P29959 (CCMA_RHOCB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c biogenesis ATP-binding export protein CcmA
EC=3.6.3.41

Alternative name(s):
Cytochrome c-type biogenesis ATP-binding protein HelA
Heme exporter protein A

Gene names

Name:	ccmA
Synonyms:	helA
Ordered Locus Names:	RCAP_rcc01785

Organism

Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) [Complete proteome] [HAMAP]

Taxonomic identifier

272942 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length	214 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system By similarity. HAMAP MF_01707
Catalytic activity	ATP + H2O + heme(In) = ADP + phosphate + heme(Out). HAMAP MF_01707
Subunit structure	The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB) By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_01707.
Sequence similarities	Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification] Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Cytochrome c-type biogenesis Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cytochrome complex assembly Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW heme-transporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 214	214	Cytochrome c biogenesis ATP-binding export protein CcmA HAMAP MF_01707		PRO_0000092203
Regions
	Domain	4 – 214	211	ABC transporter
	Nucleotide binding	36 – 43	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P29959 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 16B24318741938FA	FASTA	214	22,169
	10 20 30 40 50 60 MTLLAVDQLT VSRGGLAVLE GVSFSLAAGH ALVLRGPNGI GKTTLLRTLA GLQPPLAGRV 70 80 90 100 110 120 SMPPEGIAYA AHADGLKATL SVRENLQFWA AIHATDTVET ALARMNLNAL EHRAAASLSA 130 140 150 160 170 180 GQKRRLGLAR LLVTGRPVWV LDEPTVSLDA ASVALFAEAV RAHLAAGGAA LMATHIDLGL 190 200 210 SEARVLDLAP FKARPPEAGG HRGAFDHGFD GAFL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Bacterial cytochromes c biogenesis." Beckman D.L., Trawick D.R., Kranz R.G. Genes Dev. 6:268-283(1992) [PubMed: 1310666] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC BAA-309 / NBRC 16581 / SB1003.
[2]	"Complete genome sequence of the photosynthetic purple nonsulfur bacterium Rhodobacter capsulatus SB 1003." Strnad H., Lapidus A., Paces J., Ulbrich P., Vlcek C., Paces V., Haselkorn R. J. Bacteriol. 192:3545-3546(2010) [PubMed: 20418398] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-309 / NBRC 16581 / SB1003.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X63462 Genomic DNA. Translation: CAA45061.1. CP001312 Genomic DNA. Translation: ADE85530.1.
PIR	S23663.
RefSeq	YP_003577937.1. NC_014034.1.
3D structure databases
ProteinModelPortal	P29959.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9004608.
GenomeReviews	Gene locus RCAP_rcc01785 in contig CP001312_GR.
KEGG	rcp:RCAP_rcc01785.
PATRIC	35503716. VBIRhoCap134200_1816.
Organism-specific databases
CMR	Search...
Phylogenomic databases
ProtClustDB	PRK13539.
Family and domain databases
HAMAP	MF_01707. ABC_ATPase_CcmA. [Tree]
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR005895. ABC_transptr_haem_export_CcmA. IPR003593. ATPase_AAA+_core. [Graphical view]
KO	K02193.
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01189. CcmA. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51243. CCMA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCMA_RHOCB

Accession

Primary (citable) accession number: P29959
Secondary accession number(s): D5AU91

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program