ID   MANA_RHIME              Reviewed;         387 AA.
AC   P29954;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   27-MAR-2024, entry version 113.
DE   RecName: Full=Mannose-6-phosphate isomerase;
DE            EC=5.3.1.8;
DE   AltName: Full=Phosphohexomutase;
DE   AltName: Full=Phosphomannose isomerase;
DE            Short=PMI;
GN   Name=pmi; OrderedLocusNames=R02982; ORFNames=SMc03111;
OS   Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS   meliloti).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=266834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=RCR2011 / SU47;
RX   PubMed=1452036; DOI=10.1016/0378-1119(92)90029-o;
RA   Schmidt M., Arnold W., Niemann A., Kleickmann A., Puehler A.;
RT   "The Rhizobium meliloti pmi gene encodes a new type of phosphomannose
RT   isomerase.";
RL   Gene 122:35-43(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11481430; DOI=10.1073/pnas.161294398;
RA   Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA   Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA   Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA   Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA   Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT   "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT   meliloti strain 1021.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11474104; DOI=10.1126/science.1060966;
RA   Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA   Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA   Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA   Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA   Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA   Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA   Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA   Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA   Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA   Wong K., Yeh K.-C., Batut J.;
RT   "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL   Science 293:668-672(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-mannose 6-phosphate = D-fructose 6-phosphate;
CC         Xref=Rhea:RHEA:12356, ChEBI:CHEBI:58735, ChEBI:CHEBI:61527;
CC         EC=5.3.1.8;
CC   -!- SIMILARITY: Belongs to the N-acylglucosamine 2-epimerase family.
CC       {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-3 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; M96584; AAA26356.1; -; Genomic_DNA.
DR   EMBL; AL591688; CAC47561.1; -; Genomic_DNA.
DR   RefSeq; NP_387088.1; NC_003047.1.
DR   RefSeq; WP_010970332.1; NC_003047.1.
DR   AlphaFoldDB; P29954; -.
DR   SMR; P29954; -.
DR   EnsemblBacteria; CAC47561; CAC47561; SMc03111.
DR   GeneID; 61604447; -.
DR   KEGG; sme:SMc03111; -.
DR   PATRIC; fig|266834.11.peg.4508; -.
DR   eggNOG; COG2942; Bacteria.
DR   HOGENOM; CLU_046651_1_0_5; -.
DR   OrthoDB; 9806359at2; -.
DR   Proteomes; UP000001976; Chromosome.
DR   GO; GO:0004476; F:mannose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd00249; AGE; 1.
DR   Gene3D; 1.50.10.10; -; 1.
DR   InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR   InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR   InterPro; IPR010819; AGE/CE.
DR   InterPro; IPR034116; AGE_dom.
DR   PANTHER; PTHR15108:SF0; N-ACYLGLUCOSAMINE 2-EPIMERASE; 1.
DR   PANTHER; PTHR15108; N-ACYLGLUCOSAMINE-2-EPIMERASE; 1.
DR   Pfam; PF07221; GlcNAc_2-epim; 1.
DR   SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..387
FT                   /note="Mannose-6-phosphate isomerase"
FT                   /id="PRO_0000208953"
SQ   SEQUENCE   387 AA;  43489 MW;  334893FF7F9B3E95 CRC64;
     MGMDIHLQAG ELAGWLNDAA LPLWRQKGFD GEGGGFVETI DMKGEPTRDD RRSRVQPRQV
     YCFAAAGRRG WDGDWRTAAE GGLLYFDRVY GQPGGFYGAL ANADGKLIDA SFDLYNQAFA
     LLAFAHLAEV LPERGAEMVG RSDKLRRQLE ARCKHPLAGF EEDDPPRLPL GSNPHMHLFE
     ACLASEEVEG FDRVAWANLA DEIAHLAMDR FIDAESGALR EFFDHDWAPF PGEKGRIVEP
     GHLFEWAWLL LRWAERRGNA QAIVKARRLF EIGEKDGTCP DRDVVVMTLF DDFSVADPTA
     RLWPQTEWLK AAIRFAALTE GAERERYLAS AGRAAAALQR FLNVPVRGLW RDKQKADGSF
     VEEPAPASTF YHILCAIYEL EDCLKRM
//