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Protein

Myristoylated alanine-rich C-kinase substrate

Gene

MARCKS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.

GO - Molecular functioni

  • actin filament binding Source: ProtInc
  • calmodulin binding Source: ProtInc
  • identical protein binding Source: Ensembl
  • protein kinase C binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Calmodulin-binding

Enzyme and pathway databases

ReactomeiR-HSA-399997 Acetylcholine regulates insulin secretion
SIGNORiP29966

Names & Taxonomyi

Protein namesi
Recommended name:
Myristoylated alanine-rich C-kinase substrate
Short name:
MARCKS
Alternative name(s):
Protein kinase C substrate, 80 kDa protein, light chain
Short name:
80K-L protein
Short name:
PKCSL
Gene namesi
Name:MARCKS
Synonyms:MACS, PRKCSL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000277443.1
HGNCiHGNC:6759 MARCKS
MIMi177061 gene
neXtProtiNX_P29966

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4082
OpenTargetsiENSG00000277443
PharmGKBiPA30637

Polymorphism and mutation databases

BioMutaiMARCKS
DMDMi76803798

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001571482 – 332Myristoylated alanine-rich C-kinase substrateAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei26PhosphoserineCombined sources1
Modified residuei27PhosphoserineCombined sources1
Modified residuei29PhosphoserineCombined sources1
Modified residuei46PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei101PhosphoserineCombined sources1
Modified residuei118PhosphoserineCombined sources1
Modified residuei128PhosphoserineBy similarity1
Modified residuei135PhosphoserineCombined sources1
Modified residuei143PhosphothreonineCombined sources1
Modified residuei145PhosphoserineCombined sources1
Modified residuei147PhosphoserineCombined sources1
Modified residuei150PhosphothreonineCombined sources1
Modified residuei159Phosphoserine; by PKC1 Publication1
Modified residuei163Phosphoserine; by PKCCombined sources1 Publication1
Modified residuei167Phosphoserine; by PKCCombined sources1
Modified residuei170Phosphoserine; by PKCCombined sources1 Publication1
Modified residuei262PhosphoserineBy similarity1
Modified residuei314PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiP29966
MaxQBiP29966
PaxDbiP29966
PeptideAtlasiP29966
PRIDEiP29966
TopDownProteomicsiP29966

PTM databases

iPTMnetiP29966
PhosphoSitePlusiP29966
SwissPalmiP29966

Expressioni

Gene expression databases

BgeeiENSG00000277443
CleanExiHS_MARCKS
GenevisibleiP29966 HS

Organism-specific databases

HPAiCAB022062
HPA051913
HPA054820

Interactioni

GO - Molecular functioni

  • actin filament binding Source: ProtInc
  • calmodulin binding Source: ProtInc
  • identical protein binding Source: Ensembl
  • protein kinase C binding Source: Ensembl

Protein-protein interaction databases

BioGridi110257, 33 interactors
ELMiP29966
IntActiP29966, 17 interactors
MINTiP29966
STRINGi9606.ENSP00000357624

Structurei

3D structure databases

ProteinModelPortaliP29966
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni152 – 176Calmodulin-binding (PSD)Add BLAST25

Sequence similaritiesi

Belongs to the MARCKS family.Curated

Phylogenomic databases

eggNOGiENOG410J04K Eukaryota
ENOG4111SZ0 LUCA
GeneTreeiENSGT00730000111419
HOGENOMiHOG000113482
HOVERGENiHBG081955
InParanoidiP29966
KOiK12561
OMAiEPQPECS
OrthoDBiEOG091G1B6O
TreeFamiTF332815

Family and domain databases

InterProiView protein in InterPro
IPR002101 MARCKS
PANTHERiPTHR14353 PTHR14353, 1 hit
PfamiView protein in Pfam
PF02063 MARCKS, 1 hit
PRINTSiPR00963 MARCKS
PROSITEiView protein in PROSITE
PS00826 MARCKS_1, 1 hit
PS00827 MARCKS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29966-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAQFSKTAA KGEAAAERPG EAAVASSPSK ANGQENGHVK VNGDASPAAA
60 70 80 90 100
ESGAKEELQA NGSAPAADKE EPAAAGSGAA SPSAAEKGEP AAAAAPEAGA
110 120 130 140 150
SPVEKEAPAE GEAAEPGSPT AAEGEAASAA SSTSSPKAED GATPSPSNET
160 170 180 190 200
PKKKKKRFSF KKSFKLSGFS FKKNKKEAGE GGEAEAPAAE GGKDEAAGGA
210 220 230 240 250
AAAAAEAGAA SGEQAAAPGE EAAAGEEGAA GGDPQEAKPQ EAAVAPEKPP
260 270 280 290 300
ASDETKAAEE PSKVEEKKAE EAGASAAACE APSAAGPGAP PEQEAAPAEE
310 320 330
PAAAAASSAC AAPSQEAQPE CSPEAPPAEA AE
Length:332
Mass (Da):31,555
Last modified:January 23, 2007 - v4
Checksum:i0AB247801EF8FCBF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84A → S in BAA01392 (PubMed:1427823).Curated1
Sequence conflicti119P → A in BAA01392 (PubMed:1427823).Curated1
Sequence conflicti225G → R (PubMed:1396720).Curated1
Sequence conflicti234P → S in AAA59555 (PubMed:1860846).Curated1
Sequence conflicti235Q → E (PubMed:1396720).Curated1
Sequence conflicti287 – 308PGAPP…AAASS → LVCPRRGGSPRGGARGRRSL NQ in AAA59555 (PubMed:1860846).CuratedAdd BLAST22

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025825250P → L1 PublicationCorresponds to variant dbSNP:rs45593337Ensembl.1
Natural variantiVAR_025826274A → V1 PublicationCorresponds to variant dbSNP:rs3734458Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68956 mRNA Translation: AAA59555.1
M68955 Genomic DNA Translation: AAA59554.1
D10522 mRNA Translation: BAA01392.1
DQ341274 Genomic DNA Translation: ABC67467.1
AL132660 Genomic DNA Translation: CAI19942.1
CH471051 Genomic DNA Translation: EAW48258.1
CH471051 Genomic DNA Translation: EAW48259.1
BC089040 mRNA Translation: AAH89040.1
CCDSiCCDS5101.1
PIRiA38873
RefSeqiNP_002347.5, NM_002356.6
UniGeneiHs.519909
Hs.712658

Genome annotation databases

EnsembliENST00000612661; ENSP00000478061; ENSG00000277443
GeneIDi4082
KEGGihsa:4082
UCSCiuc032xir.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMARCS_HUMAN
AccessioniPrimary (citable) accession number: P29966
Secondary accession number(s): E1P560, Q2LA83, Q5TDB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 162 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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