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P29951

- MPI_EMENI

UniProt

P29951 - MPI_EMENI

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Protein

Mannose-6-phosphate isomerase

Gene

manA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi107 – 1071ZincBy similarity
Metal bindingi109 – 1091ZincBy similarity
Metal bindingi134 – 1341ZincBy similarity
Metal bindingi291 – 2911ZincBy similarity
Active sitei310 – 3101By similarity

GO - Molecular functioni

  1. mannose-6-phosphate isomerase activity Source: ASPGD
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell wall mannoprotein biosynthetic process Source: ASPGD
  2. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
  3. hyphal growth Source: ASPGD
  4. protein glycosylation Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00126; UER00423.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Name:manA
ORF Names:AN0667
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome VIII

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Mannose-6-phosphate isomerasePRO_0000194244Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00002007.

Structurei

3D structure databases

ProteinModelPortaliP29951.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1482.
HOGENOMiHOG000241277.
InParanoidiP29951.
KOiK01809.
OMAiPYAEFWV.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR10309. PTHR10309. 1 hit.
PfamiPF01238. PMI_typeI. 1 hit.
[Graphical view]
PIRSFiPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSiPR00714. MAN6PISMRASE.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR00218. manA. 1 hit.
PROSITEiPS00965. PMI_I_1. 1 hit.
PS00966. PMI_I_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29951-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQVPLLRLQC GVNSYDWGRV GPESAAAKYA AATAPSDFTI EADKPYAELW
60 70 80 90 100
MGTHPSLPSK DVETQRTLLD MVQDNLALMS PEVSERYGGK LPFLFKVLSI
110 120 130 140 150
RKALSIQAHP NKKLAEALHA RDPRNYPDDN HKPEMTIAIT PFEGLCGFRP
160 170 180 190 200
LAEIVHFLKA VAPLRYLIGV QTATDFENAV RGFENTEDPE QTKKNKVALR
210 220 230 240 250
TLFTSLMQSA SENIEQAARE LVAAAQSSPE TFASLVNAPD TNPTNAAELA
260 270 280 290 300
SIIIRLNEQF PNDIGLFVFF FLNFVRLEPG EAMFLKADDI HAYISGDIIE
310 320 330 340 350
CMASSDNVVR AGFTPKFKDV DTLTEMLTYS YAPIDEQKLQ PTDYPYTVLN
360 370 380 390 400
AAAYSSASDS LLYDPPIEEF SVVKTSLRRT GAKATFDPLT GPSILICTGG
410 420 430 440 450
TGKISVGHKT EEVKEGYVFF VGANAECIIE NTGTGSDEEN VFTTFKAFCD
460
LTGKEDMANG H
Length:461
Mass (Da):50,613
Last modified:May 1, 2007 - v2
Checksum:i17E0D089A6656F79
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191R → K in AAA33319. (PubMed:8307007)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85239 Genomic DNA. Translation: AAA33319.1.
AACD01000010 Genomic DNA. Translation: EAA65443.1.
BN001308 Genomic DNA. Translation: CBF89025.1.
PIRiA56239.
RefSeqiXP_658271.1. XM_653179.1.

Genome annotation databases

EnsemblFungiiCADANIAT00002007; CADANIAP00002007; CADANIAG00002007.
GeneIDi2876445.
KEGGiani:AN0667.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85239 Genomic DNA. Translation: AAA33319.1 .
AACD01000010 Genomic DNA. Translation: EAA65443.1 .
BN001308 Genomic DNA. Translation: CBF89025.1 .
PIRi A56239.
RefSeqi XP_658271.1. XM_653179.1.

3D structure databases

ProteinModelPortali P29951.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00002007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00002007 ; CADANIAP00002007 ; CADANIAG00002007 .
GeneIDi 2876445.
KEGGi ani:AN0667.2.

Phylogenomic databases

eggNOGi COG1482.
HOGENOMi HOG000241277.
InParanoidi P29951.
KOi K01809.
OMAi PYAEFWV.

Enzyme and pathway databases

UniPathwayi UPA00126 ; UER00423 .

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR10309. PTHR10309. 1 hit.
Pfami PF01238. PMI_typeI. 1 hit.
[Graphical view ]
PIRSFi PIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSi PR00714. MAN6PISMRASE.
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR00218. manA. 1 hit.
PROSITEi PS00965. PMI_I_1. 1 hit.
PS00966. PMI_I_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Purification, cDNA cloning and heterologous expression of human phosphomannose isomerase."
    Proudfoot A.E.I., Turcatti G., Wells T.N.C., Payton M.A., Smith D.J.
    Eur. J. Biochem. 219:415-423(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiMPI_EMENI
AccessioniPrimary (citable) accession number: P29951
Secondary accession number(s): C8VRS9, Q5BFL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: May 1, 2007
Last modified: November 26, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3