AAA37425. 1 Publication
Sequence conflicti200 – 2001D → N in AAA37425. 1 Publication
Sequence conflicti576 – 5761A → V in AAA37425. 1 Publication
Sequence conflicti635 – 6351R → C in AAA37425. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84742 mRNA. Translation: AAA37425.1.
U19717 mRNA. Translation: AAA85702.1.
U19715 mRNA. Translation: AAA85700.1.
U19716 mRNA. Translation: AAA85701.1.
BC141261 mRNA. Translation: AAI41262.1.
CCDSiCCDS19333.1.
RefSeqiNP_031749.2. NM_007723.2.
UniGeneiMm.436652.

Genome annotation databases

EnsembliENSMUST00000087213; ENSMUSP00000084464; ENSMUSG00000067220.
ENSMUST00000135701; ENSMUSP00000119886; ENSMUSG00000067220.
ENSMUST00000169997; ENSMUSP00000132329; ENSMUSG00000067220.
GeneIDi12788.
KEGGimmu:12788.
UCSCiuc008xrr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84742 mRNA. Translation: AAA37425.1 .
U19717 mRNA. Translation: AAA85702.1 .
U19715 mRNA. Translation: AAA85700.1 .
U19716 mRNA. Translation: AAA85701.1 .
BC141261 mRNA. Translation: AAI41262.1 .
CCDSi CCDS19333.1.
RefSeqi NP_031749.2. NM_007723.2.
UniGenei Mm.436652.

3D structure databases

ProteinModelPortali P29974.
SMRi P29974. Positions 340-588, 615-664.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P29974.

Proteomic databases

PRIDEi P29974.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000087213 ; ENSMUSP00000084464 ; ENSMUSG00000067220 .
ENSMUST00000135701 ; ENSMUSP00000119886 ; ENSMUSG00000067220 .
ENSMUST00000169997 ; ENSMUSP00000132329 ; ENSMUSG00000067220 .
GeneIDi 12788.
KEGGi mmu:12788.
UCSCi uc008xrr.1. mouse.

Organism-specific databases

CTDi 1259.
MGIi MGI:88436. Cnga1.

Phylogenomic databases

eggNOGi NOG300025.
GeneTreei ENSGT00550000074376.
HOGENOMi HOG000007898.
HOVERGENi HBG000281.
InParanoidi P29974.
KOi K04948.
OMAi WTMVIAR.
OrthoDBi EOG771268.
PhylomeDBi P29974.
TreeFami TF319048.

Enzyme and pathway databases

Reactomei REACT_188252. Activation of the phototransduction cascade.
REACT_188266. Inactivation, recovery and regulation of the phototransduction cascade.

Miscellaneous databases

NextBioi 282186.
PROi P29974.
SOURCEi Search...

Gene expression databases

Bgeei P29974.
CleanExi MM_CNGA1.
Genevestigatori P29974.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
PROSITEi PS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channel."
    Pittler S.J., Lee A.K., Altherr M.R., Howard T.A., Seldin M.F., Hurwitz R.L., Wasmuth J.J., Baehr W.
    J. Biol. Chem. 267:6257-6262(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  2. "Cloning of a cGMP-gated cation channel from mouse kidney inner medullary collecting duct."
    Karlson K.H., Ciampolillo-Bates F., McCoy D.E., Kizer N.L., Stanton B.A.
    Biochim. Biophys. Acta 1236:197-200(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCNGA1_MOUSE
AccessioniPrimary (citable) accession number: P29974
Secondary accession number(s): B9EJ09, Q60776
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi