P29961 (CCMC_RHOCB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heme exporter protein C

Alternative name(s):
Cytochrome c-type biogenesis protein HelC

Gene names

Name:	helC
Synonyms:	ccmC
Ordered Locus Names:	RCAP_rcc01787

Organism

Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) [Complete proteome] [HAMAP]

Taxonomic identifier

272942 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter › Rhodobacter capsulatus

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
Subcellular location	Cell inner membrane; Multi-pass membrane protein Probable.
Sequence similarities	Belongs to the CcmC/CycZ/HelC family.

Ontologies

Keywords
Biological process	Cytochrome c-type biogenesis Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cytochrome complex assembly Inferred from electronic annotation. Source: UniProtKB-KW respiratory chain complex IV assembly Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	heme transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	Heme exporter protein C		PRO_0000201560
Regions
	Transmembrane	21 – 41	21	Helical; Potential
	Transmembrane	61 – 81	21	Helical; Potential
	Transmembrane	93 – 113	21	Helical; Potential
	Transmembrane	127 – 147	21	Helical; Potential
	Transmembrane	158 – 178	21	Helical; Potential
	Transmembrane	201 – 221	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P29961 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 2966C2BC5160A663	FASTA	242	27,196
	10 20 30 40 50 60 MSIWEYANPV KFMQTSGRLL PWVVAATVLT LLPGLVWGFF FTPVAAEFGA TVKVIYVHVP 70 80 90 100 110 120 AATLAINIWV MMLVASLIWL IRRHHVSALA AKAAAPIGMV MTLIALITGA FWGQPMWGTW 130 140 150 160 170 180 WEWDPRLTSF LILFLFYLGY MALWEAIENP DTAADLTGVL CLVGSVFAVL SRYAAIFWNQ 190 200 210 220 230 240 GLHQGSTLSL DKEEHIADVY WQPLVLSIAG FGMLFVALLL LRTRTEIRAR RLKALEQRER MA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Bacterial cytochromes c biogenesis." Beckman D.L., Trawick D.R., Kranz R.G. Genes Dev. 6:268-283(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC BAA-309 / NBRC 16581 / SB1003.
[2]	"Complete genome sequence of the photosynthetic purple nonsulfur bacterium Rhodobacter capsulatus SB 1003." Strnad H., Lapidus A., Paces J., Ulbrich P., Vlcek C., Paces V., Haselkorn R. J. Bacteriol. 192:3545-3546(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-309 / NBRC 16581 / SB1003.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X63462 Genomic DNA. Translation: CAA45063.1. CP001312 Genomic DNA. Translation: ADE85532.1.
PIR	S23665.
RefSeq	YP_003577939.1. NC_014034.1.
3D structure databases
ModBase	Search...
Protein family/group databases
TCDB	9.B.14.2.1. putative heme handling protein (HHP) family.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADE85532; ADE85532; RCAP_rcc01787.
GeneID	9004610.
KEGG	rcp:RCAP_rcc01787.
PATRIC	35503720. VBIRhoCap134200_1818.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000274637.
KO	K02195.
OMA	YVHVPSA.
ProtClustDB	CLSK933833.
Enzyme and pathway databases
BioCyc	RCAP272942:GJIY-1812-MONOMER.
Family and domain databases
InterPro	IPR002541. Cyt_c_assembly. IPR003557. Cyt_c_biogenesis_CcmC. [Graphical view]
Pfam	PF01578. Cytochrom_C_asm. 1 hit. [Graphical view]
PRINTS	PR01386. CCMCBIOGNSIS.
TIGRFAMs	TIGR01191. ccmC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CCMC_RHOCB

Accession

Primary (citable) accession number: P29961
Secondary accession number(s): D5AU93

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program