##gff-version 3 P29972 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2007592;Dbxref=PMID:2007592 P29972 UniProtKB Chain 2 269 . . . ID=PRO_0000063920;Note=Aquaporin-1 P29972 UniProtKB Topological domain 2 7 . . . Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7507481;Dbxref=PMID:7507481 P29972 UniProtKB Transmembrane 8 36 . . . Note=Helical%3B Name%3DHelix 1 P29972 UniProtKB Topological domain 37 48 . . . Note=Extracellular;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7507481;Dbxref=PMID:7507481 P29972 UniProtKB Transmembrane 49 66 . . . Note=Helical%3B Name%3DHelix 2 P29972 UniProtKB Topological domain 67 70 . . . Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7507481;Dbxref=PMID:7507481 P29972 UniProtKB Intramembrane 71 76 . . . . P29972 UniProtKB Intramembrane 77 84 . . . Note=Helical%3B Name%3DHelix B P29972 UniProtKB Topological domain 85 94 . . . Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7507481;Dbxref=PMID:7507481 P29972 UniProtKB Transmembrane 95 115 . . . Note=Helical%3B Name%3DHelix 3 P29972 UniProtKB Topological domain 116 136 . . . Note=Extracellular;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7507481;Dbxref=PMID:7507481 P29972 UniProtKB Transmembrane 137 155 . . . Note=Helical%3B Name%3DHelix 4 P29972 UniProtKB Topological domain 156 166 . . . Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7507481;Dbxref=PMID:7507481 P29972 UniProtKB Transmembrane 167 183 . . . Note=Helical%3B Name%3DHelix 5 P29972 UniProtKB Topological domain 184 186 . . . Note=Extracellular;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7507481;Dbxref=PMID:7507481 P29972 UniProtKB Intramembrane 187 192 . . . . P29972 UniProtKB Intramembrane 193 200 . . . Note=Helical%3B Name%3DHelix E P29972 UniProtKB Topological domain 201 207 . . . Note=Extracellular;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7507481;Dbxref=PMID:7507481 P29972 UniProtKB Transmembrane 208 228 . . . Note=Helical%3B Name%3DHelix 6 P29972 UniProtKB Topological domain 229 269 . . . Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7507481;Dbxref=PMID:7507481 P29972 UniProtKB Motif 76 78 . . . Note=NPA 1 P29972 UniProtKB Motif 192 194 . . . Note=NPA 2 P29972 UniProtKB Site 56 56 . . . Note=Substrate discrimination P29972 UniProtKB Site 180 180 . . . Note=Substrate discrimination P29972 UniProtKB Site 189 189 . . . Note=Hg(2+)-sensitive residue P29972 UniProtKB Site 195 195 . . . Note=Substrate discrimination P29972 UniProtKB Modified residue 247 247 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q02013 P29972 UniProtKB Modified residue 253 253 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q02013 P29972 UniProtKB Modified residue 262 262 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q02013 P29972 UniProtKB Glycosylation 42 42 . . . Note=N-linked (GlcNAc...) asparagine P29972 UniProtKB Glycosylation 205 205 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P29972 UniProtKB Alternative sequence 1 128 . . . ID=VSP_046679;Note=In isoform 3. MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLTGNSLGRND->MFWTFGYEAVSPAGPSHLFASLLLGVLLTITFMPGARPLPLVLVPQNTLAWMQLDAKAPAHPRPLQLLGRVGPGSRQ;Ontology_term=ECO:0000305;evidence=ECO:0000305 P29972 UniProtKB Alternative sequence 1 45 . . . ID=VSP_046109;Note=In isoform 2. MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTA->MPGARPLPLVLVPQNTLAWMQLDAKAPAHPRPLQLLGRVGPGSRQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P29972 UniProtKB Alternative sequence 1 13 . . . ID=VSP_046680;Note=In isoform 4. MASEFKKKLFWRA->MQSGMGWNVLDFW;Ontology_term=ECO:0000305;evidence=ECO:0000305 P29972 UniProtKB Alternative sequence 14 128 . . . ID=VSP_046681;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 P29972 UniProtKB Alternative sequence 46 128 . . . ID=VSP_046110;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P29972 UniProtKB Natural variant 38 38 . . . ID=VAR_013279;Note=In Co(A-B-) antigen%3B non functional AQP1%3B red cells show low osmotic water permeability. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7521540;Dbxref=dbSNP:rs104894004,PMID:7521540 P29972 UniProtKB Natural variant 45 45 . . . ID=VAR_004400;Note=In Co(A-B+) antigen. A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7521882,ECO:0000269|Ref.6;Dbxref=dbSNP:rs28362692,PMID:7521882 P29972 UniProtKB Natural variant 165 165 . . . ID=VAR_022318;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6;Dbxref=dbSNP:rs28362731 P29972 UniProtKB Sequence conflict 45 45 . . . Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 P29972 UniProtKB Helix 4 6 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7UZE P29972 UniProtKB Helix 8 32 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7UZE P29972 UniProtKB Helix 34 36 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7UZE P29972 UniProtKB Beta strand 38 40 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7UZE P29972 UniProtKB Helix 49 71 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7UZE P29972 UniProtKB Helix 77 85 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7UZE P29972 UniProtKB Helix 91 115 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7UZE P29972 UniProtKB Turn 116 118 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7UZE P29972 UniProtKB Beta strand 122 127 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6POJ P29972 UniProtKB Beta strand 131 133 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6POJ P29972 UniProtKB Helix 135 156 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7UZE P29972 UniProtKB Helix 168 187 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7UZE P29972 UniProtKB Helix 193 203 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7UZE P29972 UniProtKB Turn 207 210 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7UZE P29972 UniProtKB Helix 211 229 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7UZE P29972 UniProtKB Helix 238 247 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7UZE P29972 UniProtKB Beta strand 250 252 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6POJ P29972 UniProtKB Beta strand 259 261 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6POJ