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Protein

Heme exporter protein C

Gene

helC

Organism
Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. heme transporter activity Source: InterPro

GO - Biological processi

  1. cytochrome complex assembly Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cytochrome c-type biogenesis, Transport

Enzyme and pathway databases

BioCyciRCAP272942:GJIY-1812-MONOMER.

Protein family/group databases

TCDBi9.B.14.2.1. the putative heme handling protein (hhp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Heme exporter protein C
Alternative name(s):
Cytochrome c-type biogenesis protein HelC
Gene namesi
Name:helC
Synonyms:ccmC
Ordered Locus Names:RCAP_rcc01787
OrganismiRhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
Taxonomic identifieri272942 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
ProteomesiUP000002361 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121HelicalSequence AnalysisAdd
BLAST
Transmembranei61 – 8121HelicalSequence AnalysisAdd
BLAST
Transmembranei93 – 11321HelicalSequence AnalysisAdd
BLAST
Transmembranei127 – 14721HelicalSequence AnalysisAdd
BLAST
Transmembranei158 – 17821HelicalSequence AnalysisAdd
BLAST
Transmembranei201 – 22121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242Heme exporter protein CPRO_0000201560Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the CcmC/CycZ/HelC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000274637.
KOiK02195.
OMAiWNTLHQS.

Family and domain databases

InterProiIPR002541. Cyt_c_assembly.
IPR003557. Cyt_c_biogenesis_CcmC.
[Graphical view]
PANTHERiPTHR30071:SF4. PTHR30071:SF4. 1 hit.
PfamiPF01578. Cytochrom_C_asm. 1 hit.
[Graphical view]
PRINTSiPR01386. CCMCBIOGNSIS.
TIGRFAMsiTIGR01191. ccmC. 1 hit.

Sequencei

Sequence statusi: Complete.

P29961-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIWEYANPV KFMQTSGRLL PWVVAATVLT LLPGLVWGFF FTPVAAEFGA
60 70 80 90 100
TVKVIYVHVP AATLAINIWV MMLVASLIWL IRRHHVSALA AKAAAPIGMV
110 120 130 140 150
MTLIALITGA FWGQPMWGTW WEWDPRLTSF LILFLFYLGY MALWEAIENP
160 170 180 190 200
DTAADLTGVL CLVGSVFAVL SRYAAIFWNQ GLHQGSTLSL DKEEHIADVY
210 220 230 240
WQPLVLSIAG FGMLFVALLL LRTRTEIRAR RLKALEQRER MA
Length:242
Mass (Da):27,196
Last modified:April 1, 1993 - v1
Checksum:i2966C2BC5160A663
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63462 Genomic DNA. Translation: CAA45063.1.
CP001312 Genomic DNA. Translation: ADE85532.1.
PIRiS23665.
RefSeqiYP_003577939.1. NC_014034.1.

Genome annotation databases

EnsemblBacteriaiADE85532; ADE85532; RCAP_rcc01787.
KEGGircp:RCAP_rcc01787.
PATRICi35503720. VBIRhoCap134200_1818.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63462 Genomic DNA. Translation: CAA45063.1.
CP001312 Genomic DNA. Translation: ADE85532.1.
PIRiS23665.
RefSeqiYP_003577939.1. NC_014034.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi9.B.14.2.1. the putative heme handling protein (hhp) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADE85532; ADE85532; RCAP_rcc01787.
KEGGircp:RCAP_rcc01787.
PATRICi35503720. VBIRhoCap134200_1818.

Phylogenomic databases

HOGENOMiHOG000274637.
KOiK02195.
OMAiWNTLHQS.

Enzyme and pathway databases

BioCyciRCAP272942:GJIY-1812-MONOMER.

Family and domain databases

InterProiIPR002541. Cyt_c_assembly.
IPR003557. Cyt_c_biogenesis_CcmC.
[Graphical view]
PANTHERiPTHR30071:SF4. PTHR30071:SF4. 1 hit.
PfamiPF01578. Cytochrom_C_asm. 1 hit.
[Graphical view]
PRINTSiPR01386. CCMCBIOGNSIS.
TIGRFAMsiTIGR01191. ccmC. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC BAA-309 / NBRC 16581 / SB1003.
  2. "Complete genome sequence of the photosynthetic purple nonsulfur bacterium Rhodobacter capsulatus SB 1003."
    Strnad H., Lapidus A., Paces J., Ulbrich P., Vlcek C., Paces V., Haselkorn R.
    J. Bacteriol. 192:3545-3546(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-309 / NBRC 16581 / SB1003.

Entry informationi

Entry nameiCCMC_RHOCB
AccessioniPrimary (citable) accession number: P29961
Secondary accession number(s): D5AU93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 29, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.