Reviewed, UniProtKB/Swiss-Prot P29954 (MANA_RHIME)

Names and origin

Protein names

Recommended name:
    Mannose-6-phosphate isomerase
    EC=5.3.1.8
Alternative name(s):
    Phosphomannose isomerase
      Short name=PMI
    Phosphohexomutase

Gene names

Name:	pmi
Ordered Locus Names:	R02982
ORF Names:	SMc03111

Organism

Rhizobium meliloti (Sinorhizobium meliloti) [Complete proteome] [HAMAP]

Taxonomic identifier

382 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length	387 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannose 6-phosphate = D-fructose 6-phosphate.
Sequence similarities	Belongs to the N-acylglucosamine 2-epimerase family.
Caution	It is uncertain whether Met-1 or Met-3 is the initiator.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mannose metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 387	387	Mannose-6-phosphate isomerase		PRO_0000208953

Sequences

	Sequence		Length	Mass (Da)
	P29954-1 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 334893FF7F9B3E95	FASTA	387	43,489
	10 20 30 40 50 60 MGMDIHLQAG ELAGWLNDAA LPLWRQKGFD GEGGGFVETI DMKGEPTRDD RRSRVQPRQV 70 80 90 100 110 120 YCFAAAGRRG WDGDWRTAAE GGLLYFDRVY GQPGGFYGAL ANADGKLIDA SFDLYNQAFA 130 140 150 160 170 180 LLAFAHLAEV LPERGAEMVG RSDKLRRQLE ARCKHPLAGF EEDDPPRLPL GSNPHMHLFE 190 200 210 220 230 240 ACLASEEVEG FDRVAWANLA DEIAHLAMDR FIDAESGALR EFFDHDWAPF PGEKGRIVEP 250 260 270 280 290 300 GHLFEWAWLL LRWAERRGNA QAIVKARRLF EIGEKDGTCP DRDVVVMTLF DDFSVADPTA 310 320 330 340 350 360 RLWPQTEWLK AAIRFAALTE GAERERYLAS AGRAAAALQR FLNVPVRGLW RDKQKADGSF 370 380 VEEPAPASTF YHILCAIYEL EDCLKRM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Rhizobium meliloti pmi gene encodes a new type of phosphomannose isomerase." Schmidt M., Arnold W., Niemann A., Kleickmann A., Puehler A. Gene 122:35-43(1992) [PubMed: 1452036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: RCR2011 / SU47.
[2]	"Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021." Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D. , Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F. Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001) [PubMed: 11481430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1021.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M96584 Genomic DNA. Translation: AAA26356.1. AL591688 Genomic DNA. Translation: CAC47561.1.
RefSeq	NP_387088.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1234665.
GenomeReviews	Gene locus R02982 in contig AL591688_GR.
KEGG	sme:SMc03111.
NMPDR	fig|266834.1.peg.4276.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P29954.
OMA	PASSFYH.
Enzyme and pathway databases
BioCyc	SMEL266834:SMC03111-MON.
BRENDA	5.3.1.8. 142.
Family and domain databases
InterPro	IPR012341. 6hp_glycosidase. IPR010819. AGE/RnBP. [Graphical view]
Gene3D	G3DSA:1.50.10.10. CelA/Cel48F_cat. 1 hit.
Pfam	PF07221. GlcNAc_2-epim. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MANA_RHIME

Accession

Primary (citable) accession number: P29954

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	November 3, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)