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Protein

NADH-quinone oxidoreductase chain 12

Gene

nqo12

Organism
Paracoccus denitrificans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, Ubiquinone

Protein family/group databases

TCDBi3.D.1.2.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase chain 12 (EC:1.6.5.11)
Alternative name(s):
NADH dehydrogenase I, chain 12
NDH-1, chain 12
Gene namesi
Name:nqo121 Publication
OrganismiParacoccus denitrificans
Taxonomic identifieri266 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Transmembranei325 – 345HelicalSequence analysisAdd BLAST21
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Transmembranei415 – 435HelicalSequence analysisAdd BLAST21
Transmembranei475 – 495HelicalSequence analysisAdd BLAST21
Transmembranei580 – 600HelicalSequence analysisAdd BLAST21
Transmembranei679 – 699HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001182111 – 703NADH-quinone oxidoreductase chain 12Add BLAST703

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of at least 14 different subunits, Nqo1 to Nqo14. The complex has a L-shaped structure, with the hydrophobic arm (subunits Nqo7, Nqo8, Nqo10 to Nqo14) embedded in the inner membrane and the hydrophilic peripheral arm (subunits Nqo1 to Nqo6, Nqo9) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D65. Bacteria.
COG1009. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR003945. NADHpl_OxRdtase_5.
IPR018393. NADHpl_OxRdtase_5_subgr.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
PfamiView protein in Pfam
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
PRINTSiPR01435. NPOXDRDTASE5.
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.

Sequencei

Sequence statusi: Complete.

P29924-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKFVLFAPL IASLIAGLGW RAIGEKAAQY LTTGVLFLSC LISWYLFLSF
60 70 80 90 100
DGVPRHIPVL DWVVTGDFHA EWAIRLDRLT AIMLIVVTTV SALVHMYSLG
110 120 130 140 150
YMAHDDNWTH DEHYKARFFA YLSFFTFAML MLVTADNLLQ MFFGWEGVGV
160 170 180 190 200
ASYLLIGFYY KKASANAAAM KAFIVNRVGD FGFLLGIFGI YWLTGSVQFD
210 220 230 240 250
EIFRQVPQLA QTEIDFLWRD WNAANLLGFL LFVGAMGKSA QLLLHTWLPD
260 270 280 290 300
AMEGPTPVSA LIHAATMVTA GVFLVCRMSP LYEFAPDAKN FIVIIGATTA
310 320 330 340 350
FFAATVGLVQ NDIKRVIAYS TCSQLGYMFV AAGVGVYSAA MFHLLTHAFF
360 370 380 390 400
KAMLFLGAGS VIHAMHHEQD MRNYGGLRKK IPLTFWAMMI GTFAITGVGI
410 420 430 440 450
PLTHLGFAGF LSKDAIIESA YAGSGYAFWL LVIAACFTSF YSWRLIFLTF
460 470 480 490 500
YGKPRGDHHA HDHAHESPPV MTIPLGVLAI GAVFAGMVWY GPFFGDHHKV
510 520 530 540 550
TEYFHIAGAH HEAAEGEEAE HATAEAPVEH AVADTATAEG EAAAEAEHAE
560 570 580 590 600
IAAPVGGAIY MHPDNHIMDE AHHAPAWVKV SPFVAMVLGL ITAWTFYIAN
610 620 630 640 650
PSLPRRLAAH EPALYRFLLN KWYFDEIYEF IFVRPAKWLG RVLWKGGDGA
660 670 680 690 700
VIDGTINGVA MGLIPRLTRA AVRVQSGYLF HYAFAMVLGI VGLLIWVMMR

GAH
Length:703
Mass (Da):77,706
Last modified:April 1, 1993 - v1
Checksum:i433993D4081B14CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02354 Genomic DNA. Translation: AAA25598.1.
PIRiH45456.

Similar proteinsi

Entry informationi

Entry nameiNQO12_PARDE
AccessioniPrimary (citable) accession number: P29924
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 5, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families