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P29946

- CBIA_SALTY

UniProt

P29946 - CBIA_SALTY

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Protein

Cobyrinic acid A,C-diamide synthase

Gene
cbiA, STM2035
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH2 groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei334 – 3341Nucleophile By similarity
Active sitei438 – 4381 By similarity

GO - Molecular functioni

  1. cobalamin-transporting ATPase activity Source: UniProtKB-HAMAP
  2. cobyrinic acid a,c-diamide synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cobalamin biosynthetic process Source: UniProtKB-HAMAP
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Cobalamin biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13217.
SENT99287:GCTI-2047-MONOMER.
SABIO-RKP29946.
UniPathwayiUPA00148; UER00231.

Names & Taxonomyi

Protein namesi
Recommended name:
Cobyrinic acid A,C-diamide synthase
Gene namesi
Name:cbiA
Ordered Locus Names:STM2035
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 459459Cobyrinic acid A,C-diamide synthaseUniRule annotationPRO_0000141269Add
BLAST

Proteomic databases

PaxDbiP29946.
PRIDEiP29946.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM2035.

Structurei

3D structure databases

ProteinModelPortaliP29946.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini252 – 446195GATase cobBQ-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG1797.
HOGENOMiHOG000289958.
KOiK02224.
OMAiVATYMHM.
OrthoDBiEOG6X6R8V.
PhylomeDBiP29946.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.880. 1 hit.
HAMAPiMF_00027. CobB.
InterProiIPR004484. CbiA_synth.
IPR029062. Class_I_gatase-like.
IPR017929. CobB/CobQ_GATase.
IPR002586. CobQ/CobB/MinD/ParA_Nub-bd_dom.
IPR011698. GATase_3.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01656. CbiA. 1 hit.
PF07685. GATase_3. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00379. cobB. 1 hit.
PROSITEiPS51274. GATASE_COBBQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29946-1 [UniParc]FASTAAdd to Basket

« Hide

MAARHHAFIL AGTGSGCGKT TVTLGLLRLL QKRALRVQPF KVGPDYLDTG    50
WHTAICGVAS RNLDSFMLPP PVLNALFCEQ MRQADIAVIE GVMGLYDGYG 100
VDPNYCSTAA MAKQLGCPVI LLVDGKAVST SLAATVMGFQ HFDPTLNLAG 150
VIVNRVTSDA HYQLLKNAIE HYCSLPVLGY VPPCDGVALP ERHLGLITAR 200
ESLVNQQSWH DFAATLEQTV DVDALLSLSV LSALPAGMWP ERPDNTAGAG 250
LTLALADDEA FNFYYPDNID LLERAGVNIV RFSPLHDRAL PDCQMIWLGG 300
GYPELYAADL AANTVMLKHL RAAHQRGVAI YAECGGLMYL GSTLEDSGGE 350
IHQMANIIPG HSKMGKRLTR FGYCEAQAMQ PTLLAAPGEI VRGHEFHYSD 400
FIPETPAVMA CRKVRDGRVL QEWTGGWQTG NTFASYLHVH FAQRPEMLQH 450
WLAAARRVL 459
Length:459
Mass (Da):50,037
Last modified:January 23, 2002 - v3
Checksum:iE1FEF1B5A37F5C14
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti36 – 361R → P in AAA27252. 1 Publication
Sequence conflicti111 – 1111M → I in AAA27252. 1 Publication
Sequence conflicti128 – 1281V → I in AAA27252. 1 Publication
Sequence conflicti133 – 1331A → T in AAA27252. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L12006 Genomic DNA. Translation: AAA27252.1.
AE006468 Genomic DNA. Translation: AAL20939.1.
X63012 Genomic DNA. Translation: CAA44740.1.
PIRiS20553.
RefSeqiNP_460980.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20939; AAL20939; STM2035.
GeneIDi1253556.
KEGGistm:STM2035.
PATRICi32382653. VBISalEnt20916_2157.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L12006 Genomic DNA. Translation: AAA27252.1 .
AE006468 Genomic DNA. Translation: AAL20939.1 .
X63012 Genomic DNA. Translation: CAA44740.1 .
PIRi S20553.
RefSeqi NP_460980.1. NC_003197.1.

3D structure databases

ProteinModelPortali P29946.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM2035.

Proteomic databases

PaxDbi P29946.
PRIDEi P29946.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL20939 ; AAL20939 ; STM2035 .
GeneIDi 1253556.
KEGGi stm:STM2035.
PATRICi 32382653. VBISalEnt20916_2157.

Phylogenomic databases

eggNOGi COG1797.
HOGENOMi HOG000289958.
KOi K02224.
OMAi VATYMHM.
OrthoDBi EOG6X6R8V.
PhylomeDBi P29946.

Enzyme and pathway databases

UniPathwayi UPA00148 ; UER00231 .
BioCyci MetaCyc:MONOMER-13217.
SENT99287:GCTI-2047-MONOMER.
SABIO-RK P29946.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
3.40.50.880. 1 hit.
HAMAPi MF_00027. CobB.
InterProi IPR004484. CbiA_synth.
IPR029062. Class_I_gatase-like.
IPR017929. CobB/CobQ_GATase.
IPR002586. CobQ/CobB/MinD/ParA_Nub-bd_dom.
IPR011698. GATase_3.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01656. CbiA. 1 hit.
PF07685. GATase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF52317. SSF52317. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00379. cobB. 1 hit.
PROSITEi PS51274. GATASE_COBBQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium."
    Roth J.R., Lawrence J.G., Rubenfield M., Kieffer-Higgins S., Church G.M.
    J. Bacteriol. 175:3303-3316(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LT2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  3. "Cobalamin (vitamin B12) repression of the Cob operon in Salmonella typhimurium requires sequences within the leader and the first translated open reading frame."
    Richter-Dahlfors A.A., Andersson D.I.
    Mol. Microbiol. 6:743-749(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-106.
    Strain: LT2.

Entry informationi

Entry nameiCBIA_SALTY
AccessioniPrimary (citable) accession number: P29946
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2002
Last modified: July 9, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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