P29937 (COBW_PSEDE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein CobW

Gene names

Name:

cobW

Organism

Pseudomonas denitrificans

Taxonomic identifier

43306 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Might be involved in cobalt reduction leading to cobalt(I) corrinoids.
Pathway	Cofactor biosynthesis; adenosylcobalamin biosynthesis.
Sequence similarities	Belongs to the CobW family. Contains 1 cobW C-terminal domain.

Ontologies

Keywords
Biological process	Cobalamin biosynthesis Porphyrin biosynthesis
Ligand	ATP-binding Nucleotide-binding
Gene Ontology (GO)
Biological process	cobalamin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 354	353	Protein CobW		PRO_0000089999
Regions
	Domain	261 – 354	94	CobW C-terminal
	Nucleotide binding	18 – 25	8	ATP Potential
	Nucleotide binding	80 – 84	5	ATP Potential
	Nucleotide binding	188 – 191	4	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P29937 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: B6CE32F0CB04889B	FASTA	354	38,121
	10 20 30 40 50 60 MTTARANQGK IPATVITGFL GAGKTTMIRN LLQNADGKRI GLIINEFGDL GVDGDVLKGC 70 80 90 100 110 120 GAEACTEDDI IELTNGCICC TVADDFIPTM TKLLERENRP DHIIIETSGL ALPQPLIAAF 130 140 150 160 170 180 NWPDIRSEVT VDGVVTVVDS AAVAAGRFAD DHDKVDALRV EDDNLDHESP IEELFEDQLT 190 200 210 220 230 240 AADLIVLNKT DLIDASGLKA VRDEVSSRTS RKPTMIEAKN GEVAAAILLG LGVGTESDIA 250 260 270 280 290 300 NRKSHHEMEH EAGEEHDHDE FDSFVVELGS IADPAAFIDR LKGVIAEHDV LRLKGFADVP 310 320 330 340 350 GKPMRLLIQA VGARIDQYYD RAWGAGEKRG TRLVVIGLHD MDEAAVRAAI TALV

References

[1]

"Nucleotide sequence and genetic analysis of a 13.1-kilobase-pair Pseudomonas denitrificans DNA fragment containing five cob genes and identification of structural genes encoding Cob(I)alamin adenosyltransferase, cobyric acid synthase, and bifunctional cobinamide kinase-cobinamide phosphate guanylyltransferase." Crouzet J., Levy-Schil S., Cameron B., Cauchois L., Rigault S., Rouyez M.-C., Blanche F., Debussche L., Thibaut D. J. Bacteriol. 173:6074-6087(1991) [PubMed: 1655697] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M62866 Genomic DNA. Translation: AAA25779.1.
3D structure databases
ProteinModelPortal	P29937.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR012824. Cbl_biosynth_CobW. IPR003495. Cbl_biosynth_CobW-like. IPR011629. Cbl_biosynth_CobW-like_C. [Graphical view]
Gene3D	G3DSA:3.30.1220.10. Cbl_biosynth_CobW-like_C. 1 hit.
PANTHER	PTHR13748:SF10. PTHR13748:SF10. 1 hit.
Pfam	PF02492. cobW. 1 hit. PF07683. CobW_C. 1 hit. [Graphical view]
SMART	SM00833. CobW_C. 1 hit. [Graphical view]
SUPFAM	SSF90002. Cbl_biosynth_CobW-like_C. 1 hit.
TIGRFAMs	TIGR02475. CobW. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COBW_PSEDE

Accession

Primary (citable) accession number: P29937

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	January 23, 2007
Last modified:	October 19, 2011
This is version 54 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program